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Skin Ulcer

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21. A Randomized, Controlled Clinical Study to Assess the Effect of Anodal and Cathodal Electrical Stimulation on Periwound Skin Blood Flow and Pressure Ulcer Size Reduction in Persons with Neurological Injuries. (PubMed)

A Randomized, Controlled Clinical Study to Assess the Effect of Anodal and Cathodal Electrical Stimulation on Periwound Skin Blood Flow and Pressure Ulcer Size Reduction in Persons with Neurological Injuries. The use of electrical stimulation (ES) should be considered for treating nonhealing pressure ulcers (PUs), but optimal ES wound treatment protocols have yet to be established. A randomized, controlled, double-blind clinical study was conducted to evaluate the effects of cathodal and anodal (...) high-voltage monophasic pulsed current (HVMPC) on periwound skin blood flow (PSBF) and size reduction of Stage 2 to Stage 4 PUs of at least 4 weeks' duration. Persons >18 years of age, hospitalized with neurological injuries, at high risk for PU development (Norton scale <14 points; Waterlow scale >15 points), and with at least 1 Stage 2 to Stage 4 PU were eligible to participate in the study. Persons with necrotic wounds, osteomyelitis, electronic or metal implants in the PU area, PUs in need

2018 Ostomy/wound management

22. Diagnostic Accuracy of Clinical and Microbiological Signs in Patients with Skin Lesions Resembling Buruli Ulcer in an Endemic Region. (PubMed)

Diagnostic Accuracy of Clinical and Microbiological Signs in Patients with Skin Lesions Resembling Buruli Ulcer in an Endemic Region. The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes

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2018 Clinical Infectious Diseases

23. Perianal ulcerative skin tuberculosis: A case report. (PubMed)

Perianal ulcerative skin tuberculosis: A case report. Ulcerative skin tuberculosis (TB) is a rare form of extrapulmonary TB.We present a case of a 65-year-old patient with perianal ulcer, which had been present for 1 year. Anamnesis revealed he had been persistently coughing for the same period of time. Histological examination of perianal skin showed necrotizing granulomatous lesions, acid-fast staining in sputum samples was ++++, TB antibody in the blood was positive, TB DNA test was positive (...) , and chest scan that showed secondary pulmonary TB accompanied by possible pulmonary cavity formation in the 2 upper lungs.Anti-TB therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide for 6 months. The skin ulcer completely healed after 6 months.TB should be suspected for nonhealing ulcers. Pertinent studies should be done early during the lesion; finally, TB treatment should be initiated immediately after diagnosis is made.

2018 Medicine

24. Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report (PubMed)

Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report 29760625 2018 11 14 1642-395X 35 2 2018 Apr Postepy dermatologii i alergologii Postepy Dermatol Alergol Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report. 212-216 10.5114/ada.2018.75246 Niezgoda

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

25. Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses (PubMed)

Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses 29984279 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Atypical Behçet disease with endocarditis, pyoderma gangrenosum-like ulcers and methicillin-resistant Staphylococcus aureus -positive skin abscesses. 449-451 10.1016/j.jdcr.2018.01.003 Sanchez Isabelle M IM Department of Dermatology, University of California San (...) Francisco, San Francisco, California. Shinkai Kanade K Department of Dermatology, University of California San Francisco, San Francisco, California. eng Case Reports 2018 04 30 United States JAAD Case Rep 101665210 2352-5126 BD, Behçet disease Behcet disease IE, infectious endocarditis MRSA, methicillin-resistant Staphylococcus aureus PG, pyoderma gangrenosum cardiac manifestations endocarditis methicillin-resistant Staphylococcus aureus–positive abscesses pyoderma gangrenosum–like ulcers 2018 7 10 6 0

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2018 JAAD Case Reports

26. Gap Analysis and Refinement Recommendations of Skin Alteration and Pressure Ulcer Enterprise Reference Models against Nursing Flowsheet Data Elements (PubMed)

Gap Analysis and Refinement Recommendations of Skin Alteration and Pressure Ulcer Enterprise Reference Models against Nursing Flowsheet Data Elements Reference models are an essential instrument to provide structure and guidance in the creation and use of data elements within an organizations' electronic health record (EHR). Standardization of data elements is imperative to ensure clinical data is consistently and reliably captured for use in clinical documentation, care communication (...) , and a variety of downstream data uses. Ongoing assessment and refinement of reference models and data elements are necessary to ascertain clinical data capture is applicable and inclusive across a variety of caregivers and domains. We performed a gap analysis on current state nursing data elements against two validated interprofessional reference models: skin alteration and pressure ulcer assessments. We present our findings along with recommendations for reference model refinements. We also highlight

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2018 AMIA Annual Symposium Proceedings

27. Skin ischemia and ulceration as a complication of inferior phrenic artery embolization for hepatocellular carcinoma (PubMed)

Skin ischemia and ulceration as a complication of inferior phrenic artery embolization for hepatocellular carcinoma Nontarget embolization from transarterial liver-directed therapy for hepatocellular carcinoma is a rare complication. We present a case of flank skin ulceration after embolization of the inferior phrenic artery supplying tumor. This complication of inferior phrenic artery embolization underscores caution when using small particles to embolize extrahepatic supply to hepatocellular

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2018 Radiology Case Reports

28. The abrupt temperature changes in the plantar skin thermogram of the diabetic patient: looking in to prevent the insidious ulcers (PubMed)

The abrupt temperature changes in the plantar skin thermogram of the diabetic patient: looking in to prevent the insidious ulcers Background: One of the complications of the diabetes mellitus is the amputation of the lower limbs. This complication may be developed after an insidious ulcer, that may be raised by the peripheral neuropathy or the ischaemic limb, and that the ulcer get infected. That is, to develop an ulcer, in the diabetic patient, three factors should be taken into the account (...) three hospitals and from INAOE facilities, showed, first, the thermograms of the plantar skin of two diabetic patients, acquired in two different times show that the temperature distribution and the average temperatures, vary slightly for a period of weeks. Second, the thermograms of two patients, who both developed insidious ulcers which evolved favourable, demonstrated the importance of the immune system and the drug therapy. These patients are, one who has a Charcot foot, and in the second one

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2018 Diabetic foot & ankle

29. Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp. (PubMed)

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp. Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones. (E)-2-(Hept-2-en-1-yl)quinolin-4(1H)-one (1) and (E)-2-(non-2-en-1-yl)quinolin-4(1H)-one (3) were isolated from the culture broth of strain MBAF1239 together (...) with four known alkylquinolones (2 and 4-6), pyrrolnitrin (7), and BN-227 (8). The structures of 1 and 3 were unambiguously characterized using NMR spectroscopy and mass spectrometry. Compounds 1-8 inhibited the growth of the marine bacterium Tenacibaculum maritimum, an etiological agent of skin ulcers in marine fish, offering new opportunities to develop antibacterial drugs for fish farming.

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2018 Beilstein journal of organic chemistry

30. Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers

Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers (InTREPiD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03654989 Recruitment Status : Not yet recruiting First Posted

2018 Clinical Trials

31. El Niño drives a widespread ulcerative skin disease outbreak in Galapagos marine fishes (PubMed)

El Niño drives a widespread ulcerative skin disease outbreak in Galapagos marine fishes Climate change increases local climatic variation and unpredictability, which can alter ecological interactions and trigger wildlife disease outbreaks. Here we describe an unprecedented multi-species outbreak of wild fish disease driven by a climate perturbation. The 2015-16 El Niño generated a +2.5 °C sea surface temperature anomaly in the Galapagos Islands lasting six months. This coincided with a novel (...) ulcerative skin disease affecting 18 teleost species from 13 different families. Disease signs included scale loss and hemorrhagic ulcerated patches of skin, fin deterioration, lethargy, and erratic behavior. A bacterial culture isolated from skin lesions of two of the affected fish species was identified by sequencing of the 16S rRNA gene as a Rahnella spp. Disease prevalence rates were linearly correlated with density in three fish species. In January 2016, disease prevalence reached 51.1% in the ring

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2018 Scientific reports

32. Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease (PubMed)

Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world, with a higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid-fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR

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2018 Journal of clinical microbiology

33. Prospective evaluation of the capillaroscopic skin ulcer risk index in systemic sclerosis patients in clinical practice: a longitudinal, multicentre study (PubMed)

Prospective evaluation of the capillaroscopic skin ulcer risk index in systemic sclerosis patients in clinical practice: a longitudinal, multicentre study Nailfold capillaroscopy (NC) is an important tool for the diagnosis of systemic sclerosis (SSc). The capillaroscopic skin ulcer risk index (CSURI) was suggested to identify patients at risk of developing digital ulcers (DUs). This study aims to assess the reliability of the CSURI across assessors, the CSURI change during follow-up

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2018 Arthritis research & therapy

34. Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. (PubMed)

Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker.To assess the association between pigmentation disorders and systemic involvement in patients with SSc.A total of 5 patterns of skin pigmentation disorders were defined: diffuse hyperpigmentation (...)  = 11); and acral hypopigmentation in 17% (n = 15). Diffuse hyperpigmentation was associated with diffuse SSc (P = .001), increased modified Rodnan skin score (P = .001), and shorter duration of Raynaud phenomenon (P = .002) in univariate analysis but not in multivariate analysis. Moreover, diffuse hyperpigmentation was associated with digital ulcers (P = .005), as confirmed by multivariate analysis (odds ratio, 2.96; 95% confidence interval, 1.28-6.89).This was a single-center retrospective study

2018 Journal of American Academy of Dermatology

35. Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting (PubMed)

Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness (...) of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers. Ulcers ≥28 days duration, between ≥1 and < 40 cm2 that closed ≤40% within the 28 days before treatment were included. Results: Patient baseline demographics and wound characteristics were comparable between

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2018 Advances in wound care

36. A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report. (PubMed)

A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report. Type I cryoglobulinemia is a rare and life-threatening condition. It occurs mainly in B-cell lymphoproliferative disorder. In almost half of the patients, type I cryoglobulinemia is characterized by severe cutaneous involvement.A 71-year-old man comes to our observation because of the onset of persistence of paresthesia and painful acrocyanosis in the fingers and toes. IgG-k multiple

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2018 Medicine

37. SEM Scanner for pressure ulcer prevention

of VAT). The resource impact resource impact would be greater than standard care. However, it could offer resource benefits by avoiding hospital- acquired pressure ulcers. © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 12The technology The technology SEM Scanner (Bruin Biometrics) is a hand-held, skin tissue assessment device that detects early, pressure-induced tissue damage. This includes pressure ulcers (...) at risk of becoming a pressure ulcer before visible clues are noticeable and across all skin tones. Current care pathway NICE's guideline on pressure ulcers recommends that a documented risk assessment for pressure ulcers should be done in at-risk adults. It recommends using a validated scale to support clinical judgement, and that risk is reassessed if the patient's clinical status changes. The guideline recommends strategies to prevent pressure ulcers, including regular patient repositioning, foam

2019 National Institute for Health and Clinical Excellence - Advice

38. The evidence for the use of growth factors and active skin substitutes for the treatment of non-infected diabetic foot ulcers (DFU): a health technology assessment (HTA)

The evidence for the use of growth factors and active skin substitutes for the treatment of non-infected diabetic foot ulcers (DFU): a health technology assessment (HTA) The evidence for the use of growth factors and active skin substitutes for the treatment of non-infected diabetic foot ulcers (DFU): a health technology assessment (HTA) The evidence for the use of growth factors and active skin substitutes for the treatment of non-infected diabetic foot ulcers (DFU): a health technology (...) assessment (HTA) Buchberger B, Follmann M, Freyer D, Huppertz H, Ehm A, Wasem J CRD summary This review concluded that add-on therapy with growth factors or active skin substitutes could be an alternative to standard wound care alone for treatment of diabetic foot ulcers, but their use could not be explicitly recommended without stronger evidence. These conclusions appropriately reflect the limitations of the evidence presented. Authors' objectives To assess the safety and effectiveness of growth factors

2011 DARE.

39. Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea. (PubMed)

Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea. Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU.We conducted a community-based (...) cohort study in Lihir Island, Papua New Guinea, from October 2014 through May 2016. Consenting patients with skin ulcers >1 cm in diameter were eligible for this study and had collected a lesional swab for polymerase chain reaction (PCR). All participants were treated with single-dose azithromycin (30 mg/kg) and were followed up for assessment of clinical resolution. We retrospectively classified patients according to PCR results into HD, TP, and PCR-negative groups. The primary endpoint was healing

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2017 Clinical Infectious Diseases

40. Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature. (PubMed)

Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature. Skin ulcers (SU) are one of the most frequent manifestations of systemic sclerosis (SSc). SSc-SU are very painful, often persistent and recurrent; they may lead to marked impairment of patient's activities and quality of life. Despite their severe impact on the whole SSc patient's management, the proposed definition, classification criteria, and therapeutic strategies of SSc (...) Rheumatology Unit were retrospectively evaluated with specific attention to SSc-SU. The SSc-SU were classified in 5 subtypes according to prominent pathogenetic mechanism(s) and localization, namely 1. digital ulcers (DU) of the hands or feet, 2. SU on bony prominence, 3. SU on calcinosis, 4. SU of lower limbs, and 5. DU presenting with gangrene. This latter is a very harmful evolution of both DU of the hands and feet needing a differential diagnosis with critical limb ischemia.During the follow up period

2017 Autoimmunity reviews

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