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Skin Ulcer

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161. Skin Ulcers Treatment With an Handicraft Topical Device

Skin Ulcers Treatment With an Handicraft Topical Device Skin Ulcers Treatment With an Handicraft Topical Device - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Skin Ulcers Treatment With an Handicraft (...) by (Responsible Party): Coordinación de Investigación en Salud, Mexico Study Details Study Description Go to Brief Summary: The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and arterial insufficiency. Condition or disease Intervention/treatment Phase Foot Ulcer Varicose Ulcer Procedure: drenovac handcrafted Procedure: Healing Phase 4

2015 Clinical Trials

162. A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa. (Abstract)

A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa. The objective of this study is to evaluate the antimicrobial activity and healing-promoting effect of topical photodynamic therapy (ALA-PDT) on chronic skin ulcers infected with Pseudomonas aeruginosa (PA). A total of 26 patients with chronic skin ulcers in lower limbs infected with PA were enrolled. The surface areas of the ulcers were treated with either δ-aminolevulinic acid (...) (ALA)-mediated PDT (20% ALA solution, 1.5 h incubation, 630 nm red light, 80 J/cm(2)) or red light alone, both once a week for two weeks. Before treatment, the wound areas and the bacteria levels in these two groups were comparable (p > 0.05). Results indicated that the bacteria levels in the skin ulcers of the light only group of 24 h post-treatment (3.4 × 10(7) ± 7.1 × 10(7) CFU/cm(2)) and pre-treatment (5.5 × 10(7) ± 1.6 × 10(8) CFU/cm(2)) were not significantly different. In contrast

2015 Archives of dermatological research Controlled trial quality: uncertain

163. Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. Full Text available with Trip Pro

Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. Chronic skin ulcers, such as diabetic ulcers, venous leg ulcers and pressure ulcers, are intractable and increasing in prevalence, representing a costly problem in healthcare. We developed a combination therapy with a gelatin sheet, capable of providing sustained release of platelet-rich plasma (PRP). The objective of this study (...) is to investigate the safety and efficacy of autologous PRP covered with a hydrocolloid dressing and PRP covered with a gelatin sheet in the treatment of chronic skin ulcers.Thirty patients with chronic skin ulcers who have not healed with conventional therapy for at least 1 month are being recruited. The patients will receive PRP after debridement, and the wounds will be covered with a hydrocolloid dressing or gelatin sheet. The efficacy will be evaluated according to the time from the beginning of PRP

2015 BMJ open

164. Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial

Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial (PENFUP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02565745 Recruitment Status : Terminated (Recommendation after interim analysis) First Posted : October 1, 2015 Last Update Posted : March 20, 2018 Sponsor

2015 Clinical Trials

165. Self-monitoring of lower leg skin temperature: accuracy of self-reported data and adherence to a cooling protocol for the prevention of venous leg ulcers. Full Text available with Trip Pro

Self-monitoring of lower leg skin temperature: accuracy of self-reported data and adherence to a cooling protocol for the prevention of venous leg ulcers. For intervention studies that require the use of participant self-reports, the quality and accuracy of recorded data and variability in participant adherence rates to the treatment can cause significant outcome bias.To assess the quality and accuracy of participant documentation of daily self-monitoring of leg skin temperature, adherence (...) to a graduated cooling treatment protocol to prevent venous leg ulcers, and the potential for bias in treatment effect in a randomized controlled trial that included a population with chronic venous disease.Individuals were randomized to a leg cooling intervention or placebo treatment group to daily self-monitor and record lower leg skin temperature over a 9-month period on monthly paper study logs. Returned study logs for the first 100 completed participants (n=54 cooling intervention, n=46 control) were

2015 Patient preference and adherence Controlled trial quality: uncertain

166. Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Skin (...) . Peters Veterans Affairs Medical Center Information provided by (Responsible Party): Michael LaFountaine, James J. Peters Veterans Affairs Medical Center Study Details Study Description Go to Brief Summary: Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces. As many as 85% of individuals with a spinal cord injury (SCI) report the occurrence of at least 1 PU since being injured. Despite

2015 Clinical Trials

167. Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU)

Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU) Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial Comparing SOC +Skin IQ (...) pressure redistribution surface when combined with the Skin IQ™ MCM coverlet will significantly reduce pressure ulcer (PU) incidence as compared to use of a commercially available pressure redistribution surface by itself by decreasing the effects of excessive moisture and temperature at the skin and surface interface. Condition or disease Intervention/treatment Phase Pressure Ulcer Device: Skin IQ™ MCM Coverlet Other: Pressure redistribution surface Not Applicable Detailed Description

2015 Clinical Trials

168. Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers

Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety (...) and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02361437 Recruitment Status : Terminated (Investigator's hospital sold and study cancelled) First Posted : February 11, 2015 Last Update Posted : December 13, 2017 Sponsor: Primus

2015 Clinical Trials

169. Autologous Skin Substitute for Chronic Leg/Foot Ulcers.

Autologous Skin Substitute for Chronic Leg/Foot Ulcers. Autologous Skin Substitute for Chronic Leg/Foot Ulcers. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Autologous Skin Substitute for Chronic Leg (...) Phase 1 Phase 2 Detailed Description: Multicenter, randomised clinical trial in out patient in which patients with chronic (arterio-) venous leg/foot ulcers are treated with an autologous cultured human living skin substitute (Tiscover®: test group) or with Acellular donor dermis (AS210: control group). During a pre-inclusion evaluation period of 4 weeks (non healing) chronicity of ulcer is ensured (ulcer size change of < 30%). To determine ulcer type ABI, Doppler and CEAP is performed. The test

2015 Clinical Trials

170. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. Full Text available with Trip Pro

A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 25673081 2016 03 23 2015 06 24 1651-2057 95 6 2015 Jul Acta dermato-venereologica Acta Derm. Venereol. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 754-5 10.2340/00015555-2067 Shu En E Department of Dermatology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. ghifuka@gifu-u.ac.jp. Kanoh Hiroyuki H Kito Yusuke Y Seishima Mariko M eng (...) Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Felty Syndrome complications diagnosis Female Humans Leg Ulcer complications pathology Lymphoma, Extranodal NK-T-Cell complications pathology Middle Aged Sjogren's Syndrome complications 2015 2 13 6 0 2015 2 13 6 0 2016 3 24 6 0 ppublish 25673081 10.2340/00015555-2067

2015 Acta Dermato-Venereologica

171. Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (&gt;100 cm<sup>2</sup>) chronic venous leg ulcers. Full Text available with Trip Pro

Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100 cm2) chronic venous leg ulcers. Massive (≥100 cm(2)) venous leg ulcers (VLUs) demonstrate very low closure rates with standard compression therapy and are costly to manage. Negative-pressure wound therapy (NPWT), followed by a split-thickness skin graft (STSG), can be a cost-effective alternative to this standard care. We performed (...) a cost analysis of these two treatments.A retrospective review was performed of 10 ulcers treated with surgical debridement, 7 days of inpatient NPWT with topical antiseptic instillation (NPWTi), and STSG, with 4 additional days of inpatient NPWT bolster over the graft. Independent medical cost estimators were used to compare the cost of this treatment protocol with standard outpatient compression therapy.The average length of time ulcers were present before patients entered the study was 38 months

2015 Journal of Vascular Surgery

172. Candesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice Full Text available with Trip Pro

Candesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ's protection against ischemic episodes. The present study examines whether the AT1R blocker candesartan (1) has a beneficial effect on diabetes-induced alteration of pressure-induced vasodilation (PIV, a cutaneous physiological neurovascular mechanism which (...) could delay the occurrence of tissue ischemia), and (2) could be protective against skin pressure ulcer formation.Male Swiss mice aged 5-6 weeks were randomly assigned to four experimental groups. In two groups, diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ, 200 mg.kg(-1)). After 6 weeks, control and STZ mice received either no treatment or candesartan (1 mg/kg-daily in drinking water) during 2 weeks. At the end of treatment (8 weeks of diabetes duration), C-fiber

2015 Cardiovascular diabetology

173. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers

Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation HAYES, Inc.. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: The MIST Therapy System is a noncontact, low-frequency ultrasound debridement device that promotes healing of chronic wounds by removing yellow slough, tissue exudates, fibrin, and bacteria from

2016 Health Technology Assessment (HTA) Database.

174. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers

Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers HAYES, Inc. Record Status (...) This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: The MIST Therapy System is a noncontact, low-frequency ultrasound

2016 Health Technology Assessment (HTA) Database.

175. Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study (Abstract)

Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study Introduction The early detection of systemic sclerosis (SSc) patients at high risk of developing digital ulcers could allow preventive treatment, with a reduction of morbidity and social costs. In 2009, a quantitative score, the capillaroscopic skin ulcer risk index (CSURI), calculated according to the formula 'D×M/N(2'), was proposed, which was highly predictive of the appearance (...) of scleroderma digital ulcers within 3 months of capillaroscopic evaluation.This multicentre study aims to validate the predictive value and reproducibility of CSURI in a large population of SSc patients.CSURI was analysed in 229 unselected SSc patients by nailfold videocapillaroscopy (NVC). All patients were re-evaluated 3 months later with regard to the persistence and/or appearance of new digital ulcers.57 of 229 patients presented with digital ulcers after 3 months. The receiver operating characteristic

2012 EvidenceUpdates

176. Nitric Oxide generating gel dressing for diabetic foot ulcers

&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Nitric oxide (NOx) generating gel dressing, developed by EdixoMed Ltd is a two layer dressing which releases nitric oxide when placed on the skin. It is intended to improve the healing of diabetic foot ulcers (DFUs). Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Bandages; Diabetic Foot; Humans; Nitric Oxide; Ulcer; Wound Healing Language Published English Country of organisation England English summary (...) Nitric Oxide generating gel dressing for diabetic foot ulcers Nitric Oxide generating gel dressing for diabetic foot ulcers Nitric Oxide generating gel dressing for diabetic foot ulcers NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Nitric Oxide generating gel dressing for diabetic foot ulcers. Birmingham: NIHR Horizon Scanning Research

2015 Health Technology Assessment (HTA) Database.

177. Pressure-relieving devices for treating heel pressure ulcers. (Abstract)

Pressure-relieving devices for treating heel pressure ulcers. Pressure ulcers are areas of localised damage to the skin and underlying tissue caused by pressure or shear. Pressure redistribution devices are used as part of the treatment to reduce the pressure on the ulcer. The anatomy of the heel and the susceptibility of the foot to vascular disease mean that pressure ulcers located there require a particular approach to pressure relief.To determine the effects of pressure-relieving (...) interventions for treating pressure ulcers on the heel.In May 2013, for this first update, we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid EMBASE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); and EBSCO CINAHL. No language or publication date restrictions were applied.We included randomised controlled trials (RCTs) that compared the effects of pressure-relieving devices

2014 Cochrane

178. Interventions for treating leg ulcers in people with sickle cell disease. Full Text available with Trip Pro

Interventions for treating leg ulcers in people with sickle cell disease. The frequency of skin ulceration makes it an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease.To assess the clinical effectiveness and safety of interventions for treating leg ulcers in people with sickle cell (...) of the last search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register: 21 July 2014; date of the last search of the Cochrane Wounds Group Trials Register: 18 September 2014.Randomised controlled trials of interventions for treating leg ulcers in people with sickle cell disease compared to placebo or an alternative treatment.Two authors independently selected studies for inclusion. All three authors independently assessed the risk of bias of the included

2014 Cochrane

179. Interventions for the management of oral ulcers in Behçet's disease. Full Text available with Trip Pro

Interventions for the management of oral ulcers in Behçet's disease. Behçet's disease is a chronic inflammatory vasculitis that can affect multiple systems. Mucocutaneous involvement is common, as is the involvement of many other systems such as the central nervous system and skin. Behç̧et's disease can cause significant morbidity, such as loss of sight, and can be life threatening. The frequency of oral ulceration in Behçet's disease is thought to be 97% to 100%. The presence of mouth ulcers (...) can cause difficulties in eating, drinking, and speaking leading to a reduction in quality of life. There is no cure for Behçet's disease and therefore treatment of the oral ulcers that are associated with Behçet's disease is palliative.To determine the clinical effectiveness and safety of interventions on the pain, episode duration, and episode frequency of oral ulcers and on quality of life for patients with recurrent aphthous stomatitis (RAS)-type ulceration associated with Behçet's disease.We

2014 Cochrane

180. Dyspepsia - proven peptic ulcer

Dyspepsia - proven peptic ulcer Dyspepsia - proven peptic ulcer - NICE CKS Share Dyspepsia - proven peptic ulcer: Summary The term 'dyspepsia' is used to describe a complex of upper gastrointestinal tract symptoms which are typically present for four or more weeks, including upper abdominal pain or discomfort, heartburn, acid reflux, nausea and/or vomiting. If symptoms of heartburn and acid regurgitation predominate, then gastro-oesophageal reflux disease (GORD) is the more likely diagnosis (...) . Gastric or duodenal ulcers (peptic ulcer disease) describe a breach in the epithelium of the gastric or duodenal mucosa, which is confirmed on endoscopy. The most common risk factors for the development of peptic ulcer disease are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. Complications of peptic ulcer disease include haemorrhage, perforation, and gastric outlet obstruction. Initial management of peptic ulcer disease includes: Offering advice

2018 NICE Clinical Knowledge Summaries

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