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Skin Abscess

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21. Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice (PubMed)

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus (MRSA) infection engages phagocyte chemotaxis, abscess formation, and microbial clearance. Upon infection, neutrophils and monocytes find a gradient of chemoattractants that influence both phagocyte direction and microbial (...) clearance. The bioactive lipid leukotriene B4 (LTB4) is quickly (seconds to minutes) produced by 5-lipoxygenase (5-LO) and signals through the G protein-coupled receptors LTB4R1 (BLT1) or BLT2 in phagocytes and structural cells. Although it is known that LTB4 enhances antimicrobial effector functions in vitro, whether prompt LTB4 production is required for bacterial clearance and development of an inflammatory milieu necessary for abscess formation to restrain pathogen dissemination is unknown. We found

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2018 PLoS pathogens

22. Trimethoprim-Sulfamethoxazole Therapy Reduces Failure and Recurrence in Methicillin-Resistant Staphylococcus aureus Skin Abscesses after Surgical Drainage (PubMed)

Trimethoprim-Sulfamethoxazole Therapy Reduces Failure and Recurrence in Methicillin-Resistant Staphylococcus aureus Skin Abscesses after Surgical Drainage To determine whether a 3-day vs 10-day course of antibiotics after surgical drainage of skin abscesses is associated with different failure and recurrence rates.Patients age 3 months to 17 years seeking care at a pediatric emergency department with an uncomplicated skin abscess that required surgical drainage were randomized to receive 3 (...) difference 10.3%, 95% CI 0.8%-19.9%).Patients with MRSA skin abscesses are more likely to experience treatment failure and recurrent skin infection if given 3 rather than 10 days of trimethoprim-sulfamethoxazole after surgical drainage.ClinicalTrials.gov: NCT02024867.Copyright © 2016 Elsevier Inc. All rights reserved.

2016 EvidenceUpdates

23. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. (PubMed)

Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 27468069 2016 08 02 2018 12 02 1533-4406 375 3 2016 07 21 The New England journal of medicine N. Engl. J. Med. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 285-6 10.1056/NEJMc1605392 Talan David A DA Mower William R WR Krishnadasan Anusha A eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 8064-90-2 Trimethoprim, Sulfamethoxazole Drug Combination AIM IM N Engl J Med. 2016 Mar (...) 3;374(9):823-32 26962903 N Engl J Med. 2016 Jul 21;375(3):284 27468070 N Engl J Med. 2016 Jul 21;375(3):284-5 27468071 N Engl J Med. 2016 Jul 21;375(3):285 27468072 Abscess drug therapy Anti-Bacterial Agents therapeutic use Drainage Female Humans Male Skin Diseases, Bacterial drug therapy Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use 2016 7 29 6 0 2016 7 29 6 0 2016 8 3 6 0 ppublish 27468069 10.1056/NEJMc1605392 10.1056/NEJMc1605392#SA4

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2016 NEJM

24. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. (PubMed)

Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 27468070 2016 08 02 2018 12 02 1533-4406 375 3 2016 07 21 The New England journal of medicine N. Engl. J. Med. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 284 10.1056/NEJMc1605392 Spellberg Brad B LAC+USC Medical Center, Los Angeles, CA bspellberg@dhs.lacounty.gov. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 8064-90-2 Trimethoprim, Sulfamethoxazole Drug Combination AIM IM (...) N Engl J Med. 2016 Mar 3;374(9):823-32 26962903 N Engl J Med. 2016 Jul 21;375(3):285-6 27468069 Abscess drug therapy Anti-Bacterial Agents therapeutic use Drainage Female Humans Male Skin Diseases, Bacterial drug therapy Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use 2016 7 29 6 0 2016 7 29 6 0 2016 8 3 6 0 ppublish 27468070 10.1056/NEJMc1605392 10.1056/NEJMc1605392#SA1

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2016 NEJM

25. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. (PubMed)

Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 27468071 2016 08 02 2018 12 02 1533-4406 375 3 2016 07 21 The New England journal of medicine N. Engl. J. Med. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 284-5 10.1056/NEJMc1605392 Leiner Steven S Mission Neighborhood Health Center, San Francisco, CA steven.leiner@gmail.com. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 8064-90-2 Trimethoprim, Sulfamethoxazole Drug (...) Combination AIM IM N Engl J Med. 2016 Mar 3;374(9):823-32 26962903 N Engl J Med. 2016 Jul 21;375(3):285-6 27468069 Abscess drug therapy Anti-Bacterial Agents therapeutic use Drainage Female Humans Male Skin Diseases, Bacterial drug therapy Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use 2016 7 29 6 0 2016 7 29 6 0 2016 8 3 6 0 ppublish 27468071 10.1056/NEJMc1605392 10.1056/NEJMc1605392#SA2

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2016 NEJM

26. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. (PubMed)

Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 27468072 2016 08 02 2018 12 02 1533-4406 375 3 2016 07 21 The New England journal of medicine N. Engl. J. Med. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. 285 10.1056/NEJMc1605392 Pollara Gabriele G University College London, London, United Kingdom g.pollara@ucl.ac.uk. Marks Michael M London School of Hygiene and Tropical Medicine, London, United Kingdom. eng Letter Comment United States N Engl J Med 0255562 0028 (...) -4793 0 Anti-Bacterial Agents 8064-90-2 Trimethoprim, Sulfamethoxazole Drug Combination AIM IM N Engl J Med. 2016 Mar 3;374(9):823-32 26962903 N Engl J Med. 2016 Jul 21;375(3):285-6 27468069 Abscess drug therapy Anti-Bacterial Agents therapeutic use Drainage Female Humans Male Skin Diseases, Bacterial drug therapy Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use 2016 7 29 6 0 2016 7 29 6 0 2016 8 3 6 0 ppublish 27468072 10.1056/NEJMc1605392 10.1056/NEJMc1605392#SA3

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2016 NEJM

27. A Trial of Antibiotics for Smaller Skin Abscesses. (PubMed)

A Trial of Antibiotics for Smaller Skin Abscesses. 29281570 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Daum Robert S RS University of Maryland, Baltimore, MD rdaum@som.umaryland.edu Kumar Neha N University of California at San Francisco, San Francisco, CA Chambers Henry F HF University of California at San Francisco, San Francisco, CA eng Letter Comment United (...) States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM N Engl J Med. 2017 Dec 28;377(26):e36 29281571 N Engl J Med. 2017 Dec 28;377(26):e36 29282969 N Engl J Med. 2017 Dec 28;377(26):e36 29282970 Abscess Anti-Bacterial Agents Drainage Humans Skin Diseases 2017 12 28 6 0 2017 12 28 6 0 2018 1 2 6 0 ppublish 29281570 10.1056/NEJMc1711124#SA4 10.1056/NEJMc1711124

2018 The New England journal of medicine

28. A Trial of Antibiotics for Smaller Skin Abscesses. (PubMed)

A Trial of Antibiotics for Smaller Skin Abscesses. 29282969 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Nurjadi Dennis D University Hospitals, Heidelberg, Germany Heeg Klaus K University Hospitals, Heidelberg, Germany Zanger Philipp P University Hospitals, Heidelberg, Germany philipp.zanger@uni-heidelberg.d Staph Trav Network eng Letter Comment United States N (...) Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM N Engl J Med. 2017 Jun 29;376(26):2545-2555 28657870 N Engl J Med. 2017 Dec 28;377(26):e36 29281570 Abscess Anti-Bacterial Agents Drainage Humans Skin Diseases 2017 12 29 6 0 2017 12 29 6 0 2018 1 2 6 0 ppublish 29282969 10.1056/NEJMc1711124 10.1056/NEJMc1711124#SA2

2018 The New England journal of medicine

29. A Trial of Antibiotics for Smaller Skin Abscesses. (PubMed)

A Trial of Antibiotics for Smaller Skin Abscesses. 29282970 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Yeoh Daniel K DK Princess Margaret Hospital for Children, Perth, WA, Australia daniel.yeoh@health.wa.gov.au Blyth Christopher C CC Princess Margaret Hospital for Children, Perth, WA, Australia Bowen Asha C AC Princess Margaret Hospital for Children, Perth, WA (...) , Australia eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM N Engl J Med. 2017 Jun 29;376(26):2545-2555 28657870 N Engl J Med. 2017 Dec 28;377(26):e36 29281570 Abscess Anti-Bacterial Agents Drainage Humans Skin Diseases 2017 12 29 6 0 2017 12 29 6 0 2018 1 2 6 0 ppublish 29282970 10.1056/NEJMc1711124 10.1056/NEJMc1711124#SA3

2018 The New England journal of medicine

30. Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis. (PubMed)

Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis. To assess the impact of adjunctive antibiotic therapy on uncomplicated skin abscesses.Systematic review and network meta-analysis.Medline, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov.A BMJ Rapid Recommendation panel provided input on design, important outcomes and the interpretation of the results. Eligible randomised controlled trials (RCTs) included a comparison (...) of antibiotics against no antibiotics or a comparison of different antibiotics in patients with uncomplicated skin abscesses, and reported outcomes prespecified by the linked guideline panel.Reviewers independently screened abstracts and full texts for eligibility, assessed risk of bias and extracted data. We performed random-effects meta-analyses that compared antibiotics with no antibiotics, along with a limited number of prespecified subgroup hypotheses. We also performed network meta-analysis

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2018 BMJ open

31. Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis. (PubMed)

Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis. The addition of antibiotics to standard incision and drainage is controversial, with earlier studies demonstrating no significant benefit. However, 2 large, multicenter trials have recently been published that have challenged the previous literature. The goal of this review was to determine whether systemic antibiotics for abscesses after incision and drainage improve cure (...) 0.32, 95% CI 0.23 to 0.44), with a minimally increased risk of minor adverse events (risk difference 4.4%, 95% CI 1.0% to 7.8%; odds ratio 1.29, 95% CI 1.06 to 1.58).The use of systemic antibiotics for skin and soft tissue abscesses after incision and drainage resulted in an increased rate of clinical cure. Providers should consider the use of antibiotics while balancing the risk of adverse events.Copyright © 2018 American College of Emergency Physicians. Published by Elsevier Inc. All rights

2018 Annals of Emergency Medicine

32. Management of community-associated methicillin-resistant Staphylococcus aureus skin abscesses in children

Management of community-associated methicillin-resistant Staphylococcus aureus skin abscesses in children Uncomplicated skin abscesses in previously well children are typically managed with drainage alone. An increasing percentage of such abscesses are due to methicillin-resistant Staphylococcus aureus infections. Although definitive data are lacking, drainage alone appears to be a reasonable strategy for methicillin-resistant S aureus skin abscesses, with antibiotics reserved for infants (...) younger than three months of age, or for children who are systemically unwell, have underlying medical problems or have significant surrounding cellulitis.  Key Words: Methicillin-resistant; Skin abscess; Staphylococcus aureus  

2011 Canadian Paediatric Society

33. Mastitis and breast abscess

-like symptoms, malaise, and myalgia fever breast pain decreased milk outflow breast warmth breast tenderness breast firmness breast swelling breast erythema breast mass fistula nipple discharge nipple inversion/retraction lymphadenopathy extra-mammary skin lesions female sex women aged >30 years poor breastfeeding technique lactation milk stasis nipple injury previous mastitis prolonged mastitis (breast abscess) prior breast abscess (breast abscess) shaving or plucking areola hair anatomical breast (...) defect, mammoplasty, or scar other underlying breast condition nipple piercing foreign body skin infection Staphylococcus aureus carrier immunosuppression hospital admission breast trauma primiparity overabundant milk supply post-maturity (breast abscess) complications of delivery maternal fatigue tight clothing antifungal nipple cream fibrocystic breast disease cigarette smoking vaginal manipulation (breast abscess) poor nutrition antiretroviral therapy Diagnostic investigations breast ultrasound

2018 BMJ Best Practice

34. Liver abscess

Disclosures RPS has been reimbursed by DynaMed for reviewing topics on cellulitis, skin abscess, and mammalian bites. There is no overlap in content to this topic. RPS also receives an honorarium for writing and editing American Board of Internal Medicine board examination questions. Professor of Medicine Harvard Medical School and Tufts University School of Medicine Boston MA Disclosures LSF has received royalties from Elsevier, Wiley, McGraw-Hill, and UpToDate, and has received honoraria from (...) Liver abscess Liver abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Liver abscess Last reviewed: February 2019 Last updated: March 2018 Summary A localised infection in the liver parenchyma that may be bacterial, fungal, or parasitic in origin. Patients typically present with non-specific constitutional symptoms, RUQ abdominal pain, and tenderness. The most common underlying condition in people with pyogenic

2018 BMJ Best Practice

35. Prospective observational study to assess the need for postoperative antibiotics following surgical incision and drainage of skin and soft tissue abscess in pediatric patients. (PubMed)

Prospective observational study to assess the need for postoperative antibiotics following surgical incision and drainage of skin and soft tissue abscess in pediatric patients. Post-operative antibiotics are often utilized for skin and soft tissue infection (SSTI) requiring surgical incision and drainage (I&D). We propose that antibiotics are unnecessary following I&D.Patients aged 3months to 6years with SSTI of the buttocks, groin, thigh, and/or labia requiring I&D were prospectively enrolled

2017 Journal of Pediatric Surgery

36. In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review and meta-an (PubMed)

In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review and meta-an The primary objective of this systematic review was to determine the accuracy of point-of-care ultrasonography (POCUS) in diagnosing abscess in emergency department (ED) patients with skin and soft tissue infections (SSTI). The secondary (...) with SSTI and abscess or cellulitis, a defined POCUS protocol, a clearly defined gold standard for abscess and a contingency table describing sensitivity and specificity. Two reviewers independently ascertained all potentially relevant citations for methodologic quality according to QUADAS-2 criteria. The primary outcome measure was the sensitivity and specificity of POCUS for abscess. A preplanned subgroup (secondary) analysis examined the effects in paediatric populations, and changes in management

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2017 BMJ open

37. Subgroup Analysis of Antibiotic Treatment for Skin Abscesses. (PubMed)

Subgroup Analysis of Antibiotic Treatment for Skin Abscesses. Two large randomized trials recently demonstrated efficacy of methicillin-resistant Staphylococcus aureus (MRSA)-active antibiotics for drained skin abscesses. We determine whether outcome advantages observed in one trial exist across lesion sizes and among subgroups with and without guideline-recommended antibiotic indications.We conducted a planned subgroup analysis of a double-blind, randomized trial at 5 US emergency departments (...) , demonstrating superiority of trimethoprim-sulfamethoxazole (320/1,600 mg twice daily for 7 days) compared with placebo for patients older than 12 years with a drained skin abscess. We determined between-group differences in rates of clinical (no new antibiotics) and composite cure (no new antibiotics or drainage) through 7 to 14 and 42 to 56 days after treatment among subgroups with and without abscess cavity or erythema diameter greater than or equal to 5 cm, history of MRSA, fever, diabetes

2017 Annals of Emergency Medicine

38. Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin Positive S. aureus Mimic Hyper IgE Syndrome in an Infant. (PubMed)

Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin Positive S. aureus Mimic Hyper IgE Syndrome in an Infant. We describe the clinical course of a 2-month-old infant who was evaluated for autosomal dominant Hyper IgE Syndrome based on eczema, periorbital cellulitis, skin abscesses, increased total IgE levels and blood eosinophilia. However, scabies and nasal colonization by Panton-Valentine Leucocidin-positive S. aureus were eventually diagnosed

2017 Pediatric Infectious Dsease Journal

39. Correction: In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review (PubMed)

Correction: In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review 28912196 2018 02 06 2044-6055 7 9 2017 09 14 BMJ open BMJ Open Correction: In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography (...) for the diagnosis of abscess compared to the current standard of care? A systematic review and meta-analysis . e013688corr1 10.1136/bmjopen-2016-013688corr1 eng Journal Article Published Erratum 2017 09 14 England BMJ Open 101552874 2044-6055 BMJ Open. 2017 Jan 10;7(1):e013688 28073795 2017 9 16 6 0 2017 9 16 6 0 2017 9 16 6 1 epublish 28912196 bmjopen-2016-013688corr1 10.1136/bmjopen-2016-013688corr1 PMC5640141

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2017 BMJ open

40. Bacterial Etiology and Risk Factors Associated with Cellulitis and Purulent Skin Abscesses in Military Trainees. (PubMed)

Bacterial Etiology and Risk Factors Associated with Cellulitis and Purulent Skin Abscesses in Military Trainees. Military trainees are at high risk for skin and soft-tissue infections (SSTIs). Although Staphylococcus aureus is associated with purulent SSTI, it is unclear to what degree this pathogen causes nonpurulent cellulitis. To inform effective prevention strategies and to provide novel insights into SSTI pathogenesis, we aimed to determine the etiology of SSTI in this population. We (...) conducted a prospective observational study in US Army Infantry trainees with SSTI (cutaneous abscesses and cellulitis) from July 2012 through December 2014. We used standard microbiology, serology, and high-throughput sequencing to determine the etiology of SSTI. Furthermore, we compared purported risk factors as well as anatomic site colonization for S. aureus. Among 201 SSTI cases evaluated for SSTI risk factors, cellulitis was associated with lower extremity blisters (P = 0.01) and abscess

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2016 PLoS ONE

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