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Skin Discoloration

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21. Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin

in development, the device has not yet been designed to control for high melanin content of skin. Thus only subjects with lower melanin content (i.e. Fitzpatrick skin types I - IV) will be included in the study. In addition, tattoo markings, scarring or significant natural discolorations can interfere with the imaging results by absorbing blue light and subjects with any of these will be excluded. Criteria Inclusion Criteria: Male or female Age groups: 20 - 30 and 55 - 65 Fitzpatrick skin types I, II, III (...) , and IV Exclusion Criteria: Fitzpatrick skin types V and above Tattoo markings anywhere on the arm(s) Significant scarring or discoloration (e.g. birthmarks) on the arm(s) Any current injuries, infections or wounds on the arm(s) Routinely (4+ doses per week) take high dosages of anti-inflammatory drugs (e.g. aspirin, ibuprofen, corticosteroids), immunosuppressive drugs, or antihistamine medications. However steroid nose drops and/or eye drops are permitted. Has taken an anti-inflammatory drug (e.g

2017 Clinical Trials

22. Skin Discoloration

Skin Discoloration Skin Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin Discoloration Skin Discoloration Aka: Skin (...) Discoloration , Skin Pigment Changes , Pigmentation Disorder From Related Chapters II. Causes: Pigmentation Disorders s III. Causes: Brown discoloration See (or ) See Hemosiderin ( ) IV. Causes: Blue-Gray discoloration Silver ( ) Alkaptonuria (Ochronosis) Gold (Chrysoderma) V. Causes: Yellow discoloration Medications (Quinacrine) Explosive manufacture (Dinitrophenol, Tetryl) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Skin

2015 FP Notebook

23. Discoloration of nail beds and skin from minocycline (PubMed)

Discoloration of nail beds and skin from minocycline 21098068 2011 04 05 2018 11 13 1488-2329 183 2 2011 Feb 08 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Discoloration of nail beds and skin from minocycline. 224 10.1503/cmaj.091498 Tavares John J Faculty of Medicine, University of Ottawa, Ottawa, Ont., Canada. Leung Wilson W S WW eng Case Reports Journal Article 2010 11 22 Canada CMAJ 9711805 0820-3946 0 Anti-Bacterial Agents FYY3R43WGO (...) Minocycline AIM IM Anti-Bacterial Agents adverse effects Humans Male Middle Aged Minocycline adverse effects Nail Diseases chemically induced Pigmentation Disorders chemically induced Rosacea drug therapy Skin Pigmentation drug effects 2010 11 25 6 0 2010 11 26 6 0 2011 4 6 6 0 ppublish 21098068 cmaj.091498 10.1503/cmaj.091498 PMC3033929 Drug Saf. 1998 Jun;18(6):431-40 9638388

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2011 CMAJ : Canadian Medical Association Journal

24. Unusual case of skin discoloration. (PubMed)

Unusual case of skin discoloration. 638688 1978 06 28 2018 11 30 0007-1447 1 6121 1978 May 06 British medical journal Br Med J Unusual case of skin discoloration. 1188-9 Darke C S CS Cooper R G RG eng Case Reports Journal Article England Br Med J 0372673 0007-1447 0 Anthraquinones 0 Cathartics 0 Drug Combinations 3WJQ0SDW1A Polyethylene Glycols 9003-11-6 Poloxalene AIM IM Anthraquinones adverse effects Cathartics adverse effects Drug Combinations Drug Interactions Female Humans Middle Aged

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1978 British medical journal

25. Dark Discoloration of the Dorsal Skin of the Finger Joints: A Poor Prognostic Sign in Rheumatoid Arthritis (PubMed)

Dark Discoloration of the Dorsal Skin of the Finger Joints: A Poor Prognostic Sign in Rheumatoid Arthritis 13961977 1998 11 01 2018 12 01 0003-4967 21 1962 Dec Annals of the rheumatic diseases Ann. Rheum. Dis. Dark discoloration of the dorsal skin of the finger joints. A poor prognostic sign in rheumatoid arthritis. 392-3 KALLIOMAKI J L JL eng Journal Article England Ann Rheum Dis 0372355 0003-4967 OM Arthritis Arthritis, Rheumatoid Finger Joint Fingers Humans Pigmentation Disorders ARTHRITIS

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1962 Annals of the Rheumatic Diseases

26. Blue-Gray Mucocutaneous Discoloration: A New Adverse Effect of Ezogabine. (PubMed)

Blue-Gray Mucocutaneous Discoloration: A New Adverse Effect of Ezogabine. Many drugs have been reported to induce skin and/or mucous membrane discoloration. Ezogabine (retigabine) was recently approved as an add-on drug for the treatment of partial seizures in adults with epilepsy. Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particular has not been previously reported.Two patients who had received multiple antiepileptic drugs for several years (...) presented with a blue-gray skin dyspigmentation that was most pronounced on the face and lips and was associated with nail pigmentation, blue pigmentation on the hard palate, and black pigment deposits on the conjuctivae. The sole drug common to the therapeutic regimens of both patients was ezogabine. Histopathologically, the main finding was perivascular and periadnexal dermal cells heavily laden with coarse melanin granules, which appeared ultrastructurally as intracellular electron-dense granules

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2014 JAMA dermatology (Chicago, Ill.)

27. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections

Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | Oxford Academic Search Account Menu Menu Navbar (...) Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article navigation 15 July 2014 Article Contents Article Navigation Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America Dennis L. Stevens 1Division of Infectious Diseases, Department of Veterans Affairs, Boise, Idaho Search for other works by this author on: Alan L. Bisno 2Medical

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2014 Infectious Diseases Society of America

28. Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet (PubMed)

of increased levels of lactosylceramide due to an increase in the expression of lactosylceramide synthase (GalT-V). This is accompanied with neutrophil infiltration into dermis, and enrichment of tumor necrosis factor-stimulated gene-6 (TSG-6) protein. This causes skin inflammation, hair discoloration and loss, in ApoE-/- mice. Conversely, inhibition of glycosphingolipid synthesis, by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), unbound or encapsulated in a biodegradable polymer (BPD (...) Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE-/-) decreases the level of ceramides and glucosylceramide. At the expense

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2018 Scientific reports

29. Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension (PubMed)

Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension We present two cases of paraplegic patients who developed secondary Raynaud's phenomenon. A 43-year-old man with paraplegia presented with dark purple discoloration and skin defects on his left second and third toes and complained of a cold sensation in both feet for a period of 1 year. He had been taking diuretics for 4 years. The capillary refilling time for both affected toes was delayed (...) the diuretics to olmesartan medoxmil 20 mg and amlodipine besylate 2.5 mg per day. Subsequently, he has had no unstable wounds for 30 months. If hypertensive patients with paraplegia complain of skin discoloration in their extremities, Raynaud's phenomenon should be considered and the antihypertensive drug may need to be stopped in order to improve the wound-healing process.

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2018 Drug Safety - Case Reports

30. A Prospective, Experimental Study to Assess the Effectiveness of Home Care Nursing on the Healing of Peristomal Skin Complications and Quality of Life. (PubMed)

listed in 2 ostomy supplier databases. Participants were alternatively allocated to 6 home care visits (intervention [IG], n = 18) or 2 outpatient/clinic care [CG] visits (control, n = 17). Demographic and patient variables were assessed at the initial visit in both groups. The Ostomy Skin Tool (OST) and the Stoma-Quality of Life instrument were used to assess study characteristics; data were statistically analyzed.The Discoloration, Erosion, Tissue Overgrowth scores of the OST of the 2 groups were (...) A Prospective, Experimental Study to Assess the Effectiveness of Home Care Nursing on the Healing of Peristomal Skin Complications and Quality of Life. Home care services are effective in many patient groups.The authors examined the effect of specialized ostomy care in the home on peristomal skin complications and patient quality of life (QOL).A prospective, experimental study was conducted among 35 people >18 years old with a colostomy or ileostomy and peristomal skin complications who were

2018 Ostomy/wound management

31. Medical Needling: Effect on Skin Erythema of Hypertrophic Burn Scars (PubMed)

Medical Needling: Effect on Skin Erythema of Hypertrophic Burn Scars Background Burn scars frequently tend to have pathological discolorations, which is manifested in the development of persistent erythema. Affected people suffer from psychological and physiological issues when they are restricted or rejected in their daily life. In this context, medical needling seems to be an efficient therapy for erythematous scars with a relatively low-risk rate of postoperative complications. Study (...) outcomes for normal and healthy skin. The patient cohort included 20 patients with an average age of 34.63 years. Our examinations involved scars that were at least two years old and had healed by secondary intent. Every scar showed the pathological values of persistent erythema according to the participation requirements. Methods For the practical implementation of medical needling or percutaneous collagen induction (PCI), we used a roller covered with needles of 3 mm length. The needling device

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2018 Cureus

32. Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study (PubMed)

Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study Nowadays, several approaches for skin rejuvenation of the lower eyelid are available. We present a new technique of resurfacing with ablation of periorbital skin (RAP) performed in a single session.This is a retrospective study involving 20 patients showing skin elastosis with or without evidence of the nasojugal fold and atrophic and dyschromic skin or needing a combined (...) approach of transconjuntival lower blepharoplasty for fat bag removal. RAP technique is assessed in terms of efficacy, safety, and 3D evaluation of results at 6 months' follow-up.Global Assessment Improvement Scale results highlighted an improvement in all cases, for both physicians (blinded to treatment) and individual subjects. Only minor adverse events (edema, erythema, and discoloration) were reported in almost all patients, lasting 2-3 weeks after treatment, and were resolved without intervention

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2018 Photomedicine and laser surgery

33. Study to Evaluate the Efficacy of Removing Skin Tags With Digiclamp

: University of Florida Collaborator: XDG Technologies, LLC Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The objective of this study is to assess the efficacy of using the Digiclamp device to remove achrocordons (skin tags). The hypothesis is that utilizing the device will result in low rates of re-occurrence, scars, scar tissue and discoloration at the site of removal. Condition or disease Intervention/treatment Phase Achrochordon (...) of subjects who develop scar tissue or keloid at the site of removal Rate of discoloration among subjects [ Time Frame: 3 months ] Proportion of subjects who develop discoloration at the site of removal Rate of hyposensitivity where skin tag was removed [ Time Frame: 3 months ] Proportion of subjects who develop hyposensitivity at the site of removal Rate of hypersensitivity where skin tag was removed [ Time Frame: 3 months ] Proportion of subjects who develop hypersensitivity at the site of removal

2017 Clinical Trials

34. Melanin and lipofuscin as hallmarks of skin aging (PubMed)

Melanin and lipofuscin as hallmarks of skin aging Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described

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2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

35. Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment (PubMed)

Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment Sorafenib is a multitargeted kinase inhibitor currently used in the treatment of advanced hepatocellular carcinoma (HCC). It is associated with a significant risk of skin toxicity, which nevertheless represents a clinical marker of good response to treatment. Hand-and-foot skin reaction, alopecia, mucositis, xerosis, skin discoloration, and nail (...) involvement occur frequently in course of therapy. More rarely, sorafenib can target hair follicles. We report the case of a patient who developed painful inflamed nodular-cystic lesions in both pubic and axillary regions in course of treatment with sorafenib. Because of the limited therapeutic options, the patient underwent photodynamic therapy (PDT), a topical treatment which combines a photosensitizing drug applied on lesional skin and a source of light, and had no systemic side effects. At the end

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2017 International journal of immunopathology and pharmacology

36. Randomized Study of a New Noninvasive Skin Closure Device for Use After Congenital Heart Operations. (PubMed)

discoloration (0.9%), epidermolysis (0.9%), and exfoliation of the device (1.8%); however, no serious complications developed.In congenital heart operations through a median sternotomy, the Zip surgical skin closure device was an excellent choice for improving the cosmetic appearance and reducing the wound closure time. In addition, it proved to be a device that could be used safely.Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. (...) Randomized Study of a New Noninvasive Skin Closure Device for Use After Congenital Heart Operations. We report a new, noninvasive Zip surgical skin closure device (ZipLine Medical, Campbell, CA). This device is considered to have good cosmetic outcomes after operations and reduces surgical time. In this study, skin closure using the Zip device was compared with subcuticular sutures and the usefulness and safety of this new device was evaluated.This was a prospective, randomized study of 214

2016 The Annals of thoracic surgery

37. Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model (PubMed)

analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area.Epidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide (...) Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model The wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats.Twenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact

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2016 Medical science monitor : international medical journal of experimental and clinical research

38. Use of Munsell Color Charts to Measure Skin Tone Objectively in Nursing Home Residents at Risk for Pressure Ulcer Development (PubMed)

Use of Munsell Color Charts to Measure Skin Tone Objectively in Nursing Home Residents at Risk for Pressure Ulcer Development To assess the feasibility of classifying skin tone using Munsell color chart values and to compare Munsell-based skin tone categories to ethnicity/race to predict pressure ulcer risk.Pressure ulcer classification uses level of visible tissue damage, including skin discoloration over bony prominences. Prevention begins with early detection of damage. Skin discoloration (...) in those with dark skin tones can be difficult to observe, hindering early detection.Observational cohort of 417 nursing home residents from 19 nursing homes collected between 2009-2014, with weekly skin assessments for up to 16 weeks.Assessment included forearm and buttocks skin tone based on Munsell values (Dark, Medium, Light) at three time points, ethnicity/race medical record documentation, and weekly skin assessment on trunk and heels.Inter-rater reliability was high for forearm and buttock

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2016 Journal of advanced nursing

39. Nail Discoloration

Nail Discoloration Nail Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Nail Discoloration Nail Discoloration Aka: Nail (...) ) Excessive ( ) Melanonychia striata Common in dark skinned persons Spontaneous or secondary to or Benign Uniform brown longitudinal streak localized to nail Distal nail bed discolored brown VII. Causes: Yellow Nails VIII. References Jhun, Raam and DeClerck in Herbert (2015) EM:Rap 15(12): 3-4 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Nail Discoloration." Click on the image (or right click) to open the source website in a new

2015 FP Notebook

40. Tooth Discoloration

Tooth Discoloration Tooth Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tooth Discoloration Tooth Discoloration Aka (...) : Tooth Discoloration , Drug-Induced Tooth Staining , Tooth Discoloration due to Medication From Related Chapters II. Causes: Extrinsic Staining (typically temporary staining of teeth after eruption) -Clavulanate ( ) Superficial yellow or brown stain May persist for weeks to months May be confused with Chlorhexidine (Peridex) Yellow or brain stain Reduce use of red wine coffee, tea or beats, chromogens that may compound peridex staining Preparations (liquids) Superficial brown or black staining Mix

2015 FP Notebook

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