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Skin Abscess

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81. The cutaneous microbiome in out-patients presenting acutely with skin abscesses. (PubMed)

The cutaneous microbiome in out-patients presenting acutely with skin abscesses. Previous studies have demonstrated an association between antibiotic use and the development of skin abscesses. We tested the hypothesis that alterations in the composition of the cutaneous microbiota may predispose individuals to skin abscesses.We studied 25 patients with skin abscesses and 25 age-matched controls, who each completed a questionnaire. Skin swab samples were obtained for DNA analysis from 4 sites (...) -abscess and contralateral skin samples, compared with control skin specimens. Analysis of community structure showed greater heterogeneity in the control samples than in the peri-abscess and contralateral samples. Metagenomic analysis detected significantly more predicted genes related to metabolic activity in the peri-abscess specimens than in the control samples.The peri-abscess microbiome was similar to the contralateral microbiome, but both microbiomes differed from that for control patients. Host

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2015 Journal of Infectious Diseases

82. Safety and Tolerability Study of Antimicrobial TheraGauze for Skin Abscess

Safety and Tolerability Study of Antimicrobial TheraGauze for Skin Abscess Safety and Tolerability Study of Antimicrobial TheraGauze for Skin Abscess - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety (...) and Tolerability Study of Antimicrobial TheraGauze for Skin Abscess The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02334384 Recruitment Status : Completed First Posted : January 8, 2015 Results First Posted : August 29, 2018 Last Update Posted : October 4, 2018 Sponsor: Eastern Virginia Medical School

2015 Clinical Trials

83. Multiple Skin Abscesses and Myofibrosis of Bilateral Lower Limbs Following Repeated Intramuscular Injection of Pentazocine with Concomitant Tuberculous Infection (PubMed)

Multiple Skin Abscesses and Myofibrosis of Bilateral Lower Limbs Following Repeated Intramuscular Injection of Pentazocine with Concomitant Tuberculous Infection Prescription drug abuse is a major health problem across the globe. Various complications associated with repeated injection of pentazocine are reported in the literature, including skin fibrosis, skin abscesses and ulceration, abnormal skin pigmentation and fibrous myopathy.We present a case of 48 year male with history of pentazocine (...) abuse. Patient developed multiple abscesses in both lower limbs with polymicrobial infection, one of them being mycobacterium tuberculosis. He also developed fibrous myopathy leading to stiff hip and knee.This case highlights the significance of the precaution that should be taken when prescribing opioid analgesics, such as pentazocine, as routine painkillers. With free over the counter access to these drugs in India and many developing countries, awareness of this complication is important so

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2015 Journal of orthopaedic case reports

84. Methicillin-Resistant Staphylococcus aureus: Decolonization and Prevention Prescribing Practices for Children Treated With Skin Abscesses/Boils in a Pediatric Emergency Department. (PubMed)

Methicillin-Resistant Staphylococcus aureus: Decolonization and Prevention Prescribing Practices for Children Treated With Skin Abscesses/Boils in a Pediatric Emergency Department. This study aimed to describe methicillin-resistant Staphylococcus aureus (MRSA) eradication/prevention practices of clinicians managing patients with skin and soft tissue infections (SSTIs), specifically, in those patients undergoing abscess incision and drainage (I&D) in a pediatric emergency department (ED (...) ).A retrospective cohort study was performed for children aged 0 to 18 years old undergoing I&D of cutaneous abscess between January 1, 2011, and December 31, 2011, in the Cincinnati Children's Hospital Medical Center ED.Five hundred seventy-five patients underwent abscess I&D during our study period. Approximately 25% of our population had previous history of MRSA, SSTI, or boil/abscess; in addition, 26% of our population had a household family member with a previous history of MRSA, SSTI, or boil/abscess

2015 Pediatric Emergency Care

85. The role of adjunctive antibiotics in the treatment of skin and soft tissue abscesses: a systematic review and meta-analysis. (PubMed)

The role of adjunctive antibiotics in the treatment of skin and soft tissue abscesses: a systematic review and meta-analysis. To perform a review and meta-analysis on the effect of antibiotics on treatment of skin and soft tissue abscesses (SSTAs) after incision and drainage.We searched MEDLINE, EMBASE, Web of Knowledge, and Google Scholar databases to identify randomized controlled trials (RCTs) and observational studies. For RCTs, we included studies comparing any antibiotic (treatment

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2015 CJEM

86. Single Intravenous Dose of Oritavancin for the Treatment of Gram-positive Acute Bacterial Skin and Skin Structure Infections: Summary of Safety from the Phase 3 SOLO studies. (PubMed)

Single Intravenous Dose of Oritavancin for the Treatment of Gram-positive Acute Bacterial Skin and Skin Structure Infections: Summary of Safety from the Phase 3 SOLO studies. Oritavancin is a lipoglycopeptide with bactericidal activity against Gram-positive organisms. Its rapid concentration-dependent bactericidal activity and long elimination half-life allow single-dose treatment of acute bacterial skin and skin structure infections (ABSSSI). SOLO I and SOLO II were randomized, double-blind (...) %, respectively) and vancomycin (56.9, 5.9, and 4.2%, respectively). The median time to onset (3.8 days versus 3.1 days, respectively) and the duration (3.0 days for both groups) of adverse events were also similar between the two groups. The most frequently reported events were nausea, headache, and vomiting. Greater than 90% of all events were mild or moderate in severity. There were slightly more infections and infestations, abscesses or cellulitis, and hepatic and cardiac adverse events in the oritavancin

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2018 Antimicrobial Agents and Chemotherapy

87. Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial. (PubMed)

) or adjacent to (control group) the pre-defined injection site(s). Clinicians, parents and children were blinded to group allocation. Parents reported local skin reactions using paper diaries for 15 days post-vaccination (Day 0-14). Telephone interviews were conducted Day 1, 5, and 14. The Brighton Collaboration criteria were used to diagnose cellulitis and infectious abscess Day 5 and afterward.170 children participated (May-November 2017). Baseline characteristics did not differ (p > 0.05) between groups (...) Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial. Recommendations: Regarding the need to use alcohol prior to vaccine injections are inconsistent and based on low-level evidence. The objective was to assess the effectiveness of alcohol in reducing local skin reactions and infection post-vaccination.Randomized controlled trial in a pediatric clinic. A research assistant cleansed the skin with alcohol at (swab group

2018 Human vaccines & immunotherapeutics

88. Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with systemic signs of infection diagnosed with acute bacterial skin and skin structure infection (ABSSSI) Diagnosed with Cellulitis/ erysipelas, major cutaneous abscess, or wound infections Exclusion Criteria: Uncomplicated skin infections Severe (...) Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

89. PSA: Incidental Skin and Inhalation Exposure to Fentanyl is NOT a thing!

serious infections like endocarditis, abscesses, or necrotizing fasciitis or risk exposure to HIV and hepatitis from sharing needles? One response to this is that those who are addicted to opioids have built up a tolerance so they won’t show any effects from skin or inhalational exposure but as we have just shown that is not possible. Also, let’s say you started by injecting fentanyl, wouldn’t you then want to switch over to skin absorption if that was at all possible? Carfentanil = Fentanyl (...) PSA: Incidental Skin and Inhalation Exposure to Fentanyl is NOT a thing! PSA: Incidental Skin and Inhalation Exposure to Fentanyl is NOT a thing! | EM Basic Today’s episode of the podcast is a myth busting on all the media reports about first responders overdosing by being exposed to fentanyl in the field by incidental contact. This is physically impossible and the misinformation out there has scared a lot of people, cost us lots of money in the form of hazmat responses and shutting down

2019 Publication 4890895

90. Injectable Lidocaine Provides Similar Analgesia Compared to Transdermal Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses: A Randomized, Controlled Trial. (PubMed)

Injectable Lidocaine Provides Similar Analgesia Compared to Transdermal Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses: A Randomized, Controlled Trial. Local anesthesia used for incision and drainage of abscesses is known to be painful.We studied the analgesia provided by a lidocaine/tetracaine patch compared to injectable lidocaine during incision and drainage (I&D) of skin abscesses.This was a prospective, double-blind, randomized, controlled trial carried out (...) in the Emergency Department (ED) of an adult tertiary referral center. Adult patients with a skin abscess in need of I&D were randomized to one of two groups. One group received a lidocaine/tetracaine patch and injectable normal saline for anesthesia. The second group received a placebo patch and injectable 1% lidocaine. A visual analog pain scale was used to record the patient's pain level prior to treatment, during the procedure, and after I&D.There were 20 patients enrolled in the study, including 12

2014 Journal of Emergency Medicine

91. Successful treatment following early recognition of a case of Fournier’s scrotal gangrene after a perianal abscess debridement: a case report (PubMed)

for severe scrotal and perianal pain, swelling, and high fever. A physical examination revealed a perianal abscess. Furthermore, the scrotum was gangrenous and exhibited extensive cellulitis in the perineum and bilateral inguinal area. Crepitations between the skin and fascia were palpable. A diagnosis of Fournier's gangrene was made. The patient was treated with immediate surgical debridement under general anesthesia. He received broad-spectrum antibiotics, and debridement was repeated until the wound (...) Successful treatment following early recognition of a case of Fournier’s scrotal gangrene after a perianal abscess debridement: a case report Fournier's gangrene is an acute surgical emergency characterized by high mortality rates ranging from approximately 13% to 45%. Therefore, aggressive multidisciplinary management is necessary.A 29-year-old Asian man who had undergone surgical debridement at another hospital to treat a perianal abscess 5 days earlier was admitted to our hospital

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2018 Journal of medical case reports

92. De-roofing and Curettage vs WLE for Pilonidal Abscess

links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Abscess de-roofing and curettage Abscess de-roofing and curettage. The patient will be placed in the lateral position with the buttocks spread apart using tape. The cleft of the buttocks will be shaved prior to cleaning and preparation of the skin. A spindle-shaped (elliptical) excision will be performed to the lateral aspect of the abscess formation (...) -roofing and curettage Abscess de-roofing and curettage Active Comparator: Abscess wide local excision Wide local excision. Patients will be placed in the prone position with the buttocks spread apart using tape. The cleft of the buttocks will be shaved prior to cleaning and preparation of the skin. Diluted methylene blue will be injected in all visible pits and a wide spindle-shaped (elliptical) midline excision of the skin and the underlying subcutaneous tissue down to the coccygeal (pre-sacral

2018 Clinical Trials

93. Scleredema Diabeticorum with Superimposed Cellulitis and Abscess Formation (PubMed)

Scleredema Diabeticorum with Superimposed Cellulitis and Abscess Formation Scleredema diabeticorum is a rare cutaneous manifestation of diabetes mellitus. We present a case of an obese male with poorly controlled diabetes who came to the hospital with upper back pain and subsequently developed sepsis due to a small deep-seated abscess in his back that was drained and treated with antibiotics. He was also found to have extensive induration of the skin over his back and neck. Skin biopsy

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2018 Case reports in endocrinology

94. Spontaneous subconjunctival abscess in congenital lamellar ichthyosis (PubMed)

Spontaneous subconjunctival abscess in congenital lamellar ichthyosis Congenital lamellar ichthyosis is an autosomal recessive, heterogeneous disorder presenting at birth with generalized skin involvement. The most common ophthalmic manifestation noted is bilateral ectropion of the lower eyelids. A 1-month-old female neonate, the second born of a nonconsanguineous marriage, presented with 4 days' history of redness, discharge, and swelling in the right eye. There was severe right upper eyelid (...) ectropion, conjunctival injection, chemosis, a subconjunctival mass on the temporal bulbar conjunctiva spontaneously draining pus and corneal haze. The anterior chamber, iris, lens and fundus appeared normal. Congenital lamellar ichthyosis was suspected because of scaling and excessive dryness of the entire body. The occurrence of a spontaneous subconjunctival abscess is not known in lamellar ichthyosis. We thus report the management of a rare case of unilateral upper eyelid ectropion, subconjunctival

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2018 Indian journal of ophthalmology

95. Breast abscess caused by Staphylococcus aureus in 2 adolescent girls with atopic dermatitis (PubMed)

Breast abscess caused by Staphylococcus aureus in 2 adolescent girls with atopic dermatitis Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by Staphylococcus aureus. Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused by S. aureus in 2 adolescent girls with severe AD. Methicillin (...) -sensitive S. aureus was identified from the breast abscess material. They were treated with appropriate antibiotics, however surgical drainage of the abscess was needed in case 1. Identical strains were found from the breast abscess material as well as the lesional and the nonlesional skin of the patients through matrixassisted laser desorption/ionization time-of-flight analysis. We characterized the differential abundance of Firmicutes phylum in patients' skin in microbiota analysis. In particular, S

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2018 Korean journal of pediatrics

96. Staphylococcus pseudintermedius Surface Protein L (SpsL) Is Required for Abscess Formation in a Murine Model of Cutaneous Infection (PubMed)

Staphylococcus pseudintermedius Surface Protein L (SpsL) Is Required for Abscess Formation in a Murine Model of Cutaneous Infection Staphylococcus pseudintermedius is the leading cause of pyoderma in dogs and is often associated with recurrent skin infections that require prolonged antibiotic therapy. High levels of antibiotic use have led to multidrug resistance, including the emergence of epidemic methicillin-resistant clones. Our understanding of the pathogenesis of S. pseudintermedius skin (...) deficient in expression of SpsD led to a focal accumulation of neutrophils and necrotic debris in the dermis and deeper tissues of the skin characteristic of a classical cutaneous abscess. In contrast, mice infected with mutants deficient in SpsL or both SpsD and SpsL developed larger cutaneous lesions with distinct histopathological features of regionally extensive cellulitis rather than focal abscessation. Furthermore, comparison of the bacterial loads in S. pseudintermedius-induced cutaneous lesions

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2018 Infection and immunity

97. Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis (PubMed)

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis We herein present the case of a 43-year-old male diabetic patient who presented with an aggressive form of infective endocarditis involving the tricuspid, mitral and aortic valves following a gluteal abscess due to infection with Staphylococcus lugdunensis. This coagulase-negative organism which is generally considered a component of the normal flora of the skin has however recently emerged

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2018 Saudi medical journal

98. Methicillin-resistant Staphylococcus aureus prostatic abscess after traumatic rectal injury (PubMed)

Methicillin-resistant Staphylococcus aureus prostatic abscess after traumatic rectal injury Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes infection of the skin, soft tissue, bones and heart. MRSA is a rarely reported organism of prostatic abscess (PA). We present a case of an intravenous drug user who presented with dyspareunia, dysuria and dyschezia after a traumatic injury to the rectum. He was diagnosed with PA, which was treated with transurethral resection (...) of the prostate drainage and intravenous antibiotics. MRSA PA carries a low case fatality rate on early diagnosis and treatment with proper antibiotics with or without drainage of the abscess.

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2018 Oxford Medical Case Reports

99. Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)

a written informed consent Subjects with ABSSSI characterized by any of the following infection types: Cellulitis/erysipelas: diffuse skin infection characterized by spreading areas of redness, edema, and/or induration Wound infection: An infection characterized by purulent drainage from a wound with surrounding redness, edema, and/or induration Major cutaneous abscess: An infection characterized by a collection of pus within the dermis or deeper that is accompanied by redness, edema, and/or induration (...) Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2017 Clinical Trials

100. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections

Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03137173 Recruitment Status

2017 Clinical Trials

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