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Skin Conditions in Diabetes Mellitus

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41. Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin

including combinations of soluble insulins) throughout the trial. Subjects treated with metformin in addition to insulin treatment must continue their metformin treatment throughout the entire trial. Condition or disease Intervention/treatment Phase Diabetes Diabetes Mellitus, Type 2 Drug: semaglutide Drug: placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 731 participants Allocation: Randomized Intervention Model (...) Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

42. Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus

: January 5, 2017 Last Update Posted : October 17, 2018 See Sponsor: Second Xiangya Hospital of Central South University Information provided by (Responsible Party): Zhiguang Zhou, Second Xiangya Hospital of Central South University Study Details Study Description Go to Brief Summary: The purpose of this study is to investigate the therapeutic effect of Liraglutide on autoimmune diabetes. Condition or disease Intervention/treatment Phase Type 1 Diabetes Mellitus Autoimmune Diabetes Drug: Liraglutide (...) Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

43. A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated With Basal Insulin With or Without Oral Antidiabetic Drugs

is conducted in Europe and North America. The aim of the trial is to compare the efficacy and safety of insulin degludec and insulin glargine 300 units/mL in subjects with type 2 diabetes mellitus inadequately treated with basal insulin with or without oral antidiabetic drugs. Due to change in glycaemic data collection process, this trial is amended to allow for a full 36 weeks (maintenance 2 period) of the use of the new process. Condition or disease Intervention/treatment Phase Diabetes Diabetes Mellitus (...) A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated With Basal Insulin With or Without Oral Antidiabetic Drugs A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated With Basal Insulin With or Without Oral Antidiabetic Drugs - Full Text View - ClinicalTrials.gov Hide glossary Glossary

2017 Clinical Trials

44. CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM)

CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM) CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. CS02 vs Placebo (...) With Metformin in Type 2 Diabetes Mellitus (T2DM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03317028 Recruitment Status : Recruiting First Posted : October 23, 2017 Last Update Posted : December 18, 2018 See Sponsor: Center

2017 Clinical Trials

45. Efficacy and Safety of Sotagliflozin Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents

the safety of sotagliflozin doses 1 and 2 versus placebo. Condition or disease Intervention/treatment Phase Type 2 Diabetes Mellitus Drug: sotagliflozin (SAR439954) Drug: insulin glargine (HOE901) Drug: Placebo Phase 3 Detailed Description: Up to 60 weeks (Screening phase of up to 2 weeks, a 4-week Lantus titration/single-blind placebo Run-in phase), a 52-week double blind Treatment Period, and a 2-week post-treatment Follow-up Period. Study Design Go to Layout table for study information Study Type (...) Efficacy and Safety of Sotagliflozin Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents Efficacy and Safety of Sotagliflozin Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2017 Clinical Trials

46. Home-based Proprioceptive Neuromuscular Facilitation for Subjects With Type 2 Diabetes Mellitus

of the upper extremity of patients with diabetes mellitus. And,the other is home-based PNF in conjunction with TGE provides better benefits for neuromuscular function of the upper extremity of patients with diabetes mellitus. Condition or disease Intervention/treatment Phase Diabetes Mellitus Exercise Behavioral: lifestyle changes Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 12 participants Allocation: Randomized (...) Home-based Proprioceptive Neuromuscular Facilitation for Subjects With Type 2 Diabetes Mellitus Home-based Proprioceptive Neuromuscular Facilitation for Subjects With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

47. A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Update Posted : February 8, 2018 Sponsor: MedImmune LLC Information provided by (Responsible Party): MedImmune LLC Study Details Study Description Go to Brief Summary: A Phase 2 study with two cohorts of differing doses designed to evaluate the efficacy, safety and pharmacokinetics (PK) of MEDI0382 in patients with Type 2 Diabetes Mellitus. Approximately 63 subjects will be enrolled across two cohorts. Condition or disease Intervention/treatment Phase Type 2 Diabetes Mellitus Drug: MEDI0382 Drug (...) A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus. A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

48. oxLDL in Diabetes Mellitus Patients and Disease Periodontal

. The aim of this study is to establish whether individuals with DM with or without chronic periodontitis have an increase in oxLDL and what is the influence of periodontal treatment in the reduction of oxLDL with consequent improvement in Diabetes Mellitus parameters. Condition or disease Intervention/treatment Phase Type 2 Diabetes Mellitus With Periodontal Disease Procedure: Non-surgical periodontal treatment Not Applicable Detailed Description: Periodontal disease (PD) and diabetes mellitus type 2 (...) oxLDL in Diabetes Mellitus Patients and Disease Periodontal oxLDL in Diabetes Mellitus Patients and Disease Periodontal - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. oxLDL in Diabetes Mellitus Patients

2017 Clinical Trials

49. Evaluation of Compression Therapy in Patients With Mild to Moderate PAD or Diabetes Mellitus

Posted : December 27, 2017 Last Update Posted : December 27, 2017 See Sponsor: University Hospital Erlangen Information provided by (Responsible Party): Ulrich Rother, University Hospital Erlangen Study Details Study Description Go to Brief Summary: Aim of this prospective clinical study is the Evaluation of the Effect of Compression Therapy on the Microcirculation in Patients With Leg Edema and Mild to Moderate PAD or Diabetes Mellitus. Condition or disease Intervention/treatment Phase Peripheral (...) Evaluation of Compression Therapy in Patients With Mild to Moderate PAD or Diabetes Mellitus Evaluation of Compression Therapy in Patients With Mild to Moderate PAD or Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

50. Efficacy and Bone Safety of Sotagliflozin Dose 1 and Dose 2 Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control

(SBP) for all patients; and to evaluate the proportion of patients with a HbA1C <7%. To demonstrate the superiority of sotagliflozin dose 2 versus placebo with respect to HbA1c reduction; change in BW, FPG, and SBP for all patients; and to evaluate the proportion of patients with HbA1c <7.0%. To evaluate the safety of sotagliflozin dose 1 and dose 2 compared with placebo. Condition or disease Intervention/treatment Phase Type 2 Diabetes Mellitus Drug: Sotagliflozin (SAR439954) Drug: Placebo Phase 3 (...) Efficacy and Bone Safety of Sotagliflozin Dose 1 and Dose 2 Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control Efficacy and Bone Safety of Sotagliflozin Dose 1 and Dose 2 Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail

2017 Clinical Trials

51. Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin

of patients with HbA1c <6.5% and <7.0%, and on sitting systolic blood pressure (SBP) reduction. To demonstrate the superiority of sotagliflozin versus empagliflozin on HbA1c reduction and sitting SBP reduction. To evaluate the safety of sotagliflozin versus empagliflozin, and placebo, throughout the trial. Condition or disease Intervention/treatment Phase Type 2 Diabetes Mellitus Drug: Sotagliflozin (SAR439954) Drug: Empagliflozin Drug: Placebo Phase 3 Detailed Description: Up to 34 weeks, including (...) Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2017 Clinical Trials

52. Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus

staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with Diabetes mellitus with active Charcot neuroarthropathy of foot as per following criteria: Clinical criteria Warm, swollen and erythematous foot Skin temperature exceeding 2°C at the clinically suspected site of the affected (...) Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

53. The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2)

metabolism, which may be related to hormones regulating carbohydrate, insulin and insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) metabolism. The hypothesis of our research is that patients with diabetes mellitus and oral lichen ruber lesions will have a disturbance of insulin-like growth factors 1 and 2 and hence a greater risk of malignant transformation, compared to patients with oral lichen ruber without diabetes and healthy patients without alterations in the oral mucosa. Condition or disease (...) , 2017 Last Update Posted: August 31, 2017 Last Verified: August 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Diabetes Mellitus Lichen Planus Lichen Planus, Oral Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Lichenoid Eruptions Skin Diseases

2017 Clinical Trials

54. Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)

hypothesis for this study is that at a dose with sufficient safety, the mean maximal glucose infusion rate (GIRmax) after single subcutaneous (SC) administration of MK-1092 in adult participants with T1DM is within an acceptable range. (Part 3) Condition or disease Intervention/treatment Phase Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Drug: MK-1092, 4.0 nmol/kg Drug: MK-1092, 8.0 nmol/kg Drug: MK-1092, 16 nmol/kg Drug: MK-1092, 32 nmol/kg Drug: MK-1092, 64 nmol/kg Drug: Glargine 3.0 nmol/kg Drug (...) Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001) Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2017 Clinical Trials

55. A Study to Compare Pharmacokinetics (PK) and Pharmacodynamics (PD) of SAR341402 to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus

A Study to Compare Pharmacokinetics (PK) and Pharmacodynamics (PD) of SAR341402 to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus A Study to Compare Pharmacokinetics (PK) and Pharmacodynamics (PD) of SAR341402 to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Compare Pharmacokinetics (PK) and Pharmacodynamics (PD) of SAR341402 to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

56. Wireless Innovation for Seniors With Diabetes Mellitus

Diabetes Research Foundation Information provided by (Responsible Party): Jaeb Center for Health Research Study Details Study Description Go to Brief Summary: The primary objective of the study is to determine if CGM can reduce hypoglycemia and improve quality of life in older adults with T1D. Condition or disease Intervention/treatment Phase Type 1 Diabetes Mellitus Device: Dexcom CGM Not Applicable Detailed Description: Reducing hypoglycemia is an important aspect of management of T1D in older adults (...) Wireless Innovation for Seniors With Diabetes Mellitus Wireless Innovation for Seniors With Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Wireless Innovation for Seniors With Diabetes

2017 Clinical Trials

57. Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus

or sulfonylurea on glycaemic control after 30 weeks of treatment in subjects with type 2 diabetes. Subjects will remain on their pre-trial medication. Condition or disease Intervention/treatment Phase Diabetes Diabetes Mellitus, Type 2 Drug: Semaglutide Drug: Placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 302 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant (...) Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2017 Clinical Trials

58. A Trial Comparing Insulin Degludec/Liraglutide and Insulin Degludec in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Therapy and Metformin With or Without One Other Oral Antidiabeti

, 2019 Sponsor: Novo Nordisk A/S Information provided by (Responsible Party): Novo Nordisk A/S Study Details Study Description Go to Brief Summary: This trial is conducted in Asia. The aim of this trial is to confirm the superiority of insulin degludec/liraglutide versus insulin degludec in controlling glycaemia in Chinese subjects with type 2 diabetes mellitus after 26 weeks of treatment Condition or disease Intervention/treatment Phase Diabetes Diabetes Mellitus, Type 2 Drug: Insulin degludec (...) A Trial Comparing Insulin Degludec/Liraglutide and Insulin Degludec in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Therapy and Metformin With or Without One Other Oral Antidiabeti A Trial Comparing Insulin Degludec/Liraglutide and Insulin Degludec in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Therapy and Metformin With or Without One Other Oral

2017 Clinical Trials

59. Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002)

in three predefined, increasing doses in each panel, or glargine (active comparator). The primary hypothesis of the trial is that at a dose with sufficient safety, the mean steady-state maximum level of glucose infusion rate (GIRmax) after MK-5160 administration in both T1DM and T2DM participants is between 1.5 and 4.5 mg/kg/min. Condition or disease Intervention/treatment Phase Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Biological: MK-5160 low dose Biological: MK-5160 medium dose Biological: MK (...) Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002) Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

60. Ketoacidosis in Neonatal Diabetes Mellitus, Part of Wolcott-Rallison Syndrome (PubMed)

Ketoacidosis in Neonatal Diabetes Mellitus, Part of Wolcott-Rallison Syndrome BACKGROUND Neonatal diabetes mellitus is a rare condition and it is important to differentiate it from other causes, such as hyperglycemia in infancy, for better outcomes. We report a case of an infant who presented to our neonatal intensive care unit in ketoacidosis and a comatose state. CASE REPORT Our case was an infant who presented to the neonatal intensive care unit at 38 days of age in ketoacidosis. The female (...) daily via subcutaneous route. A few days later, blood samples were sent from our hospital in India to the UK and genetic testing was performed free of charge by the Department of Molecular Genetics, University of Exeter Medical School, UK, and confirmed a genetic diagnosis of Wolcott-Rallison syndrome. CONCLUSIONS Regardless of whether permanent neonatal diabetes mellitus is associated with Wolcott-Rallison syndrome or other genetic mutations, it is important to initially stabilize the infant

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2017 The American journal of case reports

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