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121. Fistulizing Crohn's Disease

solutions, Atlanta, Georgia, USA) to aid in the consensus process before the 2-day, face-to-face consensus meeting held in Toronto, Ontario, Canada, in September 2016. The steering committee (RP , AHS, BB, RK, JKM, and LT) and one of the nonvoting methodolo- gists (GL) developed the initial statements. Using the consen- sus web-based platform, the steering committee reviewed the results of initial literature searches and identified relevant ref - erences that were then ‘tagged’ (ie, selected and linked (...) ) to each statement. All participants then used the web-based platform and a modified Delphi process 15, 16 to vote anonymously on their level of agreement with the statements, suggest revisions, and provide comments. The statements were revised through 2 separate iterations and finalized at the consensus meeting. All participants had access to all abstracts and electronic copies of the individual tagged references. The GRADE evaluations of the evidence for each statement were provided at the meeting

2018 Canadian Association of Gastroenterology

122. Iron, Zinc, and Vitamin D Supplementation During Breastfeeding

in populations around the world. Further study to assess the role of skin pigmentation, seasons, latitude, and sun exposure to ensure healthy vitamin D status for all populations is warranted. Currently,the25(OH)Dstatusassociatedwithtoxicityisnot de?ned. Identifying this upper limit of healthy vitamin D status is critical to future research. In addition, identifying infant vitamin D suf?ciency, the 25(OH)D status associated with optimal outcomes, is needed. Further research is also needed to determine (...) for the breastfeeding infant. The randomized controlled trials described in this protocol demonstrate that thisriskismitigatedbymaternalvitaminDsupplementation atadosethatisbothsafeforherandef?caciousfortheinfant. References 1. Shekelle PG, Woolf SH, Eccles M, et al. Clinical guide- lines: Developing guidelines. BMJ 1999;318:593–596. 2. Saarinen UM, Siimes MA, Dallman PR. Iron absorption in infants: High bioavailability of breast milk iron as in- dicated by the extrinsic tag method of iron absorption

2018 Academy of Breastfeeding Medicine

123. Diagnosis, staging and treatment of patients with oesophageal or oesophago-gastric junction cancer

cancer (excluding non-melanoma skin cancer) (National Cancer Registry Ireland (NCRI), 2018b). Cancer is the second leading cause of death in Ireland after diseases of the circulatory system. Deaths from cancer averaged about 8,875 deaths per year during 2013-2015, representing about 30.7% of all deaths in 2016 (NCRI, 2018b). Oesophageal cancer was ranked the sixth most common cause of cancer deaths in Ireland 2013-2015, with an average of 387 deaths annually from 2013-2015 (NCRI, 2018b). Cancer (...) incidence data from the NCRI and population projections from the Central Statistics Office (CSO) have been combined by the NCRI to estimate the number of new cancer cases expected in five year bands from 2020-2045. The total number of new invasive cancer cases (including non-melanoma skin cancer) is projected to increase by 84% for females and 111% for males between 2015 and 2045, based only on changes in population size and age distribution (demography). The incidence of oesophageal cancer in Ireland

2018 Health Service Executive (Ireland) - Clinical Guidelines

124. Rare defects in Adrenal Steroidogenesis (Full text)

Rare defects in Adrenal Steroidogenesis MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis in: European Journal of Endocrinology Volume 179 Issue 3 Year 2018 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience. If you don't change your settings, we'll assume you're happy with this. Google Translate to save searches and organize your favorite content. Not registered? Search Recently viewed (1) MECHANISMS (...) granulosa cells (and adipocytes). These tissues also express 17βHSD1 (encoded by HSD17B1 ), which converts estrone to estradiol. In genital skin (and to a lesser extent in the testis), 5α-reductase type 2 (5αRed2, encoded by SRD5A2 ) further activates testosterone to dihydrotestosterone. Figure 1 Principal pathways of steroidogenesis. The figure incorporates pathways from adrenal and gonadal steroidogenesis. StAR facilitates most cholesterol influx into steroidogenic mitochondria, but some

2018 Pediatric Endocrine Society PubMed

125. European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults (Full text)

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors in: European Journal of Endocrinology Volume 179 Issue 4 Year 2018 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing

2018 European Society of Endocrinology PubMed

126. Varicella zoster virus and pregnancy

Varicella zoster virus and pregnancy 1 Varicella zoster virus and pregnancy DSOG (Danish Society of Obstetrics and Gynecology) Approved on January 2018 by the participants at the yearly obstetric guideline meeting in DSOG Page 1-3: English summary Page 4-21: The entire guideline in Danish including references 1. How to diagnose maternal VZV infection Recommendations Grade The diagnosis of a varicella zoster virus (VZV) infection is generally based on the typical skin manifestations ? v (...) The diagnosis can be based on the detection of specific antibodies (IgM & IgG) ? v The diagnosis can be based on the use of PCR to detect VZV DNA in skin lesions ? v 2. What is the risk for the fetus when the mother is VZV-infected in pregnancy? Recommendations Grade The pregnant woman should be advised that the risk of spontaneous abortion is not increased in the case of first trimester VZV infection ? C The pregnant woman should be informed about the small risk for the unborn to develop fetal varicella

2018 Nordic Federation of Societies of Obstetrics and Gynecology

128. Duct tape to treat cutaneous warts

study indicated problems with duct tape including [4]: Most child participants (81%) indicating the duct tape not sticking Skin reactions to the duct tape Discussion and conclusion There exists limited experimental evidence on the effect of duct tape as a common wart treatment on wart recovery. The earlier and encouraging study that demonstrated some benefit from the duct tape was a study in children [4], and also involved a weekly soak and pumice stone treatment. The later study that did (...) interests are in integrated care, preventive health, and medical education. 1 comment on 5 March 2017 at 4:24 PM Thanks for the synopsis and bummer. I’ll have to move it down the list of options Leave a Reply Categories Categories Recent Posts Recent Comments on Carl on Ragel on on on Archives Archives Tags Donate! We do not accept drug company sponsorship or web based advertising for funding. The operational costs of the website is funded directly by the administrator. Please donate generously

2017 Morsels of Evidence

129. Duct tape to treat cutaneous warts

study indicated problems with duct tape including [4]: Most child participants (81%) indicating the duct tape not sticking Skin reactions to the duct tape Discussion and conclusion There exists limited experimental evidence on the effect of duct tape as a common wart treatment on wart recovery. The earlier and encouraging study that demonstrated some benefit from the duct tape was a study in children [4], and also involved a weekly soak and pumice stone treatment. The later study that did (...) interests are in integrated care, preventive health, and medical education. 1 comment on 5 March 2017 at 4:24 PM Thanks for the synopsis and bummer. I’ll have to move it down the list of options Leave a Reply Categories Categories Recent Posts Recent Comments on Carl on Ragel on on on Archives Archives Tags Donate! We do not accept drug company sponsorship or web based advertising for funding. The operational costs of the website is funded directly by the administrator. Please donate generously

2017 Morsels of Evidence

132. Oral and Dental Aspects of Child Abuse and Neglect

is suspicious for an adult human bite. 37 Bite marks found on human skin are challenging to inter- pret because of the distortion presented and the time elapsed between the injury and the analysis. 36 Recent investigations have led to questions about the scientific validity of forensic patterned evidence (bite mark analysis in particular) and its role in legal proceedings. 38 The pattern, size, contour, and color of a bite mark ideally can be evaluated by a forensic odon- tologist; a forensic pathologist (...) can be consulted if a forensic odontologist is not available. If neither specialist is available, a medical provider or dental provider experienced in identifying the patterns of child abuse injuries may examine and document the bite mark characteristics photographically with an identi- fication tag and scale marker (e.g., ruler) in the photograph. The photograph should be taken such that the angle of the camera lens is directly over the bite and in the same plane AMERICAN ACADEMY OF PEDIATRIC

2017 American Academy of Pediatric Dentistry

133. BSR guideline Management of Adults with Primary Sjögren's Syndrome (Full text)

[ ]. In general the use of topical steroids should be limited to patients under supervision by an ophthalmologist. For longer term use ciclosporin-containing eye drops have been shown to reduce subjective symptoms and improve objective signs of inflammation in patients with both primary and secondary SS [ ]. Ciclosporin 0.1% (Ikervis®) is licensed and NICE approved as a possible treatment for people with dry eye disease that has not improved despite treatment with artificial tears (NICE TAG 369 December 2015

2017 British Society for Rheumatology PubMed

134. CRACKCast E095 – Large Intestine

* Clinical features (differences are underlined!) ● Abdo pain ● Tenesmus ● Bloody diarrhea (4-6 or more stools per day) ● Weight loss ● Rectal bleeding ● Pallor / fatigue ● Abdo pain ● Tenesmus ● Bloody diarrhea (4-6 or more stools per day) ● Nausea / vomiting ● Nocturnal diarrhea ● Fissures ● Anorectal abscesses ● Ulcerated hemorrhoids ● Strictures ● Growth and pubertal delay in children ● Weight loss ● Rectal bleeding ● Pallor / fatigue ● Peri-anal skin tags ● Dry mucous membranes 9) List 4 categories (...) Management: Cecal: surgery (open vs laparoscopic) Sigmoid: endoscopic reduction versus surgery 4) List 3 Perianal complications and 6 Extra-intestinal manifestations of Crohn’s disease. Perianal: Anal Fissures Skin tags Perianal Fistula Anorectal Abscess Anal Stenosis Ulcerated Hemorrhoids Elevated risk for adenocarcinoma in fistula tract and recurrent stenosis Extra-intestinal MSK (Arthritis, ankylosing spondylitis, isolated joint, Hypertrophic osteoarthropathy – Clubbing, periostitis) Miscellaneous

2017 CandiEM

135. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting (Full text)

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting in: European Journal of Endocrinology Volume 177 Issue 3 Year 2017 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing (...) (⨁⨁◯◯). R 6.7. We recommend that, while peripheral edema mostly resolves by 2 years of age without therapy, any serious compromise of fingernails, toenails or extremity skin at any age be assessed and treated by a professional edema therapist (⨁◯◯◯). R 6.8. We recommend dental/orthodontic evaluation at diagnosis if no previous dental/orthodontic care was established. Future management and follow-up should be based on the standard of dental/orthodontic care, individual clinical findings and patient needs

2016 European Society of Human Reproduction and Embryology PubMed

136. CRACKCast E098 – Sexually Transmitted Infections

ulcers Genital herpes Primary syphilis Chancroid Lymphogranuloma venereum (rare) Granuloma inguinale (rare) Neoplasm/Trauma Genital discharge Gonorrhea Chlamydia Nongonococcal urethritis (NGU) Pelvic inflammatory disease (PID) Trichomoniasis Bacterial vaginosis Epithelial cell lesions Genital warts Secondary syphilis Molluscum contagiosum Neoplasm Nevi Skin tags Ectoparasites Pubic lice Scabies Body/Head lice Mites (chiggers) Ticks Question 2) List the differential diagnosis of painful and painless (...) symptoms of itching, burning, and paresthesias common prior to development and skin and mucosal lesions. Duration Generally lasts 2-4 weeks if untreated before spontaneous resolve. Generally shorter duration than primary with decreasing frequency and severity over time. Question 4) List 4 techniques for the diagnosis of herpes and how it is managed? Clinical: History of similar lesions in same distribution supports clinical diagnosis though insensitive and nonspecific. PCR diagnostic test of choice

2017 CandiEM

137. CRACKCast E096 – Anorectal Disorders

! Managed Medically using the WASH approach. ● Warm water sitz ● Analgesia ● Stool softeners ● High fiber diet See below Usually can be managed supportively as well. (they will ulcerate and ooze dark blood in a few days). But, if within 72 hrs of onset of symptoms, they can have the clot EXCISED. Be sure to warn patients that excision will lead to evacuation of the clot, but also rebleeding, swelling and the formation of a skin tag. People that are bad candidates for this: kids, pregnant women (...) common in the midnight summer… Causes: Focal Dermatitis Feces on the perianal skin fecal irritation Usually associated with obesity, deep perineal clefts, hair, hemorrhoids, skin tags, fistulae, Poor hygiene – tight non-breathable clothing Systemic causes: Tea, coffee, beer, spicy foods, citrus fruits, IV hydrocortisone, colchicine, tetracyclines. Contact dermatitis from topical anesthetics (lidocaine), topical corticosteroids, perfumed soap Systemic diseases Derm: Psorasis Lichen sclerosus Non

2017 CandiEM

138. Emerging Technologies for the Prevention of Pressure Ulcers in Acute Care Settings: A Review of Clinical and Cost-Effectiveness and Guidelines

. No published literature was identified relating to the cost-effectiveness of emerging interventions for the prevention of pressure ulcers in acute care setting or regarding the clinical effectiveness of emerging preventive strategies in the operating room. Tags dermatology, hydrogels, microclimate, pressure ulcer, silk, bed sore, bed sores, skin lesion, skin lesions, decubitis, decubitus, Prevention, preventing, preventive Files Rapid Response Summary with Critical Appraisal Published : September 12, 2016 (...) that prophylactic polyurethane film dressings may be effective in preventing pressures sores in individuals without existing skin or tissue damage. One evidence-based guideline was identified relating to emerging technologies for the prevention of pressure ulcers in acute care settings; recommended practices include microclimate manipulation, prophylactic dressings, silk-like fabrics designed to reduce shear and friction, and electrical stimulation of the muscles in individuals with spinal cord injury

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

140. Clinical Practice Guideline for the Management of Anal Fissures

present for fewer than 8 weeks, will appear as a longitudinal tear. fissures of a longer duration will manifest one or more stigmata of chronicity, including a hypertrophied anal papilla at the proximal aspect of the fissure, a sentinel tag at the distal aspect of the fissure, and exposed internal anal sphincter muscle within the base of the fissure. METHODOLOGY t hese guidelines were built on the last set of the a merican society of Colon and Rectal surgeons practice parameters for treatment (...) coverage with either botu- linum toxin injection or lis. a combined flap with botuli- num toxin injection has shown rapid symptom relief with healing rates ranging from 86.7% to 92% at follow-up in- tervals up to 24 months, with negligible fecal incontinence rates. 74,75 t heodoropoulos et al 76 compared the results of 30 consecutive patients who underwent lis plus V-Y peri- anal skin flap and 32 patients who previously underwent lis alone. s ignificantly less postoperative pain, faster heal- ing

2017 American Society of Colon and Rectal Surgeons

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