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41. Protecting Your Skin Is Worth the Effort

with an umbrella, a cover-up on, and sunscreen HEAVILY applied, and so are my kids. It takes a little extra planning before we go out, but I’ll do anything I can to avoid having to go through this again and to protect my kids from having to experience the same pain that I’ve had. It’s worth the effort! Posted on Thursday, April 26, 2018 by DCPC Categories Tags , , 4 comments on “Protecting Your Skin Is Worth the Effort” Comments listed below are posted by individuals not associated with CDC, unless otherwise (...) Protecting Your Skin Is Worth the Effort Protecting Your Skin Is Worth the Effort | | Blogs | CDC Search Form Controls TOPIC ONLY Search The CDC cancel submit Search Form Controls TOPIC ONLY Search The CDC cancel submit Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: . Protecting Your Skin Is Worth the Effort Posted on Thursday, April 26, 2018 by DCPC

2018 CDC The Topic Is Cancer blog

42. Going skin deep: Is a tattoo ethically binding?

Going skin deep: Is a tattoo ethically binding? Going skin deep: Is a tattoo ethically binding? Going skin deep: Is a tattoo ethically binding? | | December 14, 2017 68 Shares There’s currently an image in heavy circulation making its way around the internet of a hospital patient’s chest tattooed with the words “Do **not** resuscitate,” accompanied by what is assumed to be the man’s signature. This 70-year-old patient arrived at an emergency department unconscious with elevated blood alcohol (...) for the patient. Cody Mullens is a medical student and can be reached on Twitter . Image credit: The New England Journal of Medicine … … 68 Shares Tagged as: , Subscribe to KevinMD and never miss a story! Get free updates delivered free to your inbox. Subscribe Hire KevinMD to keynote your next event "Kevin's keynote presentation was perfect. Extremely rich in content, and a delivery that is world class." Related Posts More in Education < Previous post Next post > Find jobs at Careers by KevinMD.com Search

2017 KevinMD blog

43. MKSAP: 20-year-old male college student with a superficial skin infection

MKSAP: 20-year-old male college student with a superficial skin infection Managing a superficial skin infection MKSAP: 20-year-old male college student with a superficial skin infection | | July 15, 2017 1 Shares Test your medicine knowledge with the , in partnership with the . A 20-year-old male college student on the wrestling team is evaluated for a superficial skin infection. He has a history of several episodes of folliculitis and furunculosis over the past year that has required systemic (...) examination is unremarkable. Which of the following is the most appropriate next step in management? A. Culture a pustule B. Perform a Tzanck smear C. Start linezolid D. Start vancomycin MKSAP Answer and Critique The correct answer is A. Culture a pustule. The most appropriate first step in management is to culture a pustule to identify the causative organism prior to institution of antibiotic therapy. Bacterial skin infections are most commonly caused by Staphylococcus and Streptococcus spp. and may

2017 KevinMD blog

44. From skin cancer diagnosis to peace of mind

From skin cancer diagnosis to peace of mind From skin cancer diagnosis to peace of mind From skin cancer diagnosis to peace of mind | | June 9, 2017 29 Shares Jolean Olson’s always spent a lot of time in the sun, but she was shocked to see a large, suspicious-looking zit pop up on her left cheek. Her medical journey led her to a pathologist who performed a biopsy and rendered a diagnosis that helped Jolean make the best treatment decisions for herself and her family. Today, she’s grateful (...) for the definitive answers that put her on the road to good health and peace of mind. Created by the . … … 29 Shares Tagged as: , Subscribe to KevinMD and never miss a story! Get free updates delivered free to your inbox. Subscribe Hire KevinMD to keynote your next event "Kevin's keynote presentation was perfect. Extremely rich in content, and a delivery that is world class." Related Posts More in Video < Previous post Next post > Find jobs at Careers by KevinMD.com Search thousands of physician, PA, NP

2017 KevinMD blog

45. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. (PubMed)

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. Muscadine grape skin extract (MSKE) is derived from muscadine grape (Vitis rotundifolia), a common red grape used to produce red wine. Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR) that serves as a survival mechanism to relieve ER stress and restore ER homeostasis. However, when persistent, ER stress can (...) alter the cytoprotective functions of the UPR to promote autophagy and cell death. Although MSKE has been documented to induce apoptosis, it has not been linked to ER stress/UPR/autophagy. We hypothesized that MSKE may induce a severe ER stress response-mediated autophagy leading to apoptosis. As a model, we treated C4-2 prostate cancer cells with MSKE and performed a quantitative Tandem Mass Tag Isobaric Labeling proteomic analysis. ER stress response, autophagy and apoptosis were analyzed

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2016 PLoS ONE

46. The skin barrier function gene SPINK5 is associated with challenge proven IgE-mediated food allergy in infants. (PubMed)

The skin barrier function gene SPINK5 is associated with challenge proven IgE-mediated food allergy in infants. A defective skin barrier is hypothesized to be an important route of sensitization to dietary antigens and may lead to food allergy in some children. Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions.To determine whether genetic variants in and around SPINK5 are associated with IgE (...) -mediated food allergy.We genotyped 71 "tag" single nucleotide polymorphisms (tag-SNPs) within a region spanning ~263 kb including SPINK5 (~61 kb) in n=722 (n=367 food-allergic, n=199 food-sensitized-tolerant and n=156 non-food-allergic controls) 12-month-old infants (discovery sample) phenotyped for food allergy with the gold standard oral food challenge. Transepidermal water loss (TEWL) measures were collected at 12 months from a subset (n=150) of these individuals. SNPs were tested for association

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2017 Allergy

47. Vascular device insertion and lumbar puncture: skin preparation

Vascular device insertion and lumbar puncture: skin preparation Skin preparation for the insertion of vascular access devices | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Skin preparation for the insertion of vascular access devices Skin preparation for the insertion of vascular access devices Introduction This clinical guideline outlines the use of Chloraprep® as a product to decontaminate the skin. Chloraprep® is a licensed single use product (...) available within the Trust and contains 2% Chlorhexidine and 70% isopropyl alcohol. Chloraprep® is not licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) for use on infants below the age of two months. The Trust recognises the MHRA’s position and has concluded that the use of Chloraprep® will be used for skin decontamination prior to device insertion, on all children with intact skin including those below 32 weeks gestation and less than two weeks of life ). Although strict

2013 Publication 1593

48. Residual skin tags following procedure for prolapse and hemorrhoids: differentiation from recurrence (PubMed)

Residual skin tags following procedure for prolapse and hemorrhoids: differentiation from recurrence The aim of this study was to compare the incidence of recurrence and residual skin tag after the procedure for prolapse and hemorrhoids (PPH) versus conventional hemorrhoidectomy (CH) in the Chinese- and English-language literature to explore the definition of recurrence after PPH.Related Chinese- and English-language literature was collected by several methods. Meta-analysis was used to compare (...) the incidence of recurrence and residual skin tag of PPH versus CH.In China, 13.94% of hemorrhoids had a skin tag after PPH. The mean recurrence rate after PPH was 3.23% (range 0.40-26.44%). Our meta-analysis of PPH versus CH of the Chinese studies showed that PPH had a significantly lower recurrence rate-13 studies, odds ratio (OR) 0.27, 95% confidence interval (CI) 0.17-0.42, p < 0.00001-and a higher incidence of skin tags with no significance-6 studies, OR 3.42, 95% CI 0.49-24.04, p = 0.22. Our meta

2010 EvidenceUpdates

49. MKSAP: 32-year-old woman with a history of nonmelanoma skin cancer

MKSAP: 32-year-old woman with a history of nonmelanoma skin cancer MKSAP: 32-year-old woman with a history of nonmelanoma skin cancer MKSAP: 32-year-old woman with a history of nonmelanoma skin cancer | | December 10, 2016 9 Shares Test your medicine knowledge with the , in partnership with the . A 32-year-old woman is evaluated at a well-patient visit. Both her parents have a history of nonmelanoma skin cancer within the past year, and she is seeking counseling regarding skin cancer prevention (...) . She has a history of remote sunburns and had previously tanned as a teenager. She requests advice on how to approach sun protection to limit both future skin cancer risk as well as to prevent wrinkles and cosmetic photodamage. The patient has no other significant medical history and takes no medications. On physical examination, vital signs are normal. She has mild scattered wrinkling, scattered solar lentigines, and an average number of benign-appearing nevi. Which of the following is the most

2016 KevinMD blog

50. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. (PubMed)

Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD (...) ). These conditions possibly relate to underlying diabetogenic mechanisms. Our aim was to determine whether skin signs are feasible as cutaneous markers for the prediabetic or diabetic state.Data were collected from the databases PubMed, Embase and Cochrane. Articles were excluded if the populations presented with comorbidities or received treatment with drugs affecting the skin. Also, animal studies, studies with poor methodology and pilot studies were excluded.Among the 34 included original articles

2016 Danish medical journal

51. MKSAP: 53-year-old woman with a skin lesion

MKSAP: 53-year-old woman with a skin lesion Mohs micrographic surgery for basal cell carcinoma MKSAP: 53-year-old woman with a skin lesion | | March 5, 2016 4 Shares Test your medicine knowledge with the , in partnership with the . A 53-year-old woman is evaluated for a slowly enlarging, telangiectatic, pearly, ulcerated 1-cm plaque on the left temple. It bleeds periodically when traumatized. Medical history is significant for atrial fibrillation. She takes warfarin daily. She is otherwise (...) is a reasonable choice for BCCs in patients who are either not surgical candidates or who refuse surgery. It carries the risk of chronic radiation skin changes in subsequent years, and given the patient’s age, this makes it a less desirable option. Radiation therapy is also less cost-effective and less convenient for the patient, since it requires multiple treatments over the course of several weeks. Topical imiquimod treatment is often used for superficial BCCs and sometimes used off-label for nodular BCCs

2016 KevinMD blog

52. Skin microbiome surveys are strongly influenced by experimental design. (PubMed)

recapitulates microbial communities, but sequencing of hypervariable regions 1-3 of the 16S rRNA gene provides highly similar results. Sequencing of hypervariable region 4 poorly captures skin commensal microbiota, especially Propionibacterium. WMS sequencing, which is resource and cost intensive, provides evidence of a community's functional potential; however, metagenome predictions based on 16S rRNA sequence tags closely approximate WMS genetic functional profiles. This study highlights the importance (...) Skin microbiome surveys are strongly influenced by experimental design. Culture-independent studies to characterize skin microbiota are increasingly common, due in part to affordable and accessible sequencing and analysis platforms. Compared to culture-based techniques, DNA sequencing of the bacterial 16S ribosomal RNA (rRNA) gene or whole metagenome shotgun (WMS) sequencing provides more precise microbial community characterizations. Most widely used protocols were developed to characterize

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2016 Journal of Investigative Dermatology

53. Image of the Week: Under the Skin

Image of the Week: Under the Skin Image of the Week: Under the Skin | Wellcome Trust Blog Life from a Wellcome Trust perspective Image of the Week: Under the Skin 19 Feb, 2016 tags: , , , , by Credit: Ben Gilbert, Wellcome Images This week, , an academic and Chemist who trains Pharmacy students at the University of East Anglia, tells us about how her skin condition can both be a valuable educational tool and a work of art. Dermatographia (or to use its full term Dermatographia urticaria (...) ) is a type of rash where the skin become raised, red and itchy after being scratched. The term dermatographia actually means “skin writing” as sufferers are able to literally write on their own skin by scratching and waiting for the allergic reaction to reveal the scribbles. This type of urticaria is quite common and in most cases the red whelts, which are caused by release of histamine, subside after about half an hour. The reaction can be prevented by taking classical anti-histamines used for allergies

2016 Wellcome Trust Blog

54. Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols (PubMed)

pneumococcal growth during in vitro cocultivation on medium supplemented with human skin surface triacylglycerols (TAGs) that are likely present in the nostrils. This inhibition depends on LipS1, a TAG lipase necessary for C. accolens growth on TAGs such as triolein. We determined that C. accolens hydrolysis of triolein releases oleic acid, which inhibits pneumococcus, as do other free fatty acids (FFAs) that might be released by LipS1 from human skin surface TAGs. Our results support a model in which C (...) . accolens hydrolyzes skin surface TAGS in vivo releasing antipneumococcal FFAs. These data indicate that C. accolens may play a beneficial role in sculpting the human microbiome.Little is known about how harmless Corynebacterium species that colonize the human nose and skin might impact pathogen colonization and proliferation at these sites. We show that Corynebacterium accolens, a common benign nasal bacterium, modifies its local habitat in vitro as it inhibits growth of Streptococcus pneumoniae

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2016 mBio

55. Mechanoregulation of Wound Healing and Skin Homeostasis (PubMed)

, and restoration of the biological balance. The objective of this study is to point to the importance of mechanobiology in regeneration of skin damage and wound healing. The study describes the influence of rigidity of extracellular matrix and special restrictions on cell physiology. The study also defines how and what mechanical changes influence tissue regeneration and wound healing. The influence of mechanical signals in the process of proliferation, differentiation, and skin regeneration is tagged (...) Mechanoregulation of Wound Healing and Skin Homeostasis Basic and clinical studies on mechanobiology of cells and tissues point to the importance of mechanical forces in the process of skin regeneration and wound healing. These studies result in the development of new therapies that use mechanical force which supports effective healing. A better understanding of mechanobiology will make it possible to develop biomaterials with appropriate physical and chemical properties used to treat poorly

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2016 BioMed research international

56. VivaScope 1500 and 3000 imaging systems for detecting skin cancer lesions

VivaScope 1500 and 3000 imaging systems for detecting skin cancer lesions VivaScope 1500 and 3000 imaging VivaScope 1500 and 3000 imaging systems for detecting skin cancer lesions systems for detecting skin cancer lesions Diagnostics guidance Published: 11 November 2015 nice.org.uk/guidance/dg19 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility This guidance represents the view (...) possible. VivaScope 1500 and 3000 imaging systems for detecting skin cancer lesions (DG19) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 55Contents Contents 1 Recommendations 5 2 The technologies 7 3 Clinical need and practice 8 The problem addressed 8 The condition 8 The diagnostic and care pathways 10 4 The diagnostic tests 15 The interventions 15 The comparators 16 5 Outcomes 17 How outcomes were assessed 17

2015 National Institute for Health and Clinical Excellence - Diagnostics Guidance

57. This oncologist says the USPSTF gets it wrong on skin cancer screening

This oncologist says the USPSTF gets it wrong on skin cancer screening This oncologist says the USPSTF gets it wrong on skin cancer screening This oncologist says the USPSTF gets it wrong on skin cancer screening | | August 9, 2016 124 Shares In July 2016, the U.S. Preventative Services Task Force (USPSTF) published updated skin cancer screening guidelines in JAMA, concluding “current evidence is insufficient” to screen for skin cancer in adults. The guidelines were formulated on a literature (...) review of studies conducted in asymptomatic patients 15 years and older at general risk for skin cancer from 1995-2015; after identifying nearly 13,000 articles spanning two decades of work worldwide, the authors selected 13 studies to answer specified “key questions,” such as whether direct evidence exists that skin cancer screening reduces morbidity and mortality. One study, the SCREEN trial conducted in Northern Germany, was a population-based skin cancer screening program that included physician

2016 KevinMD blog

58. A Man with Multiple Myeloma and Skin Tightness

A Man with Multiple Myeloma and Skin Tightness Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures

2015 Now@NEJM

59. Uncomplicated Skin Infections

Uncomplicated Skin Infections Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures of resident life

2015 Now@NEJM

60. Management of Skin Abscesses

Management of Skin Abscesses Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures of resident life

2014 Now@NEJM

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