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Skin Cancer in Skin of Color

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1. Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer Full Text available with Trip Pro

Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized (...) in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin. The 25 papers that were generated by the search and their references, were reviewed; 10 papers were selected for inclusion. The cancer of the skin typically presents as round lesions. However, basal cell carcinoma and squamous cell carcinoma may arise from primary skin conditions or benign skin neoplasms

2017 Cureus

2. Skin Malignancies, Merkel Cell Carcinoma and Rare Appendageal Tumors

cell carcinoma and squamous cell carcinoma (BCC) and comprise the majority of nonmelanoma malignant skin cancers. BCC is the most common malignant neoplasm. BCC is typically locally invasive, but it can metastasize on rare occasions. The most common primary site of metastatic BCC is the scrotum, where the rate of metastatic disease is 12%. Occurrence on the head and neck can also set the stage for the spread of BCC, but this is less common. SCC is a malignant neoplasm arising from transformed (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI5NTMyNS1vdmVydmlldw== processing > Merkel Cell Carcinoma and Rare Appendageal Tumors Updated: Mar 28, 2017 Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS Share Email Print Feedback Close Sections Sections Merkel Cell Carcinoma and Rare Appendageal Tumors Overview Overview Cutaneous tumors encompass a vast array of malignancies, from neuroendocrine to lymphoid. In addition to primary malignancies, the skin can also be a major site for metastases of internal cancers

2014 eMedicine Surgery

3. Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? (Abstract)

Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? The metastatic involvement of regional lymph nodes is the most important prognostic factor for overall survival of skin cancer patients. The sonographic technique of freehand real-time tissue elastography (RTE), which displays tissue rigidity as a color overlay of the tissue image, was developed.Our (...) purpose was to evaluate the benefit of RTE for detecting lymph node metastases of skin cancer noninvasively before operation.We first selected lymph nodes of skin cancer patients which had already been diagnosed by biopsy as being reactive or metastatic, and then retrospectively collected images of RTE and B-mode and color Doppler ultrasound on those lymph nodes performed preoperatively. Twenty-one lymph nodes from 12 patients with squamous cell carcinoma (SCC), 23 lymph nodes from 14 patients

2019 Journal of the European Academy of Dermatology and Venereology

4. Cutaneous Malignant Neoplasms in Hematopoietic Cell Transplant Recipients: A Systematic Review. (Abstract)

neoplasm risk factors were extracted from included articles. The level of evidence for each study was assessed using the Strength of Recommendation Taxonomy scale.Patients who underwent hematopoietic cell transplantation had an increased risk of squamous cell carcinoma, basal cell carcinoma, and melanoma. Factors such as primary disease, chronic graft-vs-host disease, prolonged immunosuppression, radiation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignant (...) factors for cutaneous malignant neoplasms following hematopoietic cell transplantation.A systematic review was conducted using Medline and Cochrane databases from January 1995 to December 2013. Retrospective and prospective reviews containing at least 100 patients who underwent hematopoietic cell transplantation reporting skin cancer as a primary outcome were included. Information regarding the entire cohort, data for the subset who developed cutaneous malignant neoplasms, and cutaneous malignant

2015 JAMA dermatology

5. Pigmentation Phenotype, Photosensitivity, and Skin Neoplasms in Patients with Myotonic Dystrophy Full Text available with Trip Pro

Pigmentation Phenotype, Photosensitivity, and Skin Neoplasms in Patients with Myotonic Dystrophy Recent studies have suggested a possible excess risk of skin neoplasms in patients with myotonic dystrophy (DM). Risk factors related to this observation have not been defined.Information regarding personal history of skin tumors, pigmentation phenotype, and skin reaction to sun exposure were collected from 266 DM patients who were enrolled in the US National Institutes of Health National Registry (...) of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members.Seventy-seven subjects reported having skin tumors that were either benign (n = 31), malignant (n = 32) or both (n = 14). Female gender [odds ratio (OR) = 2.27, 95% confidence interval (CI) 1.02-5.05, P = 0.04], older age (OR = 1.10, 95% CI 1.05-1.16, P < 0.001) and DM1 subtype (OR = 3.42, 95% CI 1.27-9.26, P = 0.02) were associated with a malignant skin tumor. The associations between malignant skin tumors

2017 European Journal of Neurology

6. Skin Cancer in Skin of Color

Skin Cancer in Skin of Color Skin Cancer in Skin of Color Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin Cancer in Skin of Color (...) Skin Cancer in Skin of Color Aka: Skin Cancer in Skin of Color , Skin Cancer in Black Patients , Skin Cancer in African American Patients , Skin Cancer in Asian Patients , Skin Cancer in Native American Patients , Skin Cancer in Middle Eastern Patients , Skin Cancer in Hispanic Patients From Related Chapters II. Approach: Basal cell skin cancer (BCC) Most common skin cancer in white, asian and hispanic patients (second most common Skin Cancer in Black Patients) Characteristics in Pigmented s

2018 FP Notebook

7. Skin Cancer Prevention: Behavioral Counseling

persons, young adults, and persons who practice indoor or outdoor tanning. Further evidence is needed to assess the balance of benefits and harms of counseling adults about skin self-examination to prevent skin cancer and premature death. Discussion Burden of Disease Skin cancer is the most common type of cancer. Melanoma is less common than basal or squamous cell carcinoma but has a much higher death rate. In 2018, an estimated 91,270 new cases of melanoma are expected, representing 5.2% of all new (...) cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma, the 2 predominant types of nonmelanoma skin cancer, represent the vast majority of skin cancer cases. There were an estimated 3.3 million new cases of nonmelanoma skin cancer in 2012 and an estimated 91,270 new cases of melanoma skin cancer in 2018. Recognition of Risk Status Exposure to UV radiation during childhood and adolescence increases the risk of skin cancer later in life, especially when more

2018 U.S. Preventive Services Task Force

8. Clinical and pathological study on mixed tumors of the skin. Full Text available with Trip Pro

of all cases were reread and the diagnosis was verified.There were 14 males (67%) and 7 females (33%). MTS affected the face. The lesions were skin-colored or lightly red, with no subjective symptoms in most cases. Histopathologically, the tumors consisted of epithelial and interstitial components. The epithelium was mainly composed of cubic or polygonal cells, which can be seen within the tubule-like structures with bilayer epithelium. The inner cells mainly expressed cytokeratin and other (...) Clinical and pathological study on mixed tumors of the skin. Mixed tumor of the skin (MTS) is a rare benign tumor of the sweat glands with a reported frequency of 0.01% to 0.098%. The objective of the study is to investigate clinicopathological and immunohistochemical features of mixed tumor of the skin.This was a retrospective study of 21 patients diagnosed with MTS at the Institute of Dermatology and Venereology of Sichuan Provincial People's Hospital from 1980 to 2016. Pathological sections

2018 Medicine

9. Use of expanded deltopectoral skin flaps for facial reconstruction after sizeable benign tumor resections Full Text available with Trip Pro

in terms of skin texture, color, and flexibility. This particular method may thus be a reasonable choice for repairing sizeable defects in the wake of benign facial tumor excisions. (...) Use of expanded deltopectoral skin flaps for facial reconstruction after sizeable benign tumor resections The overall unsightliness of expansive benign facial tumors imposes both physical and mental suffering. Although excision is generally the optimal recourse in such instances, reconstructing the subsequent surgical defects is always a critical issue. Herein, we have described our experiences using expanded deltopectoral skin flaps to manage large facial wounds after excising benign tumors

2018 American journal of translational research

10. Texture based skin lesion abruptness quantification to detect malignancy Full Text available with Trip Pro

% specificity; that we obtained better results than in the previous study. We also compared the performances of two different NN classifiers and support vector machine classifier. The best results obtained using combination of RGB color spaces with the fully-connected multi-hidden layer NN.Computational results also show that skin lesion abrupt cutoff is a reliable indicator of malignancy. Results show that computational model of texture homogeneity along the periphery of skin lesion borders based on LSP (...) Texture based skin lesion abruptness quantification to detect malignancy Abruptness of pigment patterns at the periphery of a skin lesion is one of the most important dermoscopic features for detection of malignancy. In current clinical setting, abrupt cutoff of a skin lesion determined by an examination of a dermatologist. This process is subjective, nonquantitative, and error-prone. We present an improved computational model to quantitatively measure abruptness of a skin lesion over our

2017 BMC bioinformatics

11. Racial differences in cancer susceptibility and survival: More than the color of the skin? Full Text available with Trip Pro

Racial differences in cancer susceptibility and survival: More than the color of the skin? Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However (...) , the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants. Here, we overview the molecular basis of racial disparity in cancer susceptibility ranging from genetic polymorphisms and cancer-driver gene mutations to obesity, chronic inflammation, and immune responses. We discuss implications for race-adapted cancer screening programs and clinical trials

2017 Trends in Cancer

12. Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma. Full Text available with Trip Pro

Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma. Melanoma is the deadliest form of skin cancer and presents a significant health care burden in many countries. In addition to ultraviolet radiation in sunlight, the main causal factor for melanoma, genetic factors also play an important role in melanoma susceptibility. Although genome-wide association studies have identified many single nucleotide polymorphisms associated with melanoma, little (...) affecting gene expression in skin account for a significant proportion of the heritability, and are enriched among melanoma risk loci. Finally, by incorporating skin color into our analyses, we observed both a shift in significance for melanoma-associated loci and an enrichment of expression quantitative trait loci among melanoma susceptibility variants. These findings suggest that skin color may be an important modifier of melanoma risk. We speculate that incorporating skin color and other non-genetic

2017 PLoS ONE

13. Skin lesion Solid Skin-colored

Skin lesion Solid Skin-colored Skin lesion Solid Skin-colored Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Skin lesion Solid Skin (...) -colored Skin lesion Solid Skin-colored Aka: Skin lesion Solid Skin-colored , Skin-Colored Papule , Skin-Colored Nodule II. Causes: Keratotic (Rough surface) Warts l wart and Calluses III. Causes: Non-Keratotic Warts s s ( s) s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Skin lesion Solid Skin-colored." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database

2018 FP Notebook

14. Studies on reconstruction of large skin defects following mammary tumor excision in dogs Full Text available with Trip Pro

Studies on reconstruction of large skin defects following mammary tumor excision in dogs The main objective of the study was to describe the use of skin fold advancement flaps (SFAFs) and other reconstructive techniques for closure of large skin defects following mammary tumor excision in dogs.Twelve dogs underwent reconstruction of large ventral skin defects following mammary tumor excision with wide margins. Skin fold flaps (flank fold flap and elbow fold flap) were elevated from the flank (...) and elbow region, respectively, and transposed and sutured onto the large ventral skin defect following mastectomy in all the dogs. In addition to the skin fold flaps, other reconstructive techniques such as undermining, walking sutures, and tension-relieving suture techniques were followed during surgery in the closure of large skin defects without skin tension and compromising limb mobility. The skin flap viability was assessed subjectively by gross observation of the flap such as color, temperature

2017 Veterinary world

15. A 28-Year-Old Male Patient with Nail Tumors, Skin Lesions, and Epilepsy Full Text available with Trip Pro

A 28-Year-Old Male Patient with Nail Tumors, Skin Lesions, and Epilepsy Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of benign hamartomas in multiple organs. Most patients with TSC exhibit cutaneous manifestations.We report a 28-year-old patient with multiple pink papules at the proximal nail fold of several toes.Histopathological analysis of a biopsy of a papule was consistent with an ungual fibroma. Histopathological analysis of a biopsy (...) of an elevated skin-colored plaque at the lower back was diagnostic for a Shagreen patch. These findings were consistent with a clinical diagnosis of TSC. This patient was subsequently referred to a multidisciplinary TSC clinic for further screening, which revealed a giant cell astrocytoma and multiple subependymal tubers. Annual monitoring was recommended. The skin lesions were treated with topical rapamycin ointment.Recognizing dermatological manifestations of TSC is of importance to allow early diagnosis

2017 Case reports in dermatology

16. Skin color parameters and Fitzpatrick phototypes in estimating the risk of skin cancer: A case-control study in the Polish population. (Abstract)

Skin color parameters and Fitzpatrick phototypes in estimating the risk of skin cancer: A case-control study in the Polish population. Light skin pigmentation is a known risk factor for skin cancer.Skin color parameters and Fitzpatrick phototypes were evaluated in terms of their usefulness in predicting the risk of skin cancer.A case-control study involved 133 individuals with skin cancer (100 with basal cell carcinoma, 21 with squamous cell carcinoma, 12 with melanoma) and 156 healthy (...) pigmentation levels. The best predictors of skin cancer were R coordinate of RGB color space (area under the receiver operating characteristic curve 0.687) and melanin index (area under the receiver operating characteristic curve 0.683) for skin on the buttock.A small number of patients were studied. Models were not externally validated.Skin color parameters are more accurate predictors of skin cancer occurrence than skin phototypes. Spectrophotometry is a quick, easy, and affordable method offering

2016 Journal of American Academy of Dermatology

17. Genetics of Skin Cancer (PDQ®): Health Professional Version

malignancies include ovarian carcinoma,[ ] ovarian fibrosarcoma,[ , ] astrocytoma,[ ] melanoma,[ ] Hodgkin disease,[ , ] rhabdomyosarcoma,[ ] and undifferentiated sinonasal carcinoma.[ ] Odontogenic keratocysts–or keratocystic odontogenic tumors (KCOTs), as renamed by the World Health Organization working group–are one of the major features of BCNS.[ ] Demonstration of clonal (LOH) of common tumor suppressor genes, including PTCH1 , supports the transition of terminology to reflect a neoplastic process (...) that describe the evidence on each topic. Inheritance and Risk More than 100 types of tumors are clinically apparent on the skin; many are known to have familial and/or inherited components, either in isolation or as part of a syndrome with other features. and , which are known collectively as nonmelanoma skin cancer, are two of the most common malignancies in the United States and are often caused by sun exposure, although several hereditary syndromes and genes are also associated with an increased risk

2018 PDQ - NCI's Comprehensive Cancer Database

18. Skin Cancer Treatment (PDQ®): Patient Version

the following summaries for information on melanoma and other kinds of that affect the skin: Skin color and being exposed to sunlight can increase the risk of basal cell carcinoma and squamous cell carcinoma of the skin. Anything that increases your chance of getting a disease is called a . Having a risk factor does not mean that you will get cancer; not having risk factors doesn’t mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for basal cell carcinoma (...) is a disease in which malignant (cancer) cells form in the tissues of the skin. The skin is the body’s largest . It protects against heat, sunlight, injury, and . Skin also helps control body temperature and stores water, fat, and . The skin has several layers, but the two main layers are the (upper or outer layer) and the (lower or inner layer). begins in the epidermis, which is made up of three kinds of : : Thin, flat cells that form the top layer of the epidermis. : Round cells under the squamous cells

2018 PDQ - NCI's Comprehensive Cancer Database

19. Assessment of Dermatologists at Skin of Color Clinics

Description Go to Brief Summary: As a physician, narrowing ones' practice to a particular pathology or group of people is common. Dermatologists are able to concentrate within a number of different areas: cancer, cosmetics, pediatrics or ethnic populations to name a few. Recently, there has been an emphasis on developing skin of color (SOC) clinics and recruiting dermatologists who focus on skin diseases that effect patients with skin of color. In this study, patients with SOC is defined to encompass (...) unique characteristics of dermatologists focusing on SOC skin diseases. Condition or disease Characteristics of Dermatologists Who Focus on Ethnic Skin Detailed Description: Dermatologists who are members of the Skin of Color Society practicing in the US will be sent a recruitment letter in the mail that includes a description of the study and paper survey. The survey will collect participant first and last name so the research team can track replies. Participant first and last name

2017 Clinical Trials

20. Skin Malignancies, Basal Cell Carcinoma

Updated: Feb 21, 2019 Author: Robert S Bader, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Basal Cell Carcinoma Overview Practice Essentials Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). [ , ] The prognosis for patients with BCC is excellent, but if the disease is allowed to progress, it can cause significant morbidity (...) ; some patients may develop more than 100 skin cancers per year. Xeroderma pigmentosum This autosomal recessive disease results in the inability to repair ultraviolet-induced DNA damage. Pigmentary changes are seen early in life, followed by the development of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. Other features include corneal opacities, eventual blindness, and neurological deficits. Nevoid basal cell carcinoma syndrome In addition to basal cell carcinoma

2014 eMedicine Surgery

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