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Skin Discoloration

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21. Ferrofluid-associated Cutaneous Dyschromia: Discoloration of Hand and Fingers Following Accidental Exposure to Ferromagnetic Fluid Full Text available with Trip Pro

leaped from the bowl and contacted not only the magnet, but also the palmar surface of his hand and fingers, resulting in a black-brown dyschromia of the affected skin. The discoloration completely resolved after two weeks without any adverse sequellae.Ferrofluid has numerous current and potential applications; in addition to being of value educationally and aesthetically (after being subjected to magnetic fields), it is also utilized for audio loudspeakers, medical innovations (such as a component (...) Ferrofluid-associated Cutaneous Dyschromia: Discoloration of Hand and Fingers Following Accidental Exposure to Ferromagnetic Fluid Ferrofluid is a colloidal suspension that usually consists of surfactant-coated nanoparticles of magnetite (Fe3O4) in a carrier liquid. Ferromagnetic fluid forms spikes when the liquid is exposed to a magnetic field.The authors describe a man who developed temporary discoloration of his right palm and fingers after accidental cutaneous contact with ferrofluid

2016 The Journal of clinical and aesthetic dermatology

22. Unusual case of skin discoloration. Full Text available with Trip Pro

Unusual case of skin discoloration. 638688 1978 06 28 2018 11 30 0007-1447 1 6121 1978 May 06 British medical journal Br Med J Unusual case of skin discoloration. 1188-9 Darke C S CS Cooper R G RG eng Case Reports Journal Article England Br Med J 0372673 0007-1447 0 Anthraquinones 0 Cathartics 0 Drug Combinations 3WJQ0SDW1A Polyethylene Glycols 9003-11-6 Poloxalene AIM IM Anthraquinones adverse effects Cathartics adverse effects Drug Combinations Drug Interactions Female Humans Middle Aged

1978 British medical journal

23. Dark Discoloration of the Dorsal Skin of the Finger Joints: A Poor Prognostic Sign in Rheumatoid Arthritis Full Text available with Trip Pro

Dark Discoloration of the Dorsal Skin of the Finger Joints: A Poor Prognostic Sign in Rheumatoid Arthritis 13961977 1998 11 01 2018 12 01 0003-4967 21 1962 Dec Annals of the rheumatic diseases Ann. Rheum. Dis. Dark discoloration of the dorsal skin of the finger joints. A poor prognostic sign in rheumatoid arthritis. 392-3 KALLIOMAKI J L JL eng Journal Article England Ann Rheum Dis 0372355 0003-4967 OM Arthritis Arthritis, Rheumatoid Finger Joint Fingers Humans Pigmentation Disorders ARTHRITIS

1962 Annals of the Rheumatic Diseases

24. Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin

in development, the device has not yet been designed to control for high melanin content of skin. Thus only subjects with lower melanin content (i.e. Fitzpatrick skin types I - IV) will be included in the study. In addition, tattoo markings, scarring or significant natural discolorations can interfere with the imaging results by absorbing blue light and subjects with any of these will be excluded. Criteria Inclusion Criteria: Male or female Age groups: 20 - 30 and 55 - 65 Fitzpatrick skin types I, II, III (...) , and IV Exclusion Criteria: Fitzpatrick skin types V and above Tattoo markings anywhere on the arm(s) Significant scarring or discoloration (e.g. birthmarks) on the arm(s) Any current injuries, infections or wounds on the arm(s) Routinely (4+ doses per week) take high dosages of anti-inflammatory drugs (e.g. aspirin, ibuprofen, corticosteroids), immunosuppressive drugs, or antihistamine medications. However steroid nose drops and/or eye drops are permitted. Has taken an anti-inflammatory drug (e.g

2017 Clinical Trials

25. Fungal skin infection - scalp

Fungal skin infection - scalp Fungal skin infection - scalp - NICE CKS Share Fungal skin infection - scalp: Summary Fungal infection of the scalp is also known as 'tinea capitis' or 'scalp ringworm', and it describes infection of scalp hair follicles and the surrounding skin caused by dermatophytes. In UK cities, infection is usually caused by Trichophyton tonsurans. In Europe and rural parts of the UK, infection is usually caused by Microsporum canis. It predominantly affects prepubertal Afro (...) -Caribbean children. The clinical features of fungal scalp infection vary depending on the degree of inflammatory response, and include: Scaling and itch of the scalp, patches of hair loss. Skin erythema, pustules, crusting, and lymphadenopathy. Painful, pustular boggy masses, which may have a thick crust (kerion). Associated fungal infection at other sites. Assessment of suspected fungal scalp infection should include skin and hair sampling for fungal microscopy and culture, to confirm the diagnosis

2018 NICE Clinical Knowledge Summaries

26. Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study. (Abstract)

decreased and skin discoloration was reduced. Side effects such as burning, dryness, pruritus, and erythema during the 8-week study period were minimal.The topical formulation of liquid crystal serum with retinol 0.15% and 0.3% improves the overall skin condition after 8 weeks. Burning, pruritus, dryness, and erythema caused by the application of retinol 0.15% and 0.3% concentrations were minimal. Nevertheless, there were no significance changes found between the left and right side of the face (...) Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study. The aging process is defined as natural, biological, progressive, and physiologically irreversible phenomena occurring in the body.We attempted to evaluate the efficacy and tolerability of treating signs of the aging skin using retinol 0.15% and 0.3%. Retinol was added to the original, developed liquid crystal formula.Patients

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

27. A Prospective, Experimental Study to Assess the Effectiveness of Home Care Nursing on the Healing of Peristomal Skin Complications and Quality of Life. (Abstract)

listed in 2 ostomy supplier databases. Participants were alternatively allocated to 6 home care visits (intervention [IG], n = 18) or 2 outpatient/clinic care [CG] visits (control, n = 17). Demographic and patient variables were assessed at the initial visit in both groups. The Ostomy Skin Tool (OST) and the Stoma-Quality of Life instrument were used to assess study characteristics; data were statistically analyzed.The Discoloration, Erosion, Tissue Overgrowth scores of the OST of the 2 groups were (...) A Prospective, Experimental Study to Assess the Effectiveness of Home Care Nursing on the Healing of Peristomal Skin Complications and Quality of Life. Home care services are effective in many patient groups.The authors examined the effect of specialized ostomy care in the home on peristomal skin complications and patient quality of life (QOL).A prospective, experimental study was conducted among 35 people >18 years old with a colostomy or ileostomy and peristomal skin complications who were

2018 Ostomy/wound management Controlled trial quality: uncertain

28. Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet Full Text available with Trip Pro

of increased levels of lactosylceramide due to an increase in the expression of lactosylceramide synthase (GalT-V). This is accompanied with neutrophil infiltration into dermis, and enrichment of tumor necrosis factor-stimulated gene-6 (TSG-6) protein. This causes skin inflammation, hair discoloration and loss, in ApoE-/- mice. Conversely, inhibition of glycosphingolipid synthesis, by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), unbound or encapsulated in a biodegradable polymer (BPD (...) Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE-/-) decreases the level of ceramides and glucosylceramide. At the expense

2018 Scientific reports

29. Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study Full Text available with Trip Pro

Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study Nowadays, several approaches for skin rejuvenation of the lower eyelid are available. We present a new technique of resurfacing with ablation of periorbital skin (RAP) performed in a single session.This is a retrospective study involving 20 patients showing skin elastosis with or without evidence of the nasojugal fold and atrophic and dyschromic skin or needing a combined (...) approach of transconjuntival lower blepharoplasty for fat bag removal. RAP technique is assessed in terms of efficacy, safety, and 3D evaluation of results at 6 months' follow-up.Global Assessment Improvement Scale results highlighted an improvement in all cases, for both physicians (blinded to treatment) and individual subjects. Only minor adverse events (edema, erythema, and discoloration) were reported in almost all patients, lasting 2-3 weeks after treatment, and were resolved without intervention

2018 Photomedicine and laser surgery

30. Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension Full Text available with Trip Pro

Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension We present two cases of paraplegic patients who developed secondary Raynaud's phenomenon. A 43-year-old man with paraplegia presented with dark purple discoloration and skin defects on his left second and third toes and complained of a cold sensation in both feet for a period of 1 year. He had been taking diuretics for 4 years. The capillary refilling time for both affected toes was delayed (...) the diuretics to olmesartan medoxmil 20 mg and amlodipine besylate 2.5 mg per day. Subsequently, he has had no unstable wounds for 30 months. If hypertensive patients with paraplegia complain of skin discoloration in their extremities, Raynaud's phenomenon should be considered and the antihypertensive drug may need to be stopped in order to improve the wound-healing process.

2018 Drug Safety - Case Reports

31. Medical Needling: Effect on Skin Erythema of Hypertrophic Burn Scars Full Text available with Trip Pro

Medical Needling: Effect on Skin Erythema of Hypertrophic Burn Scars Background Burn scars frequently tend to have pathological discolorations, which is manifested in the development of persistent erythema. Affected people suffer from psychological and physiological issues when they are restricted or rejected in their daily life. In this context, medical needling seems to be an efficient therapy for erythematous scars with a relatively low-risk rate of postoperative complications. Study (...) outcomes for normal and healthy skin. The patient cohort included 20 patients with an average age of 34.63 years. Our examinations involved scars that were at least two years old and had healed by secondary intent. Every scar showed the pathological values of persistent erythema according to the participation requirements. Methods For the practical implementation of medical needling or percutaneous collagen induction (PCI), we used a roller covered with needles of 3 mm length. The needling device

2018 Cureus

32. Blue-Gray Mucocutaneous Discoloration: A New Adverse Effect of Ezogabine. Full Text available with Trip Pro

Blue-Gray Mucocutaneous Discoloration: A New Adverse Effect of Ezogabine. Many drugs have been reported to induce skin and/or mucous membrane discoloration. Ezogabine (retigabine) was recently approved as an add-on drug for the treatment of partial seizures in adults with epilepsy. Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particular has not been previously reported.Two patients who had received multiple antiepileptic drugs for several years (...) presented with a blue-gray skin dyspigmentation that was most pronounced on the face and lips and was associated with nail pigmentation, blue pigmentation on the hard palate, and black pigment deposits on the conjuctivae. The sole drug common to the therapeutic regimens of both patients was ezogabine. Histopathologically, the main finding was perivascular and periadnexal dermal cells heavily laden with coarse melanin granules, which appeared ultrastructurally as intracellular electron-dense granules

2014 JAMA dermatology (Chicago, Ill.)

33. Melanin and lipofuscin as hallmarks of skin aging Full Text available with Trip Pro

Melanin and lipofuscin as hallmarks of skin aging Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described

2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

34. Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment Full Text available with Trip Pro

Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment Sorafenib is a multitargeted kinase inhibitor currently used in the treatment of advanced hepatocellular carcinoma (HCC). It is associated with a significant risk of skin toxicity, which nevertheless represents a clinical marker of good response to treatment. Hand-and-foot skin reaction, alopecia, mucositis, xerosis, skin discoloration, and nail (...) involvement occur frequently in course of therapy. More rarely, sorafenib can target hair follicles. We report the case of a patient who developed painful inflamed nodular-cystic lesions in both pubic and axillary regions in course of treatment with sorafenib. Because of the limited therapeutic options, the patient underwent photodynamic therapy (PDT), a topical treatment which combines a photosensitizing drug applied on lesional skin and a source of light, and had no systemic side effects. At the end

2017 International journal of immunopathology and pharmacology

35. Study to Evaluate the Efficacy of Removing Skin Tags With Digiclamp

: University of Florida Collaborator: XDG Technologies, LLC Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The objective of this study is to assess the efficacy of using the Digiclamp device to remove achrocordons (skin tags). The hypothesis is that utilizing the device will result in low rates of re-occurrence, scars, scar tissue and discoloration at the site of removal. Condition or disease Intervention/treatment Phase Achrochordon (...) of subjects who develop scar tissue or keloid at the site of removal Rate of discoloration among subjects [ Time Frame: 3 months ] Proportion of subjects who develop discoloration at the site of removal Rate of hyposensitivity where skin tag was removed [ Time Frame: 3 months ] Proportion of subjects who develop hyposensitivity at the site of removal Rate of hypersensitivity where skin tag was removed [ Time Frame: 3 months ] Proportion of subjects who develop hypersensitivity at the site of removal

2017 Clinical Trials

36. An Exploratory Study of Skin Problems Experienced by UK Nursing Home Residents Using Different Pad Designs. Full Text available with Trip Pro

found between observations using the 4 pad designs. However, a wide range of skin conditions was recorded that made classification difficult; the skin was often marked with creases from absorbent products, temporary marks, and pink/purple discoloration. We observed few cases of the severe erythema, rashes, and vesicles that are commonly used descriptors in previous skin tools. Nevertheless, the collected data reflect an abundance of skin problems that were difficult to categorize neatly. Researcher (...) An Exploratory Study of Skin Problems Experienced by UK Nursing Home Residents Using Different Pad Designs. The primary aim of this study was to determine whether the severity of incontinence-associated dermatitis (IAD) among nursing home-based incontinence pad users varies between pad designs. A second aim was to examine the utility of a simple method for reporting skin health problems in which healthcare assistants were asked to record basic observational data at each pad change.Randomized

2017 Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society Controlled trial quality: uncertain

37. Nail Discoloration

Nail Discoloration Nail Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Nail Discoloration Nail Discoloration Aka: Nail (...) ) Excessive ( ) Melanonychia striata Common in dark skinned persons Spontaneous or secondary to or Benign Uniform brown longitudinal streak localized to nail Distal nail bed discolored brown VII. Causes: Yellow Nails VIII. References Jhun, Raam and DeClerck in Herbert (2015) EM:Rap 15(12): 3-4 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Nail Discoloration." Click on the image (or right click) to open the source website in a new

2015 FP Notebook

38. Tooth Discoloration

Tooth Discoloration Tooth Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tooth Discoloration Tooth Discoloration Aka (...) : Tooth Discoloration , Drug-Induced Tooth Staining , Tooth Discoloration due to Medication From Related Chapters II. Causes: Extrinsic Staining (typically temporary staining of teeth after eruption) -Clavulanate ( ) Superficial yellow or brown stain May persist for weeks to months May be confused with Chlorhexidine (Peridex) Yellow or brain stain Reduce use of red wine coffee, tea or beats, chromogens that may compound peridex staining Preparations (liquids) Superficial brown or black staining Mix

2015 FP Notebook

39. Randomized Study of a New Noninvasive Skin Closure Device for Use After Congenital Heart Operations. Full Text available with Trip Pro

discoloration (0.9%), epidermolysis (0.9%), and exfoliation of the device (1.8%); however, no serious complications developed.In congenital heart operations through a median sternotomy, the Zip surgical skin closure device was an excellent choice for improving the cosmetic appearance and reducing the wound closure time. In addition, it proved to be a device that could be used safely.Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. (...) Randomized Study of a New Noninvasive Skin Closure Device for Use After Congenital Heart Operations. We report a new, noninvasive Zip surgical skin closure device (ZipLine Medical, Campbell, CA). This device is considered to have good cosmetic outcomes after operations and reduces surgical time. In this study, skin closure using the Zip device was compared with subcuticular sutures and the usefulness and safety of this new device was evaluated.This was a prospective, randomized study of 214

2016 The Annals of thoracic surgery Controlled trial quality: uncertain

40. Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model Full Text available with Trip Pro

analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area.Epidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide (...) Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model The wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats.Twenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact

2016 Medical science monitor : international medical journal of experimental and clinical research

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