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Six Item Cognitive Impairment Test

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121. Anosognosia for memory deficit in amnestic mild cognitive impairment and Alzheimer's disease. (PubMed)

Anosognosia for memory deficit in amnestic mild cognitive impairment and Alzheimer's disease. to investigate patterns of anosognosia for memory deficit in subjects with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD).the study involved twenty-five subjects with MCI, 15 with mild AD and 21 normal controls (NC). Subjective rating of memory functioning was assessed with a six-items questionnaire that was administered before and after memory testing; an informant version from (...) memory testing. At the OJ task, MCI and AD consistently overestimated their memory performances as compared with NC. The SRD and OJ measures were not correlated with some patients being impaired on only one measure. Only the OJ measure was significantly related to executive functioning.AD and MCI subjects show unawareness for memory deficit and significant memory-monitoring disorder. This confirms that anosognosia is an important symptom of MCI. Similarities of patterns of impaired awareness between

2011 International Journal of Geriatric Psychiatry

122. Depression and Cognitive Impairment in Older Adult Emergency Department Patients: Changes over 2 Weeks. (Full text)

(Six-Item Screener) was performed. Changes were evaluated through paired comparisons.At 2-week follow-up, for depression, 27 of 97 (28%) with baseline positive tests remained positive, and 22 of 706 (3%) with baseline negative tests were positive. At 2-week follow-up, for cognitive impairment, five of 43 (12%) with baseline positive tests remained positive, and 11 of 765 (1%) with baseline negative tests were positive.Significant variability exists for depression and cognitive impairment testing (...) Depression and Cognitive Impairment in Older Adult Emergency Department Patients: Changes over 2 Weeks. To evaluate older adult emergency department (ED) patients for depression and cognitive impairment and to re-evaluate those findings 2 weeks later.Prospective cohort study.ED.One thousand two hundred six older community-dwelling ED patients consented to participate; 811 (67%) completed the 2-week follow-up.Screening for depression (9-item Patient Health Questionnaire) and cognitive impairment

2011 Journal of the American Geriatrics Society PubMed

123. How do the phq-2, the phq-9 perform in aging services clients with cognitive impairment? (Full text)

How do the phq-2, the phq-9 perform in aging services clients with cognitive impairment? To examine the performance of the Patient Health Questionnaire-2 (PHQ-2) and the PHQ-9 in detecting current major depressive episode (MDE) in aging services care management clients who screen positive for cognitive impairment (CI).Cross-sectional observational study of 236 care management clients ages ≥60 years recruited from an Upstate NY aging services agency. The test characteristics of the PHQ-2 and PHQ (...) -9 to screen for depression were calculated using the Structured Clinical Interview for DSM-IV (SCID) to identify MDE (gold standard). CI was identified with the Six-Item Screen (SIS).Participants had a mean age of 77 years, 68% female, 16% non-white, and 26% had less than a high school education. 16% of participants had CI identified by ≥2 errors on SIS. Of these, 41% had positive PHQ-2 (scores ≥3), 43% had positive PHQ-9 (scores ≥10), while 24% met criteria for MDE. In the sample with CI

2011 International Journal of Geriatric Psychiatry PubMed

124. Trajectory of Cognitive Decline After Incident Stroke. (Full text)

) cohort, residing in the continental United States, enrolled 2003-2007 and followed up through March 31, 2013. Over a median follow-up of 6.1 years (interquartile range, 5.0-7.1 years), 515 participants survived expert-adjudicated incident stroke and 23,057 remained stroke free.Time-dependent incident stroke.The primary outcome was change in global cognition (Six-Item Screener [SIS], range, 0-6). Secondary outcomes were change in new learning (Consortium to Establish a Registry for Alzheimer Disease (...) Word-List Learning; range, 0-30), verbal memory (Word-List Delayed Recall; range, 0-10), and executive function (Animal Fluency Test; range, ≥0), and cognitive impairment (SIS score <5 [impaired] vs ≥5 [unimpaired]). For all tests, higher scores indicate better performance.Stroke was associated with acute decline in global cognition (0.10 points [95% CI, 0.04 to 0.17]), new learning (1.80 points [95% CI, 0.73 to 2.86]), and verbal memory (0.60 points [95% CI, 0.13 to 1.07]). Participants

2015 JAMA PubMed

125. Five short screening tests in the detection of prevalent delirium: diagnostic accuracy and performance in different neurocognitive subgroups. (PubMed)

Five short screening tests in the detection of prevalent delirium: diagnostic accuracy and performance in different neurocognitive subgroups. Delirium is prevalent and serious, yet remains under-recognised. Systematic screening could improve detection; however, consensus is lacking as to the best approach. Our aim was to assess the diagnostic accuracy of five simple cognitive tests in delirium screening: six-item cognitive impairment test (6-CIT), clock-drawing test, spatial span forwards (...) delirium), Wilks' Lambda = 0.748, p < 0.001.The 6-CIT measures attention, temporal orientation and short-term memory and shows promise as a delirium screening test. This study suggests that it may also have potential in distinguishing the cognitive impairment of delirium from that of dementia in older patients. Copyright © 2016 John Wiley & Sons, Ltd.Copyright © 2016 John Wiley & Sons, Ltd.

2016 International Journal of Geriatric Psychiatry

126. Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery

bariatric surgery (RYGB) patients who consume alcohol. In this study the investigators propose to investigate RYGB patients with a prospective, longitudinal design. Investigators will examine driving impairment before and after surgery as well as study cognitive changes and reinforcement changes that may occur in RYGB patients while consuming alcohol. Finally, investigators aim to better characterize the changes that occur in the pharmacokinetics of alcohol following bariatric surgery and examine key (...) variables which may play a role in the development in alcohol use disorders. Condition or disease Intervention/treatment Phase Bariatric Surgery Candidate Other: Alcohol Not Applicable Detailed Description: The three major objectives of this NIH sponsored application are: 1) to characterize the severity of cognitive impairment and driving performance changes following alcohol consumption in a group of patients who have undergone Roux-en-Y Gastric Bypass (RYGB) bariatric surgery and 2) to investigate

2015 Clinical Trials

127. Do people with chronic pain have impaired executive function? A meta-analytical review. (PubMed)

Do people with chronic pain have impaired executive function? A meta-analytical review. A widely held belief within the clinical community is that chronic pain is associated with cognitive impairment, despite the absence of a definitive systematic review or meta-analysis on the topic. The current systematic review and meta-analysis aimed to establish the current evidence concerning the difference in executive function between people with chronic pain and healthy controls. Six databases were (...) pain across cognitive components, although all studies had a high risk of bias. The current evidence suggests impairment of executive function in people with chronic pain, however, important caveats exist. First, executive function involves many cognitive components and there is no standard test for it. Second, moderators of executive function, such as medication and sleep, were seldom controlled for in studies of executive function performance. Copyright © 2014 Elsevier Ltd. All rights reserved.

2014 Clinical psychology review

128. Cognitive Remediation to Improve Mobility in Sedentary Seniors

College of Medicine Collaborator: National Institute on Aging (NIA) Information provided by (Responsible Party): Joe Verghese, Albert Einstein College of Medicine Study Details Study Description Go to Brief Summary: The investigators propose to conduct a single-blind randomized clinical trial to test the efficacy of a computerized cognitive remediation intervention program on improving locomotion in sedentary seniors, a group at an especially high risk for disability. The hypothesis is that executive (...) : 2 Months ] Improvement on the Repeatable Battery for the Assessment of Neuropsychological Status, a relatively brief battery that assesses overall level of cognitive function This battery consists of 10 neurocognitive tests measuring memory (immediate and delayed), attention, language, visuospatial abilities and executive functions. Performance is converted to standardized scores derived from a normative sample. Neuroplasticity. [ Time Frame: 2 Months ] Changes in prefrontal activation measure

2015 Clinical Trials

129. Revitalize Cognition: Near Infrared Stimulation in Older Adults

with the amnestic variant of mild cognitive impairment (aMCI). While waiting for causative cures and preventive approaches, investigators are faced with the task of identifying modifying therapies that might alter the course or slow down the transition from normal cognition to MCI to dementia. The proposed study hopes to contribute to this mission by testing the viability of a different type of intervention, one involving transcranial delivery of near-infrared (NIR) wavelengths (808-904nm). Near-infrared (...) in terms of positive effects of NIR on cognition. The overall goal of the present study is to learn whether this unconventional NIR stimulation approach has potential for improving cognition in older adults. To do so, investigators will conduct a randomized sham controlled pilot trial. The intervention will involve six sessions, over a 2-week period in which real or sham stimulation is transcranially applied using a delivery system that has been FDA-approved as a nonsignificant risk since 2003

2015 Clinical Trials

130. Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

treatment effects and evidence of disease modification. Condition or disease Intervention/treatment Phase Alzheimer Disease Cognitive Decline Due to Alzheimer Disease Mild Cognitive Impairment Due to Alzheimer Disease Drug: Naproxen Drug: Placebo Phase 2 Detailed Description: The trial enrolled 195 cognitively normal persons aged 60+ with either a parental history of AD or a history of two or more affected first-degree relatives. Persons aged 55-59 were admitted if their current age was <= 15 years (...) after randomization) they were tested for cognitive abilities and undergo brain imaging with both structural and functional MRI. They are also tested for sensori-neural capacities in olfactory identification and in the ability to discern spoken language in a distracting environment (to test central auditory processing). About 2/3 of participants also volunteered to undergo a series of lumbar punctures for donation of cerebrospinal fluid (CSF), which was assayed for several biochemical markers of AD

2015 Clinical Trials

131. Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy

% of these patients develops severe cognitive dysfunction. Recovery usually occurs within six months after ECT. However, performances remain below-average compared to norm groups and there are large individual differences. The cognitive difficulties in MS and PD have a significant negative influence on the quality of life. Cognitive dysfunction in PD is associated with decreased independent daily functioning, hospitalization and the development and severity of neuropsychiatric symptoms. Furthermore, in the clinic (...) an adequately controlled design. Additionally, earlier cognitive training programs have frequently been executed in a health care organization, impairing patients to successfully attend all training sessions due to mobility impairments. Also, there are limited studies in the effects of cognitive training on improved functioning of daily living and neuropsychiatric symptoms like anxiety and depression. Given the fact that there is an absence in cognitive training studies in patients post-ECT

2015 Clinical Trials

132. Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. (Full text)

provided estimates of PA variables for 4 to 7 consecutive days. PA cut-points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six-Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function.Of (...) Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study. To examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults.Cross-sectional.REasons for Geographic and Racial Differences in Stroke (REGARDS) study.Older adults who provided valid data from accelerometer and cognitive function tests (N = 7,098).Accelerometers

2015 Journal of the American Geriatrics Society PubMed

133. Cognitive Rehab and Exposure Treatment for Hoarding

contact as CREST. Twenty-six weekly, individual ET sessions (6 months) will be delivered. The control group will receive ET for all 26 sessions and no cognitive training. As in CREST, the ET sessions will be manualized and copies utilized during session by both the patient and therapist. Outcome Measures Go to Primary Outcome Measures : Saving Inventory Revised [ Time Frame: 6 months ] Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R)56, a 23-item (...) to hoarding treatment. Condition or disease Intervention/treatment Phase Hoarding Disorder Behavioral: CREST Behavioral: ET Not Applicable Detailed Description: Objective: The investigators propose to conduct a randomized controlled trial comparing six months (26 sessions) of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) treatment to a robust comparator, six months of Exposure Therapy alone, in 136 participants with HD. Research Design: Assessments will be administered at baseline, during

2015 Clinical Trials

134. Freezing of Gait: Clinical, Cognitive, and Imaging Features

or she connects the "trail." If the participant makes an error, point it out and allow the participant to correct it. Errors affect the participant's score only in that the correction of errors is included in the completion time for the task. Participants are scored by the number of seconds taken to complete the task, with high scores revealing greater impairment. Wisconsin Card Sorting Test (WCST) score [ Time Frame: Baseline ] The WCST measures cognitive flexibility and problem solving skills (...) to match the angle and orientation of lines in space. Participants are asked to match two angled lines to a set of 11 lines that are arranged in a semicircle and separated 18 degrees from each other.The test is a standardized test with 30 items with the minimum score being 0, indicating low visual spatial cognition and the maximum score being 30, indicating high visual spatial cognition. Number of correct responses for Mental Rotation Task [ Time Frame: Baseline ] Mental rotation is the ability

2015 Clinical Trials

135. Effectiveness of Meta-Cognitive Training (EMC) in People With Psychosis of Brief Evolution.

is to assess the effectiveness of Meta-Cognitive Training (EMC) in people with a brief psychotic disorder, especially positive symptoms. The secondary objectives would be to assess the effect of EMC on metacognition (cognitive distortions and deficits in theory of mind), psychosocial functioning and quality of life, neuropsychological functioning and gender, as well as determine the changes produced by EMC in the insight of each session and the maintenance of the effects of EMC program at six months (...) measure of 15 items which evaluates how the patients assess their own judgement. It has two dimensions; self-reflection (R) (9 items), and self-certainty (C) (6 items). A compound index of cognitive insight is obtained as the subtraction of self-certainty from self-reflection (R-C). IPSAQ. Internal, Personal and Situational Attribution Questionnaire. [ Time Frame: baseline, 2 months (post-treatment) and 6 months of follow-up. ] The scale assess the attributional style in 32 situations. Hinking Task

2015 Clinical Trials

136. Observable Social Cognition: A Rating Scale (OSCARS): An Interview-Based Assessment for Schizophrenia (Full text)

Observable Social Cognition: A Rating Scale (OSCARS): An Interview-Based Assessment for Schizophrenia Individuals with schizophrenia consistently show impairments in social cognition (SC). SC has become a potential treatment target due to its association with functional outcomes. An alternative method of assessment is to administer an observer-based scale incorporating an informant's "first hand" impressions in ratings.The present study used the Observable Social Cognition: A Rating Scale (...) (OSCARS) in 62 outpatients and 50 non-psychiatric controls (NPCs) to assess performance in domains of SC (e.g. emotion perception, theory of mind).The OSCARS demonstrated sufficient internal consistency and test-retest reliability. Construct validity was assessed through an exploratory factor analysis. Patient OSCARS indices were not significantly correlated with measures of SC with the exception of aggressive attributional style. Individuals with less impairment in SC reacted more aggressively

2015 Cognitive neuropsychiatry PubMed

137. Integrative Group-based Cognitive Rehabilitation Efficacy in Multiple Sclerosis

-Color Test. Additionally, several test and scales were administered. The Expanded Disability Status Scale was used for rating the degree of neurologic impairment. Premorbid IQ was tested by The Accentuation Reading Test. Cognitive reserve was estimated with the Cognitive Reserve Questionnaire. The 15-item Geriatric Depression Scale was included to assess patients´ depressive symptoms. The Fatigue Severity Scale and the mental fatigue Visual Analogue Scale were included to evaluate physical (...) Modalities Test (SDMT), the three and six letter version of the Salthouse Perceptual Comparison Test (PCT) and the Trail Making Test A (TMTA). Change in verbal memory after receiving cognitive remediation treatment [ Time Frame: 3 months ] Verbal memory was measured using The Hopkins Verbal Learning Test - Revised (HVLT-R). Change in verbal fluency after receiving cognitive remediation treatment [ Time Frame: 3 months ] Verbal fluency was measured using the Calibrated Ideational Fluency Assessment (CIFA

2014 Clinical Trials

138. Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism

minutes for an overall education dose of 240 minutes; similar to the exercise dose. Behavioral: Exercise and Education for Parkinson's Disease Exercise and Education for Parkinson's Disease for 6 week cross-over intervention. Outcome Measures Go to Primary Outcome Measures : Change in Mini-BESTest score [ Time Frame: Three timepoints; baseline, 6 weeks (after Arm 1), 12 weeks (after Arm 2) ] The Mini-BESTest assesses dynamic balance via a 14-item test that measures multiple domains of balance (...) related to frequency and duration of each type of FoG episode. Change in PDQ-39 score [ Time Frame: Three timepoints; baseline, 6 weeks (after Arm 1), 12 weeks (after Arm 2) ] the Parkinson's Disease Quality of Life questionnaire with 39 questions reflecting 8 domains of quality of life (Mobility, ADL's, Emotional well-being, Stigma, Social support, Cognition, Communication, and Bodily discomfort). Each item scores from 0 (never) to 4 (always). Subscale scores and a summary index representing

2014 Clinical Trials

139. Effects of Exercise on Cognitive Performance of Patients With Alzheimer-type Dementia. Pilot Study.

points), orientation (1 item, 8 points), language (5 items, 25 points) and praxis (2 items, 10 points). The maximum score is 70 points.The higher the score, the greater the cognitive impairment.This is the primary outcome measure most frequently used in clinical trials with drugs. Secondary Outcome Measures : Global cognitive performance [ Time Frame: 0, 6 and 12 months ] Global cognitive performance is measured with Test Barcelona TBR-B neuropsychological battery (abreviated version).The ADAS-COG (...) : Global cognitive performance (Neuropsychological battery TBR-B),neuropsychiatric symptoms (NPI), ADL (Blessed),functional capacity (Test of 6-minute walk), cardiorespiratory Test, muscular strength (hand dynamometer and trunk); PREDICTORS AND CONFOUNDING VARIABLES: baseline cognitive performance, previous physical activity, medication, age, sex, APOE, schooling and cognitive reserve. ANALYSIS: We compared the two groups in terms of observed mean changes from baseline in ADAS measurement and other

2014 Clinical Trials

140. Testing a Multilevel Preventive Intervention in Youth Courts

, and provider and participant feedback to determine their impact on program efficacy) and quantitative (survey assessments at pretest, post-test, and six-month follow-up) methods to estimate the effect size of the adapted and combined program. By intervening with both youth court participants and youth court staff, the proposed multilevel intervention can have a broad impact on risk and protective factors at multiple levels of influence. The ultimate goal of this research is to promote the use (...) practice through homework assignments, and didactic teaching methods. Other Name: LST Outcome Measures Go to Primary Outcome Measures : Substance Use Behavior, Intentions, Attitudes and Perceived Norms at Baseline [ Time Frame: Pre-test (prior to participating in the first session of the intervention) ] Substance Use Behavior and Intentions: For 13 substance-related items (e.g., alcohol, tobacco, cocaine, methamphetamines, steroids), participants will be asked to indicate frequency of use. Drug

2015 Clinical Trials

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