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Skin Ulcer

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121. Protease-modulating matrix treatments for healing venous leg ulcers. (PubMed)

Protease-modulating matrix treatments for healing venous leg ulcers. Venous leg ulcers (VLUs) are open skin wounds on the lower leg that occur because of poor blood flow in the veins of the leg; leg ulcers can last from weeks to years, and are both painful and costly. Prevalence in the UK is about 2.9 cases per 10,000 people. First-line treatment for VLUs is compression therapy, but around 60% of people have unhealed ulcers after 12 weeks' treatment and about 40% after 24 weeks; therefore (...) , there is scope for further improvement. Limited evidence suggests non-healing leg ulcers may have persisting elevated levels of proteases, which is thought to deter the later stages of healing; thus, timely protease-modulating matrix (PMM) treatments may improve healing by physically removing proteases from the wound fluid.To determine the effects of protease-modulating matrix (PMM) treatments on the healing of venous leg ulcers, in people managed in any care setting.In September 2016 we searched

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2016 Cochrane

122. Bed rest for pressure ulcer healing in wheelchair users. (PubMed)

Bed rest for pressure ulcer healing in wheelchair users. Pressure ulcers, which are localised injury to the skin or underlying tissue, or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful, and impact negatively on the individual's quality of life. International guidelines suggest bed rest as a component of the treatment strategy to manage pressure ulcers among wheelchair users. The potential (...) benefits and risks need to be considered when assessing the effectiveness of bed rest as an intervention for treating pressure ulcers in this population. Therefore, it was important to search and appraise existing research evidence in order to determine the impact of bed rest on the healing of pressure ulcers in wheelchair users.To assess the impact of bed rest on pressure ulcer healing, in wheelchair users, of any age, who are living or being cared for in any setting.In October 2016 we searched

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2016 Cochrane

123. Antibiotics and antiseptics for pressure ulcers. (PubMed)

Antibiotics and antiseptics for pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. A range of treatments with antimicrobial properties, including impregnated dressings, are widely used in the treatment of pressure ulcers. A clear and current overview is required to facilitate decision making regarding use of antiseptic or antibiotic therapies in the treatment of pressure (...) ulcers. This review is one of a suite of Cochrane reviews investigating the use of antiseptics and antibiotics in different types of wounds. It also forms part of a suite of reviews investigating the use of different types of dressings and topical treatments in the treatment of pressure ulcers.To assess the effects of systemic and topical antibiotics, and topical antiseptics on the healing of infected and uninfected pressure ulcers being treated in any clinical setting.In October 2015 we searched

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2016 Cochrane

124. Bioengineered skin in diabetic foot ulcers

Bioengineered skin in diabetic foot ulcers Bioengineered skin in diabetic foot ulcers Bioengineered skin in diabetic foot ulcers Teng YJ, Li YP, Wang JW, Yang KH, Zhang YC, Wang YJ, Tian JH, Ma B, Wang JM, Yan X CRD summary This review concluded that patients with diabetic foot ulcers might benefit from bioengineered skin due to its effectiveness, safety, and reduced risk of infections, compared with control treatment. The authors highlighted the various limitations of the studies included (...) in the review and acknowledged that these prevented them from drawing firm conclusions. The conclusions reflect the evidence presented. Authors' objectives To evaluate the effectiveness and safety of bioengineered skin in the treatment of patients with diabetic foot ulcers. Searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Science Citation Index, Science Direct, Chinese Biomedical Database, CNKI, and Chinese Journals Full-text Database were searched. Search dates spanned

2010 DARE.

125. Heel casts do not improve heel ulcers in diabetes

the National Pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory Panel (NPUAP/EPUAP) scale. Stage 1 indicates that a local area of skin (usually over a bony prominence) is reddened (-) but the skin is intact. Stage 2 is a shallow open ulcer with a red/pink wound bed, or alternatively shiny blister, with no sloughing. Stage 3 is full thickness skin loss where subcutaneous fat is visible and slough may be present. Stage 4 is full thickness tissue loss, which can expose bone, tendon or muscles (...) Heel casts do not improve heel ulcers in diabetes Heel casts do not improve heel ulcers in diabetes Discover Portal Discover Portal Heel casts do not improve heel ulcers in diabetes Published on 19 September 2017 doi: Fibreglass casts moulded to the heel did not improve heel ulcers in people with diabetes when added to usual ulcer care. Ulcers healed within six months in 44% of people using casts compared with 37% without which was not a statistically significant difference. Foot ulcers

2019 NIHR Dissemination Centre

126. Long lasting ulcers below the knee are more common than previously thought

(sometimes known as chronic wounds) involve superficial, partial or full-thickness skin loss being treated by secondary intention. This means the wound is left open to heal as opposed to being closed by stitches or similar. Complex wounds often stem from conditions such as pressure ulcers and diabetic foot ulcers and tend to be treated by nurses in the community. The cost of delivering care to people with complex wounds is unclear, but will be high. Community prescribing costs alone for wound dressings (...) had estimated a prevalence of 0.05% (5 per 10,000 people). Complex wounds (sometimes known as chronic wounds) involve superficial, partial or full-thickness skin loss being treated by secondary intention. This means the wound is left open to heal as opposed to being closed by stitches or similar. Complex wounds often stem from conditions such as pressure ulcers and diabetic foot ulcers and tend to be treated by nurses in the community. The cost of delivering care to people with complex wounds

2019 NIHR Dissemination Centre

127. Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles

Practice Guidelines for the Prevention and Management of Diabetes in Canada and in regard to the formation of foot ulcers involves regular foot examination (which should include the assessment of skin temperature), prompt callus removal, and patient education. 28 In order to reduce pressure on the bottoms of the feet and accommodate foot deformities, people with diabetes should be advised to wear well-fitting or professionally fitted footwear. 25,28-31 Treatment of Diabetic Foot Ulcers Early detection (...) Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles | CADTH.ca CADTH Document Viewer Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles Table of Contents Search this document Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure

2017 CADTH - Issues in Emerging Health Technologies

128. Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles

Practice Guidelines for the Prevention and Management of Diabetes in Canada and in regard to the formation of foot ulcers involves regular foot examination (which should include the assessment of skin temperature), prompt callus removal, and patient education. 28 In order to reduce pressure on the bottoms of the feet and accommodate foot deformities, people with diabetes should be advised to wear well-fitting or professionally fitted footwear. 25,28-31 Treatment of Diabetic Foot Ulcers Early detection (...) Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles | CADTH.ca CADTH Document Viewer Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure-Sensing Shoe Insoles Table of Contents Search this document Prevention of Plantar Ulcers in People With Diabetic Peripheral Neuropathy Using Pressure

2017 CADTH - Issues in Emerging Health Technologies

129. VF-001 (VitroGro ECM) for venous leg ulcer

. > > > VF-001 (VitroGro ECM) for venous leg ulcer VF-001 (VitroGro ECM) for venous leg ulcer June 2017 VF-001 is a new drug that enables and accelerates chronic wound repair by providing cell attachment sites and stimulating cell activity. Consequently, skin cells are able to attach, migrate and increase rapidly to restore the wound healing process.VF-001 is applied to the wound weekly, and fits with standard care for chronic wounds. The wound closes, breaking the cycle of inflammation, and leaving (...) VF-001 (VitroGro ECM) for venous leg ulcer VF-001 (VitroGro ECM) for venous leg ulcer | Innovation Observatory toggle menu Menu Search View All Filter by Speciality Filter by Year Filter by Category This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders

2017 NIHR Innovation Observatory

130. Emerging Technologies for the Prevention of Pressure Ulcers in Acute Care Settings: A Review of Clinical and Cost-Effectiveness and Guidelines

that prophylactic polyurethane film dressings may be effective in preventing pressures sores in individuals without existing skin or tissue damage. One evidence-based guideline was identified relating to emerging technologies for the prevention of pressure ulcers in acute care settings; recommended practices include microclimate manipulation, prophylactic dressings, silk-like fabrics designed to reduce shear and friction, and electrical stimulation of the muscles in individuals with spinal cord injury (...) . No published literature was identified relating to the cost-effectiveness of emerging interventions for the prevention of pressure ulcers in acute care setting or regarding the clinical effectiveness of emerging preventive strategies in the operating room. Tags dermatology, hydrogels, microclimate, pressure ulcer, silk, bed sore, bed sores, skin lesion, skin lesions, decubitis, decubitus, Prevention, preventing, preventive Files Rapid Response Summary with Critical Appraisal Published : September 12, 2016

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

131. Diabetic Foot Ulcers: Prevention

skin and cut toe nails straight across. ( Weak; Low ) Is footwear effective in preventing a first or recurrent non-plantar foot ulcer in an at-risk patient with diabetes? Instruct an at-risk patient with diabetes to wear properly fitting footwear to prevent a first foot ulcer, either plantar or non-plantar, or a recurrent non-plantar foot ulcer. When a foot deformity or a pre-ulcerative sign is present, consider prescribing therapeutic shoes, custom-made insoles or toe orthosis. ( Strong; Low (...) treatment, adequate footwear and education. This should be repeated or re-evaluated once every 1 to 3 months as necessary. ( Strong; Low ) Is self-management of foot health effective in preventing a first or recurrent foot ulcer in at-risk patients with diabetes? Instruct a high-risk patient with diabetes to monitor foot skin temperatures at home to prevent a first or recurrent plantar foot ulcer. This aims at identifying the early signs of inflammation, followed by action taken by the patient and care

2017 National Guideline Clearinghouse (partial archive)

132. Diabetic Foot Ulcers: Wound Management

Diabetic Foot Ulcers: Wound Management Diabetic Foot Ulcers: Wound Management | National Guideline Clearinghouse success fail JUL Aug 12 2017 2018 2019 02 Oct 2017 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group is 100% composed of volunteers and interested (...) * Remember Me Don't have an account? The AHRQ National Guideline Clearinghouse (NGC, guideline.gov) Web site will not be available after July 16, 2018 because federal funding through AHRQ will no longer be available to support the NGC as of that date. For additional information, read our . Guideline Synthesis Diabetic Foot Ulcers: Wound Management Guidelines Being Compared: International Working Group on the Diabetic Foot (IWGDF) IWGDF guidance on use of interventions to enhance the healing of chronic

2017 National Guideline Clearinghouse (partial archive)

133. Varicose vein injections help new venous leg ulcers heal

was made after ulcer healing or six months after randomisation. Patients were excluded if they were pregnant, unable to adhere to compression therapy, had deep vein disease, needed skin grafting, or had the ulcer for less than six weeks or more than six months. Many people were not eligible because the ulcer had been present for too long, more than six months, or had healed by the time of referral. Some declined due to clinician or personal preference for treatment, so these results may not apply (...) ablation of varicose veins within two weeks of randomisation, or standard compression therapy but with delayed consideration of intervention. The delayed decision was made after ulcer healing or six months after randomisation. Patients were excluded if they were pregnant, unable to adhere to compression therapy, had deep vein disease, needed skin grafting, or had the ulcer for less than six weeks or more than six months. Many people were not eligible because the ulcer had been present for too long

2019 NIHR Dissemination Centre

134. Oral Aphthous Ulcer - Guidelines for Prescribing Triamcinolone Dental Paste

Oral Aphthous Ulcer - Guidelines for Prescribing Triamcinolone Dental Paste Oral Aphthous Ulcer - Guidelines for Prescribing Triamcinolone Dental Paste - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Oral Aphthous Ulcer - Guidelines for Prescribing Triamcinolone Dental Paste Mouth ulcers, also known as canker sores, aphthous ulcers or aphthous stomatitis are painful, recurrent lesions which occur on oral mucosa, especially (...) on buccal areas where teeth or dental appliances may have caused damage. They are shallow painful sores that have a shedding base with erythematous margins, may occur singly or in clusters and resolve spontaneously depending on their severity, in a week to 2 months usually with no scarring. They may recur 2 to 4 times a year or remain almost continuous. Mouth ulcers affect 10 to 20% of the population and are more common in childhood to early adulthood. Patient risk factors for developing an aphthous

2017 medSask

135. Skin care strategies to prevent pressure ulcer for patients in acute care settings: a systematic review.

Skin care strategies to prevent pressure ulcer for patients in acute care settings: a systematic review. 27819995 2018 05 14 1838-2142 7 16 Suppl 2009 JBI library of systematic reviews JBI Libr Syst Rev Skin care strategies to prevent pressure ulcer for patients in acute care settings: a systematic review. 1-12 Ligita Titan T 1Health Training Officer, Centre for Health Training, West Kalimantan Province, Indonesia 2Research Fellow, The Joanna Briggs Institute, Adelaide, South Australia

2017 JBI library of systematic reviews

136. A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns

-thickness burns (covering > 30% TBSA). 36 Epicel has been available for use in the US since 2007 under a Humanitarian Device Exemption, and it has been utilized in Canada under compassionate use regulations. 37,38 In addition to ReCell, Avita Medical has two other autologous skin cell technologies for wound and skin indications. 15 ReGenerCell is intended as an adjunct to conventional treatments for chronic wounds including venous leg ulcers, diabetic foot ulcers, and complex hard-to-heal wounds (...) A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns | CADTH.ca CADTH Document Viewer A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns Table of Contents Search this document A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns March 2018 Summary Burn injuries cause trauma and suffering, and can involve long hospital stays. The ReCell Autologous Cell

2018 CADTH - Issues in Emerging Health Technologies

137. Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence

Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cooling Leg (...) and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence (MUSTCOOL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02626156 Recruitment Status : Recruiting First Posted : December 10, 2015 Last Update Posted : May 3

2015 Clinical Trials

138. Cytomegalovirus ulcers following radiotherapy for a Marjolin ulcer in a renal transplant recipient. (PubMed)

Cytomegalovirus ulcers following radiotherapy for a Marjolin ulcer in a renal transplant recipient. Cytomegalovirus (CMV) infection represents a major cause of morbidity and mortality in immunocompromised hosts. Skin ulceration is a rare manifestation of tissue-invasive disease, with the anogenital region being the most typical site of involvement. We present a case of CMV ulceration on the right leg occurring 16 years following renal transplantation and 1 year after adjuvant radiotherapy (...) for a Marjolin ulcer at this site. We suggest radiotherapy may provide a mechanism for local reactivation of the virus in the skin of seropositive patients.© 2018 The Australasian College of Dermatologists.

2018 Australasian Journal of Dermatology

139. Pressure ulcers: prevention and management

for implementation 6 Adults: risk assessment 6 Adults: skin assessment 6 All ages: care planning 6 Adults: repositioning 7 Adults: devices for prevention of pressure ulcers 7 Neonates, infants, children and young people: risk assessment 7 All ages: healthcare professional training and education 8 Adults: management of heel pressure ulcers 8 1 Recommendations 9 T erms used in this guideline 9 1.1 Prevention: adults 10 1.2 Prevention: neonates, infants, children and young people 13 1.3 Prevention: all ages 16 1.4 (...) /terms-and- conditions#notice-of-rights). Page 3 of 29This guideline replaces CG29 and CG7. This guideline is the basis of QS89. Introduction Introduction This guideline updates and replaces 'Pressure ulcers' (NICE clinical guideline 29) and 'Pressure ulcer prevention' (NICE clinical guideline 7). See About this guideline for details. Pressure ulcers are caused when an area of skin and the tissues below are damaged as a result of being placed under pressure sufficient to impair its blood supply

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

140. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers

Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation HAYES, Inc.. Noncontact low-frequency ultrasound using the MIST Therapy System (Celleration Inc.) for treatment of venous leg ulcers. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: The MIST Therapy System is a noncontact, low-frequency ultrasound debridement device that promotes healing of chronic wounds by removing yellow slough, tissue exudates, fibrin, and bacteria from

2016 Health Technology Assessment (HTA) Database.

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