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Skin Abscess

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101. Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)

a written informed consent Subjects with ABSSSI characterized by any of the following infection types: Cellulitis/erysipelas: diffuse skin infection characterized by spreading areas of redness, edema, and/or induration Wound infection: An infection characterized by purulent drainage from a wound with surrounding redness, edema, and/or induration Major cutaneous abscess: An infection characterized by a collection of pus within the dermis or deeper that is accompanied by redness, edema, and/or induration (...) Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2017 Clinical Trials

102. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections

Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03137173 Recruitment Status

2017 Clinical Trials

103. A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to <12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018)

A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to <12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018) A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to <12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to <12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018) The safety and scientific validity of this study is the responsibility

2017 Clinical Trials

104. Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus (Full text)

Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus Staphylococcus aureus is the leading cause of skin and skin structure infections (SSSI). The high frequency of recurring SSSI due to S. aureus, including methicillin-resistant S. aureus (MRSA) strains, despite high titers of specific antibodies and circulating T cells, implies that traditional adaptive immunity imparts incomplete protection (...) . We hypothesized that innate immune memory contributes to the protective host defense against recurring MRSA infection. To test this hypothesis, SSSI was induced in wild-type and rag1-/- mice in the BALB/c and C57BL/6 backgrounds. Prior infection (priming) of wild-type and rag1-/- mice of either background afforded protection against repeat infection, as evidenced by reduced abscess severities and decreased CFU densities compared to those in naive controls. Interestingly, protection was greater

2017 Infection and immunity PubMed

105. Management of acute bacterial skin and skin structure infections with a focus on patients at high risk of treatment failure (Full text)

Management of acute bacterial skin and skin structure infections with a focus on patients at high risk of treatment failure Over the last 25 years, the terminology of skin and soft tissue infections, as well as their classification for optimal management of patients, has changed. The so-called and recently introduced term 'acute bacterial skin and skin structure infections' (ABSSSIs), a cluster of fairly common types of infection, including abscesses, cellulitis, and wound infections, require

2017 Therapeutic advances in infectious disease PubMed

106. Thoughts from the bedside on antibiotics and I&D for abscesses

at 2:23 PM There was a really nicely done RCT on clinda vs bactrim vs no antibiotics for simple skin abscesses done in NEJM just recently. Great study – may be more benefit to abx (especially clinda in kids) than what I was taught. Comments are closed. Archives Archives Links @PEMTweets on Twitter © 2012-19 PEMBlog | All Rights Reserved | (...) Thoughts from the bedside on antibiotics and I&D for abscesses Thoughts from the bedside on antibiotics and I&D for abscesses – PEMBlog Search for: Search for: | 2017-08-29T14:09:37-04:00 August 29th, 2017 | , | Share this post About the Author: Related Posts February 27th, 2019 February 12th, 2019 January 30th, 2019 January 9th, 2019 January 8th, 2019 December 17th, 2018 December 13th, 2018 December 12th, 2018 November 27th, 2018 November 23rd, 2018 One Comment Benjamin Kinnear August 29, 2017

2017 PEM Blog

107. Reducing pain during incision and drainage of abscesses (Re-post)

of lidocaine (4-5 mg/kg for 1% lidocaine without epi, 7 mg/kg with epi) and aim just deep enough to create a subtle wheal and to hit the junction point of the local nerve fibers. Insert a 27 to 30 gauge needle at an oblique angle just under the epidermis a small distance away from the edge of the abscess (avoid injecting into the abscess which can be painful and ineffective). Inject in a ring around the abscess, going through already-numb skin when possible (this is where the topical 4% lidocaine helps (...) Reducing pain during incision and drainage of abscesses (Re-post) Reducing pain during incision and drainage of abscesses (Re-post) – PEMBlog Search for: Search for: Reducing pain during incision and drainage of abscesses (Re-post) Performing incision and drainage on an abscess is painful for the patient. I realize that is as obvious a statement as I could possibly make. I wanted to briefly touch on some of the many interventions that you can use to decrease pain during I&D. Before

2017 PEM Blog

108. Teaching Incision and Drainage: Perceived Educational Value of Abscess Models. (PubMed)

Teaching Incision and Drainage: Perceived Educational Value of Abscess Models. Incision and drainage (I&D) of skin abscesses is an important procedural skill for pediatric emergency medicine providers. Practical skills training using simulation provides an opportunity to learn and gain confidence with this invasive procedure. Our objective was to assess the perceived educational value of 2 versions of an abscess model as part of an educational workshop for teaching I&D.A combined didactic (...) and practical skills workshop was developed for use at 2 national conferences. The didactic content was created through an iterative process. To facilitate hands-on training, 2 versions of an abscess model were created: 1 constructed from a negative mold and the other using a 3-dimensional printer. Participants were surveyed regarding prior experience with I&D, procedural confidence, and perceptions of the educational utility of the models.Seventy physicians and 75 nurse practitioners participated

2017 Pediatric Emergency Care

109. Comparison of the loop technique with incision and drainage for soft tissue abscesses: A systematic review and meta-analysis. (PubMed)

Comparison of the loop technique with incision and drainage for soft tissue abscesses: A systematic review and meta-analysis. Skin and soft tissue infections are a common presentation to the emergency department. Traditional management of abscesses involves a linear incision through the center of the abscess with packing placed. The loop drainage technique (LDT) is an alternate approach that may reduce pain and scarring, as well as decrease the number of follow up visits needed. This systematic (...) healthcare costs, this technique should be considered for the treatment of skin and soft tissue abscesses in the ED setting, but further studies are needed.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 The American journal of emergency medicine

110. Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of <i>Pseudomonas aeruginosa</i> Infection. (Full text)

. Despite this antagonism, sufficient numbers of functioning neutrophils remained for proper containment of the abscesses, as neutrophil depletion resulted in an increased abscess size, the formation of dermonecrotic lesions on the skin, and the dissemination of P. aeruginosa to internal organs. Consistent with the specificity of the T3SS-neutrophil interaction, P. aeruginosa bacteria lacking a functional T3SS were fully capable of causing abscesses in a neutropenic host. Phenoxyacetamide inhibitors (...) Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection. Pseudomonas aeruginosa is a leading cause of intra-abdominal infections, wound infections, and community-acquired folliculitis, each of which may involve macro- or microabscess formation. The rising incidence of multidrug resistance among P. aeruginosa isolates has increased both the economic burden and the morbidity

2017 Antimicrobial Agents and Chemotherapy PubMed

111. Disseminated cryptococcosis with recurrent multiple abscesses in an immunocompetent patient: a case report and literature review. (Full text)

latex agglutination test has been established as a reliable diagnostic tool with overall sensitivities of 93-100%.We report a rare disseminated cryptococcosis case which presented with chronic recurrent multiple abscess in an immunocompetent male involving skin, lung, spine and iliac fossa without evidence of central nerve system involving. The results of serum cryptococcal latex agglutination tests and standard microbial cultures were negative. The patient underwent empirical anti-bacterial (...) Disseminated cryptococcosis with recurrent multiple abscesses in an immunocompetent patient: a case report and literature review. Cryptococcus neoformans is frequently present as an opportunistic pathogen mainly affecting immunocompromised populations. Disseminated C. neoformans infection in immunocompetent population is rare and usually involves lung and central nerve system. Cryptococcus from biologic samples can easily grow on routine fungal and bacterial culture media. Besides, cryptococcal

2017 BMC Infectious Diseases PubMed

112. Staphylococcus aureus Bacteremia Complicated by Psoas Abscess and Infective Endocarditis in a Patient with Atopic Dermatitis (Full text)

Staphylococcus aureus Bacteremia Complicated by Psoas Abscess and Infective Endocarditis in a Patient with Atopic Dermatitis The close relationship between atopic dermatitis (AD) and infective endocarditis (IE) has been implicated. Staphylococcus aureus colonization is frequently seen observed in AD patients' skin lesions. Although a case of IE due to S. aureus bacteremia in an AD patient has been sporadically reported, a case of S. aureus bacteremia complicated by psoas abscess and IE has (...) underwent successful surgical treatment of the heart lesions and subsequent percutaneous drainage of psoas abscess and received intensive antibiotics, which successfully improved his condition. Our report emphasizes awareness of the association between AD and invasive S. aureus infections.

2017 Case reports in infectious diseases PubMed

113. Derma-Stent Novel Abscess Packing Device

, MD, MPH, Wayne State University Study Details Study Description Go to Brief Summary: In this research study, a device called the Derma-Stent will be tested. The sponsor of the study, Mar-Med Company, will supply the device. This device is used to drain a cutaneous abscess, which is a skin infection that results in buildup of pus under the skin. Currently, the normal treatment for this abscess is to cut and drain and the wound, and later pack the wound with gauze. Packing is done to prevent (...) (z+y+z) by ultrasound greater or equal to 5 cm. Consent to participate in research protocol. Assessment by attending physician that the abscess will require packing. Exclusion Criteria: Patients requiring admission for skin and soft tissue infection. Abscess drainage requiring procedural sedation. Abscesses requiring incision and drainage in the operating room. Inability to comprehend consent and follow up instructions. Prisoners. Pregnant women. Contacts and Locations Go to Information from

2017 Clinical Trials

114. Pituitary abscess in an HIV-1-infected patient (Full text)

Pituitary abscess in an HIV-1-infected patient Pituitary abscess is a rare occurrence among pituitary conditions, but one which carries life-threatening potential. An immunocompromised status is a risk factor for the development of a pituitary abscess; however, literature describes only one case among HIV-infected patients.We present here a case of pituitary abscess in an HIV-1-positive patient, who demonstrated a shock status, disturbance of consciousness and generalized skin rash (...) with laboratory findings of hypovolemia, acute inflammatory reaction and blood electrolyte abnormality. We first diagnosed the dermal manifestation as atypical generalized zoster, however, the other clinical findings could not be explained by VZV infection only. Combination with anamnesis, head magnetic resonance imaging scan and endocrine function test helped us to diagnose pituitary abscess. Although the etiology of the pituitary abscess could not be detected, the patient was successfully treated

2017 SAGE Open Medical Case Reports PubMed

115. Acute Bacterial Meningitis and Systemic Abscesses due to Streptococcus dysgalactiae subsp. equisimilis Infection (Full text)

Acute Bacterial Meningitis and Systemic Abscesses due to Streptococcus dysgalactiae subsp. equisimilis Infection Disseminated abscesses due to group G β-hemolytic Streptococcus dysgalactiae were observed in a 57-year-old cirrhotic patient with the skin being the putative way of entry for the pathogen. S. dysgalactiae is a rare agent in human infections responsible for acute pyogenic meningitis. The mortality rate associated with S. dysgalactiae bacteraemia and meningitis may be as high as 50 (...) %, particularly in the presence of endocarditis or brain abscesses. In our patient, main sites of infections were meningitis and ventriculitis, spondylodiscitis, septic arthritis, and soft-tissue infections. In contrast, no endocarditis was evidenced. Cirrhosis-related immune suppression was considered as a pathophysiological cofactor for the condition. Fortunately, clinical status improved after long-term (3 months) antimicrobial therapy.

2017 Case reports in infectious diseases PubMed

116. Simple Wound Irrigation in the Postoperative Treatment for Surgically Drained Spontaneous Soft Tissue Abscesses: Study Protocol for a Prospective, Single-Blinded, Randomized Controlled Trial (Full text)

Simple Wound Irrigation in the Postoperative Treatment for Surgically Drained Spontaneous Soft Tissue Abscesses: Study Protocol for a Prospective, Single-Blinded, Randomized Controlled Trial Skin abscesses are a frequent encountered health care problem and lead to a significant source of morbidity. They consequently have an essential impact on the quality of life and work. To date, the type of aftercare for surgically drained abscesses remains under debate. This leads to undesirable practice (...) variations. Many clinical standard protocols include sterile wound dressings twice a day by a home-care service to reduce the chance of a recurrent wound infection. It is unknown, however, whether reinfection rates are comparable to adequate wound irrigation with a nonsterile solution performed by the patient. Our hypothesis is that simple wound irrigation with nonsterile water for postoperative wound care after an abscess is surgically drained is feasible. We assume that in terms of reinfection

2017 JMIR Research Protocols PubMed

117. Paradoxical worsening of a case of TB subretinal abscess with serpiginous-like choroiditis following the initiation of antitubercular therapy (Full text)

Paradoxical worsening of a case of TB subretinal abscess with serpiginous-like choroiditis following the initiation of antitubercular therapy A 37-year-old immunocompetent male patient presented with the blurring of vision, both eyes for the past1 year. Fundus examination revealed bilateral multiple subretinal abscesses with areas of healed serpiginous-like choroiditis. Laboratory investigations showed positive tuberculin skin test, positive QuantiFERON TB-Gold Test, and high resolution

2017 Indian journal of ophthalmology PubMed

118. Cadaver-based abscess model for medical training (Full text)

Cadaver-based abscess model for medical training Ultrasound imaging is a rapid and noninvasive tool ideal for the imaging of soft tissue infections and is associated with a change of clinician management plans in 50% of cases. We developed a realistic skin abscess diagnostic and therapeutic training model using fresh frozen cadavers and common, affordable materials. Details for construction of the model and suggested variations are presented. This cadaver-based abscess model produces high (...) -quality sonographic images with internal echogenicity similar to a true clinical abscess, and is ideal for teaching sonographic diagnostic skills in addition to the technical skills of incision and drainage or needle aspiration.

2017 Advances in medical education and practice PubMed

119. Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case (Full text)

Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case An abscess is defined as a collection of pus in various tissues of the body including skin and other organs. Abscesses most commonly are formed on the skin under the armpits, groin areas, and rectal areas. Most abscesses involve microbial infections with few remaining sterile. The treatment of abscesses includes both medical and surgical intervention. In the era of multidrug resistance, isolation and identification (...) conditions. Human infections with Listeria spp. have not been frequently reported, mostly because of the difficulty in laboratory identification and complex clinical presentations. In humans, Listeria spp. have been frequently responsible for food poisoning and neonatal meningitis. Although not considered as a classic pathogen, Listeria spp. are associated with infections in elderly people, pregnant women, newborns, and persons with weakened immune systems. This report presents a case of breast abscess

2017 Cureus PubMed

120. Packing versus non-packing outcomes for abscesses after incision and drainage (Full text)

Packing versus non-packing outcomes for abscesses after incision and drainage CLINICAL QUESTION: In non-diabetic, non-immunocompromised individuals with skin abscesses, does packing after incision and drainage (I&D) reduce the risk of recurrence or reintervention compared with not packing? ANSWER: No. If the abscess is less than 5 cm, packing does not affect outcomes. LEVEL OF EVIDENCE FOR THE ANSWER: B. DATE SEARCH WAS CONDUCTED: November 2014. INCLUSION CRITERIA: Published RCTs and meta (...) -analysis studies. EXCLUSION CRITERIA: Abscess greater than 5 cm, abscess in diabetics, abscess in immunocompromised.

2017 The Journal of the Oklahoma State Medical Association PubMed

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