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Skin Discoloration

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1341. A placebo-controlled study to evaluate the efficacy of topical tetracycline and oral tetracycline in the treatment of mild to moderate acne. Dermatology Research Group. (PubMed)

, occurring in similar frequencies in both treatment groups. Skin discoloration was more frequent in patients given topical tetracycline. Overall, 90% of patients rated topical tetracycline as 'cosmetically acceptable'. In conclusion, topical tetracycline is useful in treatment of mild to moderate acne when given with an initial course of oral tetracycline and may enhance efficacy without unacceptable side-effects.

1990 The Journal of international medical research

1342. Phase I investigation of ametantrone. (PubMed)

Phase I investigation of ametantrone. Ametantrone is the third of a family of anthracene derivatives to undergo a phase I trial in man. Sixteen patients received 33 courses of drug as a single iv dose given every 3 weeks. Escalations proceeded from 120 to 180 mg/m2. Predictable and reversible leukopenia was the dose-limiting toxic effect. Four patients developed thrombocytopenia. Nonhematologic toxic effects included a marked cumulative blue discoloration of the skin seen in all patients

1983 Cancer treatment reports

1343. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II. (PubMed)

with Fitzpatrick skin phototypes I-III were treated. Single facial rhytids were treated on three separate occasions 3 weeks apart (six periorbital and three perioral). Single, control wrinkles on the contralateral sides were treated with cryogen spray cooling alone. Subjects were treated with single passes with a 5mm spot for the first two treatments. Owing to a modification in the handpiece design, a 4mm spot was used for the third and final treatment. The average power was 12 W. At each treatment visit (...) 2-3 days. Superficial, branny hyperpigmentation occurred in six patients at both treatment and control sides. This discoloration resolved within 1 week of treatment and left no residual pigment alterations. No whitening or residual scarring occurred. Rhytid scores improved from a baseline score of 2.3 to 1.8 at 6 months after treatment (p>0.05). Patient acceptance of the treatment was high, but most felt that there was little improvement of the treated rhytids.Although the 1.45 microm diode

2002 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

1344. Effect of diaspirin crosslinked hemoglobin (DCLHb HemAssist) during high blood loss surgery on selected indices of organ function. (PubMed)

. There were no occurrences of cardiac ischemia. myocardial infarction, stroke, or pulmonary edema, by clinical or laboratory parameters up to the 28th postoperative day (POD). Seven of 12 (58%) DCLHb patients had yellow skin discoloration vs. none in the PRBC group (P < 0.01). Two of four non-urologic surgery patients developed asymptomatic postoperative hemoglobinuria after DCLHb. Creatinine clearance was unchanged postoperatively. Because of hemoglobin interference, bilirubin, gamma-glutamyl transferase (...) blood cell count or coagulation tests.Administration of approximately 1000 mg/kg DCLHb was associated with transient arterial hypertension, gastrointestinal side effects, laboratory abnormalities, yellow skin discoloration, and hemoglobinuria. These observations point to opportunities for improvement in future synthetic hemoglobin design.

2002 Artificial cells, blood substitutes, and immobilization biotechnology

1345. Sample size, confidence, and contingency judgement. (PubMed)

Sample size, confidence, and contingency judgement. According to statistical models, the acquisition function of contingency judgement is due to confidence increasing with sample size. According to associative models, the function reflects the accumulation of associative strength on which the judgement is based. Which view is right? Thirty university students assessed the relation between a fictitious medication and a symptom of skin discoloration in conditions that varied sample size (4, 6, 8

2002 Canadian journal of experimental psychology = Revue canadienne de psychologie expérimentale

1346. The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. (PubMed)

in the analysis. We studied clinical outcomes and compared hematologic findings, blood chemistry values, and blood use in the two treatment groups. There were no patient deaths in this study. No pattern of clinically significant laboratory abnormalities could be attributed to exposure to HBOC-201. In the HBOC-201 group, 2 patients had a transient increased concentration of serum transaminases and 6 had transient skin discoloration. One patient in the HBOC-201 group had mast cell degranulation with hypotension

2002 Anesthesia and analgesia

1347. Serum level changes after administration of a pharmacologic dose of beta-carotene. (PubMed)

group showed essentially no change whereas levels in the treated group increased almost 10-fold after 4 mo of treatment. The relationship between change in serum levels are evaluated in regard to body mass index, alcohol consumption, amount of smoking, lipids, and other variables. The results to date clearly indicate that substantial serum response can be achieved with only 15 mg/d and that with this dosage no skin discoloration or other toxicities are observed.

1988 The American journal of clinical nutrition

1348. Intense pulsed light in the treatment of striae distensae. (PubMed)

by IPL.A prospective study was carried out in 15 women, all of them having late stage striae distensae of the abdomen. Five sessions of IPL were performed in each one, once every two weeks. Skin biopsies and before and after photographs were taken of all the patients. Data concerning skin features (number of stretch marks in a square of 5 cm per side, sum of all the stretch marks to determine the total length, discolorations and general appearance) were all assessed before each session and at the end (...) Intense pulsed light in the treatment of striae distensae. Intense Pulsed Light (IPL) is a noncoherent, nonlaser, filtered flashlamp, emitting a broadband visible light. Its efficacy has been reported recently in the treatment of photodamaged facial skin, promoting the production of neo collagen and ordering of elastic fibers. We don't know however, its efficacy in the treatment of striae distensae.To assess gross and microscopical changes that occur in the striae distensae when treated

2002 Dermatologic Surgery

1349. Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia. (PubMed)

population of B lymphocytes both in the bone marrow and in the skin. The patient received four courses of cladribine 0.12 mg kg-1 daily as a 2-h infusion for five consecutive days. The courses were repeated at monthly intervals. The lymphocytosis gradually decreased and the PB count normalized after three courses. At the same time, a significant decrease in the cutaneous symptoms was observed. The patient became free of skin tumours after the fourth course of cladribine; only slight discoloration (...) Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia. Cutaneous presentation of B-cell chronic lymphocytic leukaemia (B-CLL) is uncommon, and the influence of skin changes on B-CLL prognosis is unclear. We report a patient with B-CLL Rai II, with multiple nodular skin infiltrations on the trunk, upper arms and thighs as well as constitutional symptoms, who was successfully treated with cladribine. The peripheral blood (PB) lymphocytes

2002 British Journal of Dermatology

1350. Physical examination and chronic lower-extremity ischemia: a critical review. (PubMed)

disease, including an abnormal femoral pulse, lower-extremity bruits, warm knees, and the Buerger test. The capillary refill test and the findings of foot discoloration, atrophic skin, and hairless extremities are unhelpful in diagnostic decisions. Mathematical formulas, derived from 2 studies using multivariate analysis, allow clinicians to estimate the probability of peripheral arterial disease in their patients.Certain aspects of the physical examination help clinicians make accurate judgments

1998 Archives of internal medicine

1351. Activities and functional assessment 1 year after spinal fusion for paralytic scoliosis (PubMed)

with the variables classified according to WHO's International Classification of Impairments, Disabilities, and Handicaps (ICIDH). This consists of the patient's/relative's motives for surgery, persistent skin discoloration, ambulating or use of wheelchair, use of a brace, sitting balance, weight distribution on a sitting surface, angle of scoliosis, reaching, pain estimation, activities of daily living (ADL) Klein and Bell, care given, time spent resting, and seating supports. The set of instrument also (...) included a follow-up questionnaire comprising 12 different areas, where the patients/relatives assessed the results of surgery. The study showed that spinal fusion in paralytic scoliosis led to showed improvements in the whole group of patients at the Impairment level in the angle of scoliosis, sitting balance, weight distribution, and reduced number of patients with persistent skin discoloration, and at the Handicap level in reduced time for resting during the day, reduced number of seating supports

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1999 European Spine Journal

1352. Pharmacologic features and effects of neuroleptics. (PubMed)

. These include tardive dyskinesia, skin discoloration and corneal deposits. The clinician must consider the pattern aand severity of each patient's present and past psychotic episodes before deciding whether maintenance therapy with neuroleptics is justified. If it is, doses should be re-evaluated frequently and kept as low as possible. Concomitant administration of anticholinergic agents should be avoided if possible. Most important, the long-term administration of neuroleptics should be prescribed only

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1981 Canadian Medical Association Journal

1353. Addison, pernicious anemia and adrenal insufficiency (PubMed)

insufficiency, based particularly on the discoloration of the skin in these conditions. Three major sources of possible confusion for historians who are attempting to understand Addison's views include Addison's early attempts to link pernicious anemia with disease of the suprarenal capsules, Addison's redefinition of pernicious anemia in his monograph on adrenal disease, and several confusing statements made by Wilks and Daldy in the first reprint of Addison's monograph.

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1985 Canadian Medical Association Journal

1354. Benign Carotenemia in Children (PubMed)

Benign Carotenemia in Children The author discusses five infants, aged eight to 11 months, with carotenemia secondary to excessive consumption of carotene-containing foods. These infants had white sclerae in spite of yellow discoloration of the skin. Simple elimination of these foods led to clearing of the yellow skin color and normalization of serum carotene levels. All infants had normal vitamin A levels, white cell count, serum glucose, lipids, liver- and thyroid-function tests. The benign

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1989 Canadian Family Physician

1355. Should you remove sea urchin spikes from the skin

Should you remove sea urchin spikes from the skin Should you remove sea urchin spikes from the skin - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) , educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via Should you remove sea urchin spikes from the skin This is an unusual question! We cannot be certain if the type of sea urchin alters the answer. However, we have found some general information on the topic which might be of interest. eMedicine has a chapter, ‘Echinoderm Envenomations’ [1

2006 TRIP Answers

1356. Neuroskin Forte for Dry Skin Relief in Eczema and Psoriasis

Neuroskin Forte for Dry Skin Relief in Eczema and Psoriasis Neuroskin Forte for Dry Skin Relief in Eczema and Psoriasis - Full Text View - Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neuroskin Forte for Dry Skin Relief (...) Collaborator: AVVAA World Healthcare Products, Inc. Information provided by (Responsible Party): Rutgers, The State University of New Jersey ( University of Medicine and Dentistry of New Jersey ) Study Details Study Description Go to Brief Summary: The purpose of this study is to assess the efficacy of Neuroskin Forte in relieving the symptoms of dry skin in adults with psoriasis or eczema. Condition or disease Intervention/treatment Phase Psoriasis Eczema Drug: Neuroskin Forte Drug: Placebo Application

2005 Clinical Trials

1357. Use of topical ascorbic acid and its effects on photodamaged skin topography. (PubMed)

Use of topical ascorbic acid and its effects on photodamaged skin topography. To determine the efficacy of topical ascorbic acid application in treating mild to moderate photodamage of facial skin using an objective, computer-assisted image analysis of skin surface topography and subjective clinical, photographic, and patient self-appraisal questionnaires.A 3-month, randomized, double-blind, vehicle-controlled study.Facial plastic surgery private practice.Nineteen evaluable volunteer sample (...) patients aged between 36 and 72 years with Fitzpatrick skin types I, II, and III who were in good physical and mental health with mild to moderately photodamaged facial skin were considered for analysis.Coded, unmarked medications were randomly assigned to the left and right sides of each subject's face, one containing the active agent, topical ascorbic acid (Cellex-C high-potency serum; Cellex-C International, Toronto, Ontario), the other, the vehicle serum (Cellex-C International). Three drops (0.5

1999 Archives of otolaryngology--head & neck surgery

1358. A survey of skin disease and skin-related issues in Arab Americans. (PubMed)

, eczema/dermatitis, warts, fungal skin infections, and melasma. The most pressing skin concerns were uneven skin tone, skin discoloration, dry skin, acne, and facial hair. Significant associations exist between socioeconomic status and having seen a dermatologist. Attitudes surrounding skin perception were related to the number of years of residence in the United States.The skin condition data were gathered from a self-reported survey.Skin conditions and other related issues that affect Arab Americans (...) A survey of skin disease and skin-related issues in Arab Americans. There is a paucity of knowledge relating to dermatologic conditions in Arab Americans.To assess common skin diseases and concerns and to evaluate access to dermatologic care and perception of skin in Arab Americans.Arab Americans from 3 Southeast Michigan locations (community health center [n = 207], mosque [n = 95], and church [n = 99]) completed a survey questionnaire.The most common self-reported skin conditions were acne

2007 Journal of American Academy of Dermatology

1359. Nail discoloration induced by doxycycline. (PubMed)

Nail discoloration induced by doxycycline. All tetracyclines are deposited in calcifying areas of the bones and teeth and may cause discoloration. Although hyperpigmentation of the skin, teeth and nails have been reported and well documented due to other tetracycline intake, it has been rarely reported that discolored nails induced by doxycycline in pediatric patients. Here we report an 11-year-old-boy with nail discoloration caused by doxycycline intake.

2005 Pediatric Infectious Dsease Journal

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