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Six Item Cognitive Impairment Test

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121. Trajectory of Cognitive Decline After Incident Stroke. (PubMed)

) cohort, residing in the continental United States, enrolled 2003-2007 and followed up through March 31, 2013. Over a median follow-up of 6.1 years (interquartile range, 5.0-7.1 years), 515 participants survived expert-adjudicated incident stroke and 23,057 remained stroke free.Time-dependent incident stroke.The primary outcome was change in global cognition (Six-Item Screener [SIS], range, 0-6). Secondary outcomes were change in new learning (Consortium to Establish a Registry for Alzheimer Disease (...) Word-List Learning; range, 0-30), verbal memory (Word-List Delayed Recall; range, 0-10), and executive function (Animal Fluency Test; range, ≥0), and cognitive impairment (SIS score <5 [impaired] vs ≥5 [unimpaired]). For all tests, higher scores indicate better performance.Stroke was associated with acute decline in global cognition (0.10 points [95% CI, 0.04 to 0.17]), new learning (1.80 points [95% CI, 0.73 to 2.86]), and verbal memory (0.60 points [95% CI, 0.13 to 1.07]). Participants

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2015 JAMA

122. Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery

bariatric surgery (RYGB) patients who consume alcohol. In this study the investigators propose to investigate RYGB patients with a prospective, longitudinal design. Investigators will examine driving impairment before and after surgery as well as study cognitive changes and reinforcement changes that may occur in RYGB patients while consuming alcohol. Finally, investigators aim to better characterize the changes that occur in the pharmacokinetics of alcohol following bariatric surgery and examine key (...) variables which may play a role in the development in alcohol use disorders. Condition or disease Intervention/treatment Phase Bariatric Surgery Candidate Other: Alcohol Not Applicable Detailed Description: The three major objectives of this NIH sponsored application are: 1) to characterize the severity of cognitive impairment and driving performance changes following alcohol consumption in a group of patients who have undergone Roux-en-Y Gastric Bypass (RYGB) bariatric surgery and 2) to investigate

2015 Clinical Trials

123. Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status

), three symptom scales (fatigue, vomiting and pain) and six single item scales (dyspnea, insomnia, constipation, anorexia, diarrhea, and financial difficulties). Health-related quality of life using QLQ-BN20 [ Time Frame: at baseline and every month until 12 months ] The QLQ-BN20 questionnaire includes 20 items covering functional deficits, symptoms, toxic effects of treatment, and uncertainty about the future. Cognitive assessment MMSEs [ Time Frame: at baseline and they were repeated every month (...) months ] Assessment every 2 weeks until 12 months by physical and neurological examinations, complete blood counts and urine strip tests. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria (NCI CTCAE, version 3.0). Health-related quality of life using QLQ-C30 questionnaire [ Time Frame: at baseline and every month until 12 months ] The QLQ-C30 questionnaire includes 30 questions comprising five functioning scales (physical, role, emotional, cognitive and social

2016 Clinical Trials

124. Do people with chronic pain have impaired executive function? A meta-analytical review. (PubMed)

Do people with chronic pain have impaired executive function? A meta-analytical review. A widely held belief within the clinical community is that chronic pain is associated with cognitive impairment, despite the absence of a definitive systematic review or meta-analysis on the topic. The current systematic review and meta-analysis aimed to establish the current evidence concerning the difference in executive function between people with chronic pain and healthy controls. Six databases were (...) pain across cognitive components, although all studies had a high risk of bias. The current evidence suggests impairment of executive function in people with chronic pain, however, important caveats exist. First, executive function involves many cognitive components and there is no standard test for it. Second, moderators of executive function, such as medication and sleep, were seldom controlled for in studies of executive function performance. Copyright © 2014 Elsevier Ltd. All rights reserved.

2014 Clinical psychology review

125. Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis

symptoms in addition to antipsychotic treatment vary between small to medium. However, the effect sizes for changes in delusions are somewhat lower. Thus, it could prove beneficial to tailor CBTp interventions more precisely to the processes that are relevant to delusions. Empirically derived models of the formation and maintenance of delusions postulate an important role of cognitive biases, emotional factors and self-esteem. Additional studies have demonstrated the relevance of impaired sleep (...) that a combination of CBT-interventions within a broader therapy rational might have an even greater impact on delusions. The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and sleep quality (CBTd-E) that will be applied in 25 individual sessions. Moreover, the study aims to test whether the efficacy of CBTd-E is mediated by the postulated

2016 Clinical Trials

126. Development and Validation of a Smart Phone Based System to Enhance Gait, Cognition and Socialization in Elderly Fallers

and 3 months after completing the training ] Working memory (forward and backward digit span): Forward and backward digit span is a common measure of short-term memory (working memory). It is also a component of cognitive ability tests. Backward memory span is a more challenging variation which involves recalling items in reverse order. Changes in cognitive function: number of correct / incorrect answers [ Time Frame: At baseline, immediately after the training and 3 months after completing (...) risk and impaired cognitive function that are so common among older adults, enabling them to live longer successfully and independently. Condition or disease Intervention/treatment Phase Older Adults Device: Monitoring and training using the system Behavioral: Standard of care Not Applicable Detailed Description: A comprehensive system will be developed to promote mobility, enhance cognitive function, reduce sedentary behavior, increase independence and encourage social inclusion. This novel system

2016 Clinical Trials

127. Cognitive-Existential Group Therapy to Reduce Fear of Cancer Recurrence: A RCT Study

: Supportive Therapy Group 2 Not Applicable Detailed Description: The present study aims to further test this cognitive-existential group intervention for FCR in a randomized control clinical trial with women with breast or gynecological cancer. Participants will be recruited from Princess Margaret Hospital, Mount Sinai Hospital, the Jewish General Hospital, and the Ottawa Hospital. 144 cancer patients will be randomized to either receive the 6 week cognitive-existential group intervention or to a control (...) Completion Date : December 1, 2018 Estimated Study Completion Date : December 1, 2018 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group 1 Behavioral:Cognitive Existential Therapy Group 1- Weekly two-hour group sessions Behavioral: Cognitive Existential Therapy Group 1 Six group sessions of two hour each using a cognitive-existential group approach Active Comparator: Group 2 Behavioral

2016 Clinical Trials

128. Freezing of Gait: Clinical, Cognitive, and Imaging Features

or she connects the "trail." If the participant makes an error, point it out and allow the participant to correct it. Errors affect the participant's score only in that the correction of errors is included in the completion time for the task. Participants are scored by the number of seconds taken to complete the task, with high scores revealing greater impairment. Wisconsin Card Sorting Test (WCST) score [ Time Frame: Baseline ] The WCST measures cognitive flexibility and problem solving skills (...) to match the angle and orientation of lines in space. Participants are asked to match two angled lines to a set of 11 lines that are arranged in a semicircle and separated 18 degrees from each other.The test is a standardized test with 30 items with the minimum score being 0, indicating low visual spatial cognition and the maximum score being 30, indicating high visual spatial cognition. Number of correct responses for Mental Rotation Task [ Time Frame: Baseline ] Mental rotation is the ability

2015 Clinical Trials

129. Effectiveness of Meta-Cognitive Training (EMC) in People With Psychosis of Brief Evolution.

is to assess the effectiveness of Meta-Cognitive Training (EMC) in people with a brief psychotic disorder, especially positive symptoms. The secondary objectives would be to assess the effect of EMC on metacognition (cognitive distortions and deficits in theory of mind), psychosocial functioning and quality of life, neuropsychological functioning and gender, as well as determine the changes produced by EMC in the insight of each session and the maintenance of the effects of EMC program at six months (...) measure of 15 items which evaluates how the patients assess their own judgement. It has two dimensions; self-reflection (R) (9 items), and self-certainty (C) (6 items). A compound index of cognitive insight is obtained as the subtraction of self-certainty from self-reflection (R-C). IPSAQ. Internal, Personal and Situational Attribution Questionnaire. [ Time Frame: baseline, 2 months (post-treatment) and 6 months of follow-up. ] The scale assess the attributional style in 32 situations. Hinking Task

2015 Clinical Trials

130. The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy

stimulation applied over the left dorsolateral prefrontal cortex have been reported for working memory, attention and information processing in depressed patients. To the investigators' knowledge no studies have evaluated the potential efficacy of tDCS for the prevention of ECT induced cognitive adverse effects. In the current study, the investigators propose a double blind, randomized controlled trial to test the use of tDCS as a strategy to prevent or mitigate the memory impairments frequently (...) which can affect cognition or response to treatment; A history of medication-resistant epilepsy in the family, and/or past history of seizures or unexplained spells of loss of consciousness during the previous 36 months Current (within the past three months) diagnosis of active substance dependence, or active substance abuse within the past week, as determined by interview and chart review. Active suicidal ideation, as measured by scores of 3 or more on item 3 of the HRSD; ECT within six months

2016 Clinical Trials

131. Effect of Alternating Postures on Cognitive Performance

participants were familiarized with the study protocol. Sitting time and weekly physical activity were determined via the long version of the International Physical Activity Questionnaire (IPAQ, only on the first day of measurement). Examples of each cognitive test implemented in the cognitive phase were executed according to their guidelines. A 30 minute break in a sitting posture was used to ascertain baseline heart-rate level. Baseline heart-rate was calculated after a 20 minute rest for a 5 minute (...) interval. In the second (cognitive) phase subjects participated in a test battery containing five blocks. Each block consisted of a working speed test (text editing task), an attentional test (d2R-test of attention) and a reaction time test (Stroop-test). These tests lasted for 30 minutes to fulfill recommendations regarding postural changes. To simulate "common" working conditions (computer based and non-computer based tasks), digital (text editing task, Stroop-test) as well as pen & paper (d2R-test

2016 Clinical Trials

132. A Superiority Study To Compare The Effects Of An 8-Weeks Mindfulness-based Intervention Versus Health Education Programme On Mental Health And Wellbeing In Individuals With Subjective Cognitive Decline

in the earliest stages for intervention when neurodegeneration is still limited. Individuals clinically judged to have SCD, defined by subjectively experienced cognitive decline but normal performance on cognitive tests, are at increased risk for future cognitive decline and AD. These individuals with SCD currently have no established treatment options. Symptoms of anxiety have high prevalence in this population, and evidence from recent longitudinal research links anxiety with significantly accelerated (...) to affect a number of areas of life we will also look at changes in other areas of psycho-affective symptoms, social functioning, awareness, well being and quality of life, sleep quality, and cognition, after the intervention and 16 weeks after the end of the intervention. Validated neuropsychological tests and behavioural questionnaires were selected for their sensitivity to the domains listed above. These measures will be completed alone by the participant or in the presence of a psychometrist

2016 Clinical Trials

133. Cognition Metabolism and Exercise Among Women Living With HIV in Puerto Rico

an intervention (described above) designed for normally active but physically untrained HIV+ Hispanic women, one with (n=15) and other without (n=15) neurocognitive impairment & HIV- controls (n=15). After the HIIT intervention, measurements of CR-fitness, insulin resistance, and cognitive function including hippocampal function using the memory island test will be obtained, as well as CR-fitness, anthropometry, DEXA densitometry, and blood and urine samples for metabolic testing. The ultimate goal (...) (n=15) neuro-cognitive impairment (HAND) on antiretroviral therapy (CART) receive 2 weeks, 6 sessions of 8 x 60 seconds cycling bouts eliciting approximately 80% of maximal heart rate with 60 second rest between bouts after which they will receive 4 week, 12 sessions of 10 x 60 seconds cycling bouts eliciting approximately 90% of maximal heart rate with 60 second rest between bouts. Other: High intensity interval training (HIIT) Six weeks, three days per week (total of 18 sessions) of HIIT cycle

2016 Clinical Trials

134. The Effectiveness of TECH: Tablet Enhancement of Cognition and Health

Sponsor: Assuta Hospital Systems Information provided by (Responsible Party): Zvi Buckman, Assuta Hospital Systems Study Details Study Description Go to Brief Summary: This study assess the effectiveness of novel cognitive intervention utilizing tablet apps (TECH protocol: Tablet Enhancement of Cognition and Health) to improve cognitive abilities, daily function and health-related quality of life of older adults with MCI. Forty six older adults with MCI will be randomly allocated to the TECH protocol (...) (experimental group) or standard care (control group). Assessments will be administered pre and post the 6-week TECH protocol and at 6-month follow-up by assessors blind to group allocation. Condition or disease Intervention/treatment Phase Mild Cognitive Impairment Other: TECH: Tablet Enhancement of Cognition and Health Not Applicable Detailed Description: A single-blind randomized controlled trial (RCT) will be conducted, by assessors blind to group allocation. Participants will be referred to the study

2016 Clinical Trials

135. Revitalize Cognition: Near Infrared Stimulation in Older Adults

with the amnestic variant of mild cognitive impairment (aMCI). While waiting for causative cures and preventive approaches, investigators are faced with the task of identifying modifying therapies that might alter the course or slow down the transition from normal cognition to MCI to dementia. The proposed study hopes to contribute to this mission by testing the viability of a different type of intervention, one involving transcranial delivery of near-infrared (NIR) wavelengths (808-904nm). Near-infrared (...) in terms of positive effects of NIR on cognition. The overall goal of the present study is to learn whether this unconventional NIR stimulation approach has potential for improving cognition in older adults. To do so, investigators will conduct a randomized sham controlled pilot trial. The intervention will involve six sessions, over a 2-week period in which real or sham stimulation is transcranially applied using a delivery system that has been FDA-approved as a nonsignificant risk since 2003

2015 Clinical Trials

136. Cognitive Remediation to Improve Mobility in Sedentary Seniors

College of Medicine Collaborator: National Institute on Aging (NIA) Information provided by (Responsible Party): Joe Verghese, Albert Einstein College of Medicine Study Details Study Description Go to Brief Summary: The investigators propose to conduct a single-blind randomized clinical trial to test the efficacy of a computerized cognitive remediation intervention program on improving locomotion in sedentary seniors, a group at an especially high risk for disability. The hypothesis is that executive (...) : 2 Months ] Improvement on the Repeatable Battery for the Assessment of Neuropsychological Status, a relatively brief battery that assesses overall level of cognitive function This battery consists of 10 neurocognitive tests measuring memory (immediate and delayed), attention, language, visuospatial abilities and executive functions. Performance is converted to standardized scores derived from a normative sample. Neuroplasticity. [ Time Frame: 2 Months ] Changes in prefrontal activation measure

2015 Clinical Trials

137. Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. (PubMed)

provided estimates of PA variables for 4 to 7 consecutive days. PA cut-points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six-Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function.Of (...) Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. To examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults.Cross-sectional.REasons for Geographic and Racial Differences in Stroke (REGARDS) study.Older adults who provided valid data from accelerometer and cognitive function tests (N = 7,098).Accelerometers

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2015 Journal of the American Geriatrics Society

138. Cognitive Rehab and Exposure Treatment for Hoarding

contact as CREST. Twenty-six weekly, individual ET sessions (6 months) will be delivered. The control group will receive ET for all 26 sessions and no cognitive training. As in CREST, the ET sessions will be manualized and copies utilized during session by both the patient and therapist. Outcome Measures Go to Primary Outcome Measures : Saving Inventory Revised [ Time Frame: 6 months ] Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R)56, a 23-item (...) to hoarding treatment. Condition or disease Intervention/treatment Phase Hoarding Disorder Behavioral: CREST Behavioral: ET Not Applicable Detailed Description: Objective: The investigators propose to conduct a randomized controlled trial comparing six months (26 sessions) of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) treatment to a robust comparator, six months of Exposure Therapy alone, in 136 participants with HD. Research Design: Assessments will be administered at baseline, during

2015 Clinical Trials

139. Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

treatment effects and evidence of disease modification. Condition or disease Intervention/treatment Phase Alzheimer Disease Cognitive Decline Due to Alzheimer Disease Mild Cognitive Impairment Due to Alzheimer Disease Drug: Naproxen Drug: Placebo Phase 2 Detailed Description: The trial enrolled 195 cognitively normal persons aged 60+ with either a parental history of AD or a history of two or more affected first-degree relatives. Persons aged 55-59 were admitted if their current age was <= 15 years (...) after randomization) they were tested for cognitive abilities and undergo brain imaging with both structural and functional MRI. They are also tested for sensori-neural capacities in olfactory identification and in the ability to discern spoken language in a distracting environment (to test central auditory processing). About 2/3 of participants also volunteered to undergo a series of lumbar punctures for donation of cerebrospinal fluid (CSF), which was assayed for several biochemical markers of AD

2015 Clinical Trials

140. Integrative Group-based Cognitive Rehabilitation Efficacy in Multiple Sclerosis

-Color Test. Additionally, several test and scales were administered. The Expanded Disability Status Scale was used for rating the degree of neurologic impairment. Premorbid IQ was tested by The Accentuation Reading Test. Cognitive reserve was estimated with the Cognitive Reserve Questionnaire. The 15-item Geriatric Depression Scale was included to assess patients´ depressive symptoms. The Fatigue Severity Scale and the mental fatigue Visual Analogue Scale were included to evaluate physical (...) Modalities Test (SDMT), the three and six letter version of the Salthouse Perceptual Comparison Test (PCT) and the Trail Making Test A (TMTA). Change in verbal memory after receiving cognitive remediation treatment [ Time Frame: 3 months ] Verbal memory was measured using The Hopkins Verbal Learning Test - Revised (HVLT-R). Change in verbal fluency after receiving cognitive remediation treatment [ Time Frame: 3 months ] Verbal fluency was measured using the Calibrated Ideational Fluency Assessment (CIFA

2014 Clinical Trials

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