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Skin of Color

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61. Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.) (PubMed)

Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.) Crucian carp is a popular ornamental strain in Asia with variants in body color. To further explore the genetic mechanisms underlying gray and red body color formation in crucian carp, the skin transcriptomes and partial DNA methylation sites were obtained from red crucian carp (RCC) and white crucian carp (WCC). Here, we show significant (...) differences in mRNA expression and DNA methylation sites between skin tissues of RCC and WCC.Totals of 3434 and 3683 unigenes had significantly lower and higher expression in WCC, respectively, compared with unigenes expressed in RCC. Some potential genes for body color development were further identified by quantitative polymerase chain reaction, such as mitfa, tyr, tyrp1, and dct, which were down-regulated, and foxd3, hpda, ptps, and gch1, which were up-regulated. A KEGG pathway analysis indicated

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2017 BMC genetics

62. Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry (PubMed)

Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry Currently, there is limited knowledge about the genetics underlying pigmentary traits in East Asian populations. Here, we report the results of the first genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry.We obtained quantitative skin pigmentation measures (M-index) in the inner upper arm of the participants using a portable (...) reflectometer (N = 305). Quantitative measures of iris color (expressed as L*, a* and b* CIELab coordinates) were extracted from high-resolution iris pictures (N = 342). We also measured the color differences between the pupillary and ciliary regions of the iris (e.g., iris heterochromia). DNA samples were genotyped with Illumina's Infinium Multi-Ethnic Global Array (MEGA) and imputed using the 1000 Genomes Phase 3 samples as reference haplotypes.For skin pigmentation, we did not observe any genome-wide

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2017 PeerJ

63. Comparative Transcriptome Analysis Identifies Candidate Genes Related to Skin Color Differentiation in Red Tilapia (PubMed)

Comparative Transcriptome Analysis Identifies Candidate Genes Related to Skin Color Differentiation in Red Tilapia Red tilapia is becoming more popular for aquaculture production in China in recent years. However, the pigmentation differentiation in genetic breeding is the main problem limiting its development of commercial red tilapia culture and the genetic basis of skin color variation is still unknown. In this study, we conducted Illumina sequencing of transcriptome on three color variety (...) and the results revealed that there were 148 common significantly differentially expressed unigenes and several key genes related to pigment synthesis, i.e. tyr, tyrp1, silv, sox10, slc24a5, cbs and slc7a11, were included. The results will facilitate understanding the molecular mechanisms of skin pigmentation differentiation in red tilapia and accelerate the molecular selection of the specific strain with consistent skin colors.

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2016 Scientific reports

64. Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types The safety and scientific validity of this study is the responsibility of the study sponsor

2016 Clinical Trials

65. Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. (PubMed)

Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. Differences in cutaneous diseases in people of color call for nuanced evaluation and management. One of the most common dermatological complaints from patients with skin of color is dyspigmentation, particularly hyperpigmentation. The challenge for clinicians is to establish correct diagnoses along with consistently successful treatments to meet the needs of the increasingly diverse population served. This review (...) focuses on facial hyperpigmentation and outlines the most common skin disorders and treatment options.

2016 American journal of clinical dermatology

66. Common conditions in skin of color. (PubMed)

Common conditions in skin of color. The skin of color population is rapidly growing in the United States. This population has numerous unique and more commonly occurring dermatologic conditions. Additionally, certain cutaneous conditions can present differently in darker versus lighter skin types. This paper provides an up-to-date overview of common conditions that occur in skin of color, including their clinical presentations, pathogenesis, differential diagnoses, and treatments.©2016

2016 Seminars in Cutaneous Medicine and Surgery

67. Pediatric disorders of pigmentation commonly seen in skin of color. (PubMed)

Pediatric disorders of pigmentation commonly seen in skin of color. There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may present similarly in the clinical setting; however treatment varies widely and is dependent on accurate (...) diagnosis. Herein, we present a review of common disorders of hyperpigmentation and hypopigmentation in children with skin of color. We aim to provide physicians with information that can enhance clinical detection of common pigmentary disorders in this vulnerable population.©2016 Frontline Medical Communications.

2016 Seminars in Cutaneous Medicine and Surgery

68. Combination therapy in skin of color including injectables, laser, and light devices. (PubMed)

Combination therapy in skin of color including injectables, laser, and light devices. With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients (...) with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Fortunately, by combining a variety of treatments, these risks may be abrogated, and combination treatments may be a promising regimen for a wide variety of cosmetic complaints. An overview and evaluation of the research of combination therapy in skin of color is presented.©2016 Frontline Medical Communications.

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2016 Seminars in Cutaneous Medicine and Surgery

69. Cosmeceuticals in skin of color. (PubMed)

Cosmeceuticals in skin of color. Patients with skin of color have similar skin care needs as lighter-skin patients. However, they are less likely to use sun protection on a daily basis, which leads to an increased risk of dyschromia, skin cancer, and other disorders. This article discusses the importance of a correct and consistent skin care regimen and the various cutaneous issues that should be considered when prescribing a skin care regimen for patients with darker skin types. Adopting (...) a standardized methodology to identify affordable, efficacious products and to streamline the process of skin-type diagnosis, skin care regimen prescribing, patient communication, and staff education will result in improved patient outcomes and increased patient satisfaction.©2016 Frontline Medical Communications.

2016 Seminars in Cutaneous Medicine and Surgery

70. What devices to use or not use in skin of color. (PubMed)

What devices to use or not use in skin of color. Lasers and light sources, as well as other energy devices, including radiofrequency, ultrasound, and cold-based therapies, can be used for treatment of aging, dyschromic, or texturally uneven skin. In patients with ethnic skin (ie, skin of color), energy devices are used more cautiously to avoid adverse events. The most common and concerning adverse event is postinflammatory hyperpigmentation. Lower fluence, longer pulse durations, and careful (...) device selection can mitigate the risk of scarring and pigmentary abnormality. Modified treatment approaches can allow physicians to safely treat patients with skin of color with energy devices.©2016 Frontline Medical Communications.

2016 Seminars in Cutaneous Medicine and Surgery

71. Dermoscopy and in vivo confocal microscopy are complimentary techniques for the diagnosis of difficult amelanotic and light colored skin lesions. (PubMed)

Dermoscopy and in vivo confocal microscopy are complimentary techniques for the diagnosis of difficult amelanotic and light colored skin lesions. Amelanotic melanomas are often difficult to diagnose.To find and test the best methods of diagnosis using dermoscopy and reflectance confocal microscopy (RCM) tools.We selected consecutive, difficult-to-diagnose, light-coloured and amelanotic skin lesions from three centres (in Australia and Italy). Dermoscopy and RCM diagnostic utility were evaluated (...) misclassified by either dermoscopy or RCM were detected by the other tool.Dermoscopy and RCM represent complementary/synergistic methods for diagnosis of amelanotic/light-coloured skin lesions.© 2016 British Association of Dermatologists.

2016 British Journal of Dermatology

72. Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes (PubMed)

Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. Sampling 751 subjects from a broad range of latitudes and skin colors, we investigated possible multilocus correlated adaptation of skin color genes with the vitamin D receptor gene (VDR), using a vector correlation (...) metric and network method called BlocBuster. We discovered two multilocus networks involving VDR promoter and skin color genes that display strong latitudinal clines as multilocus networks, even though many of their single gene components do not. Considered one by one, the VDR components of these networks show diverse patterns: no cline, a weak declining latitudinal cline outside of Africa, and a strong in- vs. out-of-Africa frequency pattern. We confirmed these results with independent data from

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2016 G3: Genes|Genomes|Genetics

73. Dermoscopy-guided reflectance confocal microscopy of skin using high-NA objective lens with integrated wide-field color camera (PubMed)

Dermoscopy-guided reflectance confocal microscopy of skin using high-NA objective lens with integrated wide-field color camera Reflectance Confocal Microscopy, or RCM, is being increasingly used to guide diagnosis of skin lesions. The combination of widefield dermoscopy (WFD) with RCM is highly sensitive (~90%) and specific (~ 90%) for noninvasively detecting melanocytic and non-melanocytic skin lesions. The combined WFD and RCM approach is being implemented on patients to triage lesions (...) , providing simultaneous wide-field color images of the skin surface and RCM images of the subsurface cellular structure. The objective lens (0.9 NA) includes a hyperhemisphere lens and an ultra-miniature CMOS color camera, commanding a 4 mm wide dermoscopy view of the skin surface. The camera obscures the central portion of the aperture of the objective lens, but the resulting annular aperture provides excellent RCM optical sectioning and resolution. Preliminary testing on healthy volunteers showed

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2016 Proceedings of SPIE--the International Society for Optical Engineering

74. Use of Munsell Color Charts to Measure Skin Tone Objectively in Nursing Home Residents at Risk for Pressure Ulcer Development (PubMed)

Use of Munsell Color Charts to Measure Skin Tone Objectively in Nursing Home Residents at Risk for Pressure Ulcer Development To assess the feasibility of classifying skin tone using Munsell color chart values and to compare Munsell-based skin tone categories to ethnicity/race to predict pressure ulcer risk.Pressure ulcer classification uses level of visible tissue damage, including skin discoloration over bony prominences. Prevention begins with early detection of damage. Skin discoloration (...) values and skin tone. Mean Munsell buttocks values differed significantly by ethnicity/race. Across ethnicity/race, Munsell value ranges overlapped, with the greatest range among African Americans. Trunk pressure ulcer incidence varied by skin tone, regardless of ethnicity/race. In multinomial regression, skin tone was more predictive of skin damage than ethnicity/race for trunk locations but ethnicity/race was more predictive for heels.Given the overlap of Munsell values across ethnicity/race, color

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2016 Journal of advanced nursing

75. Skin of Color

Skin of Color Skin of Color Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin of Color Skin of Color Aka: Skin of Color , Ethnic (...) Skin , Skin Color , Dermatologic Conditions in Skin of Color , Skin Conditions in Black Patients , Skin Conditions in African American Patients , Skin Conditions in Asian Patients , Skin Conditions in Native American Patients , Skin Conditions in Middle Eastern Patients , Skin Conditions in Hispanic Patients II. Definition: Skin of Color Patients with richly pigmented skin ( s 3-6) Typically in ethnic backgrounds from Africa, Asia, Middle East, Central and South America, as well as native americans

2018 FP Notebook

76. Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients. (PubMed)

Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients. Acral lentiginous melanoma has increased mortality compared with other melanoma subtypes and disproportionately affects ethnic minorities. Acral melanocytic lesions have not been well studied in diverse populations of the United States.We sought to assess the prevalence, awareness, and dermoscopic patterns of acral melanocytic lesions in skin-of-color (...) and non-Hispanic white patients.We prospectively examined the palms and soles of 1052 patients presenting to dermatology clinics in New York, NY, and Miami, FL, from October 2013 to April 2015.Acral melanocytic lesions were observed in 36% of our cohort. Skin-of-color patients were more likely to have acral melanocytic lesions than non-Hispanic white patients (P < .01). Acral melanocytic lesions correlated with increased mole counts, particularly on non-Hispanic white patients. The majority of lesions

2016 Journal of American Academy of Dermatology

77. Skin Cancer Concerns in People of Color: Risk Factors and Prevention (PubMed)

Skin Cancer Concerns in People of Color: Risk Factors and Prevention Background: Though people of color (POC) are less likely to become afflicted with skin cancer, they are much more likely to die from it due to delay in detection or presentation. Very often, skin cancer is diagnosed at a more advanced stage in POC, making treatment difficult.The purpose of this research was to improve awareness regarding skin cancers in people of color by providing recommendations to clinicians and the general (...) public for early detection and photo protection preventive measures. Methods: Data on different types of skin cancers were presented to POC. Due to limited research, there are few resources providing insights for evaluating darkly pigmented lesions in POC. Diagnostic features for different types of skin cancers were recorded and various possible risk factors were considered. Results: This study provided directions for the prevention and early detection of skin cancer in POC based on a comprehensive

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2016 Asian Pacific journal of cancer prevention : APJCP

78. Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors (PubMed)

Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors Guanine nucleotide-binding protein subunit alpha-s (Gnαs) is a small subunit of the G protein-couple signaling pathway, which is involved in the formation of coat color. The expression level and distribution of Gnαs were detected by quantitative real-time-polymerase chain reaction (qPCR), western blot, and immunohistochemistry (...) to investigate the underlying mechanisms of coat color in white and black skin tissues of mice. qPCR and western blot results suggested that Gnαs was expressed at significantly higher levels in black mice compared with that of white mice, and transcripts and protein possessed the same expression in both colors. Immunohistochemistry demonstrated Gnαs staining in the root sheath and dermal papilla in hair follicle of mice skins. The results indicated that the Gnαs gene was expressed in both white and black

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2016 Asian-Australasian journal of animal sciences

79. Color structured light imaging of skin (PubMed)

Color structured light imaging of skin We illustrate wide-field imaging of skin using a structured light (SL) approach that highlights the contrast from superficial tissue scattering. Setting the spatial frequency of the SL in a regime that limits the penetration depth effectively gates the image for photons that originate from the skin surface. Further, rendering the SL images in a color format provides an intuitive format for viewing skin pathologies. We demonstrate this approach in skin

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2016 Journal of biomedical optics

80. The Development of White-Asian Categorization: Contributions from Skin Color and Other Physiognomic Cues (PubMed)

The Development of White-Asian Categorization: Contributions from Skin Color and Other Physiognomic Cues We examined the development of racial categorizations of faces spanning the European-East Asian ("White-Asian") categorical continuum in children between the ages of four and nine as well as adults. We employed a stimulus set that independently varied skin color and other aspects of facial physiognomy, allowing the contribution of each to be assessed independently and in interaction (...) with each other. Results demonstrated substantial development across this age range in children's ability to draw on both sorts of cue, with over twice as much variance explained by stimulus variation in adults than children. Nonetheless, children were clearly sensitive to both skin color and other aspects of facial physiognomy, suggesting that understanding of the White-Asian category boundary develops in a somewhat different way than understanding of the White-Black category boundary, in which

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2016 PloS one

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