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Skin Testing

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1. Genetic testing for prevention of severe drug-induced skin rash. (Abstract)

Genetic testing for prevention of severe drug-induced skin rash. Drug-induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes - such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) - which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these drug reactions is not yet fully understood; however, there is evidence (...) that pretreatment genetic testing may help to predict and prevent these reactions in some cases.To assess the effects of prospective pharmacogenetic screening to reduce drug-associated skin reactions in a patient population.We searched the following databases up to July 2018: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and LILACS. We also searched five trials registers, and checked the reference lists of included studies and relevant reviews for further references to relevant randomised

2019 Cochrane Controlled trial quality: predicted high

2. ASCIA Manual - Skin Prick Testing for Allergy Diagnosis

ASCIA Manual - Skin Prick Testing for Allergy Diagnosis Skin prick testing for the diagnosis of allergic disease A manual for practitioners This manual has been prepared the ASCIA skin prick testing working party (Chaired by Dr William Smith) and endorsed by the ASCIA Council. It is intended for medical and allied health practitioners and outlines the application, method and interpretation of allergy skin prick tests. © ASCIA 2016 First published in 2006 Revised March 2016 ASCIA Skin Prick Test (...) Manual 2 Contents PREAMBLE 1. INTRODUCTION 2. PRE-TEST CONSIDERATIONS 2.1 Conditions for which skin prick testing is considered an appropriate investigation 2.1.1 SPT disease indications 2.1.2 SPT not usually indicated 2.1.3 Indications for intradermal testing 2.2 Patient selection in skin prick testing 2.2.1 Patient age 2.2.2 Contraindications 2.2.3 Relative contraindications/precautions 2.2.4 Drugs that interfere with the skin prick test response 2.2.5 Drugs that may be contraindicated in skin

2018 Australasian Society of Clinical Immunology and Allergy

3. Topical itch therapy and allergy skin testing

Topical itch therapy and allergy skin testing Topical itch therapy and allergy skin testing ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Topical itch therapy and allergy skin testing | Topical itch therapy and allergy skin testing Q: 2/20/2020 Is it okay for a patient to continue (...) to use topical anti-itch creams prior to allergy skin testing? A: Table 4 on page S18 of the practice parameter on allergy testing provides a general recommendation on treatments that affect skin testing (1). The Karaz et al paper is cited as providing evidence that topical doxepin affects skin test reactivity for up to 11 days (2). There is minimal systemic absorption, plasma levels with topical therapy are 0 to 47 ng/ml vs 30 to 150 ng/ml following oral administration (3). However, the suppression

2020 Publication 4891070

4. Skin testing to narcotics

Skin testing to narcotics Skin testing to narcotics ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Skin testing to narcotics | Skin testing to narcotics Q: 1/31/2020 A 50 year-old patient had codeine and morphine three times in the past and it caused severe abdominal pain, vomiting (...) and shortness of breath. Skin test to codeine is strongly positive. How accurate is skin test? I am hesitant to do an oral challenge. She is going to have surgery. What alternative pain killer can she use? A: As you are likely aware, opioids can lead to non-specific mast-cell degranulation. Therefore, skin prick testing has little value in the evaluation of potential opioid allergy. Li et al demonstrated that challenge plays an important role in patients with history of possible opioid allergy in JACI

2020 Publication 4891070

5. Isosulfan blue skin testing

Isosulfan blue skin testing Isosulfan blue skin testing ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Isosulfan blue skin testing | Isosulfan blue skin testing Q: 3/20/202 Do you have a protocol for isosulfan blue testing? A: Thank you for your question. Mary Grace Baker MD and co (...) -workers published this method in 2014: “Allergy testing in the outpatient setting was performed three to four weeks after anaphylaxis and was conducted in a stepwise fashion consisting of the following tests (Table 1): skin prick test (SPT) with a 1:10 dilution of isosulfan blue and with full strength isosulfan blue and intradermal test (IDT) with a 1:1,000 dilution of isosulfan blue, a 1:100 dilution of isosulfan blue, and a 1:10 dilution of isosulfan blue. If a positive result to isosulfan blue

2020 Publication 4891070

6. Antihistamines and skin testing

Antihistamines and skin testing Antihistamines and skin testing ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Antihistamines and skin testing | Antihistamines and skin testing Q: 4/15/2020 Now that most of the oral antihistamine medications are over the counter, what is the new (...) recommendation for a patient (number of days) to avoid antihistamines before their skin testing and challenges? A: Generally, one week for 2nd and 3rd generation antihistamine (cetirizine, loratadine, fexofenadine and levocetirizine and desloratadine). 48 hours is usually adequate for 1st generation (diphenhydramine and chlorpheniramine). One recent study demonstrated that the wheal and flare responses returned to greater than 90% baseline within 4 days of not taking cetirizine. (1) 1) Shtessel M, Tversky J

2020 Publication 4891070

7. Semaglutide skin testing for immediate hypersensitivity

Semaglutide skin testing for immediate hypersensitivity Semaglutide skin testing for immediate hypersensitivity ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Semaglutide skin testing for immediate hypersensitivity | Semaglutide skin testing for immediate hypersensitivity Q: 3/3/2020 (...) Are there any guidelines/recommendations for skin testing to ozempic for a reported hypersensitivity reaction (uvula angioedema)? A: If there has not been a local reaction at the site of previous semaglutide injections, then I would not recommend skin testing with semaglutide as part of a work-up to determine the cause of isolated uvula angioedema. Semaglutide is a peptide molecule with a molecular weight of 4113 daltons and is over 99% protein bound. If one was going to do skin testing, then I would

2020 Publication 4891070

8. Leucovorin, irinotecan, and oxaliplatin skin testing

Leucovorin, irinotecan, and oxaliplatin skin testing Leucovorin, irinotecan and oxaliplatin skin testing ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Leucovorin, irinotecan, and oxaliplatin skin testing | Leucovorin, irinotecan, and oxaliplatin skin testing Q: 3/3/2020 Do you have (...) skin testing concentrations for leucovorin, irinotecan and oxaliplatin? A: IgE-mediated allergy has not been described with leucovorin and thus skin testing will not be useful. Skin testing is possible to irinotecan at the concentrations described by Alvarez-Cuesta et al [ J Investig Allergol Clin Immunol 2016; Vol. 26(5): 314-343]: prick test, 20 mg/mL, and intradermal tests, 2 mg/mL and 20 mg/mL. Skin prick testing with oxaliplatin 0.5 mg/mL. Intradermal testing with oxaliplatin at 0.05 mg/mL

2020 Publication 4891070

9. Concentration for intradermal skin testing to local anesthetics

Concentration for intradermal skin testing to local anesthetics Concentration for intradermal skin testing to local anesthetics ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Concentration for intradermal skin testing to local anesthetics | Concentration for intradermal skin testing (...) to local anesthetics Q: 1/24/2020 In regards to local anesthetic skin testing, is there a reference for a non-irritating percentage for these for skin testing? I am coming up empty on finding a reference. A: Garvey et al published a very helpful EAACI position paper in 2019. Table 4 from this manuscript contains the information you are seeking. It varies for skin prick testing vs. intradermal testing and also by the local anesthetic. Garvey LH, Ebo DG, Mertes PM, Dewachter P, Garcez T, Kopac P, Laguna

2020 Publication 4891070

10. Guselkumab and other humanized monoclonal antibody skin testing

Guselkumab and other humanized monoclonal antibody skin testing Guselkumab & other humanized monoclonal antibody skin testing ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Guselkumab and other humanized monoclonal antibody skin testing | Guselkumab and other humanized monoclonal (...) antibody skin testing Q: 3/11/2020 I have a 60 year-old female who was put on Tremfya for her psoriasis. After few injections she developed a localized hives at the site of the injection. My questions are: Is a skin test a valid way and at what concentration? What is her risk of systemic reaction? What is the practical way to address this issue: premeditates her or splitting the dose? A: Guselkumab, and all other monoclonal antibodies can induce IgE-mediated hypersensitivity. With continued exposure

2020 Publication 4891070

11. Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts

Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

12. Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Full Text available with Trip Pro

Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Fibrosis is a complex pathophysiological process involving interplay between multiple cell types. Experimental modelling of fibrosis is essential for the understanding of its pathogenesis and for testing of putative antifibrotic drugs. However, most current models employ either phylogenetically distant species or rely on human cells cultured in an artificial environment (...) . Here we evaluated the potential of vascularised in vitro human skin equivalents as a novel model of skin fibrosis and a platform for the evaluation of antifibrotic drugs.Skin equivalents were assembled on a three-dimensional extracellular matrix by sequential seeding of endothelial cells, fibroblasts and keratinocytes. Fibrotic transformation on exposure to transforming growth factor-β (TGFβ) and response to treatment with nintedanib as an established antifibrotic agent were evaluated

2019 Annals of the Rheumatic Diseases

13. Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries. Full Text available with Trip Pro

Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries. Skin tears are acute wounds that are frequently misdiagnosed and underreported. A standardised and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way.To measure the validity and reliability (...) of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally.A multi-country study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability, and intra-rater

2019 British Journal of Dermatology

14. Skin Testing for Allergic Rhinitis

Skin Testing for Allergic Rhinitis Health Quality Ontario The provincial advisor on the quality of health care in Ontario Let’s make our health system healthier Skin Testing for Allergic Rhinitis: OHTAC Recommendation ONTARIO HEALTH TECHNOLOGY ADVISORY COMMITTEE RECOMMENDATION ? OHTAC recommends that skin tests for allergic rhinitis continue to be publicly funded. BACKGROUND Allergic rhinitis (also known as hay fever) is a symptomatic disorder of the nose that develops when the body’s immune (...) system becomes sensitized and overreacts to airborne allergens. (1) This condition affects 10% to 40% of people worldwide (2) and 20% to 25% of Canadians. (3) In January 2015, the Ontario Ministry of Health and Long-Term Care asked Health Quality Ontario to conduct a health technology assessment to review the accuracy of skin tests for allergic rhinitis. SUMMARY OF FINDINGS The health technology assessment completed by Health Quality Ontario is available separately (4). A completed decision

2016 Health Quality Ontario

15. Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt Full Text available with Trip Pro

Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt Chronic urticaria (CU) is a debilitating disorder with variable clinical course. It is characterized by hives occurring for at least 6 weeks, and is classified as spontaneous or inducible.The aim of this study was to detect the pattern of CU, to study association between results of autologous serum skin test (ASST) and urticaria severity score (USS), and to detect serum levels of anti IgE

2018 Electronic physician

16. Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon γ release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial. (Abstract)

Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon γ release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial. Targeted screening and treatment of Mycobacterium tuberculosis infection substantially reduces the risk of developing active tuberculosis. C-Tb (Statens Serum Institute, Copenhagen, Denmark) is a novel specific skin test based on ESAT-6 and CFP10 antigens. We investigated (...) the safety and diagnostic potential of C-Tb compared with established tests in the contact-tracing setting.Negative controls, close contacts, occasional contacts, and patients with active pulmonary tuberculosis were enrolled at 13 centres in Spain. We compared C-Tb with the QuantiFERON-TB Gold In-Tube ([QFT] Qiagen, Hilden, Germany) interferon γ release assay (IGRA) and the purified protein derivative (PPD) RT 23 tuberculin skin test ([TST] Statens Serum Institute). All participants older than 5 years

2017 The lancet. Respiratory medicine Controlled trial quality: predicted high

17. The mTST - An mHealth approach for training and quality assurance of tuberculin skin test administration and reading. Full Text available with Trip Pro

The mTST - An mHealth approach for training and quality assurance of tuberculin skin test administration and reading. The Tuberculin Skin Test (TST) is a relatively simple test for detecting latent tuberculosis infection (LTBI) but requires regular quality assurance to ensure proper technique for administration and reading. The objective of this study was to estimate the accuracy and reproducibility of an mhealth approach (the mTST) to measure the size of swelling immediately following TST

2019 PLoS ONE

18. Testing the feasibility of augmented digital skin imaging to objectively compare the efficacy of topical treatments for radiodermatitis. Full Text available with Trip Pro

Testing the feasibility of augmented digital skin imaging to objectively compare the efficacy of topical treatments for radiodermatitis. Radiation-induced dermatitis (RID) is routinely graded by visual inspection. Inter-observer variability makes this approach inadequate for an objective assessment of the efficacy of different topical treatments. In this study we report on the first clinical application of a new image-analysis tool developed to measure the relevant effects quantitatively (...) could not be observed with visual inspection. By using augmented image analysis methods a statistically significant increase in a*-values (mean 4.15; 95%CI: 5.97-2.33, p<0.001) in patients treated with R1&R2 indicated more intense reddening. Digital subtraction was used to eliminate differences in individual baseline skin tone to generate a new, low-scatter parameter (ΔSEV).Visual CTCAE-based evaluation of RID was not suitable for assessing the efficacy of the skin treatment products. In contrast

2019 PLoS ONE

19. Penicillin skin testing in methicillin-sensitive staphylococcus aureus bacteremia: A cost-effectiveness analysis. Full Text available with Trip Pro

Penicillin skin testing in methicillin-sensitive staphylococcus aureus bacteremia: A cost-effectiveness analysis. Beta-lactams are the mainstay for treating methicillin-susceptible Staphylococcus aureus (MSSA) infections complicated by bacteremia due to superior outcomes compared with vancomycin. With approximately 11% of inpatients reporting a penicillin (PCN) allergy, many patients receive suboptimal treatment for MSSA bacteremia.Evaluate the cost-effectiveness of penicillin skin testing (PST (...) ) in adult patients with self-reported PCN allergy in an inpatient setting undergoing treatment for MSSA bacteremia.A decision analytic model was developed comparing an acute care PST intervention to a scenario with no confirmatory allergy testing. The primary outcome was the incremental cost-effectiveness ratio (ICER) from the health-sector perspective over a 1-year time horizon using quality-adjusted life years (QALYs) as the measure for effectiveness. One-way and probabilistic sensitivity analyses

2019 PLoS ONE

20. An Analysis of Skin Prick Tests to Latex and Patch Tests to Rubber Additives and other Causative Factors among Dental Professionals and Students with Contact Dermatoses. (Abstract)

An Analysis of Skin Prick Tests to Latex and Patch Tests to Rubber Additives and other Causative Factors among Dental Professionals and Students with Contact Dermatoses. Dental workers often experience unwanted allergic and nonallergic skin reactions resulting in different contact dermatoses (e.g., contact urticaria, irritant and allergic contact dermatitis) that are often attributed to rubber gloves.To examine allergic and nonallergic contact dermatoses by different methods amongst dental (...) professionals and dental students, more specifically, reactions to natural rubber latex (NRL), rubber additives, and other causative factors.In this cross-sectional study we surveyed a total of 444 subjects (dentists, assistants, technicians, and students); 200 agreed to be tested to latex by the standard skin prick test (SPT) and prick-by-prick test, of whom 107 were patch tested to rubber additives (mercapto mix, thiuram mix, carba mix, and N-isopropyl-N-phenyl-4-phenylenediamine [IPPD]).Skin lesions

2018 International Archives of Allergy and Immunology

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