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161. Nutrition Assessment and Interventions for Wound Care: Guidelines

guidelines for conducting nutrition assessment in patients receiving wound care? What are the evidence-based guidelines for providing nutritional support in patients receiving wound care in non-acute settings? What are the evidence-based guidelines regarding the provision of micronutrient supplementation in patients receiving wound care? Key Message Eleven systematic reviews and 14 evidence-based guidelines were identified regarding nutrition and wound care. Tags amino acids, burns, diet, dietary (...) supplements, glutamine, lacerations, micronutrients, nutrients, nutrition assessment, nutrition therapy, nutritional status, nutritional support, pressure sore, skin ulcer, soft tissue injuries, ulcer, vitamin, vitamins, wound healing, wounds, wounds and injuries, zinc, Dietary, Penetrating, Ulceration, Ulcerations, amino acid, malnourished, multivitamin, multivitamins, pressure sores Files Rapid Response Reference List Published : April 7, 2016 Follow us: © 2019 Canadian Agency for Drugs and Technologies

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

162. Chlorhexidine Gluconate Wipes for Infection Prevention in Acute and Critical Care: A Review of Clinical Effectiveness and Cost-Effectiveness

with a reduction in health care-associated infections and bacterial transmission, while two randomized controlled trials suggested that CHG wipes do not provide an advantage over alternative bathing methods with respect to infection prevention. When reported, adverse events associated with CHG wipes were limited to mild skin reactions. Considering the methodological limitations of the evidence from non-randomized trials in particular, results should be interpreted with caution. No evidence regarding (...) the clinical effectiveness of CHG wipes in acute care settings, or cost-effectiveness of CHG wipes in either acute or critical care units, was identified. Tags baths, chlorhexidine, infection control, medical devices, ChloraPrep, Chlorascrub, Hibiclens, Hibiscrub, chlorhex, cloth, cloths, washcloth, washcloths Files Rapid Response Summary with Critical Appraisal Published : April 13, 2016 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

163. Daptomycin for Methicillin-Resistant and Methicillin-Sensitive Staphylococcus Aureus Infection: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines

and vancomycin for the treatment bacteremia, skin and soft tissue infections (SSTI), and complicated skin and skin structure infections (cSSSI) caused by Staphylococcus aureus including MRSA. There was no significant difference between daptomycin, linezolid and vancomycin with regards to infection related length of stay (IRLOS) in hospital, total length of stay, medical resource utilization, and clinical response measures such as cure, improvement, no improvement, or failure. The efficacy of daptomycin (...) treatment failure, daptomycin is a preferred treatment option. Tags daptomycin, methicillin-resistant staphylococcus aureus, infection control, infectious diseases, cubicin; Mrsa; methicillin resistant staphylococcus aureus; methicillin sensitive staphylococcus aureus; MSSA; Antibiotic resistant organisms Files Rapid Response Summary with Critical Appraisal Published : January 21, 2016 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

164. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Full Text available with Trip Pro

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting in: European Journal of Endocrinology Volume 177 Issue 3 Year 2017 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing (...) (⨁⨁◯◯). R 6.7. We recommend that, while peripheral edema mostly resolves by 2 years of age without therapy, any serious compromise of fingernails, toenails or extremity skin at any age be assessed and treated by a professional edema therapist (⨁◯◯◯). R 6.8. We recommend dental/orthodontic evaluation at diagnosis if no previous dental/orthodontic care was established. Future management and follow-up should be based on the standard of dental/orthodontic care, individual clinical findings and patient needs

2016 European Society of Human Reproduction and Embryology

165. Emerging Technologies for the Prevention of Pressure Ulcers in Acute Care Settings: A Review of Clinical and Cost-Effectiveness and Guidelines

. No published literature was identified relating to the cost-effectiveness of emerging interventions for the prevention of pressure ulcers in acute care setting or regarding the clinical effectiveness of emerging preventive strategies in the operating room. Tags dermatology, hydrogels, microclimate, pressure ulcer, silk, bed sore, bed sores, skin lesion, skin lesions, decubitis, decubitus, Prevention, preventing, preventive Files Rapid Response Summary with Critical Appraisal Published : September 12, 2016 (...) that prophylactic polyurethane film dressings may be effective in preventing pressures sores in individuals without existing skin or tissue damage. One evidence-based guideline was identified relating to emerging technologies for the prevention of pressure ulcers in acute care settings; recommended practices include microclimate manipulation, prophylactic dressings, silk-like fabrics designed to reduce shear and friction, and electrical stimulation of the muscles in individuals with spinal cord injury

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

166. Cosentyx - secukinumab

Risk Assessment Committee (PRAC) adopted the PRAC Advice on the submitted Risk Management Plan. • During the meeting on 20 November 2014, the CHMP, in the light of the overall data submitted and the scientific discussion within the Committee, issued a positive opinion for granting a Marketing Authorisation to Cosentyx. Assessment report EMA/CHMP/389874/2014 Page 10/159 2. Scientific discussion 2.1. Introduction Problem statement Psoriasis is one of the most common human skin diseases affecting 2 (...) signalling pathways and involves the adapter proteins. Th17/IL-17A pathway is important in immune surveillance of mucocutaneous barrier tissues (gastrointestinal and respiratory tracts, and skin) and promotes host defense against a narrow range of mainly mucocutaneous infections with bacteria Candida albicans and to a lesser extent with fungi Staphylococcus aureus. Therefore, neutralizing critical mediators of innate and adaptive immunity may carry the risk of an increased susceptibility to infections

2015 European Medicines Agency - EPARs

167. Otezla - apremilast

skin xenograft model in mice. The studies and the relevant findings are summarised in Table 2: Table 2: In vivo pharmacodynamic activity of apremilast Study Number Treatment Duration Stimulus Dose/ Route of Administration Study Type Species/Sex Major Findings Acute TNF-a Production, Inflammation, and Hyperalgesia 5042-107 3.5 hours LPS 0.01 - 1 mg/kg, PO BALB/c mice Females Apremilast inhibited LPS- induced serum TNF-a levels with an ED 50 of 0.05 mg/kg. AP279R, AP284R, AP291R 2.5 hours LPS 0.01 (...) in control animals. Xenograft-induced psoriasis TECH1102006 14 days Human skin xenograft, psoriatic NK cells 5 mg/kg, PO divided BID beige-SCID mice Apremilast demonstrated reductions (= 50%) in both the epidermal thickness and keratinocyte proliferation index, psoriasiform histological features and immunohistochemical expression of the inflammatory markers TNF-a, HLA-DR and ICAM-1. Results were comparable to positive controls (cyclosporine). EMA/CHMP/476353/2014 Page 25/189 UVB-induced apoptosis AP2599

2015 European Medicines Agency - EPARs

168. Vargatef - nintedanib

of the GST-tag, the kinase domain was in vitro phosphorylated and cocrystallized with the ligand. Diffraction data of the VEGFR-2 kinase crystals in complex with BIBF 1120 were collected. The X-ray structure of VEGFR-2 kinase in complex with the ligand BIBF 1120 (Figure below) was solved at a resolution of 2.1 Å. The crystal contains one monomer of VEGFR-2 kinase in the asymmetric unit. BIBF 1120 is bound at the ATP-binding site in the cleft between the N- and C-terminal lobes of the kinase domain

2015 European Medicines Agency - EPARs

169. Chronic anal fissure: 2% topical diltiazem hydrochloride

In this RCT, 102 adults (mean age 30 years, range 17–61 years) with symptoms of anal fissure for more than 6 weeks or presence of a sentinel anal tag were randomised in equal numbers to receive 2% topical diltiazem ointment or 0.2% glyceryl trinitrate ointment, both applied twice daily for 12 weeks [14] . Participants were not prescribed stool softeners or bulk laxatives. Allocation concealment was not discussed but the study was double blind. Fissure healing (defined as complete skin closure over

2013 National Institute for Health and Clinical Excellence - Advice

170. Newborn Nursing Care Pathway

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Neuromuscular . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Genitalia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Elimination Urine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Stool . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Vital signs (...) through breastfeeding or skin-to-skin contact Referring to a Primary Health Care Provider (PHCP) Prior to referring to a Primary Health Care Provider (PHCP) a specific or newborn global assessment 4 (physical and feeding) including history of the pregnancy and labour and birth, will be performed by the nurse. Whenever possible, the woman/her family (supports) are present at the assessment and included in the planning, and implementation of the newborn’s care. In the intervention sections

2015 British Columbia Perinatal Health Program

171. Extracorporeal Photopheresis for Sezary Syndrome or Mycosis Fungoides: Clinical and Cost-Effectiveness

photopheresis for the management of Sezary Syndrome or Mycosis fungoides. Tags blood, cancer, granulomatous slack skin, mycosis fungoides, photopheresis, sezary syndrome, Cutaneous T Cell Lymphoma, ECP, granuloma fungoides, photophereses Files Rapid Response Summary of Abstracts Published : September 30, 2015 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

172. Constipation

loading and/or impaction. Examine the person, with their informed consent: Assess for signs of weight loss and general nutritional status. Perform an abdominal examination to check for abdominal pain, distension, masses, or a palpable colon (suggesting retained faecal masses). Perform an internal rectal examination, checking for: Anal fissures, haemorrhoids, skin tags, rectal prolapse, rectocele, skin erythema or excoriation (may be a sign of faecal leakage). Resting anal sphincter tone; rectal mass

2019 NICE Clinical Knowledge Summaries

173. Crohn's disease

in the right lower quadrant. Perianal pain or tenderness, anal or perianal skin tags, fissure, fistula, or abscess. Signs of malnutrition and malabsorption. Abnormalities of the joints, eyes, liver, and skin. If Crohn's disease is suspected, the person should be referred to secondary care for confirmation of the diagnosis and initiation of treatment. If the person is systemically unwell with symptoms of bloody diarrhoea, fever, tachycardia, or hypotension, emergency hospital admission should be arranged (...) , or fever. On examination there may be: Pallor, clubbing, aphthous mouth ulcers. Abdominal tenderness or mass, for example in the right lower quadrant. Perianal pain or tenderness, anal or perianal skin tag, fissure, fistula, or abscess. Signs of malnutrition and malabsorption — serial weight loss or, in children, faltering growth or delayed puberty. , including abnormalities of the joints, eyes, liver, and skin. Suspect a of Crohn's disease if there is: A history of recurrent urinary tract infections

2019 NICE Clinical Knowledge Summaries

174. Pilonidal sinus disease

— a chronic, relapsing-remitting, non-infectious inflammatory disease of the gastrointestinal tract. May present with perianal pain or tenderness, anal or perianal skin tag, fissure, fistula, or abscess. See the CKS topic on for more information. Infectious processes, including tuberculosis, syphilis, and actinomycosis — see the CKS topics on and for more information. Basis for recommendation Basis for recommendation The information on differential diagnoses is taken from The treatment of pilonidal (...) Pilonidal sinus disease Pilonidal sinus disease - NICE CKS Share Pilonidal sinus disease: Summary Pilonidal sinus disease is an inflammatory skin condition that usually occurs in the midline of the natal cleft (although there have been few reported cases involving other parts of the body, such as on the scalp, axilla, groin, and between the fingers). Opinions differ as to how it develops; the current consensus is that it is an acquired condition in which loose hairs in the natal cleft

2019 NICE Clinical Knowledge Summaries

176. Use of plumage and gular pouch color to evaluate condition of oil spill rehabilitated California brown pelicans (Pelecanus occidentalis californicus) post-release. Full Text available with Trip Pro

to condition can provide information on physiological status of birds. We evaluated plumage molt and gular pouch skin color of California brown pelicans (Pelecanus occidentalis californicus) following oil contamination and rehabilitation to test for differences between previously oiled and rehabilitated (post-spill) and presumably uncontaminated pelicans. Post-spill pelicans released with either color leg bands alone, or bands plus harness-mounted satellite GPS tags, were relocated and visually assessed (...) in the field at non-breeding communal roosts and compared to surrounding unmarked pelicans in the general population. Non-oiled pelicans bearing GPS tags were also included in the study. Post-spill pelicans lagged the general population in molt of ornamental yellow crown feathers but hind neck transition into white plumage was not significantly different. Both post-spill and non-oiled pelicans wearing GPS tags had lower gular redness scores than the unmarked, non-oiled population. Pre-breeding gular pouch

2019 PLoS ONE

177. Genetics of Prostate Cancer (PDQ®): Health Professional Version

cancer with the greatest risk consisting of colorectal cancer (RR, 1.78; 95% CI, 1.56–1.90), lung cancer (RR, 2.29; 95% CI, 1.65–3.18), kidney cancer (RR, 3.59; 95% CI, 1.61–7.99), bladder cancer (RR, 3.84; 95% CI, 2.63–5.60), melanoma (RR, 2.30; 95% CI, 1.86–2.93), squamous cell skin cancer (RR, 2.10; 95% CI, 1.92–2.26), and leukemia (RR, 3.88; 95% CI, 1.94–7.77). Among with prostate cancer with a family history of cancer, 47% of deaths were secondary to a second primary malignancy. The cumulative

2018 PDQ - NCI's Comprehensive Cancer Database

179. Breast Imaging and Intervention

the digital mammography image acquisition system to the stored DICOM image. Systems must provide all of the information fields listed in the chart below, ideally without additional manual entry by the operator. The DICOM header should contain the following tags: a) Facility Name b) Acquisition Date c) Acquisition Time d) Facility Address e) Station Name f) Operator Initials (or ID number) g) Patient’s First and Last Names h) Patient ID and/or Date of Birth i) kV j) Exposure Time and X-ray Tube Current (...) to tomosynthesis. 2. BREAST ULTRASOUND 48 Breast Ultrasound is an established, effective, diagnostic imaging technique which employs the use of high- frequency ultrasound waves for imaging, Doppler assessment, and elastography. INDICATIONS Appropriate indications for breast sonography include: a) Investigation of palpable abnormalities, skin changes and new dimpling (female or male) b) Investigation of serous or sanguineous nipple discharge (see NIPPLE DISCHARGE INVESTIGATION AND INTERVENTION, below) c

2016 Canadian Association of Radiologists

180. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

that a proliferating hemangioma is an attempt to normalize hypoxic tissue that occurred in utero . Clinical presentation Most infantile hemangiomas are not present at birth but precursor lesions such as telangiectasia or faint discoloration of the skin or hypopigmentation can often be seen. The lesion can be mistaken as a bruise from birth trauma or as a capillary malformation (port wine stain) (refer to ).[ , ] Figure 1. The photos on the left depict the precursor lesion (faint color with halo ). The photos (...) of hemangioma growth. Permanent sequelae, such as telangiectasia, anetodermal skin, redundant skin, and a persistent superficial component, can occur after hemangioma involution (refer to ). In a retrospective cohort study of 184 hemangiomas, the overall incidence of significant sequelae was 54.9%. Sequelae were more common in combined hemangiomas, hemangiomas with a step or abrupt border, and cobblestone surface hemangiomas. Furthermore, this study revealed that the average age to hemangioma involution

2018 PDQ - NCI's Comprehensive Cancer Database

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