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Skin of Color

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161. MKSAP: 25-year-old man with dark-colored urine

MKSAP: 25-year-old man with dark-colored urine Poststreptococcal glomerulonephritis is characterized these preceding symptoms MKSAP: 25-year-old man with dark-colored urine | | August 25, 2018 1 Shares Test your medicine knowledge with the , in partnership with the . A 25-year-old man is evaluated for dark-colored urine for 2 days, swelling of the face and hands for 1 day, and severe headaches this morning. He reports having an upper respiratory tract infection 1 week ago with fever, sore (...) throat, and swollen glands, but had otherwise felt well. Medical history is otherwise unremarkable, and he takes no medications. On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 180/90 mm Hg, pulse rate is 88/min, and respiration rate is 14/min. Cardiopulmonary and abdominal examinations are normal. No skin rash or arthritis is present. There is bilateral lower extremity edema to the mid shins. Laboratory studies: Albumin 3.3 g/dL (33 g/L) C3 Low C4 Normal Creatinine 1.4

2018 KevinMD blog

162. Molecular Phylogeography of a Human Autosomal Skin Color Locus Under Natural Selection Full Text available with Trip Pro

Molecular Phylogeography of a Human Autosomal Skin Color Locus Under Natural Selection Divergent natural selection caused by differences in solar exposure has resulted in distinctive variations in skin color between human populations. The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry. To gain insight into when and where this mutation arose, we defined common haplotypes in the genomic region around SLC24A5 across diverse

2013 G3: Genes|Genomes|Genetics

163. Melanocortin 1 Receptor And Skin Pathophysiology: Beyond Color, Much More Than Meets The Eye. (Abstract)

Melanocortin 1 Receptor And Skin Pathophysiology: Beyond Color, Much More Than Meets The Eye. The melanocortin 1 receptor (MC1R), a G protein-coupled receptor preferentially expressed in melanocytes, mediates the pigmentary effects of α melanocyte-stimulating hormone (αMSH). MC1R is also expressed in other cutaneous cell types, particularly keratinocytes and dermal fibroblasts, suggesting non-pigmentary actions of the αMSH/MC1R system. Böhm and Stegemann now report a dramatic effect of mouse (...) Mc1r functional status on susceptibility to skin fibrosis and collagen types I and III metabolism, in a study combining the powerful mouse model provided by the natural Mc1r(e/e) knockout and an established model of skin fibrosis. The study underscores the antifibrotic role for the skin αMSH/MC1R system.© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2013 Experimental Dermatology

164. Skin Color Is Relevant to Vitamin D Synthesis. (Abstract)

Skin Color Is Relevant to Vitamin D Synthesis. Whether dark skin produces less vitamin D after UVB radiation than fair skin remains controversial.To compare 25-hydroxyvitamin D [25-(OH)-D] levels after a single UVB exposure in fair (phototype II-III) and black-skinned (phototype VI) volunteers.Fair-skinned volunteers (n = 20, 4 males/16 females, mean age: 23.2 years) and black-skinned (n = 11, 6 males/5 females, mean age: 23.8 years) received a single total body UVB exposure (0.022 J/cm(2 (...) )). The 25-(OH)-D levels were measured on days 0, 2 and 6.On day 0, all volunteers were severely vitamin D deficient. On day 2, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-13.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-8.55 ng/ml, p = 0.843). Again, on day 6, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-14.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-9.57 ng/ml, p = 0.375).This study

2013 Dermatology

165. Melanoma in skin of color in Connecticut: an analysis of melanoma incidence and stage at diagnosis in non-Hispanic blacks, non-Hispanic whites, and Hispanics. (Abstract)

Melanoma in skin of color in Connecticut: an analysis of melanoma incidence and stage at diagnosis in non-Hispanic blacks, non-Hispanic whites, and Hispanics. The incidence of melanoma is increasing in Caucasians and in Hispanic subgroups in California and Florida. There is a paucity of information regarding melanoma incidence, stage at diagnosis, and other patient and tumor factors among minority subgroups in the northeast USA. This report examines melanoma in non-Hispanic white, non-Hispanic (...) <0.001).A significantly higher proportion of advanced melanomas were diagnosed in non-Hispanic blacks and Hispanics than in non-Hispanic whites. There is a growing need to educate patients and healthcare providers of the necessity for skin cancer surveillance regardless of the race of the patient.© 2013 The International Society of Dermatology.

2013 International Journal of Dermatology

166. The Effectiveness of a Near-Infrared Vascular Imaging Device to Support Intravenous Cannulation in Children with Dark Skin Color: A Cluster Randomized Clinical Trial. Full Text available with Trip Pro

The Effectiveness of a Near-Infrared Vascular Imaging Device to Support Intravenous Cannulation in Children with Dark Skin Color: A Cluster Randomized Clinical Trial. Poor vein visibility can make IV cannulation challenging in children with dark skin color. In the operating room, we studied the effectiveness of a near-infrared vascular imaging device (VascuLuminator) to facilitate IV cannulation in children with dark skin color.In the operating room of a general hospital in Curacao, all (...) -154) in the VascuLuminator group and 68 seconds (interquartile range: 40-159) in the control group (P = 0.54), and hazard ratio was 1.12 (95% CI, 0.73-1.71).The VascuLuminator has limited value in improving success at first attempt of facilitating IV cannulation in children with dark skin color.

2013 Anesthesia and analgesia Controlled trial quality: uncertain

167. Autophagy Plays a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes. Full Text available with Trip Pro

Autophagy Plays a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes. Melanin in the epidermis determines the wide variation in skin color associated with ethnic skin diversity. Ethnic differences exist regarding melanosome loss in keratinocytes, but the mechanisms underlying these differences, and their contribution to the regulation of skin color, remain unclear. Here, we explored the involvement of autophagy in determining skin color (...) together, our data reveal that autophagy has a pivotal role in skin color determination by regulating melanosome degradation in keratinocytes, and thereby contributes to the ethnic diversity of skin color.

2013 Journal of Investigative Dermatology

168. Association of melanogenesis genes with skin color variation among Japanese females. (Abstract)

Association of melanogenesis genes with skin color variation among Japanese females. Skin color mainly reflects pigmentation resulting from melanin. Although many of the detailed molecular mechanisms involved in melanin pigmentation are being revealed, little is understood about the genetic components responsible for variations in skin color within or between human populations.To investigate the contribution of the melanogenesis genes to skin color variation in Japanese population.We examined (...) A481T, H615R, T387M in OCA2, D125Y in TYR, and T500P in SLC45A2, accounted for contribution to about 11% of the melanin index.The skin color analysis among Japanese was successfully carried out to determine the association with genetic components by using the melanin index as an objective indicator. We believe that a better understanding of the genetic basis of skin color variation will be valuable for elucidating the correlation of pigmentation phenotype with skin-cancer risk.Copyright © 2012

2013 Journal of dermatological science

169. Investigation of antiaging and skin rejuvenation potential of phyto-constituents from Pyrus communis loaded topical emulgel. (Abstract)

Investigation of antiaging and skin rejuvenation potential of phyto-constituents from Pyrus communis loaded topical emulgel. Pyrus communis fruit is traditionally used for improving the skin color and texture. The current study was designed to investigate Pyrus communis fruit phytoconstituents and their in-vivo rejuvenation effects on human skin by developing a stable emulgel formulation. Hydro-alcoholic extract of Pyrus communis was subjected to phytochemical analysis (TPC, TFC, antioxidant (...) activity and anti-tyrosinase activity). A stable emulgel formulation loaded with 5% (w/w) Pyrus communis fruit extract was developed. Afterwards, this stable emulgel formulation was tested for effects on skin parameters and compared these with placebo (without fruit extract) by employing them on healthy human volunteers (n=13) for 3 months. Investigated in-vivo skin parameters were skin erythema, melanin, moisture, sebum and elasticity. Pyrus communis fruit extract showed excellent antioxidant and anti

2019 Pakistan journal of pharmaceutical sciences Controlled trial quality: uncertain

170. A randomized clinical trial using atropine, cyclopentolate, and tropicamide to compare refractive outcome in hypermetropic children with a dark iris; skin pigmentation and crying as significant factors for hypermetropic outcome. Full Text available with Trip Pro

) as a first intervention. Results: Mean SEQ±SD for C+C, C+T, atropine-(CC) and atropine-(CT) was +1.74 ± 1.35, +1.77 ± 1.34, +2.15 ± 1.43 and +2.10 ± 1.38 diopter (D). Atropine 0.5% revealed significantly more hypermetropia than C+C and C+T; +0.41 ± 0.43, 95%CI +0.31 to +0.52D and +0.33 ± 0.39, 95%CI +0.24 to +0.34D. No significant difference was present between C+C and C+T; -0.03 ± 0.56, 95%CI -0.16 to +0.11D. Ethnicity and skin-color were strongly associated (r = 0.84, p < .001). Sex was not affecting (...) outcomes (p = .101). Ethnicity was borderline significant (p = .049). Skin-color was a highly significant factor (p = .002). A statistical model combining intervention and skin-color, with light-pigmented subjects receiving atropine-(CC) as reference group (mean SEQ +2.61 ± 1.46D), indicated borderline significantly less hypermetropia in atropine-(CC)-dark: mean decrease (95%CI): -0.81 (-1.66 to +0.05)D and atropine-(CT)-dark -0.87 (-1.70 to -0.03)D, furthermore significantly less hypermetropia in C+C

2019 Strabismus Controlled trial quality: predicted high

171. Tilapia fish skin as a new biologic graft for neovaginoplasty in Mayer-Rokitansky-Kuster-Hauser syndrome: a video case report. Full Text available with Trip Pro

into the newly created cavity. The external side of the tilapia skin, which maintained its grayish coloration after the removal of the scales, stayed in contact with the acrylic mold, while the white internal side of the tilapia skin, which was previously attached to the fish's muscle, stayed in contact with the walls of the neocavity. The mold was held in position by four multifilament polyglactin 1.0 sutures in the labia majora, thus preventing expulsion.Anatomic data, such as measurement of the final (...) Tilapia fish skin as a new biologic graft for neovaginoplasty in Mayer-Rokitansky-Kuster-Hauser syndrome: a video case report. To describe a McIndoe procedure technique for surgical management of Mayer-Rokitansky-Kuster-Hauser syndrome with the use of Nile tilapia skin as a scaffold for the proliferation of new vaginal epithelium.Surgical video article. Local Institutional Review Board approval and written permission from the patient were obtained. There were no conflicts of interest.University

2019 Fertility and Sterility

172. Clinical and Histopathologic Characteristics of Melanocytic Lesions on the Volar Skin Without Typical Dermoscopic Patterns. (Abstract)

Clinical and Histopathologic Characteristics of Melanocytic Lesions on the Volar Skin Without Typical Dermoscopic Patterns. It is challenging to differentiate melanoma from melanocytic nevus on the volar skin in the absence of typical dermoscopic patterns.To identify the frequency and clinical and dermoscopic characteristics of melanocytic lesions on the volar skin not displaying a parallel furrow pattern, lattice-like pattern, fibrillar pattern, or parallel ridge pattern on results (...) of dermoscopy.In this retrospective cohort study, a total of 504 melanocytic lesions on the volar skin were evaluated in the Shinshu University Hospital department of dermatology between January 1, 2000, and December 31, 2012. Dermoscopic images were independently assessed by 3 dermoscopists for the presence of established dermoscopic criteria. Statistical analysis was performed from October 1, 2017, to April 30, 2018.Frequency of dermoscopic criteria and corresponding clinical (patient age and size

2019 JAMA dermatology (Chicago, Ill.)

173. Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? (Abstract)

Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? The metastatic involvement of regional lymph nodes is the most important prognostic factor for overall survival of skin cancer patients. The sonographic technique of freehand real-time tissue elastography (RTE), which displays tissue rigidity as a color overlay of the tissue image, was developed.Our (...) purpose was to evaluate the benefit of RTE for detecting lymph node metastases of skin cancer noninvasively before operation.We first selected lymph nodes of skin cancer patients which had already been diagnosed by biopsy as being reactive or metastatic, and then retrospectively collected images of RTE and B-mode and color Doppler ultrasound on those lymph nodes performed preoperatively. Twenty-one lymph nodes from 12 patients with squamous cell carcinoma (SCC), 23 lymph nodes from 14 patients

2019 Journal of the European Academy of Dermatology and Venereology

174. Skin Tone Matters: Racial Microaggressions and Delayed Prenatal Care. (Abstract)

Skin Tone Matters: Racial Microaggressions and Delayed Prenatal Care. Literature posits that discrimination can be a barrier to racial and ethnic minorities' healthcare use. This study examines the relationship between perceived discrimination in the form of racial microaggressions and delayed prenatal care in African American women. It also investigates whether this relationship is modified by women's shade of skin color owing to societal attitudes and beliefs tied to colorism (also known (...) a quarter (24.8%) of women had delayed prenatal care. Logistic regression models showed that a Daily Life Experiences of Racism and Bother score above the median was associated with delayed prenatal care (AOR=1.31, 95% CI=1.00, 1.71). This association was moderated by self-reported maternal skin tone (interaction p=0.03). A higher Daily Life Experiences of Racism and Bother score was associated with delayed prenatal care among African-American women at either end of the color continuum (light brown: AOR

2019 American journal of preventive medicine

175. Relative Tissue Oxygenation and Temperature Changes for Detecting Early Upper Extremity Skin Ischemia. (Abstract)

Relative Tissue Oxygenation and Temperature Changes for Detecting Early Upper Extremity Skin Ischemia. The authors' purpose was to determine whether there are reliable noninvasive methods of assessing upper extremity ischemia regardless of skin pigmentation. The authors conducted a study of healthy subjects classified based on skin pigmentation using the Fitzpatrick scale, the von Luschan color scale, and self-described race (two Hispanics, three Caucasians, and four African Americans (...) ). A surface temperature probe and a near-infrared spectroscopy monitor were placed on the posterior interosseous artery skin territory. Temporary upper limb ischemia was induced by tourniquet insufflation. Readings from both devices were taken at baseline and every 15 seconds for a total of 10 minutes of ischemia. During tourniquet insufflation, the authors found a reliable decrease in tissue oxygenation measured by near-infrared spectroscopy in all subjects and no significant change in temperature

2019 Plastic and reconstructive surgery

176. A randomized study to evaluate the efficacy and effectiveness of two sunscreen formulations on Indian skin types IV and V with pigmentation irregularities. Full Text available with Trip Pro

daily before sun exposure for ≥2 h. Primary objectives aimed at assessing possible improvement in hyperpigmented spots and overall skin appearance after 12 weeks of use. Evaluation of skin radiance and skin color was done by means of L'Oréal color chart and colorimetric measurements (Chromameter®).Among the 230 enrolled participants, 216 (93.91%) completed the study. The clinical assessment of the density of pigmented spots and skin radiance showed significant (P < 0.001) improvement in both groups (...) A randomized study to evaluate the efficacy and effectiveness of two sunscreen formulations on Indian skin types IV and V with pigmentation irregularities. Regular exposure to ultraviolet rays is high in India, where most Indians present Fitzpatrick skin phototypes IV and V.To evaluate the efficacy and compare the effectiveness of two sunscreen products on Indian skin types IV and V with pigmentation irregularities.A randomized, uncontrolled and investigator-blinded, single-center study

2019 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

177. Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study. (Abstract)

of the participants showed an improvement in the overall skin condition. These improvements were assessed after 4 and 8 weeks. Those observed after 56 days were more remarkable than those identified 28 days, however, without any statistical significance. Application of retinol formula 0.3% and serum 0.15% gives similar results after 8 weeks of daily care. Both products improve the overall skin condition considerably, even the skin color, hydration, and radiance. In a VAS assessment, the number of wrinkles (...) Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study. The aging process is defined as natural, biological, progressive, and physiologically irreversible phenomena occurring in the body.We attempted to evaluate the efficacy and tolerability of treating signs of the aging skin using retinol 0.15% and 0.3%. Retinol was added to the original, developed liquid crystal formula.Patients

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

178. A single-blind, dose-escalation, phase I study of high-fluence light-emitting diode-red light on Caucasian non-Hispanic skin: study protocol for a randomized controlled trial. Full Text available with Trip Pro

as a monotherapeutic modality or in combination with other agents. Light-emitting diode-red light (LED-RL) phototherapy may represent an important advance in light-based treatment modalities because it is non-invasive, inexpensive, portable, and easily combinable with other therapies. We previously determined the maximum tolerated dose (MTD) of high-fluence LED-RL (HF-LED-RL) in skin of color individuals to be 320 J/cm2. To the best of our knowledge, no clinical trials have been performed to determine the safety (...) A single-blind, dose-escalation, phase I study of high-fluence light-emitting diode-red light on Caucasian non-Hispanic skin: study protocol for a randomized controlled trial. Visible light (400 to 700 nm) is common in our environment, comprising 44% of total solar radiation and a large component of environmental light exposure. The effects of visible light on skin remain undefined. The red light portion of the visible spectrum (600 to 700 nm) may be used to treat skin diseases

2019 Trials Controlled trial quality: uncertain

179. The influence of MC1R dermal morphological features of photoexposed skin in women revealed by reflectance confocal microscopy and optical coherence tomography. (Abstract)

areas being represented by increased vessel density and pixel density in OCT (p=0.025 and p=0.001, respectively) and increased coarse collagen in RCM (p=0.034), as compared to non-RHC subjects. To our knowledge this is previously unreported. Additionally, previously reported correlations between light hair and skin color and pigmented spots with MC1R RHC polymorphisms have been confirmed.Our results suggest the role of RHC MC1R variants in dermal variations of facial skin, as compared to non-RHC (...) The influence of MC1R dermal morphological features of photoexposed skin in women revealed by reflectance confocal microscopy and optical coherence tomography. The melanocortin 1 receptor (MC1R) gene is one of the major determinants of skin pigmentation. It is a highly polymorphic gene and some of its polymorphisms, have been related to specific skin phenotypes, increased risk of skin cancers and skin photoaging. Currently, its contribution to changes in dermal features in photo-exposed skin

2019 Experimental Dermatology

180. Clinical evaluation of the lightening effect of cytidine on hyperpigmented skin. Full Text available with Trip Pro

Clinical evaluation of the lightening effect of cytidine on hyperpigmented skin. Melanocytes, which reside in the basal layer of the epidermis, produce the pigment melanin in cytoplasmic organelles known as melanosomes. Melanosomes are transferred to keratinocytes which provide the color in our skin. Recently, Diwakar et  al reported the crucial roles of protein glycosylation in both melanogenesis and melanosome transfer to keratinocytes, and each was inhibited by the nucleotide cytidine.The (...) index, skin brightness, and skin color parameters. In vitro skin penetration studies were conducted using Franz cell chambers for the 2% cytidine test formulation.The test group showed significant improvements in the visual assessment scores, melanin index, skin brightness, and skin color compared to the control group. Although significant dose-dependent improvements were seen in the clinical study, the in vitro Franz cell studies indicated that the clinical efficacy and potency of cytidine might

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

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