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Skin Ulcer

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161. Electromagnetic therapy for treating pressure ulcers. (PubMed)

Electromagnetic therapy for treating pressure ulcers. Pressure ulcers are defined as areas "of localized damage to the skin and underlying tissue caused by pressure, shear, friction and/or the combination of these". Electromagnetic therapy (EMT), in which electrodes produce an electromagnetic field across the wound, may improve healing of chronic wounds such as pressure ulcers.To assess the effects of EMT on the healing of pressure ulcers.For this update we searched the Cochrane Wounds Group (...) as this is a small study and this finding may be due to chance. Additionally, the outcome, percentage reduction in wound area, is less clinically meaningful than complete healing.The results provide no strong evidence of benefit in using EMT to treat pressure ulcers. However, the possibility of a beneficial or harmful effect cannot be ruled out because there were only two included trials, both with methodological limitations and small numbers of participants. Further research is recommended.

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2015 Cochrane

162. Negative pressure wound therapy for treating leg ulcers. (PubMed)

Negative pressure wound therapy for treating leg ulcers. Leg ulcers are open skin wounds that occur between the ankle and the knee that can last weeks, months or even years and are a consequence of arterial or venous valvular insufficiency. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care and is promoted for use on wounds. NPWT involves the application of a wound dressing to the wound, to which a machine is attached. The machine applies (...) included one study, with 60 randomized participants, in the review. The study population had a range of ulcer types that were venous arteriolosclerotic and venous/arterial in origin. Study participants had recalcitrant ulcers that had not healed after treatment over a six-month period. Participants allocated to NPWT received continuous negative pressure until they achieved 100% granulation (wound preparation stage). A punch skin-graft transplantation was conducted and the wound then exposed to further

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2015 Cochrane

163. Negative pressure wound therapy for treating pressure ulcers. (PubMed)

Negative pressure wound therapy for treating pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Negative pressure wound therapy (NPWT) is a treatment option for pressure ulcers; a clear, current overview of the evidence is required to facilitate decision-making regarding its use.To assess the effects of negative pressure wound therapy for treating pressure ulcers in any (...) or different types of NPWT in the treatment of pressure ulcers (stage II or above).Two review authors independently performed study selection, risk of bias assessment and data extraction.The review contains four studies with a total of 149 participants. Two studies compared NPWT with dressings; one study compared NPWT with a series of gel treatments and one study compared NPWT with 'moist wound healing'. One study had a 24-week follow-up period, and two had a six-week follow-up period, the follow-up time

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2015 Cochrane

164. Alginate dressings for treating pressure ulcers. (PubMed)

Alginate dressings for treating pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and there are many options to choose from including alginate dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding dressing use for the treatment of pressure ulcers. This review (...) is part of a suite of Cochrane reviews investigating the use of dressings in the treatment of pressure ulcers. Each review will focus on a particular dressing type.To assess the effects of alginate dressings for treating pressure ulcers in any care setting.For this review, in April 2015 we searched the following databases the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other

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2015 Cochrane

165. Associations between skin barrier characteristics, skin conditions and health of aged nursing home residents: a multi-center prevalence and correlational study. (PubMed)

residents.This observational, cross-sectional, descriptive prevalence study was conducted in a random sample of 10 institutional long-term care facilities in Berlin. In total, n = 223 residents were included. Demographic and functional characteristics, xerosis cutis, incontinence associated dermatitis, pressure ulcers and skin tears were assessed. Stratum corneum hydration, transepidermal water loss, skin surface pH and skin temperature were measured. Data analysis was descriptive and explorative. To explore (...) possible bivariate associations, a correlation matrix was created. The correlation matrix was also used to detect possible collinearity in the subsequent regression analyses.Mean age (n = 223) was 83.6 years, 67.7% were female. Most residents were affected by xerosis cutis (99.1%; 95% CI: 97.7% - 100.0%). The prevalence of pressure ulcers was 9.0% (95% CI: 5.0% - 13.0%), of incontinence associated dermatitis 35.4% (95% CI: 29.9% - 42.2%) and of skin tears 6.3% (95% CI: 3.2% - 9.5%). Biophysical skin

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2017 BMC Geriatrics

166. Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice. (PubMed)

Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice. Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. Here, we hypothesize that hyperglycemia induces skin barrier dysfunction with alterations of epidermal integrity. The effects of hyperglycemia (...) on the epidermis were examined in streptozotocin-induced diabetic mice with/without insulin therapy. The results showed that dye leakages were prominent, and transepidermal water loss after tape stripping was exacerbated in diabetic mice. These data indicate that hyperglycemia impaired skin barrier functions. Additionally, the distribution of the protein associated with the tight junction structure, tight junction protein-1 (ZO-1), was characterized by diffuse and significantly wider expression in the diabetic

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2016 PLoS ONE

167. The Effect of Skin Cleansers on the Skin Surface Microbiome

[Guardian gel hand wash]) after providing consent and during the whole study Healthy and intact skin in the test area (e.g., no skin allergy, visible bleeding, skin inflammation, skin ulcer or skin lesion, no need for cutaneous treatment) Must have given written informed consent Women of child-bearing potential who are, in the opinion of the investigator, practicing a reliable method of contraception. Exclusion Criteria: Women who are pregnant or have a positive urine pregnancy test or intending (...) The Effect of Skin Cleansers on the Skin Surface Microbiome The Effect of Skin Cleansers on the Skin Surface Microbiome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Skin Cleansers

2017 Clinical Trials

168. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections

Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03137173 Recruitment Status

2017 Clinical Trials

169. Pressure-relieving devices for treating heel pressure ulcers. (PubMed)

Pressure-relieving devices for treating heel pressure ulcers. Pressure ulcers are areas of localised damage to the skin and underlying tissue caused by pressure or shear. Pressure redistribution devices are used as part of the treatment to reduce the pressure on the ulcer. The anatomy of the heel and the susceptibility of the foot to vascular disease mean that pressure ulcers located there require a particular approach to pressure relief.To determine the effects of pressure-relieving (...) interventions for treating pressure ulcers on the heel.In May 2013, for this first update, we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid EMBASE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); and EBSCO CINAHL. No language or publication date restrictions were applied.We included randomised controlled trials (RCTs) that compared the effects of pressure-relieving devices

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2014 Cochrane

170. Interventions for the management of oral ulcers in Behçet's disease. (PubMed)

Interventions for the management of oral ulcers in Behçet's disease. Behçet's disease is a chronic inflammatory vasculitis that can affect multiple systems. Mucocutaneous involvement is common, as is the involvement of many other systems such as the central nervous system and skin. Behç̧et's disease can cause significant morbidity, such as loss of sight, and can be life threatening. The frequency of oral ulceration in Behçet's disease is thought to be 97% to 100%. The presence of mouth ulcers (...) can cause difficulties in eating, drinking, and speaking leading to a reduction in quality of life. There is no cure for Behçet's disease and therefore treatment of the oral ulcers that are associated with Behçet's disease is palliative.To determine the clinical effectiveness and safety of interventions on the pain, episode duration, and episode frequency of oral ulcers and on quality of life for patients with recurrent aphthous stomatitis (RAS)-type ulceration associated with Behçet's disease.We

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2014 Cochrane

171. Interventions for treating leg ulcers in people with sickle cell disease. (PubMed)

Interventions for treating leg ulcers in people with sickle cell disease. The frequency of skin ulceration makes it an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease.To assess the clinical effectiveness and safety of interventions for treating leg ulcers in people with sickle cell (...) of the last search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register: 21 July 2014; date of the last search of the Cochrane Wounds Group Trials Register: 18 September 2014.Randomised controlled trials of interventions for treating leg ulcers in people with sickle cell disease compared to placebo or an alternative treatment.Two authors independently selected studies for inclusion. All three authors independently assessed the risk of bias of the included

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2014 Cochrane

172. Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study. (PubMed)

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study. Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD (...) patients.We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM).354 CD patients and 136 UC/IBDU patients presented with skin manifestations at any time during their disease course. In both, CD

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2019 PLoS ONE

173. Effectiveness of rifampicin-streptomycin for treatment of Buruli ulcer: a systematic review. (PubMed)

Effectiveness of rifampicin-streptomycin for treatment of Buruli ulcer: a systematic review. Buruli ulcer (BU) disease is a chronic ulcerative skin disease caused by Mycobacterium ulcerans, which can lead to extensive destruction of the skin, soft tissues and occasionally of bones. Although several antibiotics have demonstrated bactericidal activity against M. ulcerans in vitro, no consensus on their clinical efficacy against M. ulcerans in humans has been reached.The objective (...) trials with only an intervention arm were considered for inclusion in a narrative summary.The primary outcome of interest were the treatment success rates among the various antibiotics used. Secondary outcomes included changes in lesion size, recurrence of ulcers and incidence of adverse events.The search strategy aimed to find both published and unpublished trials. A three-step search strategy was utilized in this review and included English language trials published after 1990. A search across

2017 JBI database of systematic reviews and implementation reports

174. International Consolidated Venous Ulcer Guideline

ulcer (VU) is an open skin lesion of the leg or foot that occurs in an area affected by venous hypertension (O’Donnell 2014). This condition is associated with lower leg swelling (edema) which can progress to dermatitis and VU formation. It may result from incompetent venous valves in the superficial, perforator or deep vein systems and/or inadequate calf muscle pump function (Tang et al. 2012) A VU is considered chronic if it is unresponsive to best- evidence-based management , i.e. reduces in area (...) 2007; Vasquez et al., 2010; Volikova et al., 2009) CVI= 0.952, High SOR A.2.a.i Table 1. CEAP Descriptive Venous Ulcer Scoring System Developed by the American Venous Forum Accepted as Reporting Standards In Venous Disease. A (Gloviczki et al., 2011; Vasquez et al., 2010) CVI= 0.882, High SOR Class Description C0 No visible or palpable signs of venous disease C1 Telangiectasies or reticular veins ( 3 mm diameter) C3 Edema C4 Skin and subcutaneous tissue changes secondary to cardiovascular disease

2015 Association for the Advancement of Wound Care

175. Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care

known as a pressure sore, decubitus ulcer, or bedsore, is defined as localized injury to the skin and/or underlying tissue occurring most often over a bony prominence, caused by pressure, or pressure in combination with shear. (1) According to the National Pressure Ulcer Advisory Panel’s updated pressure ulcer staging system from 2007, PrUs are classified into 6 categories: stage I, nonblanchable erythema; stage II, partial thickness skin loss; stage III, full thickness skin loss; stage IV, full (...) Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care. March 2015; pp. 1–87 Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care VE RAC, J WONG, AS BROOKER, N MITSAKAKIS, M PAULDEN, B PHAM, S CARCONE, MD KRAHN MARCH 2015 This article

2015 Health Quality Ontario

176. [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].

[Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis]. Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC (...) ).An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department.CD and UC are frequently associated with mucocutaneous symptoms; however, primary/specific disease-associations are exclusively seen in CD patients. These include peri-anal and -stomal fistulas and ulcerations, "metastatic" Crohn's disease as well as oral granulomatous disease. Moreover, in both CD and UC, there occur

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2017 Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

177. Sural artery perforator flap with posterior tibial neurovascular decompression for recurrent foot ulcer in leprosy patients (PubMed)

Sural artery perforator flap with posterior tibial neurovascular decompression for recurrent foot ulcer in leprosy patients Introduction: The sensory loss and alteration of the shape of the foot make the foot liable to trauma and pressure, and subsequently cause more callus formation, blisters, and ulcers. Foot ulcers usually are liable to secondary infection as cellulitis or osteomyelitis, and may result in amputations. Foot ulcers are a major problem and a major cause of handicaps in leprosy (...) patients. The current study is to present our clinical experience and evaluate the use of sural flap with posterior tibial neurovascular decompression (PTND) in recurrent foot ulcers in leprosy patients. Patient and methods: A total number of 9 patients were suffering from chronic sequelae of leprosy as recurrent foot ulcers. All the patients were reconstructed with the reverse sural artery fasciocutaneous flap with posterior tibial neurovascular decompression from September 2012 to August 2015. Six

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2017 GMS Interdisciplinary plastic and reconstructive surgery DGPW

178. Use of the Braden Scale for Assessing Pressure Ulcer Risk in Acute Care

-analyses, non-randomized studies, or randomized controlled trials were identified. Additional references of potential interest are provided in the appendix. Health Technology Assessments No literature identified. Systematic Reviews and Meta-analyses No literature identified. Randomized Controlled Trials No literature identified. Non-Randomized Studies No literature identified. Guidelines and Recommendations 1. Ayello EA, Sibbald RG. Preventing pressure ulcers and skin tears [Internet]. In: Boltz M (...) Use of the Braden Scale for Assessing Pressure Ulcer Risk in Acute Care Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

179. Skin involvement in systemic sclerosis: rituximab

between the groups (p=0.68) Skin involvement in systemic sclerosis: rituximab (ES7) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 39 of 63Number of participants hospitalised 3/33 (9%) (2 with RTI and 1 with UTI) 10/18 (56%) (5 with RTI, 4 with UTI and 1 with digital ulcers) No statistical analysis Other adverse effects reported 1 HBV reactivation 2 mild infusion reactions No statistical analysis a This is within (...) Skin involvement in systemic sclerosis: rituximab Skin in Skin inv volv olvement in systemic sclerosis: rituximab ement in systemic sclerosis: rituximab Evidence summary Published: 7 March 2017 nice.org.uk/guidance/es7 pathways K Ke ey points y points The content of this evidence summary was up-to-date in March 2017. See summaries of product characteristics (SPC), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Regulatory status: Regulatory status

2017 National Institute for Health and Clinical Excellence - Advice

180. Turning for the Prevention and Management of Pressure Ulcers

Turning for the Prevention and Management of Pressure Ulcers Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation. October 2014; pp. 1–12 Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation Ontario Health Technology Advisory Committee October 2014 Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation. October 2014; pp. 1–12 2 Suggested Citation This report should be cited as follows: Ontario Health (...) Technology Advisory Committee (OHTAC). Turning for the Prevention and Management of Pressure Ulcers: OHTAC recommendation [Internet]. Toronto: Queen's Printer for Ontario; 2014 October. 12 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac-recommendations/ontario-health- technology-assessment-series/turn-multisite-trial. Permission Requests All inquiries regarding permission to reproduce any content in Health Quality Ontario reports should be directed to EvidenceInfo@hqontario.ca

2014 Health Quality Ontario

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