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Skin Tag

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1821. Genetic heterogeneity in tuberous sclerosis: phenotypic correlations. (PubMed)

Genetic heterogeneity in tuberous sclerosis: phenotypic correlations. There is increasing evidence for genetic heterogeneity in tuberous sclerosis (TSC) on the basis of linkage analysis in affected kindreds. We have performed a detailed assessment of an affected South African family in which there is no evidence of linkage to chromosome 9 markers. The affected persons have atypical clinical features, namely prominent nuchal skin tags, a confetti pattern of hypopigmentation of the skin (...) of the lower legs, and absence of ungual fibromata. Further investigation of these unusual phenotypic features is warranted in order to determine whether these lesions are consistently present in families in whom the gene for TSC is not on 9q34. We conclude that confetti depigmentation and nuchal skin tags may be clinical pointers to an alternative locus for TSC.

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1990 Journal of Medical Genetics

1822. A human T cell lymphoma secreting an immunoglobulin E specific helper factor. (PubMed)

A human T cell lymphoma secreting an immunoglobulin E specific helper factor. An 8-yr-old nonallergic girl with non-Hodgkin's lymphoma had markedly elevated serum IgE at presentation (greater than 10,000 IU/ml), negative skin tests to a battery of 24 common allergens, and no evidence of parasitic infestation. Serum levels of IgG, IgA, and IgM were normal. Remission after cytotoxic chemotherapy was accompanied by a marked reduction in serum IgE levels (to less than 200 IU/ml) with no change (...) in the level of serum IgG, IgM, or IgA. Recurrence of the lymphoma 7 mo after remission was accompanied by an isotype specific rise in serum IgE (to 3,850 IU/ml). Isoelectric focusing revealed that the IgE was polyclonal. Phenotypic analysis of the lymphoma obtained during relapse revealed all (greater than 98%) cells to be T3+, T4+, and T8+. Incubation of lymphoma cells with human myeloma IgE followed by immunosorbent purified fluorescein tagged goat anti-human IgE (anti-IgE PS-adsorbed over IgE ADZ

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1985 Journal of Clinical Investigation

1823. Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation. (PubMed)

Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation. We have characterized the molecular defect causing androgen resistance in two 46,XY siblings with complete testicular feminization. Although binding studies in genital skin fibroblasts showed a reduced Bmax, an increased dissociation rate of ligand, and an 8S peak of dihydrotestosterone binding on sucrose density gradient centrifugation, no immunoreactive androgen (...) receptor (AR) was detected in immunoblots using anti-NH2-terminal antibodies, suggesting an abnormal amino terminus. Sequence analysis of the AR gene revealed a point mutation CAG-->TAG (Gln-->Stop) at nucleotide 340. In vitro mutagenesis studies suggest the synthesis of the mutant AR is initiated downstream of the termination codon at reduced levels and that each molecule is functionally impaired. These results define a novel mechanism causing androgen resistance: the combination of decreased amount

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1993 Journal of Clinical Investigation

1824. Nonsense-codon mutations of the ornithine aminotransferase gene with decreased levels of mutant mRNA in gyrate atrophy. (PubMed)

techniques of PCR, denaturing gradient gel electrophoresis, and direct sequencing, we have identified three nonsense-codon mutations and one nonsense codon-generating mutation of the OAT gene in GA pedigrees. Three of them are single-base substitutions, and one is a 2-bp deletion resulting in a reading frameshift. A nonsense codon created at position 79 (TGA) by a frameshift and nonsense mutations at codons 209 (TAT----TAA) and 299 (TAC----TAG) result in abnormally low levels of OAT mRNA in the patient's (...) skin fibroblasts. A nonsense mutation at codon 426 (CGA----TGA) in the last exon, however, has little effect on the mRNA level. Thus, the mRNA level can be reduced by nonsense-codon mutations, but the position of the mutation may be important, with earlier premature-translation termination having a greater effect than a later mutation.

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1992 American Journal of Human Genetics

1825. Can you give guidance how to differentiate between a clinically indicated minor ops skin procedure and one that is regarded as a cosmetic procedure? Patients are often keen to have lesions removed sta

by a dermatologist. For a small proportion surgical removal (cryotherapy, cautery, laser or excision) may be appropriate. Other benign skin lesions Clinically benign skin lesions should not be removed on purely cosmetic grounds. This will include, amongst other conditions, skin tags and seborrhoeic keratoses (warts). Patients with moderate to large lesions that cause actual facial disfigurement may benefit from surgical excision. The risks of scarring must be balanced against the appearance of the lesion (...) Can you give guidance how to differentiate between a clinically indicated minor ops skin procedure and one that is regarded as a cosmetic procedure? Patients are often keen to have lesions removed sta Can you give guidance how to differentiate between a clinically indicated minor ops skin procedure and one that is regarded as a cosmetic procedure? Patients are often keen to have lesions removed stating they are nuisance or catching on clothes. - Trip Database or use your Google+ account

2006 TRIP Answers

1826. Role of the Varicella-Zoster Virus Gene Product Encoded by Open Reading Frame 35 in Viral Replication In Vitro and in Differentiated Human Skin and T Cells In Vivo (PubMed)

Role of the Varicella-Zoster Virus Gene Product Encoded by Open Reading Frame 35 in Viral Replication In Vitro and in Differentiated Human Skin and T Cells In Vivo Although genes related to varicella-zoster virus (VZV) open reading frame 35 (ORF35) are conserved in the herpesviruses, information about their contributions to viral replication and pathogenesis is limited. Using a VZV cosmid system, we deleted ORF35 to produce two null mutants, designated rOkaDelta35(#1) and rOkaDelta35(#2 (...) ), and replaced ORF35 at a nonnative site, generating two rOkaDelta35/35@Avr mutants. ORF35 Flag-tagged recombinants were made by inserting ORF35-Flag at the nonnative Avr site as the only copy of ORF35, yielding rOkaDelta35/35Flag@Avr, or as a second copy, yielding rOka35Flag@Avr. Replication of rOkaDelta35 viruses was diminished in melanoma and Vero cells in a 6-day analysis of growth kinetics. Plaque sizes of rOkaDelta35 mutants were significantly smaller than those of rOka in melanoma cells. Infection

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2005 Journal of virology

1827. Immunofluorescence Deconvolution Microscopy and Image Reconstruction of Human Defensins in Normal and Burned Skin (PubMed)

Immunofluorescence Deconvolution Microscopy and Image Reconstruction of Human Defensins in Normal and Burned Skin The aim of this study was visualization and localization of the human antimicrobials human beta defensins 1, 2, and 3, neutrophil defensin alpha (human neutrophil peptide), and the cathelicidin LL-37 in normal and burned skin, and determination of the cell types in which these antimicrobials were localized.Tissue sections were probed with antimicrobial antibodies, tagged (...) with fluorescently labeled secondary antibodies, and subjected to fluorescence deconvolution microscopy and image reconstruction. Images were generated by stacking multiple-section scans, which were then volume rendered by rotating stacks 360 degrees about an axis, or modeled in 3 dimensions.This technique yields a definitive image, providing a rapid basis for further quantification and manipulation from a full 3-dimensional aspect. In normal skin, human beta defensin-1 was localized to the perinuclear region

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2005 Journal of burns and wounds

1828. Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk

Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00574574 Recruitment Status : Completed First Posted : December 17, 2007 Last Update Posted : July 14, 2009 Sponsor: University of East Anglia Collaborators: Quadram

2007 Clinical Trials

1829. Dermal delivery of topically applied oligonucleotides via follicular transport in mouse skin. (PubMed)

recently was shown to modulate cytokine-inducible target gene expression in engrafted human skin. In this study, we examined the route of entry into mouse skin of fluorochrome-tagged or naked second-generation 2'-O-methoxyethyl-modified oligonucleotides that react specifically with an antibody, using topical cream-based formulations. In hairless mouse skin, immunohistochemical analysis and fluorescence microscopy were unable to detect the presence of oligonucleotide in the epidermis or dermis following (...) Dermal delivery of topically applied oligonucleotides via follicular transport in mouse skin. Antisense oligodeoxynucleotides formulated in cream preparations are being examined in the clinic as topical therapy for psoriasis. To produce their intended anti-inflammatory effects, these large anionic molecules must penetrate the stratum corneum and reach the living epidermis and dermis. A topically applied phosphorothioate antisense oligonucleotide targeted to intercellular adhesion molecule-1

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2005 Journal of Investigative Dermatology

1830. Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo. (PubMed)

Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo. DNA codes for genetic information. Furthermore, recent findings suggest that DNA offers additional function, particularly in the recognition of microorganisms. In this study, we investigated two classes of oligodeoxynucleotides (ODN) in skin keratinocytes; namely, an ODN comprising two cytidine-phosphate-guanosine (CpG) motifs (CpG-1-phosphorothioate (PTO)) and a poly-cytidine (Non-CpG (...) -5-PTO) as control. Both fluorescence-tagged ODN were rapidly taken up by cells and accumulated already after 5 minutes in perinuclear compartments. In order to test whether ODN convey immunological effects in keratinocytes, secretion of IL-8 was measured. Interestingly, both CpG-1-PTO and Non-CpG-5-PTO suppressed basal and tumor necrosis factor alpha-induced IL-8 levels measured in cell culture supernatants. Experiments using deletion mutant revealed a critical length of approximately 16

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2007 Journal of Investigative Dermatology

1831. Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport. (PubMed)

Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport. Many cell types in atherosclerotic lesions are thought to have various biological abnormalities, such as impaired lipid homeostasis and slow cell proliferation, which may be related to senescence at cellular and individual levels. One of the common characteristics of senescent cells (...) in vitro is the alteration of actin cytoskeletons, which have been reported to be involved in the intracellular transport of lipids. Recently, we raised the hypothesis that Cdc42, which is a member of the Rho-GTPase family and is known to play an important role in actin dynamics, might be important in cellular lipid transport.In the present study, we found that the protein expression levels and GTP-binding activities of Cdc42 were decreased in aged human skin fibroblasts. Moreover, we found

2002 Thrombosis and Vascular Biology

1832. RFID tags help alert surgeons to problems. (PubMed)

RFID tags help alert surgeons to problems. Estimates say 1,500 objects are left inside patients after surgery each year in the United States; two-thirds are sponges. A handheld wand scanning device successfully detects sponges in seconds. The author recommends conducting an initial count prior to surgical incision, a second count at the beginning of wound closure, and a third count before the skin is closed.

2006 Healthcare Benchmarks and Quality Improvemen

1833. Apocrine carcinoma, adenopathies, and raised TAG-72 serum tumor marker. (PubMed)

Apocrine carcinoma, adenopathies, and raised TAG-72 serum tumor marker. The detection of tumor-associated glycoprotein-72 in the serum of patients with carcinomas, basically of the colon, has proved to be of great use in the follow-up of these gastrointestinal adenocarcinomas.We report the case of a male patient presenting adenopathies in the right axilla. The histologic study of an adjacent skin tumor enabled the diagnosis of a cutaneous apocrine carcinoma. Among the studies made, the increase (...) in the serum antibody CA72.4 can be highlighted. The tumor marker was negative after the extirpation of the skin tumor and the axillary adenopathies.To our best knowledge, this is the first case in which a tumor serum marker is associated with a cutaneous apocrine carcinoma, a fact that should be confirmed with further patients. Its use in the monitoring of this infrequent skin neoplasia is also noteworthy.

2004 Dermatologic Surgery

1834. Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens. (PubMed)

Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens. Molecular studies on scabies, a disease of considerable human and veterinary significance, have been limited because of the difficulty of obtaining the causative organism Sarcoptes scabiei, the "itch mite." We have used skin from the bedding of crusted scabies patients as a source of mites for the construction

2003 American Journal of Tropical Medicine & Hygiene

1835. Mucosal flap excision for treatment of remnant prolapsed hemorrhoids or skin tags after stapled hemorrhoidopexy. (PubMed)

Mucosal flap excision for treatment of remnant prolapsed hemorrhoids or skin tags after stapled hemorrhoidopexy. Stapled hemorrhoidopexy may leave residual skin tags or external components following its use in large prolapsed piles. Excision of redundant mucosa above the dentate line and reconstitution to the staple line reduces these prolapsed elements. We describe a novel technique that removes residual skin tags and piles while remaining true to the spirit of stapled hemorrhoidopexy.

2005 Diseases of the Colon & Rectum

1836. Surgical pearl: tissue forceps as a simple and effective instrument for treating skin tags. (PubMed)

Surgical pearl: tissue forceps as a simple and effective instrument for treating skin tags. Skin tags are one of the most common, benign, disfiguring tumors on the flexural aspects of the body of advanced aged and obese people, with higher incidences in females. Various treatment modalities have been advocated for the tags. Even a simple, noninvasive and fast cryotechnique requires approximately 1-3 min for a single skin tag. To hasten the treatment of the tags, tissue forceps have been used (...) as an effective, fast, simple instrument. By utilizing the tissue forceps, 37 skin tags at different parts of body have been treated successfully without cosmetic defects or recurrences at the sites.

2006 International Journal of Dermatology

1837. Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. (PubMed)

Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. Skin tags are common benign skin tumors usually occurring on the neck and major flexors of older people. A possible association with impaired carbohydrate metabolism has been suggested in previous studies, but the results are not conclusive.To investigate and compare the prevalence of diabetes and impaired glucose tolerance (IGT) in patients with skin tag and a control group.A case-control study (...) was conducted in individuals over 15 years old, comparing cases (n = 104) with at least three skin tags and age-, sex-, and body mass index (BMI)-matched controls (n = 94) without skin tag. Cases and controls were recruited from patients consecutively seen at an academic outpatient dermatology clinic. All patients underwent a standard 2-h oral glucose tolerance test with 75 g glucose.Patients with skin tag had higher frequency of diabetes than the control group (23.07% vs. 8.51%, chi(2)-test, P = 0.005

2007 International Journal of Dermatology

1838. Malignant transformation of anal skin tags in Crohn's disease. (PubMed)

Malignant transformation of anal skin tags in Crohn's disease. The anal skin tags of a young man with ileal and perianal Crohn's disease underwent malignant transformation. This was not associated with immunosuppressive drug therapy and has not been previously described.

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1984 Gut

1839. Skin tags and the atherogenic lipid profile (PubMed)

Skin tags and the atherogenic lipid profile This report details four patients who had skin tags, mainly on their torso, neck, and axillae, and who also displayed an abnormal lipid profile. All showed an increased serum triglyceride (fasting > 1.70 mmol/litre) and a decreased high density lipoprotein (HDL) cholesterol (< 1.1 mmol/litre in women and 1.0 mmol/litre for men) concentration. The displayed lipid profile is also known as the atherogenic profile and is associated with insulin resistance (...) , type 2 diabetes mellitus, and an increased risk of cardiovascular disease. Two of the patients had impaired glucose tolerance and one had type 2 diabetes mellitus. Three of the individuals had coronary artery disease. Skin tags might be a useful clinical sign that could alert clinicians to screen such individuals for abnormal lipids, type 2 diabetes mellitus, and cardiovascular disease.

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2000 Journal of Clinical Pathology

1840. Skin tags and the atherogenic lipid profile (PubMed)

Skin tags and the atherogenic lipid profile 12147668 2002 09 23 2018 11 13 0021-9746 55 8 2002 Aug Journal of clinical pathology J. Clin. Pathol. Skin tags and the atherogenic lipid profile. 639; author reply 639 Twomey P P eng Comment Letter England J Clin Pathol 0376601 0021-9746 0 Lipids 12629-01-5 Human Growth Hormone AIM IM J Clin Pathol. 2000 Nov;53(11):873-4 11127274 Acromegaly blood Human Growth Hormone blood Humans Hypertriglyceridemia blood Lipids blood Papilloma blood Skin Neoplasms

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2002 Journal of Clinical Pathology

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