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181. Debridement Procedures for Managing Diabetic Foot Ulcers

Debridement Procedures for Managing Diabetic Foot Ulcers Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines | CADTH.ca Find the information you need Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines Last updated (...) : September 15, 2014 Project Number: RC0579-002 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Report in Brief Context The rising prevalence of diabetes and its associated complications represent a global public health care problem and financial burden. The estimated prevalence of diabetes in Canada is 6.8% — roughly 2.4 million Canadians — and it is increasing, with a 280% increase from 1998. Diabetic foot ulcers (DFUs) are the most

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

182. Screening and Risk Stratification for Diabetic Foot Ulcers

Screening and Risk Stratification for Diabetic Foot Ulcers TITLE: Screening and Risk Stratification for Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines DATE: 30 October 2014 CONTEXT AND POLICY ISSUES The rising prevalence of diabetes mellitus (DM) and associated complications represent a global public health care problem and financial burden. 1,2 The estimated prevalence of DM in Canada was 6.8% (2.4 million) in 2009, a 230% increase from estimates (...) in 1998. Increasing prevalence and associated costs to Canada’s publically funded healthcare system is projected to continue. As of 2010 the estimated economic burden of DM and its complications in Canada was $12.2 billion. 3 The most common chronic complication of DM is diabetic foot ulcers (DFUs), with a prevalence of four to ten percent among DM patients. 1,4 Several factors predispose DM patients to DFUs including long duration of diabetes, trauma, infection, poor glycemic control, improper

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

183. Golimumab - Ulcerative colitis

pain, and constipation. If the diarrhea and blood loss are severe, anemia can result. In addition, some patients have extra-intestinal manifestations of UC, including fever, inflammation of the eyes or joints, ulcers of the mouth or skin, tender inflamed nodules on the shins, and reduced fertility in women. Respondents indicated that sustained remission/treatment response is more important than relieving any one symptom. ? UC often has a profound effect on the lives of those living (...) Golimumab - Ulcerative colitis Common Drug Review CDEC Meeting — January 15, 2014; CDEC Meeting — February 19, 2014 Notice of Final Recommendation — March 19, 2014 Page 1 of 5 © 2014 CADTH CDEC FINAL RECOMMENDATION GOLIMUMAB (Simponi — Janssen Inc.) New Indication: Ulcerative Colitis Recommendation: The Canadian Drug Expert Committee (CDEC) recommends that golimumab not be listed at the submitted price for the treatment of ulcerative colitis (UC). Reasons for the Recommendation: 1. Given

2014 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

184. Treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia: guideline update

destructive infection of skin and of adipose and soft tissue caused by Mycobacterium ulcerans , an environmental pathogen that produces a potent toxin. It is because of progressive destruction of subcutaneous tissue that the characteristic ulcer becomes widely undermined. BU only occurs in specific endemic areas, particularly coastal Victoria, where the disease is known locally as Bairnsdale ulcer. The second major Australian focus is a small region between Mossman and just beyond the Daintree River (...) . , Contact with contaminated soil may also play a role. Hence, during outbreaks in Australia, use of protective clothing, avoidance of biting insects, use of insect repellents, cleaning of skin or wounds after soil exposure, and mosquito control are logical preventive strategies that should be considered by individuals and public health authorities. Key points and recommendations for the diagnosis, treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia Diagnosis

2014 MJA Clinical Guidelines

185. Self-monitoring of lower leg skin temperature: accuracy of self-reported data and adherence to a cooling protocol for the prevention of venous leg ulcers. (PubMed)

Self-monitoring of lower leg skin temperature: accuracy of self-reported data and adherence to a cooling protocol for the prevention of venous leg ulcers. For intervention studies that require the use of participant self-reports, the quality and accuracy of recorded data and variability in participant adherence rates to the treatment can cause significant outcome bias.To assess the quality and accuracy of participant documentation of daily self-monitoring of leg skin temperature, adherence (...) to a graduated cooling treatment protocol to prevent venous leg ulcers, and the potential for bias in treatment effect in a randomized controlled trial that included a population with chronic venous disease.Individuals were randomized to a leg cooling intervention or placebo treatment group to daily self-monitor and record lower leg skin temperature over a 9-month period on monthly paper study logs. Returned study logs for the first 100 completed participants (n=54 cooling intervention, n=46 control) were

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2015 Patient preference and adherence

186. Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial

Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial (PENFUP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02565745 Recruitment Status : Terminated (Recommendation after interim analysis) First Posted : October 1, 2015 Last Update Posted : March 20, 2018 Sponsor

2015 Clinical Trials

187. Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Skin (...) . Peters Veterans Affairs Medical Center Information provided by (Responsible Party): Michael LaFountaine, James J. Peters Veterans Affairs Medical Center Study Details Study Description Go to Brief Summary: Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces. As many as 85% of individuals with a spinal cord injury (SCI) report the occurrence of at least 1 PU since being injured. Despite

2015 Clinical Trials

188. A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa. (PubMed)

A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa. The objective of this study is to evaluate the antimicrobial activity and healing-promoting effect of topical photodynamic therapy (ALA-PDT) on chronic skin ulcers infected with Pseudomonas aeruginosa (PA). A total of 26 patients with chronic skin ulcers in lower limbs infected with PA were enrolled. The surface areas of the ulcers were treated with either δ-aminolevulinic acid (...) (ALA)-mediated PDT (20% ALA solution, 1.5 h incubation, 630 nm red light, 80 J/cm(2)) or red light alone, both once a week for two weeks. Before treatment, the wound areas and the bacteria levels in these two groups were comparable (p > 0.05). Results indicated that the bacteria levels in the skin ulcers of the light only group of 24 h post-treatment (3.4 × 10(7) ± 7.1 × 10(7) CFU/cm(2)) and pre-treatment (5.5 × 10(7) ± 1.6 × 10(8) CFU/cm(2)) were not significantly different. In contrast

2015 Archives of dermatological research

189. Systematic review of the use of biological skin substitutes in venous leg ulcers

Systematic review of the use of biological skin substitutes in venous leg ulcers Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing

2018 PROSPERO

190. Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. (PubMed)

Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. Chronic skin ulcers, such as diabetic ulcers, venous leg ulcers and pressure ulcers, are intractable and increasing in prevalence, representing a costly problem in healthcare. We developed a combination therapy with a gelatin sheet, capable of providing sustained release of platelet-rich plasma (PRP). The objective of this study (...) is to investigate the safety and efficacy of autologous PRP covered with a hydrocolloid dressing and PRP covered with a gelatin sheet in the treatment of chronic skin ulcers.Thirty patients with chronic skin ulcers who have not healed with conventional therapy for at least 1 month are being recruited. The patients will receive PRP after debridement, and the wounds will be covered with a hydrocolloid dressing or gelatin sheet. The efficacy will be evaluated according to the time from the beginning of PRP

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2015 BMJ open

191. Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. (PubMed)

Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. This article provides an overview of the biology, epidemiology, clinical features, diagnostic tests, and treatment of Haemophilus ducreyi infection, with special reference to the decline of chancroid and the recent emergence of H. ducreyi as a pathogen responsible for chronic limb ulceration clinically similar to yaws.Chancroid has declined in importance as a sexually transmitted infection in most countries where (...) it was previously endemic. Chancroid may be caused by either class I or class II H. ducreyi isolates; these two classes diverged from each other approximately 1.95 million years ago. H. ducreyi has recently emerged as a cause of chronic skin ulceration in the Pacific region and Africa. Based on sequencing of whole genomes and defined genetic loci, it appears that the cutaneous H. ducreyi strains diverged from the class I genital strains relatively recently.H. ducreyi should be considered as a major cause

2015 Current Opinion in Infectious Diseases

192. Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic leg ulcers: A controlled randomized study. (PubMed)

Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic leg ulcers: A controlled randomized study. Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft.We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction (...) in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis.Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P=0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional

2015 Annales de dermatologie et de venereologie

193. A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in patients with diabetes - a randomized controlled trial. (PubMed)

A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in patients with diabetes - a randomized controlled trial. Although monitoring foot skin temperatures has been associated with diabetic foot ulcer recurrence, no studies have been carried out to test the feasibility among European Caucasians. Moreover, the educational and/or motivational models that promote cognitive or psychosocial processes in these studies are lacking. Thus, we conducted (...) a pilot randomized controlled trial to test the feasibility of monitoring foot skin temperatures in combination with theory-based counselling to standard foot care to reduce diabetic foot ulcer recurrence.In a single-blinded nurse-led 1-year controlled trial, conducted at a hospital setting in Norway, 41 patients with diabetic neuropathy and previous foot ulcer were randomized to the intervention (n = 21) or control groups (n = 20). All participants were instructed in foot care and recording

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2015 BMC endocrine disorders

194. Skin Ulcers Treatment With an Handicraft Topical Device

Skin Ulcers Treatment With an Handicraft Topical Device Skin Ulcers Treatment With an Handicraft Topical Device - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Skin Ulcers Treatment With an Handicraft (...) by (Responsible Party): Coordinación de Investigación en Salud, Mexico Study Details Study Description Go to Brief Summary: The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and arterial insufficiency. Condition or disease Intervention/treatment Phase Foot Ulcer Varicose Ulcer Procedure: drenovac handcrafted Procedure: Healing Phase 4

2015 Clinical Trials

195. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. (PubMed)

A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 25673081 2016 03 23 2015 06 24 1651-2057 95 6 2015 Jul Acta dermato-venereologica Acta Derm. Venereol. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 754-5 10.2340/00015555-2067 Shu En E Department of Dermatology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. ghifuka@gifu-u.ac.jp. Kanoh Hiroyuki H Kito Yusuke Y Seishima Mariko M eng (...) Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Felty Syndrome complications diagnosis Female Humans Leg Ulcer complications pathology Lymphoma, Extranodal NK-T-Cell complications pathology Middle Aged Sjogren's Syndrome complications 2015 2 13 6 0 2015 2 13 6 0 2016 3 24 6 0 ppublish 25673081 10.2340/00015555-2067

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2015 Acta Dermato-Venereologica

196. Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (&gt;100 cm<sup>2</sup>) chronic venous leg ulcers. (PubMed)

Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100 cm2) chronic venous leg ulcers. Massive (≥100 cm(2)) venous leg ulcers (VLUs) demonstrate very low closure rates with standard compression therapy and are costly to manage. Negative-pressure wound therapy (NPWT), followed by a split-thickness skin graft (STSG), can be a cost-effective alternative to this standard care. We performed (...) a cost analysis of these two treatments.A retrospective review was performed of 10 ulcers treated with surgical debridement, 7 days of inpatient NPWT with topical antiseptic instillation (NPWTi), and STSG, with 4 additional days of inpatient NPWT bolster over the graft. Independent medical cost estimators were used to compare the cost of this treatment protocol with standard outpatient compression therapy.The average length of time ulcers were present before patients entered the study was 38 months

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2015 Journal of Vascular Surgery

197. Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study (PubMed)

Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study Introduction The early detection of systemic sclerosis (SSc) patients at high risk of developing digital ulcers could allow preventive treatment, with a reduction of morbidity and social costs. In 2009, a quantitative score, the capillaroscopic skin ulcer risk index (CSURI), calculated according to the formula 'D×M/N(2'), was proposed, which was highly predictive of the appearance (...) of scleroderma digital ulcers within 3 months of capillaroscopic evaluation.This multicentre study aims to validate the predictive value and reproducibility of CSURI in a large population of SSc patients.CSURI was analysed in 229 unselected SSc patients by nailfold videocapillaroscopy (NVC). All patients were re-evaluated 3 months later with regard to the persistence and/or appearance of new digital ulcers.57 of 229 patients presented with digital ulcers after 3 months. The receiver operating characteristic

2012 EvidenceUpdates

198. Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU)

Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU) Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial Comparing SOC +Skin IQ (...) pressure redistribution surface when combined with the Skin IQ™ MCM coverlet will significantly reduce pressure ulcer (PU) incidence as compared to use of a commercially available pressure redistribution surface by itself by decreasing the effects of excessive moisture and temperature at the skin and surface interface. Condition or disease Intervention/treatment Phase Pressure Ulcer Device: Skin IQ™ MCM Coverlet Other: Pressure redistribution surface Not Applicable Detailed Description

2015 Clinical Trials

199. Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers

Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers Safety and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety (...) and Efficacy of Vasculera® in the Healing of Diabetic Skin Ulcers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02361437 Recruitment Status : Terminated (Investigator's hospital sold and study cancelled) First Posted : February 11, 2015 Last Update Posted : December 13, 2017 Sponsor: Primus

2015 Clinical Trials

200. Autologous Skin Substitute for Chronic Leg/Foot Ulcers.

Autologous Skin Substitute for Chronic Leg/Foot Ulcers. Autologous Skin Substitute for Chronic Leg/Foot Ulcers. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Autologous Skin Substitute for Chronic Leg (...) Phase 1 Phase 2 Detailed Description: Multicenter, randomised clinical trial in out patient in which patients with chronic (arterio-) venous leg/foot ulcers are treated with an autologous cultured human living skin substitute (Tiscover®: test group) or with Acellular donor dermis (AS210: control group). During a pre-inclusion evaluation period of 4 weeks (non healing) chronicity of ulcer is ensured (ulcer size change of < 30%). To determine ulcer type ABI, Doppler and CEAP is performed. The test

2015 Clinical Trials

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