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Skin Ulcer

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141. Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury Full Text available with Trip Pro

Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury 27563371 2016 08 26 2019 02 26 1937-5719 16 2016 Eplasty Eplasty Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury. ic31 Moonsamy Philicia P Division of Burn Surgery, Department of Surgery, Massachusetts General Hospital, Boston. Nazarian Rosalynn M RM Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Boston. Schulz John T JT Division of Burn Surgery, Department (...) of Surgery, Massachusetts General Hospital, Boston. Goverman Jeremy J Division of Burn Surgery, Department of Surgery, Massachusetts General Hospital, Boston. eng Case Reports 2016 07 25 United States Eplasty 101316107 1937-5719 acute Marjolin's ulcer burn nonhealing wound skin graft squamous cell carcinoma 2016 8 27 6 0 2016 8 27 6 0 2016 8 27 6 1 epublish 27563371 PMC4980804 Plast Reconstr Surg. 2009 Jul;124(1):156e-64e 19568055 Ann Plast Surg. 2014 May;72(5):515-20 24691319

2016 Eplasty

142. In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer Full Text available with Trip Pro

In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer Decreased nitric oxide (NO) synthesis and increased NO consumption in diabetes induces the inadequate blood flow to tissues that is primarily responsible for the pathogenesis and refractoriness of diabetic skin ulcers. The present study proposed a simple and effective therapeutic strategy for diabetic skin ulcers-in situ up-regulation of endothelial nitric oxide synthase (eNOS) expression (...) wound healing. These findings suggest that the in situ up-regulation of eNOS/NO by a statin-loaded TES may be a useful therapeutic method for intractable diabetic skin wounds.

2016 Scientific reports

143. A retrospective study of forensic cases of skin ulcerations in Danish pigs from 2000 to 2014 Full Text available with Trip Pro

A retrospective study of forensic cases of skin ulcerations in Danish pigs from 2000 to 2014 Ulcerations in pigs, as in other farm animals, are considered to be painful and therefore hampering the welfare. Farmers are obliged to provide an intervention to protect animals against unnecessary suffering and failure to do so is considered negligence. Moreover, animals with severe open wounds are considered unfit for transportation and so are pigs with ulcerations located on hernias. This paper (...) presents a retrospective study of forensic case files concerning ulcerations in Danish pigs from 2000 to 2014. The aim of the study was to clarify the number of cases, the number of pigs, the anatomical localization and size of ulcerations, evaluate changes during years and the age of the lesions.A total of 209 case files concerning 283 pigs with 459 ulcerations were included. In 2004, 2005, 2007-2009 and 2011, sows with shoulder ulcerations were the most frequently submitted, while in 2014 pigs

2016 Acta veterinaria Scandinavica

144. RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus Full Text available with Trip Pro

RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus Sea cucumber Apostichopus japonicus is an important economic species in China, which is affected by various diseases; skin ulceration syndrome (SUS) is the most serious. In this study, we characterized the transcriptomes in A. japonicus challenged with Vibrio splendidus to elucidate the changes in gene expression throughout the three stages of SUS

2016 BMC genomics

145. Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behçet's disease Full Text available with Trip Pro

Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behçet's disease A 25-year-old man was admitted to our hospital, with fever, severe ulceration of the oral and pharyngeal mucosa, and pustules on his skin. These pathergy-like lesions had emerged after placement of orthodontic braces and laser therapy for hair removal, respectively. The patient's clinical condition, together with his ethnic

2016 BMJ case reports

146. Clinical Feasibility of an Advanced Therapy Medicinal Product (ATMP) Preparation for Autologous Skin Regeneration in Case of Chronic Leg Ulcers

Clinical Feasibility of an Advanced Therapy Medicinal Product (ATMP) Preparation for Autologous Skin Regeneration in Case of Chronic Leg Ulcers Clinical Feasibility of an Advanced Therapy Medicinal Product (ATMP) Preparation for Autologous Skin Regeneration in Case of Chronic Leg Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Clinical Feasibility of an Advanced Therapy Medicinal Product (ATMP) Preparation for Autologous Skin Regeneration in Case of Chronic Leg Ulcers (MecaSkin) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2016 Clinical Trials

147. ExpressGraft-C9T1 Skin Tissue as a Treatment of Diabetic Foot Ulcers

ExpressGraft-C9T1 Skin Tissue as a Treatment of Diabetic Foot Ulcers ExpressGraft-C9T1 Skin Tissue as a Treatment of Diabetic Foot Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. ExpressGraft-C9T1 (...) Skin Tissue as a Treatment of Diabetic Foot Ulcers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02657876 Recruitment Status : Active, not recruiting First Posted : January 18, 2016 Last Update Posted : February 19, 2019 Sponsor: Stratatech, a Mallinckrodt Company Collaborator: National Institute

2016 Clinical Trials

148. Interest of Skin Graft Pellets in the Management of Ulcers Algic

Interest of Skin Graft Pellets in the Management of Ulcers Algic Interest of Skin Graft Pellets in the Management of Ulcers Algic - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Interest of Skin Graft (...) Party): Groupe Hospitalier Paris Saint Joseph Study Details Study Description Go to Brief Summary: Leg ulcers (UDJ) is defined as a chronic skin wound, lasting for more than 4 to 6 weeks, between the knee and foot, and with no tendency to spontaneous healing. In 2002, the prevalence of leg ulcers is estimated between 0.5% and 1% of the general population and 3% in subjects over 65 years. The sex ratio is generally 3 females to 1 male. It is in most cases a complication of vascular disease, usually

2016 Clinical Trials

149. UC-MSCs Gel Treatment Difficult Healing of Skin Ulcers

UC-MSCs Gel Treatment Difficult Healing of Skin Ulcers UC-MSCs Gel Treatment Difficult Healing of Skin Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. UC-MSCs Gel Treatment Difficult Healing of Skin (...) , To observe the clinical efficacy and safety. Condition or disease Intervention/treatment Phase Difficult to Healing of Skin Ulcers Biological: UC-MSCs Gel group Other: Gel group Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 20 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Umbilical Cord Mesenchymal Stem Cells Between Gel

2016 Clinical Trials

150. Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers

Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

151. When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care?

When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care? When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care? (BIOPULCER) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02889913 Recruitment Status : Completed First Posted : September 7, 2016 Last Update Posted : September 7, 2016 Sponsor

2016 Clinical Trials

152. Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care

known as a pressure sore, decubitus ulcer, or bedsore, is defined as localized injury to the skin and/or underlying tissue occurring most often over a bony prominence, caused by pressure, or pressure in combination with shear. (1) According to the National Pressure Ulcer Advisory Panel’s updated pressure ulcer staging system from 2007, PrUs are classified into 6 categories: stage I, nonblanchable erythema; stage II, partial thickness skin loss; stage III, full thickness skin loss; stage IV, full (...) Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care. March 2015; pp. 1–87 Pressure Ulcer Multidisciplinary Teams via Telemedicine (PUMTT): A Pragmatic Randomized Controlled Trial in Long-Term Care VE RAC, J WONG, AS BROOKER, N MITSAKAKIS, M PAULDEN, B PHAM, S CARCONE, MD KRAHN MARCH 2015 This article

2015 Health Quality Ontario

153. International Consolidated Venous Ulcer Guideline

ulcer (VU) is an open skin lesion of the leg or foot that occurs in an area affected by venous hypertension (O’Donnell 2014). This condition is associated with lower leg swelling (edema) which can progress to dermatitis and VU formation. It may result from incompetent venous valves in the superficial, perforator or deep vein systems and/or inadequate calf muscle pump function (Tang et al. 2012) A VU is considered chronic if it is unresponsive to best- evidence-based management , i.e. reduces in area (...) 2007; Vasquez et al., 2010; Volikova et al., 2009) CVI= 0.952, High SOR A.2.a.i Table 1. CEAP Descriptive Venous Ulcer Scoring System Developed by the American Venous Forum Accepted as Reporting Standards In Venous Disease. A (Gloviczki et al., 2011; Vasquez et al., 2010) CVI= 0.882, High SOR Class Description C0 No visible or palpable signs of venous disease C1 Telangiectasies or reticular veins ( 3 mm diameter) C3 Edema C4 Skin and subcutaneous tissue changes secondary to cardiovascular disease

2015 Association for the Advancement of Wound Care

154. Ulcerative colitis

, for example in the left lower quadrant. Signs of malnutrition or malabsorption — serial weight loss or, in children, faltering growth or delayed puberty. Eye, skin, or joint signs of . Note: be aware that physical examination may be normal in people with mild or moderate disease. Basis for recommendation Basis for recommendation The recommendations on when to suspect ulcerative colitis are largely based on the National Institute for Health and Care Excellence (NICE) clinical guideline Ulcerative Colitis (...) Ulcerative colitis Ulcerative colitis - NICE CKS Share Ulcerative colitis: Summary Ulcerative colitis is a chronic, relapsing-remitting, non-infectious inflammatory disease of the gastrointestinal tract. It is characterized by diffuse, continuous, superficial inflammation of the large bowel limited to the intestinal mucosa, and usually affects the rectum with a variable length of the colon involved proximally. It may have a number of extra-intestinal manifestations including uveitis

2019 NICE Clinical Knowledge Summaries

155. Leg ulcer - venous

Leg ulcer - venous Leg ulcer - venous - NICE CKS Share Leg ulcer - venous: Summary ​​​​​​A leg ulcer is a break in the skin below the knee which has not healed within 2 weeks. A venous leg ulcer occurs in the presence of venous disease and is the most common type of leg ulcer, accounting for 60–80% of cases. It typically occurs in the gaiter area of the leg (from the ankle to mid-calf). Other causes of leg ulceration and/or delayed wound healing include arterial disease, diabetes, rheumatoid (...) %. Repeat cycles of ulceration, healing, and recurrence are common. Assessment of a person with a venous leg ulcer should include: Asking about the symptoms experienced (type, duration, and severity). Identifying risk factors, such as immobility and a history of DVT. Examining the wound (site, edge, size, depth, wound bed, and for signs of infection). Examining the legs (for oedema, varicose veins, venous skin changes, and reduced ankle mobility). Assessing for other causes of ulceration and/or delayed

2019 NICE Clinical Knowledge Summaries

156. Use of the Braden Scale for Assessing Pressure Ulcer Risk in Acute Care

-analyses, non-randomized studies, or randomized controlled trials were identified. Additional references of potential interest are provided in the appendix. Health Technology Assessments No literature identified. Systematic Reviews and Meta-analyses No literature identified. Randomized Controlled Trials No literature identified. Non-Randomized Studies No literature identified. Guidelines and Recommendations 1. Ayello EA, Sibbald RG. Preventing pressure ulcers and skin tears [Internet]. In: Boltz M (...) Use of the Braden Scale for Assessing Pressure Ulcer Risk in Acute Care Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

157. Treatment of ulcerative compared to non-ulcerative interstitial cystitis with hyperbaric oxygen: a pilot study Full Text available with Trip Pro

Treatment of ulcerative compared to non-ulcerative interstitial cystitis with hyperbaric oxygen: a pilot study The etiology of interstitial cystitis (IC) is often idiopathic but can be due to Hunner's ulcers. Hyperbaric oxygen (HBO) is used to treat ulcerative disease of the superficial skin. We hypothesized that HBO can treat ulcerative IC (UIC) but would be less efficacious for non-ulcerative IC (NIC).Patients with NIC and UIC enrolled in this study. Following informed consent, demographic (...) . Questionnaire scores improved in both groups. Pain scores improved by 2 points in the UIC group but worsened by 1.5 points in the NIC group. Two patients with ulcers resolved at 6-month cystoscopy.HBO appeared beneficial for both UIC and NIC. Data shows slightly better benefit in patients with UIC compared to NIC; both groups showed improvement. Given the small sample size, it is difficult to draw definitive conclusions from these data. Larger studies with randomization would be beneficial to show treatment

2017 Therapeutic advances in urology

158. Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. (Abstract)

Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. This article provides an overview of the biology, epidemiology, clinical features, diagnostic tests, and treatment of Haemophilus ducreyi infection, with special reference to the decline of chancroid and the recent emergence of H. ducreyi as a pathogen responsible for chronic limb ulceration clinically similar to yaws.Chancroid has declined in importance as a sexually transmitted infection in most countries where (...) it was previously endemic. Chancroid may be caused by either class I or class II H. ducreyi isolates; these two classes diverged from each other approximately 1.95 million years ago. H. ducreyi has recently emerged as a cause of chronic skin ulceration in the Pacific region and Africa. Based on sequencing of whole genomes and defined genetic loci, it appears that the cutaneous H. ducreyi strains diverged from the class I genital strains relatively recently.H. ducreyi should be considered as a major cause

2015 Current Opinion in Infectious Diseases

159. Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic leg ulcers: A controlled randomized study. (Abstract)

Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic leg ulcers: A controlled randomized study. Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft.We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction (...) in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis.Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P=0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional

2015 Annales de dermatologie et de venereologie Controlled trial quality: uncertain

160. A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in patients with diabetes - a randomized controlled trial. Full Text available with Trip Pro

A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in patients with diabetes - a randomized controlled trial. Although monitoring foot skin temperatures has been associated with diabetic foot ulcer recurrence, no studies have been carried out to test the feasibility among European Caucasians. Moreover, the educational and/or motivational models that promote cognitive or psychosocial processes in these studies are lacking. Thus, we conducted (...) a pilot randomized controlled trial to test the feasibility of monitoring foot skin temperatures in combination with theory-based counselling to standard foot care to reduce diabetic foot ulcer recurrence.In a single-blinded nurse-led 1-year controlled trial, conducted at a hospital setting in Norway, 41 patients with diabetic neuropathy and previous foot ulcer were randomized to the intervention (n = 21) or control groups (n = 20). All participants were instructed in foot care and recording

2015 BMC endocrine disorders Controlled trial quality: uncertain

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