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Skin Testing

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1. Genetic testing for prevention of severe drug-induced skin rash. (PubMed)

Genetic testing for prevention of severe drug-induced skin rash. Drug-induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes - such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) - which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these drug reactions is not yet fully understood; however, there is evidence (...) that pretreatment genetic testing may help to predict and prevent these reactions in some cases.To assess the effects of prospective pharmacogenetic screening to reduce drug-associated skin reactions in a patient population.We searched the following databases up to July 2018: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and LILACS. We also searched five trials registers, and checked the reference lists of included studies and relevant reviews for further references to relevant randomised

2019 Cochrane

2. Interpreting diagnostic tests with continuous results and no gold standard: a common scenario explained using the tuberculin skin test

Interpreting diagnostic tests with continuous results and no gold standard: a common scenario explained using the tuberculin skin test Interpreting diagnostic tests with continuous results and no gold standard: a common scenario explained using the tuberculin skin test | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies (...) the tuberculin skin test Article Text General Medicine Interpreting diagnostic tests with continuous results and no gold standard: a common scenario explained using the tuberculin skin test Statistics from Altmetric.com You do not have access to the full text of this article, the first page of the of this article appears above. Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You

2017 Evidence-Based Medicine (Requires free registration)

3. Skin Testing for Allergic Rhinitis

Skin Testing for Allergic Rhinitis Health Quality Ontario The provincial advisor on the quality of health care in Ontario Let’s make our health system healthier Skin Testing for Allergic Rhinitis: OHTAC Recommendation ONTARIO HEALTH TECHNOLOGY ADVISORY COMMITTEE RECOMMENDATION ? OHTAC recommends that skin tests for allergic rhinitis continue to be publicly funded. BACKGROUND Allergic rhinitis (also known as hay fever) is a symptomatic disorder of the nose that develops when the body’s immune (...) system becomes sensitized and overreacts to airborne allergens. (1) This condition affects 10% to 40% of people worldwide (2) and 20% to 25% of Canadians. (3) In January 2015, the Ontario Ministry of Health and Long-Term Care asked Health Quality Ontario to conduct a health technology assessment to review the accuracy of skin tests for allergic rhinitis. SUMMARY OF FINDINGS The health technology assessment completed by Health Quality Ontario is available separately (4). A completed decision

2016 Health Quality Ontario

4. Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts

Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

5. Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. (PubMed)

Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Fibrosis is a complex pathophysiological process involving interplay between multiple cell types. Experimental modelling of fibrosis is essential for the understanding of its pathogenesis and for testing of putative antifibrotic drugs. However, most current models employ either phylogenetically distant species or rely on human cells cultured in an artificial environment (...) . Here we evaluated the potential of vascularised in vitro human skin equivalents as a novel model of skin fibrosis and a platform for the evaluation of antifibrotic drugs.Skin equivalents were assembled on a three-dimensional extracellular matrix by sequential seeding of endothelial cells, fibroblasts and keratinocytes. Fibrotic transformation on exposure to transforming growth factor-β (TGFβ) and response to treatment with nintedanib as an established antifibrotic agent were evaluated

2019 Annals of the Rheumatic Diseases

6. Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries. (PubMed)

Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries. Skin tears are acute wounds that are frequently misdiagnosed and underreported. A standardised and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way.To measure the validity and reliability (...) of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally.A multi-country study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability, and intra-rater

2019 British Journal of Dermatology

7. Skin testing for allergic rhinitis: OHTAC recommendation

Skin testing for allergic rhinitis: OHTAC recommendation Skin testing for allergic rhinitis: OHTAC recommendation Skin testing for allergic rhinitis: OHTAC recommendation Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Skin testing for allergic rhinitis: OHTAC recommendation. Toronto: Health (...) Quality Ontario (HQO). 2016 Authors' conclusions The health technology assessment completed by Health Quality Ontario is available separately. A completed decision determinants framework is included in this report. The key findings of the health technology assessment were: - Based on evidence of moderate quality, skin-prick testing is reasonably accurate in identifying patients with allergic rhinitis. Because of the small number of studies on intradermal testing and their small sample sizes

2016 Health Technology Assessment (HTA) Database.

8. Skin testing for allergic rhinitis: a health technology assessment

Skin testing for allergic rhinitis: a health technology assessment Skin testing for allergic rhinitis: a health technology assessment Skin testing for allergic rhinitis: a health technology assessment Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Skin testing for allergic rhinitis: a health (...) technology assessment. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 16(10). 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Humans; Rhinitis, Allergic; Skin Tests; Technology Assessment, Biomedical Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor

2016 Health Technology Assessment (HTA) Database.

9. Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon γ release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial. (PubMed)

Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon γ release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial. Targeted screening and treatment of Mycobacterium tuberculosis infection substantially reduces the risk of developing active tuberculosis. C-Tb (Statens Serum Institute, Copenhagen, Denmark) is a novel specific skin test based on ESAT-6 and CFP10 antigens. We investigated (...) the safety and diagnostic potential of C-Tb compared with established tests in the contact-tracing setting.Negative controls, close contacts, occasional contacts, and patients with active pulmonary tuberculosis were enrolled at 13 centres in Spain. We compared C-Tb with the QuantiFERON-TB Gold In-Tube ([QFT] Qiagen, Hilden, Germany) interferon γ release assay (IGRA) and the purified protein derivative (PPD) RT 23 tuberculin skin test ([TST] Statens Serum Institute). All participants older than 5 years

2017 The lancet. Respiratory medicine

10. Penicillin skin testing in methicillin-sensitive staphylococcus aureus bacteremia: A cost-effectiveness analysis. (PubMed)

Penicillin skin testing in methicillin-sensitive staphylococcus aureus bacteremia: A cost-effectiveness analysis. Beta-lactams are the mainstay for treating methicillin-susceptible Staphylococcus aureus (MSSA) infections complicated by bacteremia due to superior outcomes compared with vancomycin. With approximately 11% of inpatients reporting a penicillin (PCN) allergy, many patients receive suboptimal treatment for MSSA bacteremia.Evaluate the cost-effectiveness of penicillin skin testing (PST (...) ) in adult patients with self-reported PCN allergy in an inpatient setting undergoing treatment for MSSA bacteremia.A decision analytic model was developed comparing an acute care PST intervention to a scenario with no confirmatory allergy testing. The primary outcome was the incremental cost-effectiveness ratio (ICER) from the health-sector perspective over a 1-year time horizon using quality-adjusted life years (QALYs) as the measure for effectiveness. One-way and probabilistic sensitivity analyses

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2019 PLoS ONE

11. Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt (PubMed)

Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt Chronic urticaria (CU) is a debilitating disorder with variable clinical course. It is characterized by hives occurring for at least 6 weeks, and is classified as spontaneous or inducible.The aim of this study was to detect the pattern of CU, to study association between results of autologous serum skin test (ASST) and urticaria severity score (USS), and to detect serum levels of anti IgE

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2018 Electronic physician

12. The mTST - An mHealth approach for training and quality assurance of tuberculin skin test administration and reading. (PubMed)

The mTST - An mHealth approach for training and quality assurance of tuberculin skin test administration and reading. The Tuberculin Skin Test (TST) is a relatively simple test for detecting latent tuberculosis infection (LTBI) but requires regular quality assurance to ensure proper technique for administration and reading. The objective of this study was to estimate the accuracy and reproducibility of an mhealth approach (the mTST) to measure the size of swelling immediately following TST

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2019 PLoS ONE

13. Testing the feasibility of augmented digital skin imaging to objectively compare the efficacy of topical treatments for radiodermatitis. (PubMed)

Testing the feasibility of augmented digital skin imaging to objectively compare the efficacy of topical treatments for radiodermatitis. Radiation-induced dermatitis (RID) is routinely graded by visual inspection. Inter-observer variability makes this approach inadequate for an objective assessment of the efficacy of different topical treatments. In this study we report on the first clinical application of a new image-analysis tool developed to measure the relevant effects quantitatively (...) could not be observed with visual inspection. By using augmented image analysis methods a statistically significant increase in a*-values (mean 4.15; 95%CI: 5.97-2.33, p<0.001) in patients treated with R1&R2 indicated more intense reddening. Digital subtraction was used to eliminate differences in individual baseline skin tone to generate a new, low-scatter parameter (ΔSEV).Visual CTCAE-based evaluation of RID was not suitable for assessing the efficacy of the skin treatment products. In contrast

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2019 PLoS ONE

14. An Analysis of Skin Prick Tests to Latex and Patch Tests to Rubber Additives and other Causative Factors among Dental Professionals and Students with Contact Dermatoses. (PubMed)

An Analysis of Skin Prick Tests to Latex and Patch Tests to Rubber Additives and other Causative Factors among Dental Professionals and Students with Contact Dermatoses. Dental workers often experience unwanted allergic and nonallergic skin reactions resulting in different contact dermatoses (e.g., contact urticaria, irritant and allergic contact dermatitis) that are often attributed to rubber gloves.To examine allergic and nonallergic contact dermatoses by different methods amongst dental (...) professionals and dental students, more specifically, reactions to natural rubber latex (NRL), rubber additives, and other causative factors.In this cross-sectional study we surveyed a total of 444 subjects (dentists, assistants, technicians, and students); 200 agreed to be tested to latex by the standard skin prick test (SPT) and prick-by-prick test, of whom 107 were patch tested to rubber additives (mercapto mix, thiuram mix, carba mix, and N-isopropyl-N-phenyl-4-phenylenediamine [IPPD]).Skin lesions

2018 International Archives of Allergy and Immunology

15. Responsiveness of Nasal Provocation Testing-But Not Skin Test and Specific Immunoglobulin E Blood Level-Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients. (PubMed)

Responsiveness of Nasal Provocation Testing-But Not Skin Test and Specific Immunoglobulin E Blood Level-Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients. Background The results of skin and blood allergen testing are not consistently relevant to clinical manifestations in allergic patients. Objective The aim of the study was to investigate the relationship between severity of allergic rhinitis and different allergen diagnostic tests (...) in Dermatophagoides species-sensitized patients. Methods Study subjects included 65 rhinitis patients-50 with Dermatophagoides pteronyssinus (DP) sensitization (DP+) and 15 without DP sensitization (DP-), and 15 DP+ and 37 DP- healthy controls (HCs) confirmed by allergen skin prick (SPT) and blood specific immunoglobulin E (sIgE) tests. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was tested. All subjects underwent DP nasal provocation test (DP-NPT). Visual analogue scoring (VAS) of nasal symptoms

2018 American journal of rhinology & allergy

16. The effect of combining QuantiFERON-TB Gold In-Tube test with tuberculin skin test on the detection of active tuberculosis. (PubMed)

The effect of combining QuantiFERON-TB Gold In-Tube test with tuberculin skin test on the detection of active tuberculosis. Interferon-γ release assays (IGRAs) and tuberculin skin tests (TSTs) play an important role in the detection of tuberculosis (TB) infection. However, the interaction between these tests in detecting active pulmonary TB in adults has never been researched.A matched case-control study was conducted in Taiwan from 1 March 2012 to 31 December 2013 by enrolling 150 confirmed TB (...) cases and 852 matched controls dwelling at the same area (stratified by low, medium and high incidence).Compared with a negative QuantiFERON-TB Gold In-Tube (QFT-GIT) test and a negative tuberculin skin test (TST), the effect size for detecting active pulmonary TB was highest for both a positive QFT-GIT and positive TST (adjusted odds ratio [aOR] 8.77 [95% confidence interval {CI} 4.51 to 17.05]), but the detectability was substantially attenuated in the absence of either a positive TST (aOR 1.59

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2018 Transactions of the Royal Society of Tropical Medicine & Hygiene

17. Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time

Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03645629

2018 Clinical Trials

18. Evaluation of the basophil activation test and skin prick testing for the diagnosis of sesame food allergy. (PubMed)

Evaluation of the basophil activation test and skin prick testing for the diagnosis of sesame food allergy. The prevalence of sesame food allergy (SFA) has increased over recent years, with the potential of anaphylactic reactions upon exposure. Oral food challenge (OFC) remains the diagnostic standard, yet its implementation may be risky. Commercial skin prick tests (SPT) have a low sensitivity. Investigation of alternate diagnostic methods is warranted.To evaluate the utility of SPT (...) and the basophil activation test (BAT) for SFA diagnosis.Eighty-two patients with suspected SFA completed an open OFC to sesame or reported a recent confirmed reaction. Patients were administered skin prick tests (SPT) with commercial sesame seed extract (CSSE) and a high protein concentration sesame extract (HPSE) (100 mg/mL protein). Whole blood from 80 patients was stimulated with sesame seed extract (40-10 000 ng/mL protein) for BAT), assessing CD63 and CD203c as activation markers.Sixty patients (73%) had

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2018 Clinical and Experimental Allergy

19. Systematic review on the diagnostic performance of novel skin-based in vivo tests for latent TB infection compared to blood-based in vitro interferon-gamma release assays

Systematic review on the diagnostic performance of novel skin-based in vivo tests for latent TB infection compared to blood-based in vitro interferon-gamma release assays Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability (...) one experimental group, we will correct the total number of control animals in the meta-analysis by dividing the number of animals in the control group by the number of treatment groups served. Where applicable, Holm-Bonferroni correction for testing multiple subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other Subgroup analysis or meta-regression are used to explore between-study

2019 PROSPERO

20. Utility of skin tests in assessment of drug culpability in drug reaction with eosinophilia and systemic symptoms (DRESS)

Utility of skin tests in assessment of drug culpability in drug reaction with eosinophilia and systemic symptoms (DRESS) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) animals in the meta-analysis by dividing the number of animals in the control group by the number of treatment groups served. Where applicable, Holm-Bonferroni correction for testing multiple subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other Subgroup analysis or meta-regression are used to explore between-study heterogeneity and can provide insight into the relationship between study

2019 PROSPERO

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