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1. Antibiotics after incision and drainage for uncomplicated skin abscesses Full Text available with Trip Pro

Antibiotics after incision and drainage for uncomplicated skin abscesses Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline | The BMJ Intended for healthcare professionals Username * Password * Edition: Search form Search Search Antibiotics after... Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline CC BY NC Open access (Published 06 February 2018) Cite this as: BMJ 2018;360:k243 Population (...) This recommendation applies to almost all patients with skin abscesses: People with skin abscesses Children and adults Unknown or unconfirmed pathogen(s) Smaller and larger abscesses Emergency and primary care settings However the recommendation is not applicable to patients with: Evidence of systemic illness (sepsis) Pustules and papules Deep tissue infections Immunocompromising conditions Hidradenitis suppurativa Patients who do not undergo incision and drainage Comparison 1 or No antibiotics Antibiotics

2018 BMJ Rapid Recommendations

4. Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis

Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis Michael Gottlieb, MD*; Joshua M. DeMott, PharmD, MSc; Marilyn Hallock, MD, MS; Gary D. Peksa, PharmD *Corresponding Author. E-mail: michaelgottliebmd@gmail.com, Twitter: @MGottliebMD. Study objective: The addition of antibiotics to standard incision and drainage (...) /10.1016/j.annemergmed.2018.02.011 INTRODUCTION Background Skinandsofttissueinfectionsareacommonpresentation toboththe emergencydepartment(ED) and outpatient clinics, comprisingmorethan6 millionvisits each year in theUnited States. 1,2 Abscesses represent nearly halfof all cases and theoverall incidence isincreasing annually. 2-5 Although the standard clinical management of skin and soft tissue abscesses includes incision and drainage, the adjunctive use of systemic antibiotics remains controversial. 6

2018 Annals of Emergency Medicine Systematic Review Snapshots

5. Trimethoprim?Sulfamethoxazole for Uncomplicated Skin Abscess

Trimethoprim?Sulfamethoxazole for Uncomplicated Skin Abscess BestBets: Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Abscess Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Abscess Report By: Reece Baker MD and Jason Seamon DO - Emergency Medicine Physicians Institution: Grand Rapids Medical Education Research Partners/Michigan State University Date Submitted: 30th May 2016 Date Completed: 11th February 2017 Last Modified: 11th February 2017 Status: Green (complete) Three Part (...) Question In [patients with uncomplicated skin abscesses who have undergone abscess incision and drainage], does [treatment with oral trimethoprim-sulfamethoxazole compared to placebo] [reduce treatment failure at 7 days]? Clinical Scenario A man aged 21 years presents to the ED with a 3-day history of increasing redness, swelling and pain in his right thigh. On examination there is an area of fluctuance, approximately 3 cm in diameter, with associated tenderness, on the right anterior thigh. Erythema

2017 BestBETS

6. Adjunctive antibiotics for drained skin abscesses improve clinical cure rate

Adjunctive antibiotics for drained skin abscesses improve clinical cure rate Adjunctive antibiotics for drained skin abscesses improve clinical cure rate | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts (...) Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Adjunctive antibiotics for drained skin abscesses improve clinical cure rate Article Text Commentary: General medicine Adjunctive antibiotics for drained skin abscesses improve clinical cure rate David A Talan Statistics from

2017 Evidence-Based Medicine

7. Lack of Receptor for Advanced Glycation End products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound healing. Full Text available with Trip Pro

Lack of Receptor for Advanced Glycation End products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound healing. Lack of receptor for advanced glycation end products (RAGE) ameliorates several infections including Staphylococcus aureus pneumonia. We sought to investigate the role of RAGE in staphylococcal skin infection in mice.Wild-type (WT) and RAGE deficient (RAGE-/-) mice were subcutaneously inoculated with S. aureus SH1000 strain in abscess (...) -forming dose or necrotic dose. Clinical signs of dermatitis, along with histopathological changes, were compared between the groups.The skin lesion size was smaller in RAGE-/- mice. Infected RAGE-/- mice expressed lower proinflammatory cytokines in local skins compared to control mice. Low dose of bacteria caused more abscess formation in RAGE-/- mice compared to skin necrosis that was more often observed in WT mice. As a result of more abscess formation, the wound healing was prolonged in RAGE

2018 Journal of Infectious Diseases

8. Multiple neonatal Staphylococcal cold abscesses in large skin folds: a benign neonatal skin infection. (Abstract)

Multiple neonatal Staphylococcal cold abscesses in large skin folds: a benign neonatal skin infection. 30388319 2019 03 20 1468-3083 33 3 2019 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Multiple neonatal staphylococcal cold abscesses in large skin folds: a benign neonatal skin infection. e125-e128 10.1111/jdv.15323 Hubiche T T Department of Dermatology and Infectious Diseases, Fréjus Saint Raphaël Hospital, Fréjus, France. Chiaverini (...) and Infectious Diseases, Fréjus Saint Raphaël Hospital, Fréjus, France. Boralevi F F Department of Pediatric Dermatology, National Center for Rare Skin Disorders- INSERM U1035, Bordeaux, France. ‘Groupe de Recherche de la Société Française de Dermatologie Pédiatrique’ eng Letter 2018 11 25 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2018 11 6 6 0 2018 11 6 6 0 2018 11 3 6 0 ppublish 30388319 10.1111/jdv.15323

2018 Journal of the European Academy of Dermatology and Venereology

9. Mastitis and breast abscess

-like symptoms, malaise, and myalgia fever breast pain decreased milk outflow breast warmth breast tenderness breast firmness breast swelling breast erythema breast mass fistula nipple discharge nipple inversion/retraction lymphadenopathy extra-mammary skin lesions female sex women aged >30 years poor breastfeeding technique lactation milk stasis nipple injury previous mastitis prolonged mastitis (breast abscess) prior breast abscess (breast abscess) shaving or plucking areola hair anatomical breast (...) defect, mammoplasty, or scar other underlying breast condition nipple piercing foreign body skin infection Staphylococcus aureus carrier immunosuppression hospital admission breast trauma primiparity overabundant milk supply post-maturity (breast abscess) complications of delivery maternal fatigue tight clothing antifungal nipple cream fibrocystic breast disease cigarette smoking vaginal manipulation (breast abscess) poor nutrition antiretroviral therapy Diagnostic investigations breast ultrasound

2019 BMJ Best Practice

10. Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections Full Text available with Trip Pro

Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections - Journal of Vascular and Interventional Radiology Email/Username: Password: Remember me Available now: Use your SIR login to access JVIR. Search Terms Search within Search Share this page (...) Access provided by Article in Press Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections x Sean R. Dariushnia Affiliations Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image-Guided Medicine, Emory University School of Medicine, Atlanta, Georgia Correspondence Address correspondence to S.R.D., c/o Elizabeth Himes, SIR, 3975 Fair Ridge Dr., Suite 400 N

2020 Society of Interventional Radiology

11. Mastitis and breast abscess

-like symptoms, malaise, and myalgia fever breast pain decreased milk outflow breast warmth breast tenderness breast firmness breast swelling breast erythema breast mass fistula nipple discharge nipple inversion/retraction lymphadenopathy extra-mammary skin lesions female sex women aged >30 years poor breastfeeding technique lactation milk stasis nipple injury previous mastitis prolonged mastitis (breast abscess) prior breast abscess (breast abscess) shaving or plucking areola hair anatomical breast (...) defect, mammoplasty, or scar other underlying breast condition nipple piercing foreign body skin infection Staphylococcus aureus carrier immunosuppression hospital admission breast trauma primiparity overabundant milk supply post-maturity (breast abscess) complications of delivery maternal fatigue tight clothing antifungal nipple cream fibrocystic breast disease cigarette smoking vaginal manipulation (breast abscess) poor nutrition antiretroviral therapy Diagnostic investigations breast ultrasound

2018 BMJ Best Practice

12. Liver abscess

Disclosures RPS has been reimbursed by DynaMed for reviewing topics on cellulitis, skin abscess, and mammalian bites. There is no overlap in content to this topic. RPS also receives an honorarium for writing and editing American Board of Internal Medicine board examination questions. Professor of Medicine Harvard Medical School and Tufts University School of Medicine Boston MA Disclosures LSF has received royalties from Elsevier, Wiley, McGraw-Hill, and UpToDate, and has received honoraria from (...) Liver abscess Liver abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Liver abscess Last reviewed: February 2019 Last updated: March 2018 Summary A localised infection in the liver parenchyma that may be bacterial, fungal, or parasitic in origin. Patients typically present with non-specific constitutional symptoms, RUQ abdominal pain, and tenderness. The most common underlying condition in people with pyogenic

2018 BMJ Best Practice

13. A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. Full Text available with Trip Pro

A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. Uncomplicated skin abscesses are common, yet the appropriate management of the condition in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear.We conducted a multicenter, prospective, double-blind trial involving outpatient adults and children. Patients were stratified according to the presence of a surgically drainable abscess, abscess size, the number of sites of skin infection (...) , and the presence of nonpurulent cellulitis. Participants with a skin abscess 5 cm or smaller in diameter were enrolled. After abscess incision and drainage, participants were randomly assigned to receive clindamycin, trimethoprim-sulfamethoxazole (TMP-SMX), or placebo for 10 days. The primary outcome was clinical cure 7 to 10 days after the end of treatment.We enrolled 786 participants: 505 (64.2%) were adults and 281 (35.8%) were children. A total of 448 (57.0%) of the participants were male. S. aureus

2017 NEJM Controlled trial quality: predicted high

14. Is Loop Drainage Technique More Effective for Treatment of Soft Tissue Abscess Compared With Conventional Incision and Drainage?

Is Loop Drainage Technique More Effective for Treatment of Soft Tissue Abscess Compared With Conventional Incision and Drainage? TAKE-HOME MESSAGE Loop drainage technique may be associated with lower failure rate than conventional incision and drainage in treatment of skin and soft tissue abscesses, but data are limited. Further randomized controlled trial data are required. Is Loop Drainage Technique More Effective for Treatment of Soft Tissue Abscess Compared With Conventional Incision (...) in children. J Pediatr Surg. 2011;46:502-506. 3. Ladde JG, Baker S, Rodgers CN, et al. The LOOP technique: a novel incision and drainage technique in the treatment of skin abscesses in a pediatric ED. Am J Emerg Med. 2015;33:271-276. 4. Gaszynski R, Punch G, Verschuer K. Loop and drain technique for subcutaneous abscess: a safe minimally invasive procedure in an adult population. ANZ J Surg. 2018;88:87-90. 5. Özturan _ IU, Do gan NÖ, Karakayali O, et al. Comparison of loop and primary incision

2018 Annals of Emergency Medicine Systematic Review Snapshots

15. There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management

research. www.acfp.ca January 21, 2019 There’s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management Clinical Question: Does the addition of antibiotics to incision and drainage improve cure rates in single, uncomplicated skin abscesses? Bottom Line: Adding antibiotics that cover MRSA during incision and drainage for a small abscess increases the cure rate from 85% to 92%, meaning an additional one in 15 patients will be cured compared to placebo at one month. Approximately (...) There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 5,000 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care

2019 Tools for Practice

16. A Trial of Antibiotics for Smaller Skin Abscesses. (Abstract)

A Trial of Antibiotics for Smaller Skin Abscesses. 29282970 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Yeoh Daniel K DK Princess Margaret Hospital for Children, Perth, WA, Australia daniel.yeoh@health.wa.gov.au Blyth Christopher C CC Princess Margaret Hospital for Children, Perth, WA, Australia Bowen Asha C AC Princess Margaret Hospital for Children, Perth, WA (...) , Australia eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM N Engl J Med. 2017 Jun 29;376(26):2545-2555 28657870 N Engl J Med. 2017 Dec 28;377(26):e36 29281570 Abscess Anti-Bacterial Agents Drainage Humans Skin Diseases 2017 12 29 6 0 2017 12 29 6 0 2018 1 2 6 0 ppublish 29282970 10.1056/NEJMc1711124 10.1056/NEJMc1711124#SA3

2018 The New England journal of medicine Controlled trial quality: uncertain

17. A Trial of Antibiotics for Smaller Skin Abscesses. (Abstract)

A Trial of Antibiotics for Smaller Skin Abscesses. 29282969 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Nurjadi Dennis D University Hospitals, Heidelberg, Germany Heeg Klaus K University Hospitals, Heidelberg, Germany Zanger Philipp P University Hospitals, Heidelberg, Germany philipp.zanger@uni-heidelberg.d Staph Trav Network eng Letter Comment United States N (...) Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM N Engl J Med. 2017 Jun 29;376(26):2545-2555 28657870 N Engl J Med. 2017 Dec 28;377(26):e36 29281570 Abscess Anti-Bacterial Agents Drainage Humans Skin Diseases 2017 12 29 6 0 2017 12 29 6 0 2018 1 2 6 0 ppublish 29282969 10.1056/NEJMc1711124 10.1056/NEJMc1711124#SA2

2018 The New England journal of medicine Controlled trial quality: uncertain

18. Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice Full Text available with Trip Pro

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus (MRSA) infection engages phagocyte chemotaxis, abscess formation, and microbial clearance. Upon infection, neutrophils and monocytes find a gradient of chemoattractants that influence both phagocyte direction and microbial (...) clearance. The bioactive lipid leukotriene B4 (LTB4) is quickly (seconds to minutes) produced by 5-lipoxygenase (5-LO) and signals through the G protein-coupled receptors LTB4R1 (BLT1) or BLT2 in phagocytes and structural cells. Although it is known that LTB4 enhances antimicrobial effector functions in vitro, whether prompt LTB4 production is required for bacterial clearance and development of an inflammatory milieu necessary for abscess formation to restrain pathogen dissemination is unknown. We found

2018 PLoS pathogens

19. Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses Full Text available with Trip Pro

Atypical Behçet disease with endocarditis, pyoderma gangrenosum–like ulcers and methicillin-resistant Staphylococcus aureus–positive skin abscesses 29984279 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Atypical Behçet disease with endocarditis, pyoderma gangrenosum-like ulcers and methicillin-resistant Staphylococcus aureus -positive skin abscesses. 449-451 10.1016/j.jdcr.2018.01.003 Sanchez Isabelle M IM Department of Dermatology, University of California San (...) Francisco, San Francisco, California. Shinkai Kanade K Department of Dermatology, University of California San Francisco, San Francisco, California. eng Case Reports 2018 04 30 United States JAAD Case Rep 101665210 2352-5126 BD, Behçet disease Behcet disease IE, infectious endocarditis MRSA, methicillin-resistant Staphylococcus aureus PG, pyoderma gangrenosum cardiac manifestations endocarditis methicillin-resistant Staphylococcus aureus–positive abscesses pyoderma gangrenosum–like ulcers 2018 7 10 6 0

2018 JAAD Case Reports

20. The LOOP Trial in Treatment of Skin Abscesses

The LOOP Trial in Treatment of Skin Abscesses The LOOP Trial in Treatment of Skin Abscesses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The LOOP Trial in Treatment of Skin Abscesses The safety (...) to Brief Summary: This prospective, randomized controlled trial enrolled a convenience sample of adults and children presenting to two Level 1 trauma centers over 12-months with subcutaneous skin abscesses necessitating drainage. Two methods of drainage were compared: 1) the LOOP technique or 2) standard packing technique. Condition or disease Intervention/treatment Phase Abscess Procedure: LOOP Technique Procedure: Standard incision and drainage Not Applicable Detailed Description: This prospective

2018 Clinical Trials

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