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Six Item Cognitive Impairment Test

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121. Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis

symptoms in addition to antipsychotic treatment vary between small to medium. However, the effect sizes for changes in delusions are somewhat lower. Thus, it could prove beneficial to tailor CBTp interventions more precisely to the processes that are relevant to delusions. Empirically derived models of the formation and maintenance of delusions postulate an important role of cognitive biases, emotional factors and self-esteem. Additional studies have demonstrated the relevance of impaired sleep (...) that a combination of CBT-interventions within a broader therapy rational might have an even greater impact on delusions. The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and sleep quality (CBTd-E) that will be applied in 25 individual sessions. Moreover, the study aims to test whether the efficacy of CBTd-E is mediated by the postulated

2016 Clinical Trials

122. Development and Validation of a Smart Phone Based System to Enhance Gait, Cognition and Socialization in Elderly Fallers

and 3 months after completing the training ] Working memory (forward and backward digit span): Forward and backward digit span is a common measure of short-term memory (working memory). It is also a component of cognitive ability tests. Backward memory span is a more challenging variation which involves recalling items in reverse order. Changes in cognitive function: number of correct / incorrect answers [ Time Frame: At baseline, immediately after the training and 3 months after completing (...) risk and impaired cognitive function that are so common among older adults, enabling them to live longer successfully and independently. Condition or disease Intervention/treatment Phase Older Adults Device: Monitoring and training using the system Behavioral: Standard of care Not Applicable Detailed Description: A comprehensive system will be developed to promote mobility, enhance cognitive function, reduce sedentary behavior, increase independence and encourage social inclusion. This novel system

2016 Clinical Trials

123. Robot-assisted therapy for long-term upper limb impairment after stroke

. Nearly all patients are disabled immediately following a stroke event. Common disabilities include permanent paralysis of one side of the body, speech or swallowing difficulties, problems with memory, personality changes or a range of other difficulties. Depression, anxiety and cognitive impairment are also common after stroke. By the end of the first year, about half of all survivors of stroke remain dependent on others for activities of daily living. Stroke mainly affects older people (...) paralysis restricted to one side of the body 6 Robot-assisted therapy for upper limb impairment after stroke: November 2010 on patients in the acute and subacute phase of their stroke (= 3 months) and those in the chronic phase (>3 months duration). The primary and secondary outcomes of the included studies were an improvement in daily living activity and changes in arm motor function impairment, respectively. The methodological quality of the included studies was assessed using the PEDro scale. 5 Six

2011 Australia and New Zealand Horizon Scanning Network

124. Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. Full Text available with Trip Pro

provided estimates of PA variables for 4 to 7 consecutive days. PA cut-points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six-Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function.Of (...) Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. To examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults.Cross-sectional.REasons for Geographic and Racial Differences in Stroke (REGARDS) study.Older adults who provided valid data from accelerometer and cognitive function tests (N = 7,098).Accelerometers

2015 Journal of the American Geriatrics Society

125. Cognitive Rehab and Exposure Treatment for Hoarding

contact as CREST. Twenty-six weekly, individual ET sessions (6 months) will be delivered. The control group will receive ET for all 26 sessions and no cognitive training. As in CREST, the ET sessions will be manualized and copies utilized during session by both the patient and therapist. Outcome Measures Go to Primary Outcome Measures : Saving Inventory Revised [ Time Frame: 6 months ] Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R)56, a 23-item (...) to hoarding treatment. Condition or disease Intervention/treatment Phase Hoarding Disorder Behavioral: CREST Behavioral: ET Not Applicable Detailed Description: Objective: The investigators propose to conduct a randomized controlled trial comparing six months (26 sessions) of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) treatment to a robust comparator, six months of Exposure Therapy alone, in 136 participants with HD. Research Design: Assessments will be administered at baseline, during

2015 Clinical Trials

126. Freezing of Gait: Clinical, Cognitive, and Imaging Features

or she connects the "trail." If the participant makes an error, point it out and allow the participant to correct it. Errors affect the participant's score only in that the correction of errors is included in the completion time for the task. Participants are scored by the number of seconds taken to complete the task, with high scores revealing greater impairment. Wisconsin Card Sorting Test (WCST) score [ Time Frame: Baseline ] The WCST measures cognitive flexibility and problem solving skills (...) to match the angle and orientation of lines in space. Participants are asked to match two angled lines to a set of 11 lines that are arranged in a semicircle and separated 18 degrees from each other.The test is a standardized test with 30 items with the minimum score being 0, indicating low visual spatial cognition and the maximum score being 30, indicating high visual spatial cognition. Number of correct responses for Mental Rotation Task [ Time Frame: Baseline ] Mental rotation is the ability

2015 Clinical Trials

127. Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy

% of these patients develops severe cognitive dysfunction. Recovery usually occurs within six months after ECT. However, performances remain below-average compared to norm groups and there are large individual differences. The cognitive difficulties in MS and PD have a significant negative influence on the quality of life. Cognitive dysfunction in PD is associated with decreased independent daily functioning, hospitalization and the development and severity of neuropsychiatric symptoms. Furthermore, in the clinic (...) an adequately controlled design. Additionally, earlier cognitive training programs have frequently been executed in a health care organization, impairing patients to successfully attend all training sessions due to mobility impairments. Also, there are limited studies in the effects of cognitive training on improved functioning of daily living and neuropsychiatric symptoms like anxiety and depression. Given the fact that there is an absence in cognitive training studies in patients post-ECT

2015 Clinical Trials

128. Cognitive Remediation to Improve Mobility in Sedentary Seniors

College of Medicine Collaborator: National Institute on Aging (NIA) Information provided by (Responsible Party): Joe Verghese, Albert Einstein College of Medicine Study Details Study Description Go to Brief Summary: The investigators propose to conduct a single-blind randomized clinical trial to test the efficacy of a computerized cognitive remediation intervention program on improving locomotion in sedentary seniors, a group at an especially high risk for disability. The hypothesis is that executive (...) : 2 Months ] Improvement on the Repeatable Battery for the Assessment of Neuropsychological Status, a relatively brief battery that assesses overall level of cognitive function This battery consists of 10 neurocognitive tests measuring memory (immediate and delayed), attention, language, visuospatial abilities and executive functions. Performance is converted to standardized scores derived from a normative sample. Neuroplasticity. [ Time Frame: 2 Months ] Changes in prefrontal activation measure

2015 Clinical Trials

129. Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

treatment effects and evidence of disease modification. Condition or disease Intervention/treatment Phase Alzheimer Disease Cognitive Decline Due to Alzheimer Disease Mild Cognitive Impairment Due to Alzheimer Disease Drug: Naproxen Drug: Placebo Phase 2 Detailed Description: The trial enrolled 195 cognitively normal persons aged 60+ with either a parental history of AD or a history of two or more affected first-degree relatives. Persons aged 55-59 were admitted if their current age was <= 15 years (...) after randomization) they were tested for cognitive abilities and undergo brain imaging with both structural and functional MRI. They are also tested for sensori-neural capacities in olfactory identification and in the ability to discern spoken language in a distracting environment (to test central auditory processing). About 2/3 of participants also volunteered to undergo a series of lumbar punctures for donation of cerebrospinal fluid (CSF), which was assayed for several biochemical markers of AD

2015 Clinical Trials

130. Revitalize Cognition: Near Infrared Stimulation in Older Adults

with the amnestic variant of mild cognitive impairment (aMCI). While waiting for causative cures and preventive approaches, investigators are faced with the task of identifying modifying therapies that might alter the course or slow down the transition from normal cognition to MCI to dementia. The proposed study hopes to contribute to this mission by testing the viability of a different type of intervention, one involving transcranial delivery of near-infrared (NIR) wavelengths (808-904nm). Near-infrared (...) in terms of positive effects of NIR on cognition. The overall goal of the present study is to learn whether this unconventional NIR stimulation approach has potential for improving cognition in older adults. To do so, investigators will conduct a randomized sham controlled pilot trial. The intervention will involve six sessions, over a 2-week period in which real or sham stimulation is transcranially applied using a delivery system that has been FDA-approved as a nonsignificant risk since 2003

2015 Clinical Trials

131. Observable Social Cognition: A Rating Scale (OSCARS): An Interview-Based Assessment for Schizophrenia Full Text available with Trip Pro

Observable Social Cognition: A Rating Scale (OSCARS): An Interview-Based Assessment for Schizophrenia Individuals with schizophrenia consistently show impairments in social cognition (SC). SC has become a potential treatment target due to its association with functional outcomes. An alternative method of assessment is to administer an observer-based scale incorporating an informant's "first hand" impressions in ratings.The present study used the Observable Social Cognition: A Rating Scale (...) (OSCARS) in 62 outpatients and 50 non-psychiatric controls (NPCs) to assess performance in domains of SC (e.g. emotion perception, theory of mind).The OSCARS demonstrated sufficient internal consistency and test-retest reliability. Construct validity was assessed through an exploratory factor analysis. Patient OSCARS indices were not significantly correlated with measures of SC with the exception of aggressive attributional style. Individuals with less impairment in SC reacted more aggressively

2015 Cognitive neuropsychiatry

132. Effectiveness of Meta-Cognitive Training (EMC) in People With Psychosis of Brief Evolution.

is to assess the effectiveness of Meta-Cognitive Training (EMC) in people with a brief psychotic disorder, especially positive symptoms. The secondary objectives would be to assess the effect of EMC on metacognition (cognitive distortions and deficits in theory of mind), psychosocial functioning and quality of life, neuropsychological functioning and gender, as well as determine the changes produced by EMC in the insight of each session and the maintenance of the effects of EMC program at six months (...) measure of 15 items which evaluates how the patients assess their own judgement. It has two dimensions; self-reflection (R) (9 items), and self-certainty (C) (6 items). A compound index of cognitive insight is obtained as the subtraction of self-certainty from self-reflection (R-C). IPSAQ. Internal, Personal and Situational Attribution Questionnaire. [ Time Frame: baseline, 2 months (post-treatment) and 6 months of follow-up. ] The scale assess the attributional style in 32 situations. Hinking Task

2015 Clinical Trials

133. Reliability and Physiological Analysis of an Isometric Test of Localized Muscular Fatigue

on the average of the answers to these six questions, in order to obtain an overall sleep problems score Need for Recovery Scale [ Time Frame: Day 7 ] This is an 11 item scale which aims to evaluate work fatigue symptoms, related to a series of emotional, cognitive and behavioral aspects characterized as temporary overload feelings, irritability, social seclusion, lack of energy for new efforts and performance reduction Borg Scale [ Time Frame: Day 7 ] Participants' physical effort perception will also (...) 1 ] This scale is intended to evaluate participants' sleep and tiredness, which consists in six questions about sleep issues in the previous month. Questions are about (1) problems initiating sleep, (2) awakening from sleep, (3) early morning awakening, (4) not feeling adequately rested, (5) experiencing daytime impairment and (6) being dissatisfied with sleep. To each question participants will answer on a zero to seven days a week scale. The quantity of days will be calculated based

2017 Clinical Trials

134. Testing if Reductions in Negative Affect Yield Decreased Emotional Eating Symptoms

) Actual Enrollment : 28 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: Testing if Reductions in Negative Affect Yield Decreased Emotional Eating Symptoms: A Cognitive Bias Intervention Actual Study Start Date : March 28, 2017 Actual Primary Completion Date : May 3, 2017 Actual Study Completion Date : May 3, 2017 Arms and Interventions Go to Arm Intervention/treatment Experimental: Cognitive Bias (...) being tested by other researchers utilizing cognitive bias modification paradigms. The relaxation training sessions will be matched to the length of the treatment condition and therefore will last approximately 30 minutes. Outcome Measures Go to Primary Outcome Measures : Change in Emotional Overeating Questionnaire Scores [ Time Frame: Assessed at baseline (time zero), mid-treatment (8 days after baseline), and post-treatment (2 weeks after baseline). ] Emotional eating will be measured using the 6

2017 Clinical Trials

135. Validation, Reliability and Pilot Test of the Personalized Exercise Questionnaire (PEQ)

-Square test. Secondary Outcome Measures : Preferences to exercise [ Time Frame: 3 months ] Using the PEQ, domains two and four, will be used to quantify the frequency of each preference. Results will be presented in a table with column one representing the survey item and column two representing the frequency of the reported outcome. Barriers to exercise [ Time Frame: 3 months ] Using the PEQ, domain six, will be used to quantify the frequency of each barrier. Results will be presented in a table (...) and/or steroid use. The participant is diagnosed with a reading disability or dyslexia The participant has a cognitive impairment of some severity as to adversely affect the validity of the data Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03125590

2017 Clinical Trials

136. Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers

weak or cognitively impaired to participate in the intervention and complete the assessments Per self-report/screening measures, has received cognitive-behavioral therapy since cancer diagnosis As per medical record or self-report, currently being treated for schizophrenia, substance use or dependence, and/or bi-polar disorder Anxiety due solely to a medical procedure as determined by a patient-report item on the screening questionnaire CAREGIVERS: Endorsing active suicidal ideation on the item (...) Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

137. This Study Tests Whether BI 409306 Prevents Patients With a Specific Type of Mental Illness (Attenuated Psychosis Syndrome) From Becoming Worse. This Study Looks at How Well Patients Tolerate the Medicine and How Effective it is Over 1 Year

baseline in everyday functional capacity as measured by Schizophrenia Cognition Rating Scale (SCoRS) total score after 24 and 52 weeks of treatment [ Time Frame: Baseline, Week 24 and Week 52 ] Change from baseline in the BAC App composite T score after 52 weeks of treatment [ Time Frame: Baseline and Week 52 ] Change from baseline in Positive and Negative Syndrome Scale (PANSS) positive items score, negative items score, and total score after 52 weeks of treatment [ Time Frame: Baseline and Week 52 (...) This Study Tests Whether BI 409306 Prevents Patients With a Specific Type of Mental Illness (Attenuated Psychosis Syndrome) From Becoming Worse. This Study Looks at How Well Patients Tolerate the Medicine and How Effective it is Over 1 Year This Study Tests Whether BI 409306 Prevents Patients With a Specific Type of Mental Illness (Attenuated Psychosis Syndrome) From Becoming Worse. This Study Looks at How Well Patients Tolerate the Medicine and How Effective it is Over 1 Year - Full Text View

2017 Clinical Trials

138. Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status

), three symptom scales (fatigue, vomiting and pain) and six single item scales (dyspnea, insomnia, constipation, anorexia, diarrhea, and financial difficulties). Health-related quality of life using QLQ-BN20 [ Time Frame: at baseline and every month until 12 months ] The QLQ-BN20 questionnaire includes 20 items covering functional deficits, symptoms, toxic effects of treatment, and uncertainty about the future. Cognitive assessment MMSEs [ Time Frame: at baseline and they were repeated every month (...) months ] Assessment every 2 weeks until 12 months by physical and neurological examinations, complete blood counts and urine strip tests. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria (NCI CTCAE, version 3.0). Health-related quality of life using QLQ-C30 questionnaire [ Time Frame: at baseline and every month until 12 months ] The QLQ-C30 questionnaire includes 30 questions comprising five functioning scales (physical, role, emotional, cognitive and social

2016 Clinical Trials

139. Effects of Exercise on Cognitive Performance of Patients With Alzheimer-type Dementia. Pilot Study.

points), orientation (1 item, 8 points), language (5 items, 25 points) and praxis (2 items, 10 points). The maximum score is 70 points.The higher the score, the greater the cognitive impairment.This is the primary outcome measure most frequently used in clinical trials with drugs. Secondary Outcome Measures : Global cognitive performance [ Time Frame: 0, 6 and 12 months ] Global cognitive performance is measured with Test Barcelona TBR-B neuropsychological battery (abreviated version).The ADAS-COG (...) : Global cognitive performance (Neuropsychological battery TBR-B),neuropsychiatric symptoms (NPI), ADL (Blessed),functional capacity (Test of 6-minute walk), cardiorespiratory Test, muscular strength (hand dynamometer and trunk); PREDICTORS AND CONFOUNDING VARIABLES: baseline cognitive performance, previous physical activity, medication, age, sex, APOE, schooling and cognitive reserve. ANALYSIS: We compared the two groups in terms of observed mean changes from baseline in ADAS measurement and other

2014 Clinical Trials

140. Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism

minutes for an overall education dose of 240 minutes; similar to the exercise dose. Behavioral: Exercise and Education for Parkinson's Disease Exercise and Education for Parkinson's Disease for 6 week cross-over intervention. Outcome Measures Go to Primary Outcome Measures : Change in Mini-BESTest score [ Time Frame: Three timepoints; baseline, 6 weeks (after Arm 1), 12 weeks (after Arm 2) ] The Mini-BESTest assesses dynamic balance via a 14-item test that measures multiple domains of balance (...) related to frequency and duration of each type of FoG episode. Change in PDQ-39 score [ Time Frame: Three timepoints; baseline, 6 weeks (after Arm 1), 12 weeks (after Arm 2) ] the Parkinson's Disease Quality of Life questionnaire with 39 questions reflecting 8 domains of quality of life (Mobility, ADL's, Emotional well-being, Stigma, Social support, Cognition, Communication, and Bodily discomfort). Each item scores from 0 (never) to 4 (always). Subscale scores and a summary index representing

2014 Clinical Trials

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