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Skin Discoloration

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141. Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Patient Version

on the risk of prostate cancer, including high-grade prostate cancer. Have any side effects or risks been reported from vitamin E? In the Physicians’ Health Study II, there were no different rates of , , drowsiness, skin discoloration or rashes, or migraine between men who took vitamin E and those who took a placebo. However, there was a higher number of hemorrhagic strokes in men who took vitamin E than in men who took a placebo. In the Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (...) , there was also an increase in hemorrhagic strokes among men in the group that took vitamin E. Earlier results from the SELECT trial showed no different rates of less (such as hair loss, skin, and ) in the groups that took vitamin E compared to the other treatment groups. Later showed an increased risk of prostate cancer among men in the vitamin E alone group. Is vitamin E approved by the U.S. Food and Drug Administration (FDA) for use as a cancer treatment in the United States? The U.S. has not approved

2017 PDQ - NCI's Comprehensive Cancer Database

143. Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li Fraumeni syndrome and Cowden syndrome

of glans penis (a discolored area on the skin) 12 Oncogenetic testing for breast and ovarian cancer KCE Report 236Cs ? Mucocutaneous lesions o One biopsy proven trichilemmoma o Multiple palmoplantar keratoses (abnormal thickening of the hands and feet) o Multifocal or extensive oral mucosal papillomatosis o Multiple cutaneous facial papules (often verrucous) ** Minor Criteria: ? Autism spectrum disorder ? Colon cancer ? Esophageal glycogenic acanthosis ( =3) ? Mental retardation (i.e. IQ<75 (...) Introduction Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer syndrome caused by heterozygous germline mutations in the TP53 gene. Half of the patients with LFS develop at least one LFS-associated cancer by age 30. While many tumor types can be seen in patients with LFS, four core cancers (breast, sarcoma, brain, and adrenocortical carcinoma) make up about 80% of LFS associated tumours. 4 The next most frequently associated cancers include leukemia, lung, colorectal, skin, gastric, and ovarian

2015 Belgian Health Care Knowledge Centre

144. Breastfeeding problems

, gastro-oesophageal reflux disease, or cows' milk protein allergy. For more information, see the CKS topics on and . Known ankyloglossia or cleft lip and/or palate; any treatments to date. Use of a dummy or pacifier. Examine the: Woman's nipples: Flat or inverted nipples. Skin integrity. Sensitivity to palpation. Nipple discharge. Skin discolouration, lesions, or rashes. Woman's breasts: Any breast lumps, such as a . Tenderness to light or deep palpation. Skin discoloration, lesions, or rashes. Infant (...) , if appropriate. Treatment of any skin conditions or other underlying causes of symptoms, if present. Arranging a paediatric referral for the infant if there are concerns about dehydration, faltering growth, infant development, or the presence of an anatomical abnormality such as ankyloglossia (tongue-tie) that may be affecting infant attachment and feeding. Considering specialist referral for possible drug treatment if Raynaud's disease of the nipple, or prolactin deficiency causing a low milk supply

2017 NICE Clinical Knowledge Summaries

145. Topiloric/Uriadec (topiroxostat)

). Allopurinol, which, as with topiroxostat, is an XOR inhibitor classified as a uric acid production inhibitor, has been reported to cause serious skin disorders such as toxic epidermal necrolysis and oculomucocutaneous syndrome as clinically significant adverse drug reactions. Moreover, the skin disorders may become serious when accompanied by abnormal 5 renal function. Administration to patients with renal impairment requires adequate caution and appropriate measures (e.g. dose reduction (...) , an XOR related enzyme, and on non-XOR enzymes 1 of purine and pyrimidine metabolism were studied. The results showed that topiroxostat (100 ?mol/L) inhibited the enzymes tested by only 2000 mg/kg in mice, dogs, and monkeys and >750 mg/kg in rats after oral administration; and 300 mg/kg in mice and 500 to 600 mg/kg in rats after intraperitoneal administration. Toxicity findings included white discoloration of the kidney in rats after oral administration. Bloody stools and loose stools were observed

2013 Pharmaceuticals and Medical Devices Agency, Japan

146. Vyndaqel (tafamidis meglumine)

disorder; night blindness; corneal deposits; corneal leukoma; corneal lesion; corneal degeneration; and dry skin. 13 ) Events in the MedDRA SMQ “hyperglycaemia/new onset diabetes mellitus”, HLGT “diabetic complications”, and HLTs “hyperglycaemic conditions NEC”, “diabetes mellitus (incl subtypes)”, and “carbohydrate tolerance analyses (incl diabetes)” (excluding “decreased” PTs under the HLT “carbohydrate tolerance analyses (incl diabetes)”). 16 3.(ii) Summary of pharmacokinetic studies 3.(ii (...) /animal) (vehicle, 7.5% VE TPGS) to male and female albino rats, radioactivity levels peaked within 2 hours post-dose in the majority of tissues and then declined gradually, but radioactivity was still present at 168 hours post-dose. The organ/plasma ratio was >1 at 0.5 hours post-dose for the liver and stomach and at ?1 hour post-dose for the harderian glands (at all time points after 6 hours post-dose), liver (at all timepoints), and perirenal fat and skin (at 168 hours post-dose). The blood/plasma

2013 Pharmaceuticals and Medical Devices Agency, Japan

149. Down and Almost Out in Scotland: George Orwell, 1948, and Nineteen Eighty-Four

of discoloration appeared at the base of my fingers & toe nails. Then my face became noticeably redder & the skin had a tendency to flake off, & a sort of rash appeared all over my body, especially down my back. There was no itching associated with this. After about 3 weeks I got a severe sore throat, which did not go away & was not affected by sucking penicillin lozenges. It was very painful to swallow & I had to have a special diet for some weeks. There was now ulceration with blisters in my throat

2017 PLOS Blogs Network

150. Down and Almost Out in Scotland: George Orwell, 1948, and Nineteen Eighty-Four

the secondary symptoms produced by streptomycin when I was treated with it last year. Streptomycin was then almost a new drug & had never been used at that hospital before. The symptoms in my case were quite different from those described in the American medical journal in which we read the subject up beforehand. At first, though the streptomycin seemed to produce an almost immediate improvement in my health, there were no secondary symptoms, except that a sort of discoloration appeared at the base of my (...) fingers & toe nails. Then my face became noticeably redder & the skin had a tendency to flake off, & a sort of rash appeared all over my body, especially down my back. There was no itching associated with this. After about 3 weeks I got a severe sore throat, which did not go away & was not affected by sucking penicillin lozenges. It was very painful to swallow & I had to have a special diet for some weeks. There was now ulceration with blisters in my throat & in the insides of my cheeks, & the blood

2017 Absolutely Maybe

151. Nanoparticles: The new One True Cause of All Disease?

. Of course, it turns out that most of the titanium dioxide particles used in food are not true nanoparticles, but consist of larger particles. Not surprisingly, : Millions of tons of titanium dioxide are produced globally each year. It adds whiteness and brightness to products and also helps them resist discoloration. Titanium dioxide also reflects ultraviolet (UV) light, which is why it’s often used as an ingredient in sunscreens. Most titanium dioxide (close to 70 percent) is used as a pigment (...) in paints, but it’s also added to cosmetics, toothpastes, pharmaceuticals, paper and food. Titanium dioxide is generally considered to be a relatively inert, safe material, but an increasing number of products are now using titanium dioxide nanoparticles, and that may change everything. Nanoparticles are ultramicroscopic in size, making them able to readily penetrate your skin and travel to underlying blood vessels and your bloodstream. Evidence suggests that some nanoparticles may induce toxic effects

2017 Respectful Insolence

152. Allergic Rhinitis

) Clinicians should make the clinical diagnosis of AR when patients present with a history and physical examination consistent with an allergic cause and 1 or more of the following symptoms: nasal congestion, runny nose, itchy nose, or sneezing. Findings of AR consistent with an allergic cause include, but are not limited to, clear rhinorrhea, nasal congestion, pale discoloration of the nasal mucosa, and red and watery eyes. (2) Clinicians should perform and interpret, or refer to a clinician who can (...) perform and interpret, specific IgE (skin or blood) allergy testing for patients with a clinical diagnosis of AR who do not respond to empiric treatment, or when the diagnosis is uncertain, or when knowledge of the specific causative allergen is needed to target therapy. (3) Clinicians should assess patients with a clinical diagnosis of AR for, and document in the medical record, the presence of associated conditions such as asthma, atopic dermatitis, sleep-disordered breathing, conjunctivitis

2015 American Academy of Otolaryngology - Head and Neck Surgery

153. Adult Sinusitis

attention should be paid to the presence or absence of the following: altered (hyponasal) speech indicating nasal obstruction, swelling, redness of the skin due to congestion of the capillaries (erythema) or abnormally large fluid volume (edema) localized over the involved cheek bone or periorbital area; palpable cheek tenderness or percussion tenderness of the upper teeth; purulent drainage in the nose or posterior pharynx; and signs of extra-sinus involvement (orbital or facial cellulitis, orbital

2015 American Academy of Otolaryngology - Head and Neck Surgery

154. Peyronie's Disease

. Measurement of stretched penile length (SPL) from the penopubic skin junction to the coronal sulcus or the tip is recommended to establish baseline penile length prior to any intervention. Close Guideline Statement 2 Clinicians should perform an in-office intracavernosal injection (ICI) test with or without duplex Doppler ultrasound prior to invasive intervention. (Expert Opinion) × Discussion A careful history, physical examination of the genitalia, and documentation of the presence or absence

2015 American Urological Association

155. Allergic Rhinitis

are consistent with an allergic cause (e.g., clear rhinorrhea, pale discoloration of nasal mucosa, and red and watery eyes) and one or more of the following symptoms: nasal congestion, runny nose, itchy nose, or sneezing. Individuals with AR should be assessed for the presence of associated conditions such as asthma, atopic dermatitis, sleep-disordered breathing, conjunctivitis, rhinosinusitis, and otitis media. Specific IgE testing (blood or skin) should be performed for patients with a clinical diagnosis

2015 American Academy of Family Physicians

156. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for UGT1A1 and Atazanavir Prescribing

by drugs 6 results in the accumulation of unconjugated (indirect) bilirubin in blood and tissues. When bilirubin eleva- tion is high enough to cause visible yellow discoloration of the skin and eyes it is called jaundice (also known as icterus). In neo- nates, extreme bilirubin accumulation can lead to severe adverse neurological effects, namely, kernicterus. 5 Genetic variants that have been identi?ed in UGT1A1 exon 1, promoter, enhancer, and shared UGT1A exons 2 to 5 as well as the accepted allele (...) Recommendeduseofatazanavir(boostedwitheitherritonavirorcobicistat*)byUGT1A1phenotype Phenotype Implicationsforphenotypic measures Dosingrecommendations Classificationofrecommendations a Extensive metabolizer Reference b UGT1A1 activity; very low likelihood of bilirubin-related discon- tinuation of atazanavir. There is no need to avoid prescribing of atazanavir based on UGT1A1 genetic test result. Inform the patient that some patients stop atazanavir because of jaun- dice (yellow eyes and skin), but that this patient’s

2015 Clinical Pharmacogenetics Implementation Consortium

157. ACS/ASCO Breast Cancer Survivorship Care Guideline

of local or regional recurrence, including new lumps (eg, in underarm or neck), rash or skin changes on the breast or chest wall, chest pain, changes in the contour/shape/size of the breast, and swelling of the breast or arm. Evaluation of patient-reported symptoms is essential in detecting a recurrence as early as possible, which may impact survival. Risk Evaluation and Genetic Counseling Recommendation 1.5. It is recommended that primary care clinicians (a) should assess the patient's cancer family (...) of a periodic health examination, the cancer-related checkup should include examination for cancers of the thyroid, ovaries, lymph nodes, oral cavity, and skin as well as health counseling about tobacco, sun exposure, diet and nutrition, risk factors, sexual practices, and environmental and occupational exposures Abbreviations: CT, computed tomography; DCBE, double-contrast barium enema; DRE, digital rectal examination; FIT, fecal immunochemical test; FOBT, fecal occult blood test; FSIG, flexible

2015 American Society of Clinical Oncology Guidelines

158. Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms

(at the muzzle) in the skin with or without red discoloration. Haemorrhage with septic meningeal inflammation in spinal cord, focal necrosis with septic embolus in liver. Cortical hypertrophy in the adrenal, Kupffer cell hypertrophy and hepatocellular vacuolation, ?uterus, ? number of corpus luteum. Recovery: There was treatment-related very slight to slight arterial hypertrophy in the heart of female and male rats and very slight to marked increased amount of trabecula in the bone (femur) of female and male (...) histiocytosis, depletion in red pulp in spleen (M, very slight), ? spermatogenic epithelium in testes (very slight to slight), depletion of the bone marrow (slight to marked). Septicaemia (septic emboli and/or septic necrosis in 1 or more organs/tissues) were confined to the dead males. Septic emboli and/or septic necrosis with or without oedema corresponded to grossly observed adhesion of the heart, grey-white discoloration/foci of the heart, liver, kidney, and spleen, and scab or thickened area

2017 European Medicines Agency - EPARs

159. Adalimumab (Cyltezo) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Crohn Disease, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

and a clinical assessment including a risk assessment as well as corrective actions which have been implemented, were presented. The provided information allowed a conclusive and an in-depth assessment, and potential safety issues arising from the presence of particles could be ruled out. In addition the product specification for the visible particles has been revised and the instructions for use (label section 7) include the statement: “Do not use if: Medication is cloudy, discolored, frozen, or contains

2017 European Medicines Agency - EPARs

160. Brodalumab (Kyntheum) - plaque psoriasis

the meeting on 18 May 2017, the CHMP, in the light of the overall data submitted and the scientific discussion within the Committee, issued a positive opinion for granting a marketing authorisation to Kyntheum on 18 May 2017. 2. Scientific discussion 2.1. Problem statement 2.1.1. Disease or condition Kyntheum is indicated for the treatment of moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy. 2.1.2. Epidemiology Psoriasis is one of the most common human skin (...) inflammation and destruction; the proliferation, maturation, and chemotaxis of neutrophils; and the maturation of dendritic cells. Assessment report EMA/381484/2017 Page 9/135 The IL-17 receptor plays a central role in the pathogenesis of psoriasis. Blocking the IL-17 receptor on keratinocytes and immune cell types has emerged as a critical target for the treatment of psoriasis. IL-17R blocking has been shown to reduce inflammation, hyperproliferation, and skin thickening in a number of experimental models

2017 European Medicines Agency - EPARs

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