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81. Overview of sport-related injuries

of patellofemoral problems are multifactorial. There is no one physical examination test that is a standard for a diagnosis. In bursitis there is thickening and proliferation of the synovial lining, bursal adhesions, villus formation, tags, and deposition of chalky deposits. This may result from repetitive stress, infection, autoimmune disease, or trauma. Key diagnostic findings are localised pain and tenderness over a bursa and swelling if superficially sited. An overuse syndrome that typically affects young (...) of the leg and the volar compartment of the forearm are most commonly affected. It can arise acutely from bony or soft-tissue traumatic injury, or can occur as a chronic and recurrent condition as a result of intense muscular activity. The term "ankle fracture" generally refers to a fracture of the medial, lateral, or posterior malleolus. A "pop" is commonly heard on falling. Tenting of the skin over the medial malleolus and ankle deformity is a common sign of dislocation. Sporting injury is the third

2018 BMJ Best Practice

82. Overview of musculoskeletal pain

=bestpractice.com Most commonly results from motor vehicle accidents, gunshot or stab wounds, contact sports, or workplace accidents during heavy physical labour. The effects of the injury include paralysis, loss of sensation, and pain. The specific clinical presentation will depend on the nerve roots involved and the degree of injury to each root. A bursa is a sac containing a small amount of synovial fluid that lies between a tendon and either skin or bone to act as a friction buffer. In bursitis (...) , there is thickening and proliferation of the synovial lining, bursal adhesions, villus formation, tags, and deposition of chalky deposits. This may result from repetitive stress, infection, autoimmune disease, or trauma. Key diagnostic findings are localised pain and tenderness over a bursa and swelling if superficially sited. Calcium pyrophosphate arthritis is caused by deposition of articular calcium pyrophosphate (CPP) crystals. It can be difficult to diagnose. CPP crystals in synovial fluids can be small

2018 BMJ Best Practice

83. Bursitis

Bursitis Bursitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bursitis Last reviewed: February 2019 Last updated: March 2018 Summary The acute or chronic inflammation of a bursa. A bursa is a sac containing a small amount of synovial fluid that lies between a tendon and either skin or bone to act as a friction buffer. There are >150 bursae in the body and these can be deep (e.g., the subacromial bursa (...) ) or superficial (e.g., the olecranon bursa). In bursitis there is thickening and proliferation of the synovial lining, bursal adhesions, villus formation, tags, and deposition of chalky deposits. This may result from repetitive stress, infection, autoimmune disease, or trauma. Key diagnostic findings are localised pain and tenderness over a bursa and swelling if superficially sited. Treatment for non-septic bursitis involves modified physical activity, rest, and analgesia. Corticosteroid injections

2018 BMJ Best Practice

84. Tramadol

the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol , Tramacet Files Rapid Response Summary of Abstracts 2015 11. Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. 22533391 2012 04 26 2012 08 23 2013 11 21 1943-5681 73 5 2012 May American journal of veterinary research Am. J. Vet. Res. Effect of ketamine (...) the risk of congenital malformation alone. Data considering the risk of other adverse pregnancy outcomes are highly limited. Data regarding malformation risk are conflicting. A large prospective population-based study identified possible associations between first trimester 2014 17. Tramadol Tramadol Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy

2018 Trip Latest and Greatest

85. Traumatic brain injury

Search By Keyword: and / or SEARCH BY TAG: Assessment Management Acute Inpatient Outpatient/ Community Coping/ Adaptation Cognitive Motor Communication Neurobehavioural Medical/ Nursing Caregiver Role Service 2016 3. Cognitive rehabilitation therapy for traumatic brain injury (TBI) Cognitive rehabilitation therapy for traumatic brain injury (TBI) Cognitive rehabilitation therapy for traumatic brain injury (TBI) HAYES, Inc Record Status This is a bibliographic record of a published health technology (...) complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other (...) clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI. OBJECTIVES: To assess the effects

2018 Trip Latest and Greatest

86. Palliative care

large meals. Drinking cool fizzy drinks rather than still or hot drinks. Relaxation techniques. Parenteral hydration, if appropriate. Cognitive behavioural therapy (for anticipatory 2017 8. Guidelines on Management of Pain in Cancer and/or Palliative Care | Cancer Care Ontario Google Tag Manager You are using an outdated browser. We suggest you update your browser for a better experience. for update. Browse Guidelines Browse Pathway Maps Sort by You are here / / Guidelines on Management of Pain (...) oedema Bronchorrhoea (the production of 100 mL or more per day of watery mucus) When managing a person with noisy respiratory secretions at the end of life : It is essential to recognize the signs of dying 2017 10. Palliative care - malignant skin ulcer Palliative care - malignant skin ulcer - NICE CKS Clinical Knowledge Summaries Share Palliative care - malignant skin ulcer: Summary A malignant ulcer is a proliferative or cavitating primary or secondary cancer in the skin. It may appear as a crater

2018 Trip Latest and Greatest

87. Colon cancer screening

will provide a critical appraisal of cost-effectiveness analyses of CT colonography. Authors' conclusions The conclusions of this Assessment rely on the generalizability of the ACRIN trial to general screening populations 2009 6. Colon Cancer Screening with Colonoscopy Colon Cancer Screening with Colonoscopy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management (...) Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Colon (...) Cancer Screening with Colonoscopy Colon Cancer Screening with Colonoscopy Aka: Colon Cancer Screening with Colonoscopy , Colonoscopy , Home Medications Before Colonoscopy II. Efficacy Identifies up 94-98% of Identifies up to 98% of adenomatous polyps >1 cm (but only 74

2018 Trip Latest and Greatest

88. ACE inhibitors

of institutional accounts Username * Password * your user name or password? You are here ACE inhibitors in African Americans with hypertension associated with worse outcomes as compared to other antihypertensives Article Text Prognosis Cohort study ACE inhibitors in African Americans with hypertension associated with worse outcomes 2016 12. ACE Inhibitor ACE Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics (...) Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 ACE Inhibitor ACE Inhibitor Aka: ACE Inhibitor (...) , Angiotensin Converting Enzyme Inhibitor , Captopril , Capoten , Lisinopril , Prinivil , Zestril , Enalapril , Vasotec , Fosinopril , Monopril , Benzapril , Lotensin , Moexipril

2018 Trip Latest and Greatest

89. Amiodarone

-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect guinea pigs from a lethal dose of Ebola virus. 2018 9. Amiodarone Pulmonary Toxicity Amiodarone Pulmonary Toxicity Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound (...) Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Amiodarone Pulmonary (...) Toxicity Amiodarone Pulmonary Toxicity Aka: Amiodarone Pulmonary Toxicity From Related Chapters II. Epidemiology Occurs in 1-2% of patients on per year III. Pathophysiology Acute or subacute pneumonitis related to pulmonary drug deposition IV. Symptoms and cough may occur V. Differential Diagnosis VI. Imaging Diffuse s In some

2018 Trip Latest and Greatest

90. Breast Masses, Breast Complaints, and Diagnostic Breast Imaging in the Lactating Woman

, and breast pain. Skin conditions A number of skin conditions can be diagnosed by history and physical examination and thus do not require diagnostic imaging. Benign lesions that are interfering with breast- feeding, such as a skin tag on the nipple–areolar complex (NAC), warrant referral to a breast surgeon. Lesions that raise suspicion for Paget’s disease, in?ammatory breast cancer, or other malignancy require both diagnostic imaging and re- ferral to a breast surgeon. Examples of skin conditions (...) term that includes pre- invasive disease and invasive disease. Diagnosis is established histologically. Management is multidisciplinary in nature and is complex, tailored to the individual patient. Non-Mass Breast Complaints Breastfeeding women seeking medical evaluation of breast symptoms who do not have a palpable mass on examination may present with a variety of conditions, some of which require diagnostic imaging. These conditions can be cate- gorized into skin conditions, nipple discharge

2019 Academy of Breastfeeding Medicine

91. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease

., A.H.S., B.B., R.K., J.K.M., L.T.) and one of the nonvoting methodologists (G.L.) developed the initial statements. Using the consensus web-based platform, the steering com- mittee reviewed the results of initial literature searches and identified relevant references that were then “tagged” (selected and linked) to each statement. All participants then used the web-based platform and a modified Delphi process 18,19 to vote anonymously on their level of agreement with the statements, suggest revisions (...) , and provide comments. The statements were revised through 2 separate iterations and finalized at the Journal of the Canadian Association of Gastroenterology, 2019, Vol. 2, No. 3 e3consensus meeting. All participants had access to all abstracts and electronic copies of the individual “tagged” references. The GRADE evaluations of the evidence for each statement were provided at the meeting. At the consensus conference, participants presented data, reviewed GRADE evaluations of the evidence

2019 Canadian Association of Gastroenterology

92. British Association of Dermatologists guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in children and young people

and young people Survivorship/survival 9 Internal organ dysfunction and support – PELOD, modified SOFA or MODS score 8 No residual impairment Eyes – ocular surface disease, eyelid management, trichiasis, meibomian Skin – scarring, dyschromia, dyspigmentation Genital – phimosis, adhesion, meatal scarring 7 7 7 7 Quality of life and psychosocial well‐being – cDLQI and other measures, time to recovery, time to return to school/work 7 Duration of hospitalization 6 Ventilated days 6 Recurrence 6 Outcomes (...) hypersecretion, haemoptysis Symptoms indicating bowel involvement, i.e. diarrhoea, abdominal distension Date when the patient developed the first symptom or sign of the disorder, e.g. sore throat, rash, skin pain, sore eyes/mouth Previous or ongoing medical problems; specifically, history of previous drug reactions, recurrent herpes simplex virus (HSV) infections, chest infections, diagnosis and treatment for malignancy and/or stem cell transplant. Diagnosis and causality R2 (↑↑) Exclude* the differential

2019 British Association of Dermatologists

93. The economic evaluation of early intervention with Anti-Tumor Necrosis Factor-? treatments in pediatric Crohn's disease

of activity/well 0 Occasional difficulty maintaining age appropriate activity/subpar 10 Frequent limitation/very poor 20 Stools (per day) 0 to 1 liquid, no blood 0 =2 semi-formed with small blood or 2 to 5 liquid 7.5 Gross bleeding, =6 liquid, or nocturnal diarrhea 15 Erythrocyte Sedimentation Rate ESR (mm/hour) 50 15 Albumin (g/dL) =3.5 0 3.1–3.4 10 =3.0 20 Weight Gain or voluntary stable/loss=0 0 Involuntary stable or loss of 1% to 9% 5 Loss =10% 10 Perirectal disease None/asymptomatic tags=0 0 1 to 2

2019 SickKids Reports

95. Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn’s Disease

in the Supplementary Material Appendix 1. The consensus process was facilitated by the CAG via a web-based consensus platform (ECD Solutions, Atlanta, GA). Using this platform, the steering committee reviewed the results of initial literature searches and identified relevant references that were then “tagged” (selected and linked) to each statement. Copies of the tagged references were avail- able to all members of the consensus group. The full consensus group voted anonymously on their level of agreement (...) = 206) found that antibiotics significantly reduced the risk of relapse compared to placebo in patients with quiescent CD (RR, 0.58; 95% CI, 0.45–0.75). 37 The anti-mycobacterial therapies were associated with a greater risk of adverse events compared to placebo (RR, 2.57; 95% CI, 1.45–4.55). 37 The most common adverse events included increased skin pigmentation and rashes. One addi- tional RCT , which did not include an anti-mycobacterial agent, reported a statistically greater rate of maintenance

2019 Canadian Association of Gastroenterology

96. Diagnosis, staging and treatment of patients with oesophageal or oesophagogastric junction cancer

, approximately 22,641 people are diagnosed with invasive cancer (excluding non-melanoma skin cancer) (National Cancer Registry Ireland (NCRI), 2018b). Cancer is the second leading cause of death in Ireland after diseases of the circulatory system. Deaths from cancer averaged about 8,875 deaths per year during 2013-2015, representing about 30.7% of all deaths in 2016 (NCRI, 2018b). Oesophageal cancer was ranked the sixth most common cause of cancer deaths in Ireland 2013-2015, with an average of 387 deaths (...) annually from 2013-2015 (NCRI, 2018b). Cancer incidence data from the NCRI and population projections from the Central Statistics Office (CSO) have been combined by the NCRI to estimate the number of new cancer cases expected in five year bands from 2020-2045. The total number of new invasive cancer cases (including non-melanoma skin cancer) is projected to increase by 84% for females and 111% for males between 2015 and 2045, based only on changes in population size and age distribution (demography

2019 National Clinical Guidelines (Ireland)

97. Guideline regarding treatment of haemorrhoids

by the prolapsed tissue may cause itching of the perianal skin (image 2). 15 Images 2: (circular) prolapsed haemorrhoids The most commonly used classification of haemorrhoids was described by Goligher. In the Goligher classification, Grade I describes haemorrhoidal prolapse through the proctoscope, grade II describes haemorrhoidal prolapse during straining which reduces spontaneously, grade III describes haemorrhoidal prolapse occuring during straining and requires manual reduction back into the anal canal (...) fissures, the passage of stool may be accompanied by a small amount of bright rectal bleeding usually limited to the toilet paper or on the surface of stool. Some patients complain of itching or perianal skin irritation; o Inflammatory bowel diseases (i.e. Crohn’s and Colitis): (bloody) diarrhoea, abdominal pain and/or general malaise; o Sexually transmitted infections: intermittent rectal bleeding associated with the passage of mucus, mild diarrhoea with fewer than four small loose stools per day

2019 Palliative Care Evidence Review Service (PaCERS)

98. Screening and Management of the Hyperandrogenic Adolescent

fat distribution, skin tags, and acanthosis nigricans. Examination of androgen- sensitive skin areas such as the face, chest, abdomen, and back provide an assessment of the degree of hirsutism and can be used to chart patient progress over time; Ferriman–Gallwey scoring can be done if desired. Modified Ferriman–Gallwey (Fig. 2) scoring evaluates nine areas of the body; a score greater than 8 is indicative of hirsutism (3). Grading systems for acne include quantity (mild, moderate, or severe (...) . c Monitoring serum androgens is not recommended. Introduction Although androgen excess can manifest in many ways, the most common and recognizable symptoms are hirsutism and acne. (Alopecia also may be a symptom.) Hirsutism affects 5–10% of reproductive-aged females and is defined as excessive terminal hair growth in a distribution typically seen in adult men (face, sternum, lower abdomen, back, and thighs) (1). Acne vulgaris is a multifactorial skin con

2019 American College of Obstetricians and Gynecologists

99. Caplacizumab (Cablivi) - thrombotic thrombocytopenic purpura (aTTP)

samples possibly containing anti-caplacizumab antibodies were pre-incubated overnight with an excess of biotinylated and sulpho-tagged caplacizumab. The formed immune complexes were captured on a streptavidine coated MSD plate and detected via electrochemiluminescence (ECL). ADA positive subjects included in the TTP PhII study ALX-0681-2.1/10 were further characterized in an additional assay to differentiate pre-Ab from treatment emerging (TE) ADA. This assay (mADA) is a modification of the homogenous (...) bridging assay on the MSD platform, by using a C-terminal alanine extended analogue of caplacizumab (addition of one alanine) as the sulpho tagged detection tool (sulfo tagged ALX-0081-ala). The mADA assay predominantly measures TE ADA, as pre-Ab will not or to a lesser extent bridge in this assay format. Only TE ADA responses restricted to the C-terminal region in the Nanobody will be left undetected using the mADA assay and cannot be differentiated from pre-Ab. Data analysis A population PK/PD model

2018 European Medicines Agency - EPARs

100. Hyaluronic acid as an adjunct to periodontal treatment

healing as has shown positive benefits in repair of connective tissues bones and skin. Studies have also suggested beneficial impact on periodontal outcomes. The aim of this review was to evaluate the potential clinical effects of hyaluronic acid (HA)when used in conjunction with non-surgical and surgical periodontal therapy. Methods Searches were conducted in the Medline/PubMed, Embase, Cochrane, Web of Science, Scopus and Grey literature databases (www.greynet.org; https://scholar.google.ch/; www (...) Share on Google+ Share via email Tagged with: , , , , , , , Derek Richards is the Director of the Centre for Evidence-based Dentistry, Editor of the Evidence-based Dentistry Journal, Consultant in Dental Public Health with Forth Valley Health Board and Honorary Senior Lecturer at Dundee & Glasgow Dental Schools. He helped to establish both the Centre for Evidence-based Dentistry and the Evidence-based Dentistry Journal. He has been involved with teaching EBD and a wide range of evidence-based

2019 The Dental Elf

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