How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

15,504 results for

Skin Ulcer

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers

Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers HAYES, Inc. Record Status (...) This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of lower extremity arterial and diabetic foot ulcers. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: The MIST Therapy System is a noncontact, low-frequency ultrasound

2016 Health Technology Assessment (HTA) Database.

142. Pressure ulcer prevention program study: a randomized, controlled prospective comparative value evaluation of 2 pressure ulcer prevention strategies in nursing and rehabilitation centers

for Healthcare Research and Quality guidelines and standard skin care products, briefs, pads, and mattresses). Location/setting USA/residential care. Methods Analytical approach: A randomised controlled prospective unblinded cohort study was conducted across two nursing and rehabilitation centres (83 participants in PUPP intervention group; 50 participants in control group). All nursing staff received formal education on pressure ulcer prevention prior to commencement of the trial. Residents were followed (...) and rehabilitation centres. Effectiveness data: The key effectiveness input was the incidence of pressure ulcers. Residents included in the study were prospectively followed for six months to determine the six-month incidence of pressure ulcers in the randomly assigned intervention and control groups. Rates were calculated using weekly skin records completed by nursing staff. In addition, a six-month retrospective review of facility-acquired pressure ulcers was completed to determine the pressure ulcer incidence

2012 NHS Economic Evaluation Database.

143. Negative Pressure Wound Therapy for Patients with Diabetic Foot Ulcers and Pressure Ulcers: A Review of the Clinical Effectiveness

), also known as decubitus ulcers or bedsores, are caused by uninterrupted pressure on soft tissues overlying a bony prominence which obstructs the blood flow to the superficial tissues. The most commonly affected body parts are the sacrum or the hips, but other sites such as the elbows or knees can be affected. 5 People with reduced mobility and poor skin condition in nursing homes or hospitals are more likely afffected. 5 Approximately 3 million adults in the United States suffer from pressure (...) Negative Pressure Wound Therapy for Patients with Diabetic Foot Ulcers and Pressure Ulcers: A Review of the Clinical Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

144. CRACKCast E137 – Skin Infections

-Clav Erythema migrans Borrelia burgdorferi Doxycycline Puncture wound through foot Pseudomomas aeruginosa Ciprofloxacin [1] List 6 risk factors for cellulitis From Uptodate: Predisposing factors for development of cellulitis and/or skin abscess include: Skin barrier disruption due to trauma (such as abrasion, penetrating wound, pressure ulcer, venous leg ulcer, insect bite, injection drug use) Skin inflammation (such as eczema, radiation therapy) Edema due to impaired lymphatic drainage Edema due (...) CRACKCast E137 – Skin Infections CRACKCast E137 - Skin Infections - CanadiEM CRACKCast E137 – Skin Infections In , , by Adam Thomas December 21, 2017 This episode of CRACKCast covers Rosen’s Chapter 129, Skin Infections. These are common and rarely life threatening, but careful consideration should be given for those who may benefit from admission over outpatient treatment. This is a big episode covering the bugs, presentations, and useful tips when treating these infections in the ED

2017 CandiEM

145. Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis

dermatitis: Did the patient have any recent contact with an unknown plant, chemical, or topical medicine? Lesions would be limited to exposed area Distinguished by: Sudden onset of severe pruritus Asymmetric distribution Location Allergy history : An ulcerative, deeper form of impetigo usually found on the lower leg area following a trauma to the skin such as a scratch or cut. Punched out ulcers covered with a yellow crust; raised purple margins Commonly on buttocks, thighs, legs, ankles or feet Diabetes (...) Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis The skin has an effective

2017 medSask

146. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. (PubMed)

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. The efficacy of ustekinumab, an antagonist of the p40 subunit of interleukin-12 and interleukin-23, as induction and maintenance therapy in patients with ulcerative colitis is unknown.We evaluated ustekinumab as 8-week induction therapy and 44-week maintenance therapy in patients with moderate-to-severe ulcerative colitis. A total of 961 patients were randomly assigned to receive an intravenous induction dose (...) weeks of exposure, there were two deaths (one each from acute respiratory distress syndrome and hemorrhage from esophageal varices) and seven cases of cancer (one each of prostate, colon, renal papillary, and rectal cancer and three nonmelanoma skin cancers) among 825 patients who received ustekinumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received placebo.Ustekinumab was more effective than placebo for inducing and maintaining remission in patients

2019 NEJM

147. Effect of a Basic Skin Care Product on the Structural Strength of the Skin

-epidermal separation (blistering time) is a measure of the dermo-epidermal adhesion. It has been proposed that the blistering time might be a clinically relevant parameter reflecting the mechanical integrity/stability of the dermo-epidermal junction. Clinical practice guidelines recommend the use of topical skin care products to reduce the risk for pressure ulcer and skin tear development. However, the underlying working mechanisms of most basic skin care products are poorly understood. It is known (...) Effect of a Basic Skin Care Product on the Structural Strength of the Skin Effect of a Basic Skin Care Product on the Structural Strength of the Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect

2018 Clinical Trials

148. Assessing Tissue Remodeling in the Skin Using SFI (Skin Fluorescence Imaging)

Assessing Tissue Remodeling in the Skin Using SFI (Skin Fluorescence Imaging) Assessing Tissue Remodeling in the Skin Using SFI (Skin Fluorescence Imaging) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Assessing Tissue Remodeling in the Skin Using SFI (Skin Fluorescence Imaging) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03535077 Recruitment Status : Recruiting First Posted : May 24, 2018 Last Update Posted : May 24

2018 Clinical Trials

149. Coban 2 for venous leg ulcers

Coban 2 for venous leg ulcers Coban 2 for v Coban 2 for venous leg ulcers enous leg ulcers Medtech innovation briefing Published: 16 February 2018 nice.org.uk/guidance/mib140 pathways Summary Summary The technology technology described in this briefing is Coban 2 compression bandage for venous leg ulcers. The inno innovativ vative aspect e aspect is that it is thinner than 4-layer bandages. This aims to improve mobility and convenience. The intended place in ther place in therap apy y would (...) be as an alternative to current compression bandages in selected people with venous leg ulcers. The main points from the e main points from the evidence vidence summarised in this briefing are from 3 studies (2 in UK, 1 in Italy; comprising 2 randomised controlled trials [RCTs] and 1 observational study) including a total of 1,456 adults with venous leg ulcers. The evidence is limited in quantity and quality. One randomised study showed that Coban 2 slipped significantly less than 4-layer bandages. The studies

2018 National Institute for Health and Clinical Excellence - Advice

150. Heel casts do not improve heel ulcers in diabetes

the National Pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory Panel (NPUAP/EPUAP) scale. Stage 1 indicates that a local area of skin (usually over a bony prominence) is reddened (-) but the skin is intact. Stage 2 is a shallow open ulcer with a red/pink wound bed, or alternatively shiny blister, with no sloughing. Stage 3 is full thickness skin loss where subcutaneous fat is visible and slough may be present. Stage 4 is full thickness tissue loss, which can expose bone, tendon or muscles (...) Heel casts do not improve heel ulcers in diabetes Heel casts do not improve heel ulcers in diabetes Discover Portal Discover Portal Heel casts do not improve heel ulcers in diabetes Published on 19 September 2017 doi: Fibreglass casts moulded to the heel did not improve heel ulcers in people with diabetes when added to usual ulcer care. Ulcers healed within six months in 44% of people using casts compared with 37% without which was not a statistically significant difference. Foot ulcers

2018 NIHR Dissemination Centre

151. A new tool may help identify more patients at risk of developing pressure ulcers

by following a and assesses eight risk factors: mobility; skin; previous pressure ulcer; sensory perception; perfusion (blood flow); nutrition; moisture; and diabetes. Field testing by nurses showed very good agreement between tests and between assessors. This tool, drawing on new research, has many advantages over the various current assessment tools, which show numerous inconsistencies. PURPOSE-T is already being used by early adopter Trusts and could help to reduce the incidence of pressure ulcers (...) . Share your views on the research. Why was this study needed? Pressure ulcers are areas of damaged skin and tissue, caused when an area of skin is placed under pressure. Typically they occur in a person confined to bed or a chair by an illness, and so are sometimes called bedsores or pressure sores. They can lead to extended hospital stays and reduced quality of life. There are an estimated 180,000 new cases each year in the NHS, with an annual cost for prevention and treatment of between £1.4

2018 NIHR Dissemination Centre

152. A new tool may help identify more patients at risk of developing pressure ulcers

by following a and assesses eight risk factors: mobility; skin; previous pressure ulcer; sensory perception; perfusion (blood flow); nutrition; moisture; and diabetes. Field testing by nurses showed very good agreement between tests and between assessors. This tool, drawing on new research, has many advantages over the various current assessment tools, which show numerous inconsistencies. PURPOSE-T is already being used by early adopter Trusts and could help to reduce the incidence of pressure ulcers (...) . Share your views on the research. Why was this study needed? Pressure ulcers are areas of damaged skin and tissue, caused when an area of skin is placed under pressure. Typically they occur in a person confined to bed or a chair by an illness, and so are sometimes called bedsores or pressure sores. They can lead to extended hospital stays and reduced quality of life. There are an estimated 180,000 new cases each year in the NHS, with an annual cost for prevention and treatment of between £1.4

2018 NIHR Dissemination Centre

153. Long lasting ulcers below the knee are more common than previously thought

(sometimes known as chronic wounds) involve superficial, partial or full-thickness skin loss being treated by secondary intention. This means the wound is left open to heal as opposed to being closed by stitches or similar. Complex wounds often stem from conditions such as pressure ulcers and diabetic foot ulcers and tend to be treated by nurses in the community. The cost of delivering care to people with complex wounds is unclear, but will be high. Community prescribing costs alone for wound dressings (...) had estimated a prevalence of 0.05% (5 per 10,000 people). Complex wounds (sometimes known as chronic wounds) involve superficial, partial or full-thickness skin loss being treated by secondary intention. This means the wound is left open to heal as opposed to being closed by stitches or similar. Complex wounds often stem from conditions such as pressure ulcers and diabetic foot ulcers and tend to be treated by nurses in the community. The cost of delivering care to people with complex wounds

2018 NIHR Dissemination Centre

154. Foot ulcers in people with diabetes: evidence round-up

of skin) and macrovascular and microvascular complications. Infected, non-healing foot ulcers can result in limb amputation. 85% of all non-traumatic lower limb amputations in people with diabetes are preceded by a foot ulcer. reports that there are more than 135 leg, foot or toe amputations in England alone each week and that up to 80% can be avoided with good diabetes management and foot care. Four years ago, Diabetes UK launched their campaign, which includes a leaflet to help people with diabetes (...) Foot ulcers in people with diabetes: evidence round-up Foot ulcers in people with diabetes: evidence round-up - Evidently Cochrane Search and hit Go By April 8, 2016 // If you ever nurse people with diabetes (that’s most of you, I think), then keep reading! Yesterday was , which this year focused on diabetes, and the World Health Organization published its first global report on diabetes. It’s well worth reading and there are useful resources accompanying it. Yesterday I blogged about

2016 Evidently Cochrane

155. Evidence for infliximab dose intensification (5mg/kg every 4-6 weeks) for the maintenance treatment of Ulcerative Colitis in patients who have lost response

Evidence for infliximab dose intensification (5mg/kg every 4-6 weeks) for the maintenance treatment of Ulcerative Colitis in patients who have lost response 1 This LMEN review is produced by the NHS for the NHS and is not to be used for commercial and marketing purposes. London Medicines Evaluation Network Review Evidence for infliximab dose intensification (5mg/kg every 4-6 weeks) for the maintenance treatment of Ulcerative Colitis in patients who have lost response December 2016 Background (...) The National Institute for Health and Care Excellence (NICE) guidance on the treatment of moderately to severely active ulcerative colitis (UC) after the failure of conventional therapy (TA329) 3 recommend infliximab 5mg/kg given as an intravenous infusion followed by additional 5mg/kg infusion doses at 2 and 6 weeks after the first infusion, then every 8 weeks thereafter. Commissioning groups are being asked to fund requests for infliximab dose intensification (i.e. reducing intervals to 4-6 weeks

2017 Specialist Pharmacy Services

156. Treatment of ulcerative compared to non-ulcerative interstitial cystitis with hyperbaric oxygen: a pilot study (PubMed)

Treatment of ulcerative compared to non-ulcerative interstitial cystitis with hyperbaric oxygen: a pilot study The etiology of interstitial cystitis (IC) is often idiopathic but can be due to Hunner's ulcers. Hyperbaric oxygen (HBO) is used to treat ulcerative disease of the superficial skin. We hypothesized that HBO can treat ulcerative IC (UIC) but would be less efficacious for non-ulcerative IC (NIC).Patients with NIC and UIC enrolled in this study. Following informed consent, demographic (...) . Questionnaire scores improved in both groups. Pain scores improved by 2 points in the UIC group but worsened by 1.5 points in the NIC group. Two patients with ulcers resolved at 6-month cystoscopy.HBO appeared beneficial for both UIC and NIC. Data shows slightly better benefit in patients with UIC compared to NIC; both groups showed improvement. Given the small sample size, it is difficult to draw definitive conclusions from these data. Larger studies with randomization would be beneficial to show treatment

Full Text available with Trip Pro

2017 Therapeutic advances in urology

157. The venous ulcer continues to be a clinical challenge: an update (PubMed)

. The pathogenesis of venous ulcers is unrelieved or ambulatory venous hypertension resulting mostly from deep venous thrombosis leading to venous incompetence, lipodermatosclerosis, leucocyte plugging of the capillaries, tissue hypoxia and microvascular dysfunction. It is not known what initiates venous ulcers. Triggers vary from trauma of the lower extremity to scratching to relieve itchy skin over the ankle region. Venous ulcers can be painful, and this condition presents an increasing burden of care (...) The venous ulcer continues to be a clinical challenge: an update Venous ulcers are a common chronic problem in many countries especially in Northern Europe and USA. The overall prevalence of this condition is 1% rising to 3% in the over 65 years of age. Over the last 25 years, there have been many developments applicable to its diagnosis and treatment. These advances, notwithstanding healing response and recurrence, are variable, and the venous ulcer continues to be a clinical challenge

Full Text available with Trip Pro

2018 Burns & trauma

158. Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial (PubMed)

, double-blind, randomized clinical study was conducted from October 2015 to September 2016. The inclusion criteria for leg ulcers were (1) diabetes or critical limb ischemia and (2) wound size <6 cm in diameter. Twelve patients were randomized into four groups and administered 0.02%, 0.1%, or 0.5% SR-0379 or placebo treatment on skin ulcers once per day for 28 days. Efficiency was evaluated by determining the rate of wound size reduction as a primary endpoint at 4 weeks after the first treatment (...) compared with the pre-treatment wound size. As a secondary endpoint, the DESIGN-R score index, time to wound closure, and the 50% wound size reduction ratio were also evaluated. The safety of SR-0379 was evaluated during the study period. In the evaluation of efficiency, the skin ulcer reduction rates at the last evaluation were 44.73% for the 0.02% SR-0379 group, 68.25% for the 0.1% group, and 71.61% for the 0.5% group, compared with 9.95% for the placebo group. Six adverse events were reported

Full Text available with Trip Pro

2018 NPJ aging and mechanisms of disease

159. British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease

British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease GUIDELINES BJD British Journal of Dermatology British Association of Dermatologists’ guidelines for the safe and effective prescribing of methotrexate for skin disease 2016 R.B. Warren, 1 S.C. Weatherhead, 2 C.H. Smith, 3 L.S. Exton, 4 M.F. Mohd Mustapa, 4 B. Kirby 5 and P.D. Yesudian 6 1 The Dermatology Centre, Salford Royal NHS Foundation Trust, The University (...) - language references was a pragmatic decision, but the authors recognize this may exclude some important information pub- lished in other languages. 5.0 Plans for guideline revision The proposed revision date for this set of recommendations is scheduled for 2021; where necessary, important interim changes will be updated on the BAD website. 6.0 Introduction MTX is an immunosuppressant drug that occupies a key place in the management of many autoimmune and in?ammatory skin diseases. Although MTX has been

2016 British Association of Dermatologists

160. Wound-care teams for preventing and treating pressure ulcers. (PubMed)

Wound-care teams for preventing and treating pressure ulcers. Pressure ulcers, which are localised injury to the skin or underlying tissue, or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful and impact negatively on the individual's quality of life. The cost implications of pressure ulcer treatment are considerable, compounding the challenges in providing cost effective, efficient health (...) service delivery. International guidelines suggest that to prevent and manage pressure ulcers successfully a team approach is required. Therefore, this review has been conducted to clarify the role of wound-care teams in the prevention and management of pressure ulcers.To assess the impact of wound-care teams in preventing and treating pressure ulcers in people of any age, nursed in any healthcare setting.In April 2015 we searched: The Cochrane Wounds Group Specialised Register; The Cochrane Central

Full Text available with Trip Pro

2015 Cochrane

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>