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Skin Discoloration

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181. Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery (PubMed)

Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might

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2018 International journal of nanomedicine

182. Confocal Laser Endomicroscopy With Topical Cresyl Violet for Colorectal Polyps

: August 8, 2018 See Sponsor: Shandong University Information provided by (Responsible Party): Yanqing Li, Shandong University Study Details Study Description Go to Brief Summary: Probe-based confocal laser endomicroscopy (pCLE) has been shown to a reliable diagnostic method enabling in vivo microscopic imaging during ongoing endoscopy. Usually fluorescein then serves as a contrast agent for pCLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin (...) discoloration, and may have allergic side effects. This study aimed to establish a single topical dye, cresyl violet (CV) for pCLE imaging, to describe pCLE interpretation criteria for the characterization of colorectal polyps with histopathological correlation, and to perform the validation of these criteria. Condition or disease Colorectal Polyps Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 60 participants Observational Model: Cohort Time

2018 Clinical Trials

183. Cantharone for the Treatment of Perenial Warts

likely are you to recommend this method to a friend or using it again yourself". Presence of scarring or skin discoloration [ Time Frame: 2 weeks from starting therapy ] At the time of wart eradication, the treatment area is examined for healing. The clinician rates cosmesis on a scale from 0-5 with 5-skin grows back perfectly, 4-slight discoloration, 3-thickened skin, 1-slight scarring and 0-scarring. Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) : No Product Manufactured in and Exported from the U.S.: No Keywords provided by Maurice-Andre Recanati, Wayne State University: warts trichloroacetic acid Additional relevant MeSH terms: Layout table for MeSH terms Warts Condylomata Acuminata Papillomavirus Infections DNA Virus Infections Virus Diseases Skin Diseases, Viral Tumor Virus Infections Skin Diseases, Infectious Skin Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Cantharidin Enzyme Inhibitors Molecular Mechanisms

2018 Clinical Trials

184. Clinical Study Of caNNabidiol in childrEn and adolesCenTs With Fragile X (CONNECT-FX)

substrate of CYP3A4. Use of minocycline for 30 days prior to screening or throughout the study. Use of any benzodiazepine at screening or throughout the study. Use of THC or CBD-containing product within three months of Screening Visit or during the study. Change in pharmacologic or non-pharmacologic intervention during the course of the study. Any skin disease or condition including eczema, psoriasis, melanoma, acne, contact dermatitis, scarring, imperfections, lesions, tattoos, or discoloration (...) 3, 2018 Last Update Posted : February 27, 2019 See Sponsor: Zynerba Pharmaceuticals, Inc. Information provided by (Responsible Party): Zynerba Pharmaceuticals, Inc. Study Details Study Description Go to Brief Summary: This study will evaluate the efficacy and safety of ZYN002, a clear cannabidiol (CBD) gel that can be applied to the skin (called transdermal application) twice a day for the treatment of behavioral symptoms of Fragile X Syndrome (FXS). Eligible participants will then participate

2018 Clinical Trials

185. The Effects of Kinesio Tape® on Arthrogenic Muscle Inhibition and Rate of Torque Development

in individuals with AMI. Kinesio Tape® is commonly used to facilitate muscle contraction in athletic populations. This elastic therapeutic tape is popular in the athletic setting because it can be applied and used continually during exercise and activities of daily living for up to 2-3 days without restricting movement. It has been suggested that Kinesio Tape® facilitates muscle contraction by inducing increased sensory input via skin stimulation. The tape activates cutaneous mechanoreceptors (...) to the musculoskeletal structures of other joints of either lower extremity in the previous 3 months which impacted joint integrity and function (i.e., sprains, fractures, etc.) and resulted in at least 1 interrupted day of desired physical activity. Are not able to be matched according to our group allocation procedure Have had a past allergic reaction to Kinesio Tape® Currently display symptoms of an acute sprain including swelling, heat, redness, pain, discoloration, and/or loss of range of motion or function Any

2018 Clinical Trials

186. A Study of the Feasibility of Prehospital Remote Ischemic Conditioning

hours from end of RIC ] Anticipated adverse events related to RIC including minor arm discomfort, temporary discoloration of the arm or hand, and minor skin bruising or abrasions on the upper arm will be collected via in-person and telephone evaluation. Themes on patient experiences while undergoing RIC [ Time Frame: up to 15 minutes ] Qualitative themes related to the RIC procedure will be derived from semi-structured interviews with subjects. Eligibility Criteria Go to Information from

2018 Clinical Trials

187. A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD

in the Investigator's Static Global Assessment (ISGA) (defined as an ISGA score of Clear (0) or Almost Clear (1) with at least a 2 grade improvement from Baseline) by scheduled time points. [ Time Frame: Day 1 (Baseline) ] ISGA assessed the severity of AD (except scalp) on a 5-point scale ranged from 0 (clear) to 4 (maximum severe), where higher scores indicate higher degree of AD. Grades for classification of severity: 0= clear (minor residual discoloration, no erythema or induration or papulation, no oozing (...) Static Global Assessment (ISGA) (defined as an ISGA score of Clear (0) or Almost Clear (1) with at least a 2 grade improvement from Baseline) by scheduled time points. [ Time Frame: Day 8 ] ISGA assessed the severity of AD (except scalp) on a 5-point scale ranged from 0 (clear) to 4 (maximum severe), where higher scores indicate higher degree of AD. Grades for classification of severity: 0= clear (minor residual discoloration, no erythema or induration or papulation, no oozing or crusting), 1= almost

2018 Clinical Trials

188. Trending of Respiratory Rate Using the Nellcorâ„¢ Bedside Respiratory Patient Monitoring System

hours and are without any contact skin allergies to adhesives found in standard pulse oximetry sensors. Potential subjects are those who will be admitted to the General Care Floor. The subject pool will be approximately divided equally between medical/non-surgical and surgical patients. Criteria Inclusion Criteria: 18 years or older. A patient who meets the weight requirement for the sensor (e.g. >30kg). A patient at the study site on a General Care Floor (surgical or medical/non-surgical (...) is in atrial fibrillation. Patient has a documented history of frequent premature atrial contractions (PACs) or premature ventricular contractions (PVCs), defined as greater than 3 in 30 seconds or greater than 6 in 60 seconds within the past 3 months. Patient has an implanted pacemaker. Patient has excessive nail polish that cannot be removed or other dye or discoloration of the finger. Patient has diagnosed central apnea or diagnosed significant obstructive sleep apnea. Patient is currently using

2018 Clinical Trials

189. Efficacy of Platelet-rich Plasma in for Melasma Treatment

, Instituto Mexicano del Seguro Social Study Details Study Description Go to Brief Summary: The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with melasma. Condition or disease Intervention/treatment Phase Melasma Biological: Platelet-Rich Plasma Phase 2 Detailed Description: 832/5000 Objective: To evaluate the effect of PRP for Melasma (...) for one year. We included patients older than 18 years with a diagnosis of melanoma and a history of pregnancy with a time greater than 6 months, who were not in the period of lactation, with no history of skin cancer, with a history of liver, thyroid or injury, of acne and traumatic injuries on the face, in addition, with no work history of PRP. The patients received three sessions of PRP application, at intervals of 15 days between each of them. Masking: None (Open Label) Primary Purpose: Treatment

2018 Clinical Trials

190. BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris. (PubMed)

observed in the other endpoints. Across both studies, BPX-01 treatment was well-tolerated, with no photosensitivity, postinflammatory hyperpigmentation, or skin discoloration reported. A single subject (out of 259 study participants ) was identified to have detectable levels of plasma minocycline at low levels (42ng/mL) after 12 weeks of treatment but had no signs or symptoms associated with systemic administration of minocycline. Conclusion: BPX-01 appears to exhibit an effectiveness profile (...) BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris. Background and objectives: Acne vulgaris is a highly prevalent and multifactorial skin disorder that can adversely impact health-related quality of life. Factors that contribute to the pathogenesis of acne include pilosebaceous proliferation of proinflammatory Propionibacterium acnes (P. acnes) bacteria, presence of circulating androgens, excess sebum production, abnormal follicular

2018 The Journal of clinical and aesthetic dermatology

191. Giant pseudoaneurysm of subclavian artery after blunt chest trauma (PubMed)

increasing large painful swelling (10 by 8 cm) in left clavicular region along with purplish discoloration of the overlying skin. The diagnosis was confirmed after computed tomography angiography and the patient was successfully treated with surgical evacuation of clots, primary repair of the rent in the SCA, and plating of clavicular fracture.

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2018 Journal of Vascular Surgery Cases and Innovative Techniques

192. Lorazepam as a Cause of Drug-Induced Liver Injury (PubMed)

Lorazepam as a Cause of Drug-Induced Liver Injury Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam

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2018 Case reports in gastroenterology

193. Platelet-Rich Plasma for Elbow Pathologies: a Descriptive Review of Current Literature (PubMed)

for pain management and for patient-reported outcomes in lateral epicondylitis. PRP injection does not seem to have the potential complications associated with a steroid injection such as skin atrophy, discoloration, and secondary tendon tears. Only a few manuscripts comparing the results of PRP treatment with either extracorporeal shockwave (ESW), dry needling, or even surgical treatments in lateral epicondylitis exist. The use of PRP in other elbow pathologies such as golfer's elbow, ulnar collateral

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2018 Current reviews in musculoskeletal medicine

194. Severe bilateral adrenal hemorrhages in a newborn complicated by persistent adrenal insufficiency (PubMed)

process.Risk factors for adrenal hemorrhage include fetal macrosomia, traumatic vaginal delivery and critical acidemia.Signs of adrenal hemorrhage include jaundice, flank mass, skin discoloration or scrotal hematoma.Adrenal insufficiency often is a transient process when related to adrenal hemorrhage.Severe adrenal hemorrhages can occur in the absence of symptoms.Though rare, persistent adrenal insufficiency may occur in extremely severe cases of bilateral adrenal hemorrhage.Consider adrenal hemorrhage

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2018 Endocrinology, diabetes & metabolism case reports

195. A case report of thrombosed varicosities of pubic collateral veins: Ideal treatment strategy and contribution of era imaging technologies in diagnosis (PubMed)

A case report of thrombosed varicosities of pubic collateral veins: Ideal treatment strategy and contribution of era imaging technologies in diagnosis Collateral circulation is an alternative path occurring in case of venous or artery obstruction. This path may usually develop after primary recanalization. In our case, a 62-year-old woman presented to our Emergency Department complaining about a suprapubic swelling with a cyanotic discoloration of the overlying skin for the past 10 days

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2018 SAGE Open Medical Case Reports

196. Preoperative radiation in large angiomatosis of the breast, attempting breast conserving surgery: multidisciplinary approach (PubMed)

Preoperative radiation in large angiomatosis of the breast, attempting breast conserving surgery: multidisciplinary approach Angiomatosis of the breast is very rare. The presentations are including breast mass, skin discoloration and breast enlargement that mimic to angiosarcoma. The imaging could suggest non-specific vascular tumors. The histology should be obtained for the certain diagnosis. Surgical excision is the standard treatment. To our knowledge, this is the first case

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2018 Journal of surgical case reports

197. Pathology of carbon monoxide poisoning in two cats (PubMed)

exposures in human beings and provide valuable information in concurrent forensic investigations.Two adult Singapura brown ticked cats were submitted to the California Animal Health and Food Safety Laboratory (CAHFS) for necropsy and diagnostic work-up. These animals were found dead along with their two deceased owners. Similar lesions were observed in both cats. At necropsy, gross lesions consisted of multifocal, large, irregular, bright red spots on the skin of the abdomen and the inner surface of ear (...) pinnae, bright red muscles and blood. The carcasses, and tissues fixed in formalin retained the bright red discoloration for up to two weeks. Microscopic lesions included diffuse pulmonary congestion and edema, and multifocal intense basophilia of cardiomyocytes mostly affecting whole fibers or occasionally a portion of the fiber. Based on the clinical history,gross and microscopic changes, cyanide or carbon monoxide poisoning was suspected. Blood samples analyzed for carbon monoxide showed 57 and 41

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2018 BMC veterinary research

198. Impact of Clofazimine Dosing on Treatment-Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis. (PubMed)

Impact of Clofazimine Dosing on Treatment-Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis. The antileprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment shortening when added to the first-line regimen for drug-susceptible tuberculosis in a mouse model. However, clofazimine causes dose- and duration-dependent skin discoloration in patients, and the optimal (...) dosing strategies to optimize the antituberculosis effect while minimizing skin discoloration. The results also underscore the importance of conducting long-term studies to allow the full evaluation of drugs administered in combination over long durations.Copyright © 2018 American Society for Microbiology.

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2018 Antimicrobial Agents and Chemotherapy

199. The Anatomy behind Adverse Events in Hand Volumizing Procedures: Retrospective Evaluations of 11 Years of Experience. (PubMed)

percent) aged 52.3 ± 11.4 years, treated bilaterally for hand rejuvenation were investigated between the years 2006 and 2017. Cadaveric dissections (n = 12), fluoroscopic (n = 4), ultrasound (n = 22), and computed tomographic (n = 4) imaging were also performed to guide conclusions.Thirty-two of 440 hands (7.3 percent) developed adverse events within the first 15 days, with swelling in 11 (5 percent), pain in four (1.8 percent), erythema in three (1.4 percent), and discoloration in one (0.5 percent (...) to 81.76; p < 0.001), and single-line technique (OR, 26.68; 95 percent CI, 7.45 to 95.48; p < 0.001).The results of this study support the use of cannula versus needle and the proximal-to-distal fanning technique. The underlying anatomy supports the positioning of the material into the subdermal space, which can be identified less than 1 mm deep to the skin surface, and is termed the dorsal superficial lamina.

2018 Plastic and reconstructive surgery

200. Suction Mask vs Conventional Mask Ventilation in Term and Near-Term Infants in the Delivery Room: A Randomized Controlled Trial. (PubMed)

did not reduce facemask leak. Adverse effects such as the inability to achieve the set pressures and transient skin discoloration are concerning.Australian and New Zealand Clinical Trial Registry ACTRN12616000768493.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Journal of Pediatrics

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