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Skin Discoloration

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121. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

that a proliferating hemangioma is an attempt to normalize hypoxic tissue that occurred in utero . Clinical presentation Most infantile hemangiomas are not present at birth but precursor lesions such as telangiectasia or faint discoloration of the skin or hypopigmentation can often be seen. The lesion can be mistaken as a bruise from birth trauma or as a capillary malformation (port wine stain) (refer to ).[ , ] Figure 1. The photos on the left depict the precursor lesion (faint color with halo ). The photos (...) of hemangioma growth. Permanent sequelae, such as telangiectasia, anetodermal skin, redundant skin, and a persistent superficial component, can occur after hemangioma involution (refer to ). In a retrospective cohort study of 184 hemangiomas, the overall incidence of significant sequelae was 54.9%. Sequelae were more common in combined hemangiomas, hemangiomas with a step or abrupt border, and cobblestone surface hemangiomas. Furthermore, this study revealed that the average age to hemangioma involution

2018 PDQ - NCI's Comprehensive Cancer Database

122. Melanoma Treatment (PDQ®): Health Professional Version

% of the cases arise in apparently normal areas of the skin. Although melanoma can occur anywhere, including on mucosal surfaces and the uvea, melanoma in women occurs more commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[ ] Early signs in a nevus that would suggest a malignant change include the following: Darker or variable discoloration. Itching. An increase in size or the development of satellites. Ulceration or bleeding (later signs). Melanomas (...) in the skin, they may also arise from mucosal surfaces or at other sites to which neural crest cells migrate, including the uveal tract. Uveal melanomas differ significantly from cutaneous melanoma in incidence, prognostic factors, molecular characteristics, and treatment. (Refer to the PDQ summary on for more information.) Incidence and Mortality Estimated new cases and deaths from melanoma in the United States in 2019:[ ] New cases: 96,480. Deaths: 7,230. Skin cancer is the most common malignancy

2018 PDQ - NCI's Comprehensive Cancer Database

123. Langerhans Cell Histiocytosis Treatment (PDQ®): Patient Version

quickly. This causes LCH cells to build up in certain parts of the body, where they can damage or form . LCH is not a disease of the Langerhans cells that normally occur in the skin. LCH may occur at any age, but is most common in young children. Treatment of LCH in children is different from treatment of LCH in adults. The and the are described in separate sections of this summary. Use our to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based (...) the following: Having a parent who was exposed to certain . Having a parent who was exposed to metal, granite, or wood dust in the workplace. A of cancer, including LCH. Having a or family history of disease. Having infections as a newborn. Smoking, especially in young adults. Being Hispanic. Not being as a child. The signs and symptoms of LCH depend on where it is in the body. These and other and may be caused by LCH or by other . Check with your doctor if you or your child have any of the following: Skin

2018 PDQ - NCI's Comprehensive Cancer Database

124. Gastrointestinal Complications (PDQ®): Health Professional Version

. Trigger dehydration. Create electrolyte imbalance. Impair function. Cause fatigue. Impair skin integrity. Limit activity. Diarrhea, in some cases, can be life-threatening. Furthermore, diarrhea can lead to increased caregiver burden. Specific definitions of diarrhea vary widely. Acute diarrhea is generally considered to be an abnormal increase in stool liquid that lasts more than 4 days but less than 2 weeks. Another definition suggests that diarrhea is an increase in stool liquidity (>300 mL of stool (...) . Stimulant laxatives Stimulant laxatives increase motor activity of the bowels by direct action on the intestines. Onset: 6 to 10 hours. Caution: Prolonged use of these drugs causes laxative dependency and loss of normal bowel function. Prolonged use of danthron discolors rectal mucosa and discolors alkaline urine red. Bisacodyl must be excreted in bile to be active and is not effective with biliary obstruction or diversion. Avoid bisacodyl with known or suspected ulcerative lesions of the colon

2018 PDQ - NCI's Comprehensive Cancer Database

125. Childhood Vascular Tumors Treatment (PDQ®): Patient Version

or discolored skin may appear before the hemangioma does. Hemangiomas occur as firm, warm, bright red to crimson lesions on the skin or may look like a bruise. Lesions that form are also painful. Later, as the hemangiomas go away, they begin fading in the center before flattening and losing color. Lesions below the skin: Lesions that grow under the skin in the fat may appear blue or purple. If the lesions are deep enough under the skin surface, they may not be seen. Lesions in an organ: There may (...) echoes. The echoes form a picture of body tissues called a . The picture can be printed to be looked at later. Abdominal ultrasound. An ultrasound transducer connected to a computer is pressed against the skin of the abdomen. The transducer bounces sound waves off internal organs and tissues to make echoes that form a sonogram (computer picture). (CAT scan) : A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer

2018 PDQ - NCI's Comprehensive Cancer Database

126. SNMMI Procedure Standard/EANM Practice Guideline for Amyloid PET Imaging of the Brain 1.0

for an amyloid PET examination. The radiopharmaceutical dose solution should be inspected before administration. It should not be used if it contains particulate matter or is discolored. The radiotracer should be injected using a short intravenous catheter (4 cm [1.5 inches] or less) to minimize the potential for adsorption of substantial amounts of the drug to the catheter. Portions of the radiotracer dose may readily adhere to longer catheters. C. Radiopharmaceuticals Several radiotracers for amyloid PET (...) Osteogenic cells 28 13 15 Ovaries 18 33 16 Pancreas 14 17 14 Red marrow 14 15 12 Skin 6 6 7 Small intestine 66 155 31 Spleen 9 16 10 Stomach wall 12 15 12 Testes 7 5 9 Thymus 7 6 9 Thyroid 7 7 8 Upper large intestine wall 74 173 38 Urinary bladder wall 27 62 70 Uterus 16 27 16 Total body 12 14 11 Effective dose (µSv/MBq) 19 34 19 1320 THE JOURNAL OF NUCLEAR MEDICINE • Vol. 57 • No. 8 • August 2016 personal use only. by DEUTSCHE ZENTRALBIBLIOTHEK FUER MEDIZIN on August 4, 2016. For jnm.snmjournals.org

2016 European Association of Nuclear Medicine

127. Hand Pain and Sensory Deficits: Carpal Tunnel Syndrome

of skin R20.1 Paresthesia of skin R20.2 Unspecified disturbances of skin sensation (includes temperature, localization, tactile discrimination, texture, vibration) R20.9 Methods (continued) GRADES OF RECOMMENDATION STRENGTH OF EVIDENCE A Strong evidence A preponderance of level I and/ or level II studies support the recommendation. This must include at least 1 level I study B Moderate evidence A single high-quality randomized controlled trial or a preponderance of level II studies support (...) Power of isolated muscles and muscle groups b7300 Control of simple voluntary movements b7600 Coordination of voluntary movements b7602 Protective functions of the skin b810 ICF activities and participation codes Writing d170 Carrying out daily routine d230 Using telecommunication devices and techniques d3600 Fine hand use d440 Picking up d4400 Grasping d4401 Manipulating d4402 Fine hand use other specified d4408 Driving d475 T oileting d530 Dressing d540 Eating d550 Drinking d560 Preparing meals

2019 The Orthopaedic Section of the American Physical Therapy Association (APTA), Inc.

128. Diagnosis and Management of Hemochromatosis

, and clinical expertise and experience in Alberta RECOMMENDATIONS SCREENING ? Consider patients* for screening if they have: o Unexplained bronze or gray skin discoloration o End-organ disease o Family history of confirmed hemochromatosis (see Algorithm) * Hemochromatosis is more common in people of Northern European heritage ? Screen using percent iron saturation and ferritin, in the fasting state, on one occasion if suspicion is low. If suspicion is high, screen twice to confirm. ? Suspect genetic (...) Page 9 of 9 Algorithm ALGORITHM Assess for Non-Genetic Cause for Iron Overload If None Found: - Counsel re Other Courses - Assess for End-Organ Damage - Follow Clinically - Phlebotomy if Ferritin ? - Avoid Contributory Behaviour - Iron Indices on First Degree Relatives - End-Organ Damage - Unexplained bronze or grey skin discoloration - Sore joints or if other suspicion Note: Hemochromatosis is more common in people of Northern European heritage Family Hx of Hemochromatosis % Fe Sat & Ferritin (x2

2014 Toward Optimized Practice

129. Colorectal cancer: "antioxidants" have no preventive effect

them. Adverse effects were observed with the antioxidants: itching (with vitamin A + C + E combinations), nosebleeds, hair loss (with selenium), and skin discoloration with beta-carotene. Strokes occurred more frequently in people taking vitamin E. Another study showed a higher mortality in groups taking vitamins A and E or beta-carotene compared with those not taking antioxidants. Antioxidants have no place in disease prevention: they have no proven efficacy, but are likely to cause harm

2014 Prescrire

130. Nail damage: sometimes due to medication

, trauma, tumours and various skin diseases. Prolonged exposure to water and irritants or allergens can cause nail brittleness and loss, coloration anomalies. Nail damage is observed in many general medical conditions, including psoriasis and other skin diseases and chronic illness. Several drugs expose patients to nail lesions through various mechanisms, particularly cytotoxic agents (anticancer drugs) and anti-infectives. Cytotoxic drugs often cause embarrassing and sometimes severe or painful nail (...) lesions. Anti-infectives, including tetracyclines, fluoroquinolones, antimalarial and leprosy drugs expose patients to lesions associated with light, such as nail loosening and discoloration. Retinoids, used in the treatment of acne, expose patients to nail brittleness, inflammation and deformation. The damage is generally reversible but sometimes persists for several years. ©Prescrire 1 July 2014 Download the full review. | | | Prescrire Your change of address has been received and will be processed

2014 Prescrire

131. Endovenous mechanochemical ablation for varicose veins

guidance 435). 2 2 Indications and current treatments Indications and current treatments 2.1 Varicose veins are a sign of underlying venous insufficiency and affect 20–30% of adults. Most people with varicose veins have no symptoms but venous insufficiency may cause fatigue, heaviness, aching, throbbing, itching and cramps in the legs. Chronic venous insufficiency can lead to skin discoloration, inflammatory dermatitis and ulceration. Great saphenous vein insufficiency is the most common form of venous (...) insufficiency in people presenting with symptoms. 2.2 A NICE guideline describes recommendations for the diagnosis and management of varicose veins. Many people have varicose veins that do not cause any symptoms or need treatment on medical grounds. However, some people will need treatment for the relief of symptoms or if there is evidence of skin discolouration, inflammation or ulceration. Treatment options include endothermal ablation, ultrasound-guided foam sclerotherapy and surgery (usually stripping

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

132. Congenital Erythropoietic Porphyria with Erythrodontia: A Case Report. (PubMed)

Congenital Erythropoietic Porphyria with Erythrodontia: A Case Report. The causes for intrinsic tooth discoloration can be separated into two categories as systemic and local. Systemic causes are either genetic or drug-induced effects. The development of dentition can also be affected by a number of systemic factors and metabolic diseases such as porphyria. Congenital erythropoietic porphyria (CEP), also known as Gunther's disease, is a metabolic disease caused by a transformation in the gene (...) that codifies uroporphyrinogen-3 synthesis, leading to porphyrin aggregation in urine, skin, bone, and dentin.A 21-month-old girl with erythrodontia was referred to Paediatric Dentistry Department in September 2017. A physical examination revealed blisters on her face, nose, hands, and feet. Laboratory findings showed highly elevated urine total uroporphyrin and total coproporphyrin I and III levels. Next-generation sequencing multigene panel testing for porphyria demonstrated a homozygous c.10C>T (p.L4F

2019 International Journal of Paediatric Dentistry

133. Eponymythology: Atraumatic Abdominal Ecchymosis

); scrotum (Bryant) and upper thigh (Fox) may be useful clues directing the examiner to consider potentially serious causes of abdominal pathology. Cullen sign (1869–1953) was a Canadian gynecologist Non-traumatic peri-umbilical ecchymoses associated with intra-abdominal haemorrhage, originally described in ectopic pregnancy – Original publication: (n=1) 1918 – Cullen first described a bluish black discoloration of the periumbilical skin in a female patient with a ruptured extrauterine pregnancy (...) associated with retroperitoneal haemorrhage, originally described in acute pancreatitis – Original publication: (n=1) 1919 – George Grey Turner submitted his article for publication as following a “…cursory examination of the voluminous literature on pancreatitis”, where he was unable to “…observe any mention of this sign” 1920 – George Grey Turner published ‘ Local discoloration of the abdominal wall as a sign of acute pancreatitis ‘ citing two cases of acute pancreatitis with fat necrosis

2018 Life in the Fast Lane Blog

134. <i>In vitro</i> and <i>in vivo</i> activities of the riminophenazine TBI-166 against <i>Mycobacterium tuberculosis</i>. (PubMed)

In vitro and in vivo activities of the riminophenazine TBI-166 against Mycobacterium tuberculosis. The riminophenazine agent clofazimine (CFZ) is repurposed as an important component of the new short-course multidrug-resistant tuberculosis regimen and significantly shortens first-line regimen for drug-susceptible tuberculosis in mice. However, CFZ use is hampered by its unwelcome skin discoloration in patients. A new riminophenazine analog TBI-166 was selected (...) as a potential next-generation antituberculosis riminophenazine following an extensive medicinal chemistry effort. Here, we evaluated the activity of TBI-166 against Mycobacterium tuberculosis and its potential to accumulate and discolor skin. In vitro activity of TBI-166 against both drug-sensitive and drug-resistant M. tuberculosis is more potent than that of CFZ. Spontaneous mutants resistant to TBI-166 were found at a frequency of 2.3x10-7 in wild strains of M. tuberculosis TBI-166 demonstrates at least

2019 Antimicrobial Agents and Chemotherapy

135. Hypereosinophilic vasculitis: A case report. (PubMed)

. This is a condition that involves a vascular injury due to either a primary eosinophilic vasculitis or an underlying connective tissue disease and it predisposes patients to a prothrombotic state.A 39-year-old patient presented with left hand digital ischemia, preceded by Raynaud phenomenon, and vasculitic rash. For 3 months, he was having digital ischemia affecting the left 2nd and 3rd digits in the form of pallor and gangrenous discoloration with a preceding history of a pinpoint pruritic rash affecting his (...) of the left ulnar artery distally and the radial artery branches in the left hand and subsequently was diagnosed with hypereosinophilic vasculitis.He was started on oral prednisone of 1 mg/kg daily orally tapering done as well as azathioprine for maintenance.Two weeks postdischarge, the patient was seen in the outpatient department where his ischemic symptoms improved, and his skin rash healed. Noticed improvement in his splinter hemorrhages was also detected. He continued to do well on 2 years follow-up

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2019 Medicine

136. The fate of delayed revascularization for neglected vascular injury of incompletely amputated digits and hands. (PubMed)

The fate of delayed revascularization for neglected vascular injury of incompletely amputated digits and hands. We report the fate of neglected vascular injury in cases of incomplete amputation of the digits and hand after delayed revascularization. Twelve patients underwent primary bone fixation, tendon or skin repair for hand injuries without vessel repair despite ischaemic findings. There was discoloration or necrosis of the fingertips during follow-up examination and the patients were

2019 Journal of Hand Surgery - European

137. Predictive fiberoptic endoscopic findings of upper airway in children with allergic rhinitis. (PubMed)

Predictive fiberoptic endoscopic findings of upper airway in children with allergic rhinitis. To determine predictive fiberoptic findings of upper airway in children with allergic rhinitis.129 children had fiberoptic evaluation of nasal cavity, pharynx and larynx. They were divided into allergic rhinitis group and normal group based on skin prick test results. All video recordings were randomly reviewed by three independent national board-certified otolaryngologists who were blinded (...) to the clinical details and outcomes of the participants' allergy testing. Each physician assessed and documented 10-item questionnaire. Intra-rater, inter-rater reliability and correlation between items and allergic status was calculated.Intra-rater reliability was moderate to perfect for all physicians on all items (kappa = 0.578-0.962). Inferior turbinate hypertrophy (κ = 0.714, p = 0.02), middle turbinate hypertrophy (κ = 0.728, p = 0.01), discoloration of inferior turbinate (κ = 0.685, p = 0.01), adenoid

2019 International Journal of Pediatric Otorhinolaryngology

138. An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic. (PubMed)

An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic. Omadacycline is a semisynthetic tetracycline antibiotic. Phase III clinical trial results have shown that omadacycline has an acceptable safety profile in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Similar to most tetracyclines, transient nausea and vomiting and low-magnitude increases in liver aminotransferases were the most frequent (...) treatment-emergent adverse events in phase III studies but were not treatment limiting. Package insert warnings and precautions for omadacycline include tooth discoloration; enamel hypoplasia; inhibition of bone growth following use in late pregnancy, infancy, or childhood up to 8 years of age; an imbalance in mortality (2%, compared with 1% in moxifloxacin-treated patients) was observed in the phase III study in patients with community-acquired bacterial pneumonia. Omadacycline has no effect on the QT

2019 Clinical Infectious Diseases

139. Gastrointestinal Stromal Tumors Treatment (PDQ®): Health Professional Version

effects associated with sunitinib therapy include the following:[ , ] Fatigue. Nausea and vomiting. Anemia. Neutropenia. Diarrhea. Abdominal pain. Mucositis. Anorexia. Skin or hair discoloration. Hypothyroidism (thyroid function monitoring with TSH is generally recommended to detect subclinical hypothyroidism). (Refer to the PDQ summary on for more information on some of the conditions listed above.) Less frequent toxicities include bleeding, fever, and hand-foot syndrome.[ ] Therapy with sunitinib

2017 PDQ - NCI's Comprehensive Cancer Database

140. Chronic wounds: advanced wound dressings and antimicrobial dressings

of the surrounding skin patient preference. In primary care in England, prescription costs of advanced wound dressings and antimicrobial dressings are over £110 million each year, and other procurement routes add to the total NHS expenditure on these products. The wide range of wound dressings and their associated costs present a challenge for healthcare professionals who are managing wounds. Choice requires knowledge of the safety and clinical and cost effectiveness of a wide range of dressings. However (...) -and- conditions#notice-of-rights). Page 5 of 43with the hydrocolloid dressings group. However, although the authors stated that the methodological quality of the included studies was assessed using the Cochrane Collaboration tool and the risk of bias is reported, the quality of the evidence is not graded. They noted that the included trials have many limitations and stressed that dressings do not replace best practices, such as turning and repositioning, skin care, good nutrition and continence management

2016 National Institute for Health and Clinical Excellence - Advice

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