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Skin Ulcer

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21. A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report. Full Text available with Trip Pro

A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report. Type I cryoglobulinemia is a rare and life-threatening condition. It occurs mainly in B-cell lymphoproliferative disorder. In almost half of the patients, type I cryoglobulinemia is characterized by severe cutaneous involvement.A 71-year-old man comes to our observation because of the onset of persistence of paresthesia and painful acrocyanosis in the fingers and toes. IgG-k multiple

2018 Medicine

22. Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report Full Text available with Trip Pro

Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report 29760625 2018 11 14 1642-395X 35 2 2018 Apr Postepy dermatologii i alergologii Postepy Dermatol Alergol Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report. 212-216 10.5114/ada.2018.75246 Niezgoda

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

23. Gap Analysis and Refinement Recommendations of Skin Alteration and Pressure Ulcer Enterprise Reference Models against Nursing Flowsheet Data Elements Full Text available with Trip Pro

Gap Analysis and Refinement Recommendations of Skin Alteration and Pressure Ulcer Enterprise Reference Models against Nursing Flowsheet Data Elements Reference models are an essential instrument to provide structure and guidance in the creation and use of data elements within an organizations' electronic health record (EHR). Standardization of data elements is imperative to ensure clinical data is consistently and reliably captured for use in clinical documentation, care communication (...) , and a variety of downstream data uses. Ongoing assessment and refinement of reference models and data elements are necessary to ascertain clinical data capture is applicable and inclusive across a variety of caregivers and domains. We performed a gap analysis on current state nursing data elements against two validated interprofessional reference models: skin alteration and pressure ulcer assessments. We present our findings along with recommendations for reference model refinements. We also highlight

2018 AMIA Annual Symposium Proceedings

24. Prospective evaluation of the capillaroscopic skin ulcer risk index in systemic sclerosis patients in clinical practice: a longitudinal, multicentre study Full Text available with Trip Pro

Prospective evaluation of the capillaroscopic skin ulcer risk index in systemic sclerosis patients in clinical practice: a longitudinal, multicentre study Nailfold capillaroscopy (NC) is an important tool for the diagnosis of systemic sclerosis (SSc). The capillaroscopic skin ulcer risk index (CSURI) was suggested to identify patients at risk of developing digital ulcers (DUs). This study aims to assess the reliability of the CSURI across assessors, the CSURI change during follow-up

2018 Arthritis research & therapy

25. Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp. Full Text available with Trip Pro

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp. Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones. (E)-2-(Hept-2-en-1-yl)quinolin-4(1H)-one (1) and (E)-2-(non-2-en-1-yl)quinolin-4(1H)-one (3) were isolated from the culture broth of strain MBAF1239 together (...) with four known alkylquinolones (2 and 4-6), pyrrolnitrin (7), and BN-227 (8). The structures of 1 and 3 were unambiguously characterized using NMR spectroscopy and mass spectrometry. Compounds 1-8 inhibited the growth of the marine bacterium Tenacibaculum maritimum, an etiological agent of skin ulcers in marine fish, offering new opportunities to develop antibacterial drugs for fish farming.

2018 Beilstein journal of organic chemistry

26. Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses Full Text available with Trip Pro

Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses 29984279 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Atypical Behçet disease with endocarditis, pyoderma gangrenosum-like ulcers and methicillin-resistant Staphylococcus aureus -positive skin abscesses. 449-451 10.1016/j.jdcr.2018.01.003 Sanchez Isabelle M IM Department of Dermatology, University of California San (...) Francisco, San Francisco, California. Shinkai Kanade K Department of Dermatology, University of California San Francisco, San Francisco, California. eng Case Reports 2018 04 30 United States JAAD Case Rep 101665210 2352-5126 BD, Behçet disease Behcet disease IE, infectious endocarditis MRSA, methicillin-resistant Staphylococcus aureus PG, pyoderma gangrenosum cardiac manifestations endocarditis methicillin-resistant Staphylococcus aureus–positive abscesses pyoderma gangrenosum–like ulcers 2018 7 10 6 0

2018 JAAD Case Reports

27. Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease Full Text available with Trip Pro

Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world, with a higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid-fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR

2018 Journal of clinical microbiology

28. Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. Full Text available with Trip Pro

Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. Lipoxin A4 (LXA4) is involved in the resolution of inflammation and wound healing; however, it is extremely unstable. Thus, to preserve its biological activities and confer stability, we encapsulated LXA4 in poly-lactic-co-glycolic acid (PLGA) microparticles (LXA4-MS) and assessed its application in treating dorsal rat skin lesions. Ulcers were sealed with fibrin adhesive and treated with either LXA4-MS (...) of skin ulcers.

2017 PLoS ONE

29. Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. (Abstract)

Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker.To assess the association between pigmentation disorders and systemic involvement in patients with SSc.A total of 5 patterns of skin pigmentation disorders were defined: diffuse hyperpigmentation (...)  = 11); and acral hypopigmentation in 17% (n = 15). Diffuse hyperpigmentation was associated with diffuse SSc (P = .001), increased modified Rodnan skin score (P = .001), and shorter duration of Raynaud phenomenon (P = .002) in univariate analysis but not in multivariate analysis. Moreover, diffuse hyperpigmentation was associated with digital ulcers (P = .005), as confirmed by multivariate analysis (odds ratio, 2.96; 95% confidence interval, 1.28-6.89).This was a single-center retrospective study

2018 Journal of American Academy of Dermatology

30. Perianal ulcerative skin tuberculosis: A case report. Full Text available with Trip Pro

Perianal ulcerative skin tuberculosis: A case report. Ulcerative skin tuberculosis (TB) is a rare form of extrapulmonary TB.We present a case of a 65-year-old patient with perianal ulcer, which had been present for 1 year. Anamnesis revealed he had been persistently coughing for the same period of time. Histological examination of perianal skin showed necrotizing granulomatous lesions, acid-fast staining in sputum samples was ++++, TB antibody in the blood was positive, TB DNA test was positive (...) , and chest scan that showed secondary pulmonary TB accompanied by possible pulmonary cavity formation in the 2 upper lungs.Anti-TB therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide for 6 months. The skin ulcer completely healed after 6 months.TB should be suspected for nonhealing ulcers. Pertinent studies should be done early during the lesion; finally, TB treatment should be initiated immediately after diagnosis is made.

2018 Medicine

31. Diagnostic Accuracy of Clinical and Microbiological Signs in Patients with Skin Lesions Resembling Buruli Ulcer in an Endemic Region. Full Text available with Trip Pro

Diagnostic Accuracy of Clinical and Microbiological Signs in Patients with Skin Lesions Resembling Buruli Ulcer in an Endemic Region. The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes

2018 Clinical Infectious Diseases

32. Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting Full Text available with Trip Pro

Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness (...) of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers. Ulcers ≥28 days duration, between ≥1 and < 40 cm2 that closed ≤40% within the 28 days before treatment were included. Results: Patient baseline demographics and wound characteristics were comparable between

2018 Advances in wound care

33. The abrupt temperature changes in the plantar skin thermogram of the diabetic patient: looking in to prevent the insidious ulcers Full Text available with Trip Pro

The abrupt temperature changes in the plantar skin thermogram of the diabetic patient: looking in to prevent the insidious ulcers Background: One of the complications of the diabetes mellitus is the amputation of the lower limbs. This complication may be developed after an insidious ulcer, that may be raised by the peripheral neuropathy or the ischaemic limb, and that the ulcer get infected. That is, to develop an ulcer, in the diabetic patient, three factors should be taken into the account (...) three hospitals and from INAOE facilities, showed, first, the thermograms of the plantar skin of two diabetic patients, acquired in two different times show that the temperature distribution and the average temperatures, vary slightly for a period of weeks. Second, the thermograms of two patients, who both developed insidious ulcers which evolved favourable, demonstrated the importance of the immune system and the drug therapy. These patients are, one who has a Charcot foot, and in the second one

2018 Diabetic foot & ankle

34. El Niño drives a widespread ulcerative skin disease outbreak in Galapagos marine fishes Full Text available with Trip Pro

El Niño drives a widespread ulcerative skin disease outbreak in Galapagos marine fishes Climate change increases local climatic variation and unpredictability, which can alter ecological interactions and trigger wildlife disease outbreaks. Here we describe an unprecedented multi-species outbreak of wild fish disease driven by a climate perturbation. The 2015-16 El Niño generated a +2.5 °C sea surface temperature anomaly in the Galapagos Islands lasting six months. This coincided with a novel (...) ulcerative skin disease affecting 18 teleost species from 13 different families. Disease signs included scale loss and hemorrhagic ulcerated patches of skin, fin deterioration, lethargy, and erratic behavior. A bacterial culture isolated from skin lesions of two of the affected fish species was identified by sequencing of the 16S rRNA gene as a Rahnella spp. Disease prevalence rates were linearly correlated with density in three fish species. In January 2016, disease prevalence reached 51.1% in the ring

2018 Scientific reports

35. Skin ischemia and ulceration as a complication of inferior phrenic artery embolization for hepatocellular carcinoma Full Text available with Trip Pro

Skin ischemia and ulceration as a complication of inferior phrenic artery embolization for hepatocellular carcinoma Nontarget embolization from transarterial liver-directed therapy for hepatocellular carcinoma is a rare complication. We present a case of flank skin ulceration after embolization of the inferior phrenic artery supplying tumor. This complication of inferior phrenic artery embolization underscores caution when using small particles to embolize extrahepatic supply to hepatocellular

2018 Radiology Case Reports

36. SEM Scanner for pressure ulcer prevention

of VAT). The resource impact resource impact would be greater than standard care. However, it could offer resource benefits by avoiding hospital- acquired pressure ulcers. © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 12The technology The technology SEM Scanner (Bruin Biometrics) is a hand-held, skin tissue assessment device that detects early, pressure-induced tissue damage. This includes pressure ulcers (...) at risk of becoming a pressure ulcer before visible clues are noticeable and across all skin tones. Current care pathway NICE's guideline on pressure ulcers recommends that a documented risk assessment for pressure ulcers should be done in at-risk adults. It recommends using a validated scale to support clinical judgement, and that risk is reassessed if the patient's clinical status changes. The guideline recommends strategies to prevent pressure ulcers, including regular patient repositioning, foam

2019 National Institute for Health and Clinical Excellence - Advice

37. Coban 2 for venous leg ulcers

Coban 2 for venous leg ulcers Coban 2 for v Coban 2 for venous leg ulcers enous leg ulcers Medtech innovation briefing Published: 16 February 2018 nice.org.uk/guidance/mib140 pathways Summary Summary The technology technology described in this briefing is Coban 2 compression bandage for venous leg ulcers. The inno innovativ vative aspect e aspect is that it is thinner than 4-layer bandages. This aims to improve mobility and convenience. The intended place in ther place in therap apy y would (...) be as an alternative to current compression bandages in selected people with venous leg ulcers. The main points from the e main points from the evidence vidence summarised in this briefing are from 3 studies (2 in UK, 1 in Italy; comprising 2 randomised controlled trials [RCTs] and 1 observational study) including a total of 1,456 adults with venous leg ulcers. The evidence is limited in quantity and quality. One randomised study showed that Coban 2 slipped significantly less than 4-layer bandages. The studies

2018 National Institute for Health and Clinical Excellence - Advice

38. Tofacitinib for moderately to severely active ulcerative colitis

, symptoms elsewhere in the body (such as the joints, eyes, skin and liver) and fatigue. Complications such as intestinal perforation and abscesses may need surgery. The clinical expert stated that many people who have ulcerative colitis are teenagers and younger adults. They explained that tofacitinib is a novel treatment with a different mode of action compared with biological therapies T ofacitinib for moderately to severely active ulcerative colitis (TA547) © NICE 2019. All rights reserved. Subject (...) Tofacitinib for moderately to severely active ulcerative colitis T T ofacitinib for moder ofacitinib for moderately to se ately to sev verely erely activ active ulcer e ulcerativ ative colitis e colitis T echnology appraisal guidance Published: 28 November 2018 nice.org.uk/guidance/ta547 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

39. Ustekinumab for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic, or have medical contrai

Ustekinumab for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic, or have medical contrai October 2019 EUnetHTA Joint Action 3 WP4 1 EUnetHTA Joint Action 3 WP4 Version 1.0, 22/10/2019 Relative effectiveness assessment of pharmaceutical technologies USTEKINUMAB FOR THE TREATMENT OF ADULT PATIENTS WITH MODERATELY TO SEVERELY ACTIVE (...) ULCERATIVE COLITIS (UC) WHO HAVE HAD AN INADEQUATE RESPONSE WITH, LOST RESPONSE TO OR WERE INTOLERANT TO EITHER CONVENTIONAL THERAPY OR A BIOLOGIC OR HAVE MEDICAL CONTRAINDICATIONS TO SUCH THERAPIES Project ID: PTJA07 PTJA07 - Ustekinumab for active ulcerative colitis October 2019 EUnetHTA Joint Action 3 WP4 1 DOCUMENT HISTORY AND CONTRIBUTORS Version Date Description V0.1 04/09/19 First draft V0.2 04/10/19 Input from dedicated reviewers has been processed. V0.3 17/10/19 Input from manufacturer

2020 EUnetHTA

40. Adalimumab (Idacio) - Arthritis, Rheumatoid, Arthritis, Juvenile Rheumatoid, Psoriasis, Arthritis, Psoriatic, Spondylitis, Ankylosing, Uveitis, Hidradenitis Suppurativa, Colitis, Ulcerative, Crohn Disease

arthritis (both rare diseases causing inflammation in the joints); • Crohn’s disease (a disease causing inflammation of the gut); • ulcerative colitis (a disease causing inflammation and ulcers in the lining of the gut); • hidradenitis suppurativa (also known as acne inversa, a long-term skin disease that causes lumps, abscesses (collections of pus) and scarring on the skin); • non-infectious uveitis (inflammation of the layer beneath the white of the eyeball). Idacio is mostly used in adults when (...) Adalimumab (Idacio) - Arthritis, Rheumatoid, Arthritis, Juvenile Rheumatoid, Psoriasis, Arthritis, Psoriatic, Spondylitis, Ankylosing, Uveitis, Hidradenitis Suppurativa, Colitis, Ulcerative, Crohn Disease EMA/85985/2019 EMEA/H/C/004475 Idacio (adalimumab) An overview of Idacio and why it is authorised in the EU What is Idacio and what is it used for? Idacio is a medicine that acts on the immune system (the body’s natural defences) and is used to treat the following conditions: • plaque

2019 European Medicines Agency - EPARs

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