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Skin Ulcer

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61. WITHDRAWN: Interventions for skin changes caused by nerve damage in leprosy. (PubMed)

WITHDRAWN: Interventions for skin changes caused by nerve damage in leprosy. More than three million persons are disabled by leprosy worldwide. The main complication of sensory nerve damage is neuropathic ulceration, particularly of the feet. In this review we explored interventions that can prevent and treat secondary damage to skin and limbs.To assess the effects of self-care, dressings and footwear in preventing and healing secondary damage to the skin in persons affected by leprosy.We (...) searched the Cochrane Skin Group Specialised Register (April 2008), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2008), MEDLINE (from 2003 to April 2008), EMBASE (from 2005 to April 2008), CINAHL (1982-2006) and LILACS (1982- April 2008 ) as well as online registers of ongoing trials (April 2008).Randomised controlled trials involving anyone with leprosy and damage to peripheral nerves treated with any measures designed to prevent damage with the aim of healing

2019 Cochrane

62. Dressings and topical agents for treating venous leg ulcers. (PubMed)

Dressings and topical agents for treating venous leg ulcers. Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes of prolonged ulceration. First-line treatment for venous leg ulcers is compression therapy, but a wide range of dressings and topical treatments are also used. This diversity (...) of treatments makes evidence-based decision-making challenging, and a clear and current overview of all the evidence is required. This review is a network meta-analysis (NMA) which assesses the probability of complete ulcer healing associated with alternative dressings and topical agents.To assess the effects of (1) dressings and (2) topical agents for healing venous leg ulcers in any care setting and to rank treatments in order of effectiveness, with assessment of uncertainty and evidence quality.In March

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2018 Cochrane

63. Extracorporeal shock wave therapy for the healing and management of venous leg ulcers. (PubMed)

Extracorporeal shock wave therapy for the healing and management of venous leg ulcers. Leg ulcers are chronic wounds of the lower leg, caused by poor blood flow, that can take a long time to heal. The pooling of blood in the veins can damage the skin and surrounding tissues, causing an ulcer to form. Venous leg ulcers are associated with impaired quality of life, reduced mobility, pain, stress and loss of dignity. The standard treatment for venous leg ulcers is compression bandages or stockings (...) of extracorporeal shock wave therapy in the healing and management of venous leg ulceration.Two review authors independently performed study selection. We planned that two review authors would also assess the risk of bias of included studies, extract study data and rate the certainty of the evidence using GRADE.We found no RCTs that met the inclusion criteria for this review.We found no RCTs assessing the effectiveness of extracorporeal shock wave therapy in the healing and management of venous leg ulceration

2018 Cochrane

64. Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease). (PubMed)

Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease). Buruli ulcer is a necrotizing cutaneous infection caused by infection with Mycobacterium ulcerans bacteria that occurs mainly in tropical and subtropical regions. The infection progresses from nodules under the skin to deep ulcers, often on the upper and lower limbs or on the face. If left undiagnosed and untreated, it can lead to lifelong disfigurement and disabilities. It is often treated with drugs and surgery.To summarize (...) observational studies, with 1665 participants. Studies evaluated various drugs usually in addition to surgery, and were carried out across eight countries in areas with high Buruli ulcer endemicity in West Africa and Australia. Only one RCT reported adequate methods to minimize bias. Regarding monotherapy, one RCT and one observational study evaluated clofazimine, and one RCT evaluated sulfamethoxazole/trimethoprim. All three studies had small sample sizes, and no treatment effect was demonstrated

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2018 Cochrane

65. Support surfaces for treating pressure ulcers. (PubMed)

Support surfaces for treating pressure ulcers. Pressure ulcers are treated by reducing pressure on the areas of damaged skin. Special support surfaces (including beds, mattresses and cushions) designed to redistribute pressure, are widely used as treatments. The relative effects of different support surfaces are unclear. This is an update of an existing review.To assess the effects of pressure-relieving support surfaces in the treatment of pressure ulcers.In September 2017 we searched (...) of publication or study setting.We included published or unpublished randomised controlled trials (RCTs), that assessed the effects of support surfaces for treating pressure ulcers, in any participant group or setting.Data extraction, assessment of 'Risk of bias' and GRADE assessments were performed independently by two review authors. Trials with similar participants, comparisons and outcomes were considered for meta-analysis. Where meta-analysis was inappropriate, we reported the results of the trials

2018 Cochrane

66. Pressure ulcer

are appropriate strategies to prevent pressure ulcers. Management of pressure ulcers is determined by the location and condition or severity of the wound. Wounds should be managed in accordance with wound care practices or policies. Definition Pressure ulcers have been defined by the National Pressure Ulcer Advisory Panel and the European Pressure Ulcer Advisory Panel as localised injury to the skin and/or underlying tissue usually over a bony prominence, as a result of pressure or of pressure in combination (...) Pressure ulcer Pressure ulcer - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Pressure ulcer Last reviewed: February 2019 Last updated: March 2018 Summary Pressure ulcers are commonly encountered in patients admitted to hospital and those in long-term care facilities. Older people, and all patients with limited mobility or impaired sensation, are at particular risk. Pressure damage most commonly occurs over bony

2018 BMJ Best Practice

67. Ulcerative colitis

Ulcerative colitis Ulcerative colitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Ulcerative colitis Last reviewed: February 2019 Last updated: September 2018 Summary Ulcerative colitis is a type of inflammatory bowel disease characterised by diffuse inflammation of the colonic mucosa and a relapsing, remitting course. Patients commonly experience bloody diarrhoea, chronic diarrhoea (or both), lower abdominal (...) adenocarcinoma is a complication in 3% to 5% of patients. Definition Ulcerative colitis (UC) is a type of inflammatory bowel disease that characteristically involves the rectum and extends proximally to affect a variable length of the colon. It is recognised as a multifactorial polygenic disease, as the exact aetiology is still unknown. Included in the aetiological theories are environmental factors, immune dysfunction, and a likely genetic predisposition. Podolsky DK. Inflammatory bowel disease. N Engl J

2018 BMJ Best Practice

68. Assessment of oral ulceration

system'. J Oral Pathol Med. 2009 Mar;38(3):241-53. http://www.ncbi.nlm.nih.gov/pubmed/19141062?tool=bestpractice.com Simple: a single ulcer without the involvement of the remaining mucosa. Complex: a single or multiple ulcers with changes to the surrounding mucosa, skin, and/or systemic manifestations. The lesion may be white, red, or vesiculobullous. Destroying: diffuse lesion with tissue destruction and severe systemic involvement. Epidemiology Oral ulcerations are common, but most occurrences go (...) Assessment of oral ulceration Assessment of oral ulceration - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of oral ulceration Last reviewed: February 2019 Last updated: June 2018 Summary Oral mucosal ulcerations are common. Most are self-resolving and transient (e.g., after a simple cheek bite). However, some may require the intervention of a medical or dental practitioner. For example, the serious

2018 BMJ Best Practice

69. Ulcerative colitis

Ulcerative colitis Ulcerative colitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Ulcerative colitis Last reviewed: February 2019 Last updated: September 2018 Summary Ulcerative colitis is a type of inflammatory bowel disease characterised by diffuse inflammation of the colonic mucosa and a relapsing, remitting course. Patients commonly experience bloody diarrhoea, chronic diarrhoea (or both), lower abdominal (...) adenocarcinoma is a complication in 3% to 5% of patients. Definition Ulcerative colitis (UC) is a type of inflammatory bowel disease that characteristically involves the rectum and extends proximally to affect a variable length of the colon. It is recognised as a multifactorial polygenic disease, as the exact aetiology is still unknown. Included in the aetiological theories are environmental factors, immune dysfunction, and a likely genetic predisposition. Podolsky DK. Inflammatory bowel disease. N Engl J

2018 BMJ Best Practice

70. Organisation of health services for preventing and treating pressure ulcers. (PubMed)

Organisation of health services for preventing and treating pressure ulcers. Pressure ulcers, which are a localised injury to the skin, or underlying tissue, or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful, expensive to manage and have a negative impact on quality of life. While individual patient safety and quality care stem largely from direct healthcare practitioner-patient (...) interactions, each practitioner-patient wound-care contact may be constrained or enhanced by healthcare organisation of services. Research is needed to demonstrate clearly the effect of different provider-orientated approaches to pressure ulcer prevention and treatment.To assess the effects of different provider-orientated interventions targeted at the organisation of health services, on the prevention and treatment of pressure ulcers.In April 2018 we searched the Cochrane Wounds Specialised Register

2018 Cochrane

71. Dressings and topical agents for preventing pressure ulcers. (PubMed)

Dressings and topical agents for preventing pressure ulcers. Pressure ulcers, localised injuries to the skin or underlying tissue, or both, occur when people cannot reposition themselves to relieve pressure on bony prominences. These wounds are difficult to heal, painful, expensive to manage and have a negative impact on quality of life. Prevention strategies include nutritional support and pressure redistribution. Dressing and topical agents aimed at prevention are also widely used, however (...) , it remains unclear which, if any, are most effective. This is the first update of this review, which was originally published in 2013.To evaluate the effects of dressings and topical agents on pressure ulcer prevention, in people of any age, without existing pressure ulcers, but considered to be at risk of developing one, in any healthcare setting.In March 2017 we searched the Cochrane Wounds Group Specialised Register, CENTRAL, MEDLINE, MEDLINE (In-Process & Other Non-Indexed Citations), Embase

2018 Cochrane

72. Pressure ulcer

& Lifestyle Close Health in Norway Close Quality and Knowledge Close More topics Close Norwegian studies imply that between 7 (...) and 15 per cent of inpatients develop pressure ulcers . They develop more often in specific groups of patients, like patients with spinal cord injury, hip fracture and patients in intensive care. Pressure ulcers are areas of localized damage to the skin and underlying tissue, believed to be caused by pressure , shear force or friction. Pressure ulcers occur fast, it has been (...) in fewer pressure ulcers , or do they take up nurses’ time which could be better spent with the patient? An updated Cochrane review gives us (...) the current state of the evidence. Barts student nurses learning the ‘Australian lift’ in 1983 Looking back on my nurse training in the 1980s, it seems that efforts to prevent pressure ulcers were a really basic, and essential, part of caring for our patients. Any new reddening of the skin was like a mark of shame for the nurse looking after the bearer

2018 Trip Latest and Greatest

73. Accel-Heal for the management of non-healing venous leg ulcers

the head for patients with epilepsy. Adequate care is needed to ensure the device does not become wet. The device also needs to be removed prior to electrical investigations like magnetic resonance imaging, electroencephalograms and echocardiograms 1 . SHTG Innovative Medical Technology Overview | 2 Patient group Accel-Heal® is an adjunct treatment for managing patients with non-healing venous leg ulcers (VLUs) and those who are unable to use standard treatment. A VLU is an open skin lesion (...) recommendations. Wounds International. 2015. 5. Scottish Intercollegiate Guidelines Network. Management of chronic venous ulcer. 2010 [cited 2019 Jan 21]; Available from: https://www.sign.ac.uk/assets/sign120.pdf. 6. NHS Inform. Venous leg ulcer. 2019 [cited 2019 Jan 21]; Available from: https://www.nhsinform.scot/illnesses-and-conditions/skin-hair-and-nails/venous-leg-ulcer. 7. Bishop A, White R. Venous leg ulcers in the UK: the local burden of illness and the allocation of resources. Wounds UK. 2017;13(5

2019 SHTG Advice Statements

74. Infliximab (Zessly) - Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Crohn Disease, Psoriasis, Ankylosing Spondylitis

Infliximab (Zessly) - Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Crohn Disease, Psoriasis, Ankylosing Spondylitis 22 March 2018 EMA/223369/2018 Committee for Medicinal Products for Human Use (CHMP) CHMP assessment report Zessly International non-proprietary name: infliximab Procedure No. EMEA/H/C/004647/0000 Note Assessment report as adopted by the CHMP with all information of a commercially confidential nature deleted. 30 Churchill Place ? Canary Wharf ? London E14 5EU (...) therapy; or who are intolerant to or have contraindications for such therapies. Infliximab has been studied only in combination with conventional immunosuppressive therapy. Ulcerative colitis Zessly is indicated for treatment of moderately to severely active ulcerative colitis in adult patients who have had an inadequate response to conventional therapy including corticosteroids and 6-mercaptopurine (6-MP) or azathioprine (AZA), or who are intolerant to or have medical contraindications

2018 European Medicines Agency - EPARs

75. Foam dressings for treating pressure ulcers. (PubMed)

Foam dressings for treating pressure ulcers. Pressure ulcers, also known as pressure injuries and bed sores, are localised areas of injury to the skin or underlying tissues, or both. Dressings made from a variety of materials, including foam, are used to treat pressure ulcers. An evidence-based overview of dressings for pressure ulcers is needed to enable informed decision-making on dressing use. This review is part of a suite of Cochrane Reviews investigating the use of dressings (...) in the treatment of pressure ulcers. Each review will focus on a particular dressing type.To assess the clinical and cost effectiveness of foam wound dressings for healing pressure ulcers in people with an existing pressure ulcer in any care setting.In February 2017 we searched: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase; EBSCO CINAHL Plus and the NHS Economic Evaluation

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2017 Cochrane

76. Anabolic steroids for treating pressure ulcers. (PubMed)

Anabolic steroids for treating pressure ulcers. Pressure ulcers, also known as bed sores, pressure sores or decubitus ulcers develop as a result of a localised injury to the skin or underlying tissue, or both. The ulcers usually arise over a bony prominence, and are recognised as a common medical problem affecting people confined to a bed or wheelchair for long periods of time. Anabolic steroids are used as off-label drugs (drugs which are used without regulatory approval) and have been used (...) as adjuvants to usual treatment with dressings, debridement, nutritional supplements, systemic antibiotics and antiseptics, which are considered to be supportive in healing of pressure ulcers. Anabolic steroids are considered because of their ability to stimulate protein synthesis and build muscle mass. Comprehensive evidence is required to facilitate decision making, regarding the benefits and harms of using anabolic steroids.To assess the effects of anabolic steroids for treating pressure ulcers.In March

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2017 Cochrane

77. Dressings and topical agents for treating pressure ulcers. (PubMed)

Dressings and topical agents for treating pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear (...) topical agent applied directly to an open pressure ulcer and left in situ. We excluded from this review dressings attached to external devices such as negative pressure wound therapies, skin grafts, growth factor treatments, platelet gels and larval therapy.Two review authors independently performed study selection, risk of bias assessment and data extraction. We conducted network meta-analysis using frequentist mega-regression methods for the efficacy outcome, probability of complete healing. We

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2017 Cochrane

78. Compression for venous leg ulcers

Media Releases 2013 Media Releases 2012 Media Releases Search Compression for venous leg ulcers Compression for venous leg ulcers Introduction Venous leg ulcers are the most common type of skin ulcer that mainly occur just above the ankle and usually affect older people and are more common in women; other signs include varicose veins and haemosiderin staining above the ankles (brown pigmentation). Intervention Medical compression therapy applied externally to the lower leg to provide a constant (...) (or butler or donner), is helpful for patients with limited strength or hand mobility or patients who have difficulty bending over (e.g. obesity, spine problems). Higher grade compression stockings may go on more easily if a light .liner sleeve is worn (eg Jobst Ulcer Care Compression Liners or a single layer of Tubifast retention bandage) is worn under the compression garment. Compression stockings absorb skin oils and cause the skin to dry out so the skin should be moisturised in the evening

2017 Handbook of Non-Drug interventions (HANDI)

79. In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer (PubMed)

In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer Decreased nitric oxide (NO) synthesis and increased NO consumption in diabetes induces the inadequate blood flow to tissues that is primarily responsible for the pathogenesis and refractoriness of diabetic skin ulcers. The present study proposed a simple and effective therapeutic strategy for diabetic skin ulcers-in situ up-regulation of endothelial nitric oxide synthase (eNOS) expression (...) wound healing. These findings suggest that the in situ up-regulation of eNOS/NO by a statin-loaded TES may be a useful therapeutic method for intractable diabetic skin wounds.

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2016 Scientific reports

80. Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury (PubMed)

Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury 27563371 2016 08 26 2019 02 26 1937-5719 16 2016 Eplasty Eplasty Acute Marjolin's Ulcer Arising in a Split-Thickness Skin Graft Postburn Injury. ic31 Moonsamy Philicia P Division of Burn Surgery, Department of Surgery, Massachusetts General Hospital, Boston. Nazarian Rosalynn M RM Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Boston. Schulz John T JT Division of Burn Surgery, Department (...) of Surgery, Massachusetts General Hospital, Boston. Goverman Jeremy J Division of Burn Surgery, Department of Surgery, Massachusetts General Hospital, Boston. eng Case Reports 2016 07 25 United States Eplasty 101316107 1937-5719 acute Marjolin's ulcer burn nonhealing wound skin graft squamous cell carcinoma 2016 8 27 6 0 2016 8 27 6 0 2016 8 27 6 1 epublish 27563371 PMC4980804 Plast Reconstr Surg. 2009 Jul;124(1):156e-64e 19568055 Ann Plast Surg. 2014 May;72(5):515-20 24691319

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2016 Eplasty

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