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specific cognitive and behavioral dysfunctions in patients with Alzheimer's disease. The cognitive subscale comprises 11 items which measure word recall (0-10), ability to follow single and multi-step commands (0-5), constructional praxis (0-5), ideational praxis (0-5), naming objects(0-5), word recognition (0-12), orientation (0-8), comprehension of spoken language (0-5), word finding difficulty(0-5) and ability to remember test instructions (0-5). 0 = no impairment with higher scores indicating more (...) scores indicate more severe impairment. Rey Complex Figure Test [ Time Frame: baseline and 12 months ] This is a measure of visual-spatial and constructional ability as well as higher order cognitive processes including planning, organizing, and problem solving. Subjects are asked to copy a complicated drawing. 18 elements are scored from 0-2 depending on accuracy/distortion and location of the reproduction. The maximum score is 36 points. Lower scores indicate more severe impairment Trail Making
and 8 weeks (or end of study iif patient ended participation before the 8-weeks) ] The MATRICS Consensus Cognitive Battery (MCCB)(Measurement and Treatment Research to Improve Cognition in Schizophrenia) was used to measure cognitive performance. Six Domain scores and a Composite score are calculated by the proprietary MCCB Computer Scoring Program (modified beta version) from raw scores on 10 individually administered subtests. The social cognitiontest was not assessed in this study. The Domain T (...) Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies
with organic brain syndrome, mental retardation, or other cognitive dysfunction that could interfere with their capacity to participate in CBT or to complete safety and efficacy assessments; has any history of head trauma causing ongoing cognitiveimpairment; has any history of seizures (apart from childhood febrile seizures); has an uncontrolled, unstable clinically significant medical condition (e.g., renal, endocrine, hepatic, respiratory, cardiovascular, hematologic, immunologic or cerebrovascular (...) Org 25935 Versus Placebo as Augmentation to Cognitive-behavioral Therapy to Treat Panic Disorder (P05705AM3)(TERMINATED) Org 25935 Versus Placebo as Augmentation to Cognitive-behavioral Therapy to Treat Panic Disorder (P05705) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved
, lipid screen including triglycerides, urea and electrolytes, cytokines and neuroimmune markers) will performed on each patient both at baseline (t = -7 days) and at t = 56 days. At 4 weeks, blood sample will be taken for fasting plasma glucose, HbA1c and transaminases. At baseline (-7 days) and completion (56 days) a battery of neurocognitive-impairmenttests (see Appendix A) will be administered. In addition, the Hamilton Rating Scale for Depression (21-ITEM HAM-D GRID), Montgomery -Asberg (...) at nine time points: a baseline prior to treatment (t = -7 days), an assessment one week after treatment has begun (t = 7 days), two weeks after (t = 14 days), three weeks after (t = 21 days), four weeks after (t = 28 days), five weeks after (t = 35 days), six weeks after (t = 42 days), seven weeks after (t = 49 days) and after 8 weeks of treatment (t = 56 days). Evaluation of cognition, mood and anxiety, will be done blind to which time point is being measured. Basic blood work (fasting blood glucose
., BPRS Conceptual Disorganization item score 4) No more than "moderate" severity rating on negative symptoms (i.e., all Scale for the Assessment of Negative Symptoms global items 3) A minimal level of extrapyramidal symptoms (i.e., Simpson-Angus Scale total score 6) A minimal level of depressive symptoms (i.e., Calgary Depression Scale total score 10). Cognitive Status: Performance less than the maximum cutoff (in parentheses) for ONE of the following MCCB tests: Letter-number span (.20) Hopkins (...) impairments in schizophrenia (HHSN 27820044 1003C; P.I.: Steve Marder, M.D.). Despite advances in the safety, tolerability, and effectiveness of antipsychotic medications for the treatment of schizophrenia, many patients continue to be plagued by impairments in social and work functioning. Persons with schizophrenia commonly show deficits in a number of areas of cognition that include impairments in attention, memory, and executive functioning (the ability and organize one's behavior). Importantly
Date : June 2006 Actual Primary Completion Date : May 2011 Actual Study Completion Date : December 2011 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Cognitive Behavioral Therapy (CBT) Patients in this arm only received Cognitive Behavioral Therapy (CBT). Six, 60 minute weekly sessions were followed by 4 bi-weekly sessions and 3 monthly booster sessions. Behavioral: Cognitive Behavioral Therapy (CBT (...) ) CBT is based upon the cognitive and perceptual model of hypochondriasis and incorporates established behavioral techniques. There will be six 60-minute individual sessions conducted at weekly intervals. Booster sessions of 20 to 30 minutes will be conducted at Weeks 8 and 12. The introduction of boosters will make the CBT alone and medication alone arms identical in length. Placebo Comparator: Placebo Patients only received placebo pills accompanied by medication management supportive therapy
Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia. Cholinesterase inhibitors with additional nicotinic activity, such as galantamine, may be useful in PD patients with dementia (PDD) since stimulation of nicotinic receptors may prevent the down-regulation that is likely to accompany cholinesterase inhibition and facilitate dopamine release in the striatum.Sixteen PDD patients (six female) with onset of cognitiveimpairment after at least one year (...) with parkinsonism participated in this open-label trial of galantamine. Cognitive, psychiatric, and motor symptoms were assessed before and after 8 weeks of treatment with galantamine using unstructured clinical assessment as well as rating scales including the Mini-Mental State Examination (MMSE), clock drawing test, verbal fluency and selected items from the Neuropsychiatric Inventory (NPI).Age (mean, SD) was 75.6 (5.2) years, duration of PD 13.4 (5.9), duration of dementia 2.1 (1.7) years, Hoehn and Yahr
Nicotine Treatment of Mild CognitiveImpairment (MCI) Nicotine Treatment of Mild CognitiveImpairment (MCI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nicotine Treatment of Mild CognitiveImpairment (...) on Aging (NIA) Information provided by: National Institute on Aging (NIA) Study Details Study Description Go to Brief Summary: The purpose of this 12-month study is to determine whether nicotine, administered in the form of nicotine patches, can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as "mild cognitiveimpairment" or MCI). Condition or disease Intervention/treatment Phase Age-Related Memory Disorders Drug: Transdermal nicotine patch
. Participants With CognitiveImpairment by SixItem Screener [ Time Frame: 2 hours ] Number of participants with cogintiive impairment as measured by the SixItem Screener, with greater than 2 questions incorrect Participants With Anxiety by Generalized Anxiety Disorder - 7 [ Time Frame: 2 hours ] Participants with anxiety as measured by the Generalized Anxiety Disorder - 7, with a score greater than or equal to 10. Secondary Outcome Measures : Depression and CognitiveImpairment at 2 Weeks [ Time Frame: 2 (...) weeks ] For the individuals who are able to be contacted in 2 weeks, how many still test positive for depression and cognitiveimpairment. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general
of cognitiveimpairment. Patients will meet entry criteria if they have a RBANS total score of 90 or less (one standard deviation below the normal control mean). Exclusion Criteria: History of an organic brain disease History of DSM-IV alcohol or substance abuse (within the last month), or DSM-IV alcohol or substance dependence (within the last six months). Pregnant women and women taking oral contraceptives (because of the theoretical risk of breakthrough ovulation). Current treatment with galantamine (...) Efficacy Study of Galantamine for CognitiveImpairments in Schizophrenia Efficacy Study of Galantamine for CognitiveImpairments in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy
An evaluation of two screening tools for cognitiveimpairment in older emergency department patients. Screening for cognitiveimpairment in older emergency department (ED) patients is recommended to ensure quality care. The Mini-Mental State Examination (MMSE) may be too long for routine ED use. Briefer alternatives include the Six-Item Screener (SIS) and the Mini-Cog. The objective of this study was to describe the test characteristics of the SIS and the Mini-Cog compared with the MMSE when (...) a sensitivity of 75% (95% CI = 48% to 93%) and a specificity of 85% (95% CI = 73% to 93%).The SIS, using a cutoff of impaired, is a promising test for ED use. It is short, easy to administer, and unobtrusive, allowing it to be easily incorporated into the initial assessment of older ED patients.
; NINCDS-ADRDA criteria; n = 66; age 65.9 +/- 7.3 years (mean +/- SD); Mini Mental State Examination (MMSE) score 23.4 +/- 4.1], mild cognitiveimpairment (MCI; criteria of Petersen et al.; n = 48; age 66.4 +/- 7.1 years; MMSE score 28.3 +/- 1.5), and major depressive disorder (DSM-IV criteria; n = 61; age 63.4 +/- 8.0 years; MMSE score 28.6 +/- 1.6). Diagnosis was secured with extensive neuropsychological, clinical, radiological, and laboratory investigations. Six brief screening tests including (...) Screening for cognitiveimpairment: a triage for outpatient care. The current increase in aged individuals in number and proportion of the general population warrants dependable strategies to improve early detection of cognitiveimpairment. It was the goal of the present study to develop a triage for bedside testing and outpatient services. In a prospective clinical cohort study at the outpatient Memory Clinic, University of Ulm, Germany, 232 subjects were diagnosed with Alzheimer's disease [AD
persons with dementia or MCI at baseline; follow-up data were available on 1,256 persons without cognitiveimpairment (95% of those eligible). At baseline, they completed a six-item measure of neuroticism (mean = 15.6, SD = 6.6), an indicator of the tendency to experience psychological distress.During up to 12 years of follow-up, 482 persons (38%) developed MCI. Risk of MCI increased by about 2% for each one unit increase on the distress scale (relative risk [RR] = 1.02; 95% CI: 1.01, 1.04 (...) Chronic distress and incidence of mild cognitiveimpairment. Mild cognitiveimpairment (MCI) is associated with increased morbidity and mortality but its development is not well understood. Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age.Participants are older persons from two cohort studies with uniform annual clinical evaluations which included detailed cognitivetesting and clinical classification of MCI. We excluded
by psychiatrists and is highly regarded. [ , ] It has some methodological issues and may discriminate positively for those with a higher level of educational attainment. There is no strong evidence to support the use of MMSE as a stand-alone test for the identification of patients with mild cognitiveimpairment who may develop dementia. [ ] The Six-itemCognitiveImpairmentTest (6CIT) Developed in 1983, the is relatively unknown, although because of recognition by The Royal College of General Practitioners (...) :CD010783. doi: 10.1002/14651858.CD010783.pub2. ; Screening for cognitiveimpairment in older general hospital patients: comparison of the Six-ItemCognitiveImpairmentTest with the Mini-Mental State Examination. Int J Geriatr Psychiatry. 2011 Aug 27. doi: 10.1002/gps.2776. ; Biostatistics Unit, University of Melbourne ; Screening for cognitiveimpairment in older people attending accident and emergency using the 4-item Abbreviated Mental Test. Eur J Emerg Med. 2010 Dec17(6):340-2. ; Test Your Memory
Cognitive and functional neuroimaging correlate for anosognosia in mild cognitiveimpairment and Alzheimer's disease. To investigate the correlation between anosognosia and behavioural symptoms, performance on executive tests, and frontal cortex regional cerebral blood flow (rCBF) in patients with 'amnestic mild cognitiveimpairment' (MCI) and mild Alzheimer's disease (AD).From a prospective Memory Clinic cohort including consecutively referred patients, age 60 years or above, and with MMSE (...) score 20 or above, 36 patients with AD and 30 with MCI were included in this study. Anosognosia was assessed using a categorical scale and discrepancy scores between patients' and relatives' reports on a 20-item Memory Questionnaire (MQ). Behavioural symptoms were assessed with Frontal Behavioural Inventory (FBI). Executive functions were examined with a range of neuropsychological tests. Tc99m-HMPAO SPECT was obtained in an unselected sample of 55 of the 66 patients, and rCBF was analysed in six
Nursing home assessment of cognitiveimpairment: development and testing of a brief instrument of mental status. To test the accuracy of a brief cognitive assessment of nursing home (NH) residents and to determine whether facility nurses can reliably perform this assessment.Cross-sectional, independent cognitive screening tests with NH residents.Six Department of Veteran Affairs nursing facilities.Three hundred seventy-four residents from six regionally distributed Veteran Affairs NHs.Three (...) cognitive assessment instruments: the Brief Interview of Mental Status (BIMS), created for this study; the Minimum Data Set (MDS) 2.0 Cognitive Performance Scale (CPS), and the Modified Mini-Mental State Examination (3MS) as the criterion standard. The 15-point BIMS tests memory and orientation and includes free and cued recall items. Research assistants administered the 3MS and BIMS to all subjects. Facility nurses administered the same BIMS to a subsample.Three hundred seventy-four of 417 (89.7
Validation of short screening tests for depression and cognitiveimpairment in older medically ill inpatients. To investigate the criterion validity of the four-item Geriatric Depression Scale (GDS4) and the six-item Orientation-Memory-Concentration-test (OMC) against longer widely used screening instruments.Participants were 153 patients (aged 65 or over) admitted to four acute medical wards of a northern UK town. The validity of the GDS4 was determined using the 30-item geriatric depression (...) . There was a significant correlation between the OMC and the SMMSE (rho = -0.827, p < 0.0005).The GDS4 and OMC appear to be useful instruments for screening for depression and cognitiveimpairment among older medical inpatients.Copyright 2004 John Wiley & Sons, Ltd.
cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use (...) , and accompany the subject to all clinic visits for the duration of the protocol. CT or MRI scans within 12 months prior to screening without evidence of infection, infarction, or other focal lesions and without clinical symptoms suggestive of intervening neurological disease. A lacune in a non-critical brain area which is not believed to contribute to the subject's cognitiveimpairment is permissible. Adequate visual and auditory acuity to allow neuropsychological testing. Good general health
The Six-item Screener to Detect CognitiveImpairment in Older Emergency Department Patients. Cognitiveimpairment due to delirium or dementia is common in older emergency department (ED) patients. To prevent errors, emergency physicians (EPs) should use brief, sensitive tests to evaluate older patient's mental status. Prior studies have shown that the Six-Item Screener (SIS) meets these criteria.The goal was to verify the performance of the SIS in a large, multicenter sample of older ED (...) standard for cognitiveimpairment; the SIS cutoff was 4 or less for cognitiveimpairment. Standard operator characteristics of diagnostic tests were calculated with 95% confidence intervals (CIs), and a receiver operating characteristic curve was plotted.The authors enrolled 352 subjects; 111 were cognitivelyimpaired by MMSE (32%, 95% CI = 27% to 37%). The SIS was 63% sensitive (95% CI = 53% to 72%) and 81% specific (95% CI = 75% to 85%). The area under the receiver operating characteristic curve