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Skin Ulcer

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181. Pressure-relieving devices for treating heel pressure ulcers. (Abstract)

Pressure-relieving devices for treating heel pressure ulcers. Pressure ulcers are areas of localised damage to the skin and underlying tissue caused by pressure or shear. Pressure redistribution devices are used as part of the treatment to reduce the pressure on the ulcer. The anatomy of the heel and the susceptibility of the foot to vascular disease mean that pressure ulcers located there require a particular approach to pressure relief.To determine the effects of pressure-relieving (...) interventions for treating pressure ulcers on the heel.In May 2013, for this first update, we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid EMBASE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); and EBSCO CINAHL. No language or publication date restrictions were applied.We included randomised controlled trials (RCTs) that compared the effects of pressure-relieving devices

2014 Cochrane

182. Interventions for treating leg ulcers in people with sickle cell disease. Full Text available with Trip Pro

Interventions for treating leg ulcers in people with sickle cell disease. The frequency of skin ulceration makes it an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease.To assess the clinical effectiveness and safety of interventions for treating leg ulcers in people with sickle cell (...) of the last search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register: 21 July 2014; date of the last search of the Cochrane Wounds Group Trials Register: 18 September 2014.Randomised controlled trials of interventions for treating leg ulcers in people with sickle cell disease compared to placebo or an alternative treatment.Two authors independently selected studies for inclusion. All three authors independently assessed the risk of bias of the included

2014 Cochrane

183. Interventions for the management of oral ulcers in Behçet's disease. Full Text available with Trip Pro

Interventions for the management of oral ulcers in Behçet's disease. Behçet's disease is a chronic inflammatory vasculitis that can affect multiple systems. Mucocutaneous involvement is common, as is the involvement of many other systems such as the central nervous system and skin. Behç̧et's disease can cause significant morbidity, such as loss of sight, and can be life threatening. The frequency of oral ulceration in Behçet's disease is thought to be 97% to 100%. The presence of mouth ulcers (...) can cause difficulties in eating, drinking, and speaking leading to a reduction in quality of life. There is no cure for Behçet's disease and therefore treatment of the oral ulcers that are associated with Behçet's disease is palliative.To determine the clinical effectiveness and safety of interventions on the pain, episode duration, and episode frequency of oral ulcers and on quality of life for patients with recurrent aphthous stomatitis (RAS)-type ulceration associated with Behçet's disease.We

2014 Cochrane

184. Dyspepsia - proven peptic ulcer

Dyspepsia - proven peptic ulcer Dyspepsia - proven peptic ulcer - NICE CKS Share Dyspepsia - proven peptic ulcer: Summary The term 'dyspepsia' is used to describe a complex of upper gastrointestinal tract symptoms which are typically present for four or more weeks, including upper abdominal pain or discomfort, heartburn, acid reflux, nausea and/or vomiting. If symptoms of heartburn and acid regurgitation predominate, then gastro-oesophageal reflux disease (GORD) is the more likely diagnosis (...) . Gastric or duodenal ulcers (peptic ulcer disease) describe a breach in the epithelium of the gastric or duodenal mucosa, which is confirmed on endoscopy. The most common risk factors for the development of peptic ulcer disease are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. Complications of peptic ulcer disease include haemorrhage, perforation, and gastric outlet obstruction. Initial management of peptic ulcer disease includes: Offering advice

2018 NICE Clinical Knowledge Summaries

185. Randomised controlled trial: Skin protection wheelchair cushions for older nursing home residents reduce 6-month incidence of ischial tuberosity pressure ulcers compared with segmented foam cushions

Randomised controlled trial: Skin protection wheelchair cushions for older nursing home residents reduce 6-month incidence of ischial tuberosity pressure ulcers compared with segmented foam cushions Skin protection wheelchair cushions for older nursing home residents reduce 6-month incidence of ischial tuberosity pressure ulcers compared with segmented foam cushions | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage (...) wheelchair cushions for older nursing home residents reduce 6-month incidence of ischial tuberosity pressure ulcers compared with segmented foam cushions Article Text Care of the older person Randomised controlled trial Skin protection wheelchair cushions for older nursing home residents reduce 6-month incidence of ischial tuberosity pressure ulcers compared with segmented foam cushions Dimitri Beeckman 1 , 2 , Katrien Vanderwee 2 Statistics from Altmetric.com Commentary on: Brienza D , Kelsey S , Karg P

2011 Evidence-Based Nursing

186. Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study. Full Text available with Trip Pro

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study. Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD (...) patients.We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM).354 CD patients and 136 UC/IBDU patients presented with skin manifestations at any time during their disease course. In both, CD

2019 PLoS ONE

187. Excess skin problems among adolescents after bariatric surgery. (Abstract)

. Abdominal pannus severity (graded 0-5) and excess skin symptoms were evaluated preoperatively and for the first 5 years after bariatric surgery.Among the 217 study participants, 198 (90%) had an abdominal pannus and 16 (7%) reported pannus-related symptoms at the time of bariatric surgery. Preoperative symptoms included intertriginous infections (n = 12, 75%), recurrent cellulitis (n = 5, 31%), and superficial cutaneous ulcerations (n = 1, 6%). Participants with a higher pannus grade preoperatively (...) Excess skin problems among adolescents after bariatric surgery. Bariatric surgery results in significant and durable weight loss and improved health in severely obese adolescents. An important adverse consequence of the massive weight loss after bariatric surgery is excess skin and soft tissue. The prevalence and clinical characteristics of excess skin-related symptoms have been described in adults undergoing bariatric surgery but not in adolescents. Although the higher skin elasticity

2020 Surgery for Obesity and Related Diseases

188. Associations between skin barrier characteristics, skin conditions and health of aged nursing home residents: a multi-center prevalence and correlational study. Full Text available with Trip Pro

residents.This observational, cross-sectional, descriptive prevalence study was conducted in a random sample of 10 institutional long-term care facilities in Berlin. In total, n = 223 residents were included. Demographic and functional characteristics, xerosis cutis, incontinence associated dermatitis, pressure ulcers and skin tears were assessed. Stratum corneum hydration, transepidermal water loss, skin surface pH and skin temperature were measured. Data analysis was descriptive and explorative. To explore (...) possible bivariate associations, a correlation matrix was created. The correlation matrix was also used to detect possible collinearity in the subsequent regression analyses.Mean age (n = 223) was 83.6 years, 67.7% were female. Most residents were affected by xerosis cutis (99.1%; 95% CI: 97.7% - 100.0%). The prevalence of pressure ulcers was 9.0% (95% CI: 5.0% - 13.0%), of incontinence associated dermatitis 35.4% (95% CI: 29.9% - 42.2%) and of skin tears 6.3% (95% CI: 3.2% - 9.5%). Biophysical skin

2017 BMC Geriatrics

189. The Effect of Skin Cleansers on the Skin Surface Microbiome

[Guardian gel hand wash]) after providing consent and during the whole study Healthy and intact skin in the test area (e.g., no skin allergy, visible bleeding, skin inflammation, skin ulcer or skin lesion, no need for cutaneous treatment) Must have given written informed consent Women of child-bearing potential who are, in the opinion of the investigator, practicing a reliable method of contraception. Exclusion Criteria: Women who are pregnant or have a positive urine pregnancy test or intending (...) The Effect of Skin Cleansers on the Skin Surface Microbiome The Effect of Skin Cleansers on the Skin Surface Microbiome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Skin Cleansers

2017 Clinical Trials

190. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections

Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03137173 Recruitment Status

2017 Clinical Trials

191. Foot ulcers in people with diabetes: evidence round-up

of skin) and macrovascular and microvascular complications. Infected, non-healing foot ulcers can result in limb amputation. 85% of all non-traumatic lower limb amputations in people with diabetes are preceded by a foot ulcer. reports that there are more than 135 leg, foot or toe amputations in England alone each week and that up to 80% can be avoided with good diabetes management and foot care. Four years ago, Diabetes UK launched their campaign, which includes a leaflet to help people with diabetes (...) Foot ulcers in people with diabetes: evidence round-up Foot ulcers in people with diabetes: evidence round-up - Evidently Cochrane Search and hit Go By April 8, 2016 // If you ever nurse people with diabetes (that’s most of you, I think), then keep reading! Yesterday was , which this year focused on diabetes, and the World Health Organization published its first global report on diabetes. It’s well worth reading and there are useful resources accompanying it. Yesterday I blogged about

2016 Evidently Cochrane

192. Nicorandil (Ikorel): now second-line treatment for angina - risk of ulcer complications

2016 From: Therapeutic area: Contents Advice for healthcare professionals: Use nicorandil for treatment of stable angina only in patients whose angina is inadequately controlled by first line anti-anginal therapies, or who have a contraindication or intolerance to first line anti-anginal therapies such as beta-blockers or calcium antagonists Nicorandil can cause serious skin, mucosal, and eye ulceration, including gastrointestinal ulcers which may progress to perforation, haemorrhage, fistula (...) , or abscess Stop nicorandil treatment if ulceration occurs—consider the need for alternative treatment or specialist advice if angina symptoms worsen Please continue to report suspected adverse drug reactions to nicorandil or any other medicines on a Ulcers Nicorandil-induced ulceration has been most frequently reported for the gastrointestinal tract (rarely ); very rarely, the skin and mucosa are affected, including the eye. A review by the UK’s Commission on Human Medicine’s Pharmacovigilance Expert

2016 MHRA Drug Safety Update

193. Sural artery perforator flap with posterior tibial neurovascular decompression for recurrent foot ulcer in leprosy patients Full Text available with Trip Pro

Sural artery perforator flap with posterior tibial neurovascular decompression for recurrent foot ulcer in leprosy patients Introduction: The sensory loss and alteration of the shape of the foot make the foot liable to trauma and pressure, and subsequently cause more callus formation, blisters, and ulcers. Foot ulcers usually are liable to secondary infection as cellulitis or osteomyelitis, and may result in amputations. Foot ulcers are a major problem and a major cause of handicaps in leprosy (...) patients. The current study is to present our clinical experience and evaluate the use of sural flap with posterior tibial neurovascular decompression (PTND) in recurrent foot ulcers in leprosy patients. Patient and methods: A total number of 9 patients were suffering from chronic sequelae of leprosy as recurrent foot ulcers. All the patients were reconstructed with the reverse sural artery fasciocutaneous flap with posterior tibial neurovascular decompression from September 2012 to August 2015. Six

2017 GMS Interdisciplinary plastic and reconstructive surgery DGPW

194. Genetics of Skin Cancer (PDQ®): Health Professional Version

invade tissue locally or regionally, sometimes following along nerves. A tendency for superficial necrosis has resulted in the name rodent ulcer .[ ] Some debate remains about the origin of SCC; however, these cancers are likely derived from epidermal stem cells associated with the hair follicle.[ ] A variety of tissues, such as lung and uterine cervix, can give rise to SCC, and this cancer has somewhat differing behavior depending on its source. Even in cancer derived from the skin, SCC from (...) cancers in these areas can lead to reconstructive challenges and have significant cosmetic and social ramifications.[ ] Clinical Presentation of Skin Cancers While the appearance of any one skin cancer can vary, there are general physical presentations that can be used in screening. BCCs most commonly have a pearly rim or can appear somewhat eczematous (refer to and ). They often ulcerate (refer to ). SCCs frequently have a thick keratin top layer (refer to ). Both BCCs and SCCs are associated

2018 PDQ - NCI's Comprehensive Cancer Database

195. Turning for the Prevention and Management of Pressure Ulcers

Turning for the Prevention and Management of Pressure Ulcers Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation. October 2014; pp. 1–12 Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation Ontario Health Technology Advisory Committee October 2014 Turning for the Prevention and Management of Pressure Ulcers: OHTAC Recommendation. October 2014; pp. 1–12 2 Suggested Citation This report should be cited as follows: Ontario Health (...) Technology Advisory Committee (OHTAC). Turning for the Prevention and Management of Pressure Ulcers: OHTAC recommendation [Internet]. Toronto: Queen's Printer for Ontario; 2014 October. 12 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac-recommendations/ontario-health- technology-assessment-series/turn-multisite-trial. Permission Requests All inquiries regarding permission to reproduce any content in Health Quality Ontario reports should be directed to EvidenceInfo@hqontario.ca

2014 Health Quality Ontario

196. Treatment of Pressure Ulcers: A Clinical Practice Guideline From the American College of Physicians Full Text available with Trip Pro

complication rates (49%), whereas rotation flaps were associated with the lowest complication rates (12%) compared with other surgical flap procedures ( ). Adjunctive Therapies The most common adverse effect reported with electrical stimulation was skin irritation (low-quality evidence) ( ). No substantial adverse effects were reported for light therapy ( ) or laser therapy ( ) (low-quality evidence). Harms of Pressure Ulcer Treatments Based on Pressure Ulcer Features, Patient Characteristics, and Health (...) wound healing, there was no evidence that they improved complete wound healing compared with other dressings. Dextranomer paste was inferior to other dressings for reducing wound size. Platelet-derived growth factor improved ulcer healing compared with placebo for more severe ulcers, and evidence was insufficient to determine the effect of other biological agents. The most commonly reported harms for local wound applications included skin irritation, inflammation, and tissue damage and maceration

2015 American College of Physicians

197. Risk Assessment and Prevention of Pressure Ulcers: A Clinical Practice Guideline From the American College of Physicians

: strong recommendation, moderate-quality evidence) Recommendation 3: ACP recommends against using alternating-air mattresses or alternating-air overlays in patients who are at an increased risk of developing pressure ulcers. (Grade: weak recommendation, moderate-quality evidence) Pressure ulcers are defined as localized injury to the skin and/or underlying tissue, usually over a bony prominence, as a result of pressure alone or in combination with shear ( ). They commonly occur in patients (...) various support surfaces (such as mattresses, integrated bed systems, overlays, and cushions), repositioning, nutritional supplementation, skin care (for example, dressing and management of incontinence), and topical creams ( ). Studies have suggested that prevention of hospital-acquired pressure ulcers is more effective than standard care ( ). Although this guideline focuses on a comparative effectiveness review of individual interventions, we understand that care teams often implement multicomponent

2015 American College of Physicians

198. Salazopyrine (A07EC01 (intestinal anti-inflammatory agents)) - Ulcerative colitis, Crohn's disease in the colon, Rheumatoid arthritis

Salazopyrine (A07EC01 (intestinal anti-inflammatory agents)) - Ulcerative colitis, Crohn's disease in the colon, Rheumatoid arthritis HAS - Medical, Economic and Public Health Assessment Division 1/15 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 23 July 2014 SALAZOPYRINE 500 mg, tablet Bottle of 100 tablets - CIP code: 322 688-0 Applicant: PFIZER INN Sulfasalazine ATC Code (2014) A07EC01 (intestinal anti (...) -inflammatory agents) Reason for the review Renewal of inclusion List concerned National Health Insurance (French Social Security Code L.162-17) Indications concerned "Gastroenterology: Ulcerative colitis: treatment of attacks and prevention of relapses. Crohn's disease in the colon. Rheumatology: Rheumatoid arthritis." HAS - Medical, Economic and Public Health Assessment Division 2/15 01 ADMINISTRATIVE AND REGULATORY INFORMATION Marketing Authorisation (national procedure) Date initiated: 31 March 1992

2015 Haute Autorite de sante

199. Treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia: guideline update Full Text available with Trip Pro

destructive infection of skin and of adipose and soft tissue caused by Mycobacterium ulcerans , an environmental pathogen that produces a potent toxin. It is because of progressive destruction of subcutaneous tissue that the characteristic ulcer becomes widely undermined. BU only occurs in specific endemic areas, particularly coastal Victoria, where the disease is known locally as Bairnsdale ulcer. The second major Australian focus is a small region between Mossman and just beyond the Daintree River (...) . , Contact with contaminated soil may also play a role. Hence, during outbreaks in Australia, use of protective clothing, avoidance of biting insects, use of insect repellents, cleaning of skin or wounds after soil exposure, and mosquito control are logical preventive strategies that should be considered by individuals and public health authorities. Key points and recommendations for the diagnosis, treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia Diagnosis

2014 MJA Clinical Guidelines

200. Debridement Procedures for Managing Diabetic Foot Ulcers

Debridement Procedures for Managing Diabetic Foot Ulcers Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines | CADTH.ca Find the information you need Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines Last updated (...) : September 15, 2014 Project Number: RC0579-002 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Report in Brief Context The rising prevalence of diabetes and its associated complications represent a global public health care problem and financial burden. The estimated prevalence of diabetes in Canada is 6.8% — roughly 2.4 million Canadians — and it is increasing, with a 280% increase from 1998. Diabetic foot ulcers (DFUs) are the most

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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