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Skin Abscess

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121. Single-dose dalbavancin and patient satisfaction in an outpatient setting in the treatment of acute bacterial skin and skin structure infections. Full Text available with Trip Pro

Single-dose dalbavancin and patient satisfaction in an outpatient setting in the treatment of acute bacterial skin and skin structure infections. Treatment of acute bacterial skin and skin structure infections (ABSSSIs) in the outpatient setting has potential advantages. We performed a subanalysis of outcomes for patients treated as outpatients versus inpatients with dalbavancin, a long-acting lipoglycopeptide, in a phase 3 clinical trial of ABSSSI.The study was a double-blind trial of patients (...) with ABSSSI randomised to receive dalbavancin 1500 mg intravenously as a single dose or two doses (1000 mg followed by 500 mg a week later). The primary endpoint was ≥20% reduction in erythema at 48-72 h after the start of therapy. Patient satisfaction and preference for antibiotic treatment and care setting were measured using the 10-item Skin and Soft Tissue Infection (SSTI) questionnaire at Day 14.A total of 698 patients were randomised (386 treated as outpatients and 312 as inpatients). Outpatients

2019 Journal of global antimicrobial resistance Controlled trial quality: uncertain

122. Once-daily oral omadacycline versus twice-daily oral linezolid for acute bacterial skin and skin structure infections (OASIS-2): a phase 3, double-blind, multicentre, randomised, controlled, non-inferiority trial. (Abstract)

Once-daily oral omadacycline versus twice-daily oral linezolid for acute bacterial skin and skin structure infections (OASIS-2): a phase 3, double-blind, multicentre, randomised, controlled, non-inferiority trial. Pathogen resistance and safety concerns limit oral antibiotic options for the treatment of acute bacterial skin and skin structure infections (ABSSSI). We aimed to compare the efficacy and safety of once-daily oral omadacycline, an aminomethylcycline antibiotic, versus twice-daily (...) or erysipelas, or major abscess) and receipt (yes or no) of allowed previous antibacterial treatment. Investigators, funders, and patients were masked to treatment assignments. Primary endpoints were early clinical response, 48-72 h after first dose, in the modified intention-to-treat (mITT) population (randomised patients without solely Gram-negative ABSSSI pathogens at baseline), and investigator-assessed clinical response at post-treatment evaluation, 7-14 days after the last dose, in the mITT population

2019 Lancet infectious diseases Controlled trial quality: predicted high

123. Omadacycline for Acute Bacterial Skin and Skin Structure Infections. Full Text available with Trip Pro

(ABSSSI). Omadacycline in Acute Skin and Skin Structure Infections Study 1 (OASIS-1) initiated patients on intravenous omadacycline or linezolid, with the option to transition to an oral formulation after day 3. OASIS-2 was an oral-only study of omadacycline versus linezolid.In total, 691 patients received omadacycline and 689 patients received linezolid. Infection types included wound infection in 46.8% of patients, cellulitis/erysipelas in 30.5%, and major abscess in 22.7%. Pathogens were identified (...) Omadacycline for Acute Bacterial Skin and Skin Structure Infections. Within the last decade, methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a frequent cause of purulent skin and soft tissue infections. New therapeutic options are being investigated for these infections.We report an integrated analysis of 2 randomized, controlled studies involving omadacycline, a novel aminomethylcycline, and linezolid for the treatment of acute bacterial skin and skin structure infections

2019 Clinical Infectious Diseases

124. Injectable Lidocaine Provides Similar Analgesia Compared to Transdermal Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses: A Randomized, Controlled Trial. (Abstract)

Injectable Lidocaine Provides Similar Analgesia Compared to Transdermal Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses: A Randomized, Controlled Trial. Local anesthesia used for incision and drainage of abscesses is known to be painful.We studied the analgesia provided by a lidocaine/tetracaine patch compared to injectable lidocaine during incision and drainage (I&D) of skin abscesses.This was a prospective, double-blind, randomized, controlled trial carried out (...) in the Emergency Department (ED) of an adult tertiary referral center. Adult patients with a skin abscess in need of I&D were randomized to one of two groups. One group received a lidocaine/tetracaine patch and injectable normal saline for anesthesia. The second group received a placebo patch and injectable 1% lidocaine. A visual analog pain scale was used to record the patient's pain level prior to treatment, during the procedure, and after I&D.There were 20 patients enrolled in the study, including 12

2014 Journal of Emergency Medicine Controlled trial quality: predicted high

125. Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis

, such as: recurrent boils or abscesses, previous MRSA infection and underlying medical conditions, close contact with others with the infection and also skin trauma such as scrapes, tattoos, injection drug use, shaving and/or sharing equipment that is not sterilized. Many people who get MRSA have no risk factors. Topical therapy with mupirocin 2% is a treatment option for MRSA if there are no signs of systemic infection, however there is a high resistance level and treatment failure associated with this use. MRSA (...) Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis The skin has an effective

2017 medSask

126. CRACKCast E137 – Skin Infections

, and surgical consultation. Emergency clinicians should be familiar with toxic shock syndromes and Rocky Mountain spotted fever, which are rare, life-threatening, skin infection–related syndromes. Lyme disease should be considered in endemic areas. For the management of most skin abscesses, antibiotics are not recommended. Adequate analgesia or sedation are essential to good patient care. There is debate about the necessity of wound culture and Gram staining. Current recommendations for the treatment (...) -Clav Erythema migrans Borrelia burgdorferi Doxycycline Puncture wound through foot Pseudomomas aeruginosa Ciprofloxacin [1] List 6 risk factors for cellulitis From Uptodate: Predisposing factors for development of cellulitis and/or skin abscess include: Skin barrier disruption due to trauma (such as abrasion, penetrating wound, pressure ulcer, venous leg ulcer, insect bite, injection drug use) Skin inflammation (such as eczema, radiation therapy) Edema due to impaired lymphatic drainage Edema due

2017 CandiEM

127. Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial. Full Text available with Trip Pro

) or adjacent to (control group) the pre-defined injection site(s). Clinicians, parents and children were blinded to group allocation. Parents reported local skin reactions using paper diaries for 15 days post-vaccination (Day 0-14). Telephone interviews were conducted Day 1, 5, and 14. The Brighton Collaboration criteria were used to diagnose cellulitis and infectious abscess Day 5 and afterward.170 children participated (May-November 2017). Baseline characteristics did not differ (p > 0.05) between groups (...) Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial. Recommendations: Regarding the need to use alcohol prior to vaccine injections are inconsistent and based on low-level evidence. The objective was to assess the effectiveness of alcohol in reducing local skin reactions and infection post-vaccination.Randomized controlled trial in a pediatric clinic. A research assistant cleansed the skin with alcohol at (swab group

2018 Human vaccines & immunotherapeutics Controlled trial quality: uncertain

128. Single Intravenous Dose of Oritavancin for the Treatment of Gram-positive Acute Bacterial Skin and Skin Structure Infections: Summary of Safety from the Phase 3 SOLO studies. Full Text available with Trip Pro

Single Intravenous Dose of Oritavancin for the Treatment of Gram-positive Acute Bacterial Skin and Skin Structure Infections: Summary of Safety from the Phase 3 SOLO studies. Oritavancin is a lipoglycopeptide with bactericidal activity against Gram-positive organisms. Its rapid concentration-dependent bactericidal activity and long elimination half-life allow single-dose treatment of acute bacterial skin and skin structure infections (ABSSSI). SOLO I and SOLO II were randomized, double-blind (...) %, respectively) and vancomycin (56.9, 5.9, and 4.2%, respectively). The median time to onset (3.8 days versus 3.1 days, respectively) and the duration (3.0 days for both groups) of adverse events were also similar between the two groups. The most frequently reported events were nausea, headache, and vomiting. Greater than 90% of all events were mild or moderate in severity. There were slightly more infections and infestations, abscesses or cellulitis, and hepatic and cardiac adverse events in the oritavancin

2018 Antimicrobial Agents and Chemotherapy Controlled trial quality: uncertain

129. Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with systemic signs of infection diagnosed with acute bacterial skin and skin structure infection (ABSSSI) Diagnosed with Cellulitis/ erysipelas, major cutaneous abscess, or wound infections Exclusion Criteria: Uncomplicated skin infections Severe (...) Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

130. A Comparison of Techniques for Treating Skin Abscesses

A Comparison of Techniques for Treating Skin Abscesses A Comparison of Techniques for Treating Skin Abscesses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Comparison of Techniques for Treating Skin (...) more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adult patient over 18 years of age Presenting to the Boston Medical Center main Emergency Department or Urgent Care area for initial treatment of a skin abscess English

2013 Clinical Trials

131. Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses

Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02066818 Recruitment Status : Completed First Posted : February 20, 2014 Last Update Posted : February

2013 Clinical Trials

132. Efficacy Study of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage

Efficacy Study of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02024867 Recruitment Status : Completed First Posted : December 31, 2013 Results First Posted : September 15, 2014 Last Update Posted

2013 Clinical Trials

133. Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses. Full Text available with Trip Pro

Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses. The present work aimed to evaluate the effectiveness of Plectranthus amboinicus (Lour.) Spreng against MRSA clinical isolates. The in vitro antimicrobial activity of the hydroalcoholic extract (HE), the ethyl acetate (EA) fraction and its subfractions were determined by broth microdilution and bioautography against MRSA clinical isolates. The microdilution (...) checkerboard method was used to assess in vitro drug combination studies. To induce abscess formation, bacterial suspensions were added to Citodex and inoculated subcutaneously into male Swiss mice. The treatment protocol consisted of 2 doses of HE, the EA fraction or vancomycin introduced intraperitoneally into mice 3 and 12 h after infection. The EA fraction and its subfractions presented the lowest minimal inhibitory concentrations (MIC, 0.25 to 0.5 mg/mL). The plant samples were bacteriostatic at 2x

2013 Evidence-based Complementary and Alternative Medicine (eCAM)

134. Complete Genome Sequence of Propionibacterium avidum Strain 44067, Isolated from a Human Skin Abscess Full Text available with Trip Pro

Complete Genome Sequence of Propionibacterium avidum Strain 44067, Isolated from a Human Skin Abscess Propionibacterium avidum is an anaerobic Gram-positive bacterium that forms part of the normal human cutaneous microbiota, colonizing moist areas such as the vestibule of the nose, axilla, and perineum. Here we present the complete genome sequence of P. avidum strain 44067, which was isolated from a carbuncle of the trunk.

2013 Genome Announcements

135. Point-of-care ultrasonography for the diagnosis of abscess in patients presenting with skin and soft tissue infections to the emergency department

Point-of-care ultrasonography for the diagnosis of abscess in patients presenting with skin and soft tissue infections to the emergency department Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2015 PROSPERO

136. To evaluate if there is any treatment effect of antibiotics, in treating skin abscesses, after incision and drainage has been performed

To evaluate if there is any treatment effect of antibiotics, in treating skin abscesses, after incision and drainage has been performed Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2015 PROSPERO

137. Skin Abscess

Skin Abscess Skin Abscess Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin Abscess Skin Abscess Aka: Skin Abscess , Furunculosis (...) , Furuncle , Carbuncle , Skin Boil , Recurrent Skin Abscess From Related Chapters II. Definitions Abscess Walled-off of purulent infection Firm wall with inner fluctuant core Carbuncle Coalition of Furuncles Deeper, more extensive involvement Require greater degree of debridement III. Pathophysiology infection that spreads to deeper tissue (often begins as ) IV. Risk Factors Impaired function use V. Causes (most common) species Mixed VI. Signs Tender, erythematous skin mass Often spontaneously opens

2015 FP Notebook

138. Lactational mastitis and breast abscess. Diagnosis and management in general practice

, which may be tense or fluctuant. The mass may have overlying skin necrosis suggesting that the abscess is ‘pointing’ (abscess is sitting close to the surface of the skin). Less frequently, breast abscess presents as a non- tender lump without erythema (‘cold abscess’). Examination of the infant and attachment to the breast The infant should be examined to ensure adequate growth and hydration. Examination of the baby’ s mouth can exclude candida infection (white film adherent to the buccal mucosa), 2 (...) (such as when fluid is aspirated from an abscess). 14 As S. aureus is the common causative organism, antibiotic therapy of choice at least 5 days of flucloxacillin or dicloxacillin in a dose of 500 mg four times per day. 15 Due to antibiotic packaging in Australia this may require two consecutive 6 day courses of antibiotics. For patients allergic to penicillin, Figure 3. Inflammatory breast cancer may mimic mastitis. Classically it presents with a poorly defined clinical mass with erythema, skin thickening

2011 Clinical Practice Guidelines Portal

139. Case of the Month: Vertebral Osteomyelitis and Psoas Abscess with Acinetobacter Baumanii: Report of an Unusual Case

Case of the Month: Vertebral Osteomyelitis and Psoas Abscess with Acinetobacter Baumanii: Report of an Unusual Case Case of the Month: Vertebral Osteomyelitis and Psoas Abscess with Acinetobacter Baumanii: Report of an Unusual Case – Clinical Correlations Search Case of the Month: Vertebral Osteomyelitis and Psoas Abscess with Acinetobacter Baumanii: Report of an Unusual Case April 6, 2011 6 min read By Michael C. Brabeck, MD, Adam Davis, MD, and Shaun Rodgers, MD Faculty Peer Reviewed Case (...) of the lumbar spine on HD 1 demonstrated multilevel discitis; vertebral osteomyelitis involving L1-3, subsequently confirmed by MR (Figure); and an adjacent discrete left psoas fluid collection at L-3, assumed to be a psoas abscess. Vancomycin and piperacillin/tazobactam were begun. Culture of percutaneous bone biopsy of the L-3 vertebral body done at that time yielded pansensitive E coli . At surgery for debridement and spinal fixation six days after admission, a left psoas abscess was confirmed. The L2-3

2011 Clinical Correlations

140. Reducing pain during incision and drainage of abscesses (Re-post)

of lidocaine (4-5 mg/kg for 1% lidocaine without epi, 7 mg/kg with epi) and aim just deep enough to create a subtle wheal and to hit the junction point of the local nerve fibers. Insert a 27 to 30 gauge needle at an oblique angle just under the epidermis a small distance away from the edge of the abscess (avoid injecting into the abscess which can be painful and ineffective). Inject in a ring around the abscess, going through already-numb skin when possible (this is where the topical 4% lidocaine helps (...) Reducing pain during incision and drainage of abscesses (Re-post) Reducing pain during incision and drainage of abscesses (Re-post) – PEMBlog Search for: Search for: Reducing pain during incision and drainage of abscesses (Re-post) Performing incision and drainage on an abscess is painful for the patient. I realize that is as obvious a statement as I could possibly make. I wanted to briefly touch on some of the many interventions that you can use to decrease pain during I&D. Before

2017 PEM Blog

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