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Skin Discoloration

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61. Comparison of standardized peristomal skin care and crusting technique in prevention of peristomal skin problems in ostomy patients. (Full text)

. A total of 81 ostomates, who were recruited from a tertiary hospital, completed the baseline, 1-month, 2-month, and 3-month follow-up (SPSC group, n=45; CT group, n=36). SPSC consisted of water cleansing and direct application of ostomy appliances. CT involved crusting hydrocolloid powder and patting with water sponge or protective barrier liquid film. The outcomes of the study were assessed by skin problems, such as discoloration, erosion and tissue overgrowth; the domains of the evaluation tool used (...) in examining the peristomal skin. A generalized estimating equation model was used to examine the effects according to time and group.In both SPSC and CT groups, the likelihood of occurrence of discoloration (OR, 1.99; 95% CI, 1.61-2.46), erosion (OR, 1.87; 95% CI, 1.55-2.25) and tissue enlargement (OR, 1.94; 95% CI, 1.36-2.77) increased with time. There was no significant difference in discoloration between the groups, whereas the probability of erosion (OR, 0.38; 95% CI, 0.16-0.89) and tissue overgrowth

2011 Journal of Korean Academy of Nursing PubMed

62. How Long Will I Be Blue? Prolonged Skin Staining Following Sentinel Lymph Node Biopsy Using Intradermal Patent Blue Dye (Full text)

How Long Will I Be Blue? Prolonged Skin Staining Following Sentinel Lymph Node Biopsy Using Intradermal Patent Blue Dye Blue dye used for sentinel lymph node biopsy (SLNB) in breast cancer patients may cause prolonged skin discoloration at the site of injection. The aim of this study was to assess the duration of such skin discoloration.236 consecutive patients who had undergone breast conserving surgery and SLNB for breast cancer were reviewed prospectively from January 2007 to December 2009 (...) .Of the 236 patients, 2 had undergone bilateral surgery, and 41 had been examined in consecutive yearly reviews. Blue discoloration remained visible at the injection site after 12, 24, and > 36 months in 36.5, 23.6, and 8.6% of the patients, respectively.The use of patent blue for identification of the sentinel lymph node in patients undergoing breast cancer surgery may result in prolonged discoloration of the skin at the injection site.

2013 Breast Care PubMed

63. A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure

A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record (...) Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2012 Clinical Trials

64. Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin. (PubMed)

colorimetrically.The dermal samples obtained from the photo-aged facial skin exhibited an appearance of yellowish color, whereas neither the facial epidermis nor the dermis obtained from the abdomen or buttock showed such a yellowish discoloration. The upper layer of the dermis that revealed the yellowish color showed elastosis whose elastic fibers were found to colocalize with carbonyl protein as detected by a labeled hydrazide, as well as by an immunohistochemical examination using the antibody against acrolein (...) Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin. The photo-aged facial skin is characterized by various unique features such as dark spots, wrinkles, and sagging. Elderly people, particularly Asians, tend to show a yellowish skin color change with photo-aging. However, there has been no analytical study conducted on this unique skin color change of the aged facial skin.The purpose of the present study is to examine whether the carbonyl

2011 Journal of dermatological science

65. Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation

of South Carolina Collaborator: National Institute of Nursing Research (NINR) Information provided by (Responsible Party): Teresa Kelechi, Medical University of South Carolina Study Details Study Description Go to Brief Summary: Leg vein circulation problems can damage the skin of the lower legs, especially around the ankles, by making it discolored, hard, itchy, red, and swollen. Ulcers often develop. Inflammation is often present in the damaged skin. This study will test whether using a special low (...) Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2011 Clinical Trials

66. PRODUCTION OF HEMORRHAGIC NECROTIC SKIN LESIONS IN THE RABBIT BY MEANS OF HEMOPHILUS INFLUENZAE AND HEMOPHILUS PERTUSSIS (Full text)

PRODUCTION OF HEMORRHAGIC NECROTIC SKIN LESIONS IN THE RABBIT BY MEANS OF HEMOPHILUS INFLUENZAE AND HEMOPHILUS PERTUSSIS 1. The intradermal injection of H. influenzae in the abdominal wall of rabbits induces inflammation, frequently combined with a central pustule. The corresponding injection of H. pertussis causes a bluish violet discoloration of the skin area involved which undergoes slight hemorrhagic necrotic changes within a few days. 2. The intravenous injection of living H. influenzae (...) , 24 hours after the intradermal inoculation with living H. influenzae, is able to transform the respective skin areas into severe hemorrhagic necrotic lesions within 3 to 5 hours. 3. Heat-killed H. influenzae, if injected intravenously, may produce hemorrhagic-necrotic lesions in areas previously prepared with living or heat-killed H. influenzae. 4. H. pertussis, if injected intravenously, may cause, perhaps to a lesser extent, hemorrhagic necrotic lesions in skin areas 24 hours previously

1937 The Journal of experimental medicine PubMed

67. Discoloration of skin and urine after treatment with hydroxocobalamin for cyanide poisoning (Full text)

Discoloration of skin and urine after treatment with hydroxocobalamin for cyanide poisoning 19153403 2009 02 11 2018 11 13 1488-2329 180 2 2009 Jan 20 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Discoloration of skin and urine after treatment with hydroxocobalamin for cyanide poisoning. 251 10.1503/cmaj.080727 Cescon David W DW Department of Medicine, University of Toronto, Toronto, Ont. Juurlink David N DN eng Case Reports Journal Article (...) Canada CMAJ 9711805 0820-3946 0 Cyanides 0 Hematinics Q40X8H422O Hydroxocobalamin AIM IM Cyanides poisoning Female Hematinics pharmacology urine Humans Hydroxocobalamin pharmacology urine Middle Aged Photography Poisoning diagnosis drug therapy etiology Skin Pigmentation drug effects Smoke Inhalation Injury complications 2009 1 21 9 0 2009 1 21 9 0 2009 2 12 9 0 ppublish 19153403 180/2/251 10.1503/cmaj.080727 PMC2621289 Ann Pharmacother. 2008 May;42(5):661-9 18397973 Ann Emerg Med. 2007 Jun;49(6):794

2009 CMAJ : Canadian Medical Association Journal PubMed

68. Actinomycosis

soft-tissue swelling multiple sinuses skin discoloration chewing difficulties constitutional symptoms change in bowel habits abdominal discomfort nausea and vomiting sensation of abdominal mass vaginal bleeding or discharge dry or productive cough blood-streaked sputum shortness of breath chest pain focal neurological defects male gender injury or inflammation of the oral cavity diabetes mellitus immunosuppression malnutrition local tissue damage by neoplasia, trauma, or irradiation intra-uterine

2019 BMJ Best Practice

69. Neonatal jaundice

includes phototherapy and/or exchange transfusion. The major complication of unconjugated hyperbilirubinaemia is kernicterus. Definition Neonatal jaundice is the yellowing discoloration of the skin and sclera of a neonate, which is caused by increased levels of bilirubin in the blood. A neonate refers to an infant in the first 28 days of life. This topic focuses on recognising and managing early neonatal jaundice, which is most commonly caused by unconjugated hyperbilirubinaemia. While prolonged

2019 BMJ Best Practice

70. Canadian guideline for Parkinson disease

inherited forms of it, Lewy body inclusion may be absent in surviving neurons. Moreover, expecting neuropathological assessment of brain tissue for diagnostic purposes is not realistic in living patients; in the future, peripheral organ biopsy (e.g., skin) may serve as a surrogate marker of brain pathology. Of note, up to 20% of patients diagnosed in life with typical Parkinson disease have an alternative diagnosis at autopsy. Given the potential error in making a diagnosis of Parkinson disease

2019 CPG Infobase

72. Human skin color

or participate in hormone replacement therapy. Disorders of pigmentation [ ] Uneven pigmentation of some sort affects most people, regardless of bioethnic background or skin color. Skin may either appear lighter, or darker than normal, or lack pigmentation at all; there may be blotchy, uneven areas, patches of brown to gray discoloration or freckling. Apart from blood-related conditions such as , , or , skin pigmentation disorders generally occur because the body produces either too much or too little (...) . describes skin discolorations caused by hormones. These hormonal changes are usually the result of pregnancy, birth control pills or estrogen replacement therapy. , also known as "liver spots" or "senile freckles", refers to darkened spots on the skin caused by aging and the sun. These spots are quite common in adults with a long history of unprotected sun exposure. Aside from sun exposure and hormones, hyperpigmentation can be caused by skin damage, such as remnants of blemishes, wounds or rashes

2012 Wikipedia

73. Human skin

appear hairless. There are two general types of skin, hairy and (hairless). The adjective cutaneous literally means "of the skin" (from Latin cutis , skin). Because it interfaces with the environment, skin plays an important role in protecting the body against and excessive . Its other functions are , , sensation, synthesis of , and the protection of folates. Severely damaged skin will try to heal by forming . This is often discolored and depigmented. In humans, varies among populations, and skin (...) is the decreasing ability of skin to heal itself as a person ages. Among other things, skin aging is noted by a decrease in volume and elasticity. There are many to skin aging. For example, aging skin receives less blood flow and lower glandular activity. A validated comprehensive grading scale has categorized the clinical findings of skin aging as laxity (sagging), rhytids (wrinkles), and the various facets of photoaging, including (redness), and , dyspigmentation (brown discoloration), solar elastosis

2012 Wikipedia

74. Kwashiorkor

in addition to oedema. Kwashiorkor typically occurs in children around the time of weaning and up to 4 years of age, although it may present later, particularly when associated with tuberculosis (TB) or HIV. Oedema of kwashiorkor is evident in the soft tissues of the extremities, rather than as ascites. History and exam presence of risk factors low weight for height, low height for age, or a low mid upper arm circumference (MUAC) bilateral pitting oedema hair discoloration dermatosis/ulceration apathy (...) serum protein serum albumin blood glucose chest x-ray (CXR) urine culture blood culture stool culture tuberculosis (TB) skin testing HIV serology/polymerase chain reaction (PCR) malaria screen echocardiography Treatment algorithm ACUTE Contributors Authors Helene B. Roberson Professor of Pediatrics Washington University School of Medicine St Louis MO Disclosures MJM is an author of a number of references cited in this monograph. Medical Director Lao Friends Hospital for Children Luang Prabang Laos

2018 BMJ Best Practice

75. Antiphospholipid syndrome

or current dx of vascular thrombosis hx of pregnancy loss hx of pregnancy-associated morbidity hx of SLE features of thrombocytopenia arthralgia/arthritis livedo reticularis hx of other rheumatological disorders or connective tissue disorders cardiac murmur oedema seizure, headache, memory loss, signs of transverse myelopathy limb discomfort, swelling, skin discoloration, and ulcers hx of SLE hx of other autoimmune rheumatological disorders hx of other autoimmune diseases hx of autoimmune haematological

2018 BMJ Best Practice

76. Dermatophyte infections

, vesicles, and maceration vesicles, pustules with or without bullae on the soles fissuring, maceration, and scaling in the interdigital spaces of the fourth and fifth toes chronically scaly, hyperkeratotic plantar skin with erythema of the soles, heels, and sides of the feet folliculitis with nodules thickened nail with subungual hyperkeratosis, onycholysis, and white-yellow to brown discoloration small, white speckled patches on the surface of the nail plate with crumbling nail lymphadenopathy absence (...) is sufficient for most tinea infections. Fungicidal topical allylamines demonstrate good cure rates with short duration of treatment. Systemic therapy is preferred for tinea capitis, tinea barbae, tinea manuum, and onychomycosis. Definition Superficial fungal infection with varying presentation depending on site. Dermatophytes are fungal organisms that require keratin for growth. These fungi can cause superficial infections of the hair, skin, and nails. Dermatophytes are spread by direct contact from other

2018 BMJ Best Practice

77. Raynaud's phenomenon

be a painful condition and can lead to complications. History and exam presence of risk factors digit pain/discomfort digital paraesthesia pallor of digits red and/or blue discoloration of digits dilated capillaries at nailbeds well-defined discoloration magnification of nailbeds heartburn dysphagia puffy hands tight skin arthralgia photosensitivity oral/nasal ulcers alopecia butterfly rash sclerodactyly telangiectasia pleuritic chest pain digital ulcers digital pits digital tuft resorption gangrene

2018 BMJ Best Practice

78. Anatomical penile abnormalities

prepuce penile curvature and/or torsion recent genital examination or procedure history of short or small penis penile pain and swelling foreskin adherent to glans penile adhesions and smegma penile cicatrix penile glans oedema prominent pre-pubic fat pad presence of hernia or hydrocele forced retraction of foreskin dyspareunia recent penile trauma history of balanitis or balanoposthitis urinary obstruction or retention necrosis of penile skin discoloration of glans penile length discrepancy history (...) that often presents as a genital mass present with urination in the newborn. It is characterised by excessive inner preputial skin with a tight phimotic ring, leading to severe ballooning of the penile skin and scrotum with urination. [Figure caption and citation for the preceding image starts]: Congenital penile curvature (congenital chordee) From the collection of Nicol Corbin Bush, MD [Citation ends]. [Figure caption and citation for the preceding image starts]: Infant with distal hypospadias

2018 BMJ Best Practice

79. Gangrene

oedema skin discoloration crepitus (gas gangrene) diminished pedal pulses and ankle-brachial index (ischaemic gangrene) low-grade fever and chills (infectious gangrene) diabetes mellitus atherosclerosis (ischaemic gangrene) smoking (ischaemic gangrene) renal disease drug and alcohol abuse malignancy trauma or abdominal surgery (infectious gangrene) contaminated wounds (infectious gangrene) malnutrition (infectious gangrene) hypercoagulable states (ischaemic gangrene) prolonged application (...) of tourniquets (ischaemic gangrene) Diagnostic investigations FBC comprehensive metabolic panel serum LDH coagulation panel blood cultures serum C-reactive protein plain x-rays CT of affected site MRI of affected site Doppler ultrasonography surgical exploration and skin biopsy CT angiography magnetic resonance angiography (MRA) CT chest and abdomen ANA, lupus anticoagulant, anticardiolipin, and anti beta2 glycoprotein-1 antibodies serum cold agglutinins serum cryofibrinogens plasma cryoglobulin Treatment

2018 BMJ Best Practice

80. Frostbite

the viability of the injured tissue and surgery should normally be delayed. Risk factors for amputation include severe injury grades, late presentation, lower extremity involvement, and wound infection. Definition Frostbite is an injury produced by tissue freezing following exposure to cold. Frostbite requires temperatures of 0°C (32°F) or colder to occur. History and exam presence of risk factors cold or numbness of affected extremity pain during rewarming purplish skin discoloration white or yellow skin (...) plaque superficial skin vesiculation deep purple blisters tissue necrosis and mummification (dry gangrene) erythema joint dislocation fractures cold exposure previous frostbite vascular insufficiency high altitude hypoxia alcohol tobacco dehydration extremity trauma constrictive clothing or equipment Diagnostic investigations clinical diagnosis technetium-99 pertechnetate scintigraphy magnetic resonance angiogram of affected extremity plain radiography thermography and duplex imaging Treatment

2018 BMJ Best Practice

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