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21. Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract-A role for antioxidants in skin health. (PubMed)

Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract-A role for antioxidants in skin health. Skin acts as a protective barrier against direct contact with pollutants but inhalation and systemic exposure have indirect effect on keratinocytes. Exposure to diesel exhaust has been linked to increased oxidative stress.To investigate global proteomic alterations in diesel particulate extract (DPE)/its vapor exposed skin keratinocytes.We employed Tandem Mass Tag (...) (TMT)-based proteomics to study effect of DPE/DPE vapor on primary skin keratinocytes.We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Mass spectrometry-based quantitative proteomics led to identification 4490 proteins of which 201 and 374 proteins were significantly dysregulated (≥1.5 fold, p≤0.05) in each condition

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2018 Journal of dermatological science

22. Smad7 ameliorates TGFβ-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis. (PubMed)

TGF-β and NF-κB activation. Next, we produced recombinant human Smad7 protein with a Tat-tag (Tat-Smad7) that rapidly enters cells. Subcutaneous injection of Tat-Smad7 attenuated infiltration of F4/80+ and CD11b+ leukocytes and α-smooth muscle actin+ fibroblasts before attenuating epidermal hyperplasia in K5.TGFβ1 skin. Furthermore, topically applied Tat-Smad7 on K5.TGFβ1 skin wounds accelerated wound closure, with improved re-epithelialization and reductions in inflammation and fibrotic response (...) Smad7 ameliorates TGFβ-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis. We assessed the roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expression reversed transforming growth factor (TGF)-β1 transgene-induced inflammation, fibrosis, and subsequent epidermal hyperplasia and molecularly abolished

2018 Journal of Investigative Dermatology

23. Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri (PubMed)

Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri Immersion-vaccines (bacterins) are routinely used for aquacultured rainbow trout to protect against Yersinia ruckeri (Yr). During immersion vaccination, rainbow trout take up and process the antigens, which induce protection. The zebrafish was used as a model organism to study uptake mechanisms and subsequent antigen transport in fish. A genetically modified Yr was developed (...) to constitutively express green fluorescent protein (GFP) and was used for bacterin production. Larval, juvenile and adult transparent zebrafish (tra:nac mutant) received a bath in the bacterin for up to 30 minutes. Samples were taken after 1 min, 15 min, 30 min, 2 h, 12 h and 24 h. At each sampling point fish were used for live imaging of the uptake using a fluorescence stereomicroscope and for immunohistochemistry (IHC). In adult fish, the bacterin could be traced within 30 min in scale pockets, skin

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2016 PloS one

24. Tagged Red Blood Cell Scan

Tagged Red Blood Cell Scan Tagged Red Blood Cell Scan Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tagged Red Blood Cell Scan (...) Tagged Red Blood Cell Scan Aka: Tagged Red Blood Cell Scan , Tagged Red Cell Scan , Radionuclide Red Cell Scan II. Indications Acute without obvious source based on Most useful in slower (<0.4 ml/minute) Often used to preselect patients with non-brisk for angiography III. Description Radionuclide scan with Technetium 99m-labeled red cells Labeled s circulate for 48 hours (allows for repeat scanning) Identifies sites of ing via gamma camera scan Detects bleeding down to rates as low as 0.1 ml/min IV

2018 FP Notebook

25. EEG frequency tagging to explore the cortical activity related to the tactile exploration of natural textures (PubMed)

EEG frequency tagging to explore the cortical activity related to the tactile exploration of natural textures When sliding our fingertip against a textured surface, complex vibrations are produced in the skin. It is increasingly recognised that the neural transduction and processing of these vibrations plays an important role in the dynamic tactile perception of textures. The aim of the present study was to develop a novel means to tag the cortical activity related to the processing (...) induced by the fingertip-texture interactions elicited an SS-EP at the frequency of modulation (3 Hz) as well as its second harmonic (6 Hz), maximal over parietal regions contralateral to the stimulated side. Textures generating stronger vibrations also generated SS-EPs of greater magnitude. Our results suggest that frequency tagging using SS-EPs can be used to isolate and explore the brain activity related to the tactile exploration of natural textures.

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2016 Scientific reports

26. Prevention of Pressure Ulcers and Skin Degradation in Wheelchair Users: Guidelines

: Reference List Result type: Report Question What are the evidence-based guidelines regarding the management of heat and moisture in seating systems of wheelchair bound individuals? Key Message One evidence-based guideline regarding the management of heat and moisture for pressure ulcer prevention for wheelchair bound individuals was identified. Tags hot temperature, pressure ulcer, skin ulcer, wheelchairs, wounds and injuries, other miscellaneous topics, automated chair, cushion, decubitis, decubitus (...) Prevention of Pressure Ulcers and Skin Degradation in Wheelchair Users: Guidelines Prevention of Pressure Ulcers and Skin Degradation in Wheelchair Users: Guidelines | CADTH.ca Find the information you need Prevention of Pressure Ulcers and Skin Degradation in Wheelchair Users: Guidelines Prevention of Pressure Ulcers and Skin Degradation in Wheelchair Users: Guidelines Published on: October 7, 2015 Project Number: RA0810-000 Product Line: Research Type: Devices and Systems Report Type

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

27. The Presence of Alpha‐Synuclein in Skin from Melanoma and Patients with Parkinson's Disease (PubMed)

The Presence of Alpha‐Synuclein in Skin from Melanoma and Patients with Parkinson's Disease The misfolding and prion-like propagation of the protein α-synuclein (α-syn) is the leading molecular signature in Parkinson's disease (PD). There is a significant coincidence of PD and melanoma that may suggest a shared pathophysiology. This study compared the presence of α-syn in neural crest-derived tissues, such as nevi, melanoma, skin tags, and skin biopsies from patients with PD and healthy (...) controls.Biopsies from participants with PD were obtained from patients from a tertiary referral center for dermatology and neurology in Mexico and a private dermatopathology center in Florida between January 2015 and March 2016. Biopsies from 7 patients with melanoma, 15 with nevi, 9 with skin tags, 8 with PD, and 9 skin biopsies from healthy volunteers were analyzed for immunohistochemical determination of α-syn and tyrosinase. All analyses were performed by pathologists who were blinded with respect

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2017 Movement disorders clinical practice

28. MKSAP: 40-year-old man with a new skin rash of 10 days’ duration

MKSAP: 40-year-old man with a new skin rash of 10 days’ duration Eruptive xanthomas in patients with diabetes mellitus MKSAP: 40-year-old man with a new skin rash of 10 days’ duration | | March 9, 2019 2 Shares Test your medicine knowledge with the , in partnership with the . A 40-year-old man is evaluated for a new skin rash of 10 days’ duration. The rash appeared abruptly and is not tender or pruritic. The patient has poorly controlled type 2 diabetes mellitus. His current medications include (...) metformin and glyburide. Family history is unremarkable. On physical examination, vital signs are normal. BMI is 25. There are several grouped 1- to 5-mm yellow papules on extensor surfaces of extremities and buttocks. Some of the papules have surrounding erythema. The remainder of the examination is normal. Laboratory studies show an HbA1c value of 12%. Which of the following disorders is associated with the patient’s skin findings? A. Familial dysbetalipoproteinemia B. Familial hypercholesterolemia C

2019 KevinMD blog

29. Pharmacology and the Treatment of Complicated Skin and Skin-Structure Infections

Pharmacology and the Treatment of Complicated Skin and Skin-Structure Infections Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides

2014 Now@NEJM

30. Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags. (PubMed)

Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags. Skin tags are common cutaneous lesions with an indefinite aetiology.To assess serum leptin, insulin resistance and metabolic syndrome in different body mass index (BMI) patients with skin tags.Three equally distributed groups of patients with multiple skin tags: 30 normal BMI, 30 overweight and 30 obese were included. Controls were age-, gender- and BMI-matched healthy subjects. Serum leptin (...) , insulin resistance based on homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome were assessed in all groups.Number and extent of skin tags increase with the increase in BMI. Highest leptin levels were found in obese patients, with significant differences when compared to normal BMI and overweight patients. Similar findings existed in controls. Significantly higher leptin levels were found in obese patients compared to obese controls. HOMA-IR was significantly higher

2012 Journal of the European Academy of Dermatology and Venereology

31. Skin Tag

Skin Tag Skin Tag Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin Tag Skin Tag Aka: Skin Tag , Acrochordon From Related Chapters (...) II. Definition Benign epidermal hyperplastic lesion (Skin Tag) III. Epidemiology Very common (occur in 25%) and increase with age IV. Risk factors Advancing age Pregnancy V. Pathophysiology Develop in regions of increased skin friction and irritation VI. Signs Characteristics Usually pedunculated (narrow stalk) but may be sessile Flesh-color to brown Typically 2-5 mm in size (may be up to 1 cm) Distribution Axilla Neck Inguinal area VII. Differential diagnosis Pedunculated intradermal nevus

2015 FP Notebook

32. Old wine poured into a newer skin: The Society for Integrative Oncology updates its clinical guidelines for breast cancer

clinical studies have advanced knowledge enough to justify a new set of guidelines, and these guidelines suffer from the same issue that integrative medicine itself suffers from, mixing cow pie with apple pie as though they were equivalent. I called the previous guidelines old wine in a new skin. Greenlee et al have just poured that old wine out of the new skin into a newer skin, seemingly expecting it to make the vinegary wine better. Tags Categories to post comments More like this It should come (...) Old wine poured into a newer skin: The Society for Integrative Oncology updates its clinical guidelines for breast cancer Old wine poured into a newer skin: The Society for Integrative Oncology updates its clinical guidelines for breast cancer | ScienceBlogs Advertisment Search Search Toggle navigation Main navigation Old wine poured into a newer skin: The Society for Integrative Oncology updates its clinical guidelines for breast cancer By on May 1, 2017. "Integrative medicine" is a term

2017 Respectful Insolence

33. New Clinical Decisions article: Skin Abscess

New Clinical Decisions article: Skin Abscess Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures

2016 Now@NEJM

34. Uncomplicated Skin Abscess

Uncomplicated Skin Abscess Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures of resident life

2016 Now@NEJM

35. A Woman with a Skin Ulcer

A Woman with a Skin Ulcer Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures of resident life

2016 Now@NEJM

36. Randomized Trial of Skin Antiseptics at Cesarean Delivery

Randomized Trial of Skin Antiseptics at Cesarean Delivery Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping

2016 Now@NEJM

37. Skin biopsy: punch method

Skin biopsy: punch method Skin biopsy: punch method | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Skin biopsy: punch method Skin biopsy: punch method ). NOTE: We review our guidelines regularly and this guideline is now past its review date. The content of the guideline below may not reflect the most recent evidence based practice. Please use with caution. Children and young people can present with a wide range of skin anomalies. Some of these can prove (...) to be relatively normal whilst, in the extreme, others can be life threatening making timely assessment and accurate diagnosis crucial. It should be noted that despite reference to the 'child' throughout, this guideline equally applies to the young person. Many skin disorders can be diagnosed through direct observation and palpation but others may require referral to a dermatology specialist or expert. Children with a persistent skin problem or an unusual presentation may be referred to a dermatologist

2014 Great Ormond Street Hospital

38. Atypical Skin Manifestations in FGFR2-Related Craniosynostosis Syndromes Broaden the Phenotypic Spectrum (PubMed)

Atypical Skin Manifestations in FGFR2-Related Craniosynostosis Syndromes Broaden the Phenotypic Spectrum Crouzon syndrome (CS) and Beare-Stevenson syndrome (BSS) are craniosynostosis syndromes caused by mutations in the fibroblast growth factor 2 (FGFR2) gene. CS is more common (1 in 60,000 live births) than BSS, where fewer than 20 individuals have been reported. The cardinal features of BSS are craniosynostosis, cutis gyrata, acanthosis nigricans, skin furrows, skin tags, anogenital anomalies (...) , and a prominent umbilical stump. Previously described individuals with BSS have typically had mutations in exon 11 of FGFR2. Here, we present 2 patients with CS who have significant skin manifestations and some phenotypic overlap with BSS. De novo mutations in exon 8 of FGFR2 were identified in both; one is a mutation (c.799T>C; p.Ser267Pro) previously identified in individuals with CS and the other a novel in-frame deletion (c.820_824delinsTT; p.Val274_Glu275delinsLeu). No mutations in exon 11 of FGFR2

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2018 Molecular syndromology

39. Magnetosensitive e-skins with directional perception for augmented reality (PubMed)

Magnetosensitive e-skins with directional perception for augmented reality Electronic skins equipped with artificial receptors are able to extend our perception beyond the modalities that have naturally evolved. These synthetic receptors offer complimentary information on our surroundings and endow us with novel means of manipulating physical or even virtual objects. We realize highly compliant magnetosensitive skins with directional perception that enable magnetic cognition, body position (...) tracking, and touchless object manipulation. Transfer printing of eight high-performance spin valve sensors arranged into two Wheatstone bridges onto 1.7-μm-thick polyimide foils ensures mechanical imperceptibility. This resembles a new class of interactive devices extracting information from the surroundings through magnetic tags. We demonstrate this concept in augmented reality systems with virtual knob-turning functions and the operation of virtual dialing pads, based on the interaction

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2018 Science advances

40. Modified bolster dressing with continuous suction improves skin graft survival for an oral cavity wound (PubMed)

reviewed 31 patients reconstructed with skin graft in their intraoral defect. The patients were divided into two groups; conventional bolster group (n = 21) and modified bolster group (n = 10). In the modified bolster group, a polyvinyl alcohol sponge was designed to fit the skin graft and a suction drain was inserted with tagging suture to apply continuous suction. We analyzed the success rate, the size of the skin grafts and clinical variables of each method.The overall success rate of oral skin (...) Modified bolster dressing with continuous suction improves skin graft survival for an oral cavity wound Skin engraftment of intraoral defects is known to be inconsistent due to mobility of the oral structure, uneven wounds, and accumulation of saliva under the skin graft. To improve the success rate of oral skin graft, we proposed a novel and simple dressing technique for intraoral skin graft to control saliva accumulation, in comparison with the conventional bolster dressing.We retrospectively

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2018 Journal of Otolaryngology - Head & Neck Surgery

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