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Six Item Cognitive Impairment Test

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1361. Treatment of ADHD With Atomoxetine in Children & Adolescents With ADHD & Comorbid Dyslexia

from 0-54. Higher scores indicate higher impairment. Change From Baseline in Attention-Deficit/Hyperactivity Disorder Rating Scale (ADHDRS) Total and Subscores - Teacher Version at Week 16 Endpoint [ Time Frame: Baseline, 16 weeks ] The ADHDRS-IV-Teacher is an 18-item scale with 1 item for each of the 18 symptoms contained in the DSM-IV diagnosis of ADHD. Each item is scored on a 0 to 3 scale: 0=none (never or rarely); 1=mild (sometimes); 2=moderate (often); 3=severe (very often). Hyperactivity (...) -impulsivity scores range from 0-27, and inattention scores range from 0-27. Total scores range from 0-54. Higher scores indicate higher impairment. Change From Baseline in Woodcock-Johnson III Scores at Week 16 Endpoint [ Time Frame: Baseline, 16 weeks ] The Woodcock Johnson Tests of Achievement has a Standard Battery (Tests 1-12) of a broad set of scores and an Extended Battery (Tests 13-22) on specific academic strengths and weaknesses. Tests associated with reading skills (1, 2, 7, 9, 13, 17, 20) were

2008 Clinical Trials

1362. Re-Evaluation of GAmma3 Intramedullary Nails in Hip Fracture (REGAIN)

osteodystrophy, or osteomalacia). Moderate or severe cognitively impaired patients (i.e., Six Item Screener with three or more errors). Patients with Parkinson's disease (or dementia) severe enough to increase the likelihood of falling or severe enough to compromise rehabilitation. Likely problems, in the judgment of the investigators, with maintaining follow-up. We will, for example, exclude patients with no fixed address, those who report a plan to move out of town in the next year, or intellectually (...) to trial protocol, confirm or refute our anticipated ability to achieve close to 100% follow- up, assess our ability to maintain 100% data quality, field test our case report forms for clarity and appropriateness, and to determine whether we can successfully manage the logistics of coordinating trial activities across multiple sites. This trial is a pilot, multi-center, concealed randomized controlled trial. Surgeons will use one of the two surgical strategies in patients who have sustained

2007 Clinical Trials

1363. ELND005 in Patients With Mild to Moderate Alzheimer's Disease

of the six items range from 0 to 3; hence the total score is between 0 and 18. Higher scores suggest greater cognitive impairment. Change in Neuropsychiatric Inventory (NPI) Score From Baseline to Week 78 (Full Analysis Set; FAS) [ Time Frame: Baseline and 78 weeks ] The NPI is used to obtain information on the presence of severity of neuropsychological symptoms, and was specifically designed for use in Alzheimer's disease subjects. The scale consists of 12 items with each item having outcomes from 0 (...) weeks ] The NTB assessment is comprised of 9 instruments that measure cognition and executive function. Three of these tests measure immediate memory, next three measure delayed memory, and remaining three assess executive function. The total score is a weighted mean of the nine tests, referred to as the Z-score. Typically, scores range from -3 and 3, with lower scores suggesting greater cognitive impairment. Additional Analysis of Primary Outcome Measure: Change From Baseline to Week 78

2007 Clinical Trials

1364. The Effect of Exercise on Individuals With Parkinson's Disease

27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. Secondary Outcome Measures : On Medication UPDRS-III [ Time Frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period ] UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used (...) as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for the UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. L-dopa equivalent-mg/Day [ Time Frame: obtained during initial evaluation & then every 6 six months to end of 2-yr

2007 Clinical Trials

1365. Study on the Tolerability of Duloxetine in Depressed Patients With Parkinson's Disease

Score [ Time Frame: baseline, 12 weeks ] The PDQ-39 has 39 items. Higher scores reflect lower quality of life. The PDQ-39 has eight subscales: mobility (10 items), activities of daily living (six items), emotional wellbeing (six items), stigma (four items), social support (three items), cognition (four items), communication (three items), and bodily discomfort (three items). Items in each subscale, as well in the total scale, can be summarized into an index and transformed linearly to a 0-100 scale (...) . Change From Baseline to 12 Weeks on the UKU (Udvalg for Kliniske Undersogelser: Committee for Clinical Investigations) Side Effect Rating Scale [ Time Frame: baseline, 12 weeks ] Clinician-rated scale, providing side effect ratings of psychopharmacological medications. 48 items, each item is rated on a 4-point scale (0=not present; 1=mild; 2=moderate; 3=severe). The test is divided in 6 subscales, total scores for each subscale are calculated based on a weighted secondary scoring system. Subscales

2007 Clinical Trials

1366. Treatment of Aggression, Anger and Emotional Dysregulation in Borderline Personality Disorder

, psychophysiology testing and fMRI neuroimaging. Condition or disease Intervention/treatment Phase Borderline Personality Disorder Behavioral: Dialectical Behavior Not Applicable Detailed Description: Borderline Personality Disorder (BPD) is a disabling disorder characterized by poor affect regulation and poor impulse control. This often results in impaired interpersonal relationships and maladaptive behavioral patterns, including anger dyscontrol, aggression towards others and self-destructive behaviors (...) emotional intensity5 and may reflect limbic system over activity. The impairment in emotional modulation results in a slow return to the baseline emotional state and may reflect deficits in prefrontal regulatory regions. While data supporting this formulation are limited, self-report measures of responses to various emotional stimuli and more recently, objective, non-verbal physiological measures including startle eye blink modulation (SEM), have been used to test this theory. SEM is a well-established

2007 Clinical Trials

1367. Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury

or she is told to fill in the remaining boxes as quickly as possible, completing one box at a time, one row at a time, before proceeding to the next. Skipping from box to box with the same geometric figure is not permitted. Subjects receive one point for each correctly completed box. The total score is the total number of correctly completed boxes in the time allowed. The practice items are not counted in the scoring. The test can be administered by having the subject write out the correct response (...) is the total number of correctly completed boxes in the time allowed. The practice items are not counted in the scoring. The test can be administered by having the subject write out the correct response or by having the subject report the correct answer (i.e., number) aloud. Higher scores are better scores and the range of scores can be from 0 to 110 for SDMT oral scores. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal

2007 Clinical Trials

1368. Citicoline for Bipolar 1 Disorder and Cocaine Dependence

identical in appearance to Citicoline throughout the study. Placebo will be given beginning at two capsules (500 mg/day) with an increase to four capsules (1000 mg/day) at week 2, six capsules (1500 mg/day) at week 4, and eight capsules (2000 mg/day) at week 6. Doses will be decreased, based on clinician judgment, due to side effects. Drug: Placebo Inactive ingredient matching the active medication in appearance. Other Name: Sugar pill Behavioral: Cognitive Behavioral Therapy (CBT) Participants (...) retardation or other severe cognitive impairment, prison or jail inmates, pregnant or nursing women, or women of childbearing age who will not use hormonal contraceptives, abstinence, or other acceptable methods of birth control during the study. Currently experiencing psychotic features (delusions, hallucinations, disorganized thought processes). Initiation of antidepressants, mood stabilizers, or psychotherapy within the past 14 days. High risk for suicide, defined as any suicide attempt in the past 6

2008 Clinical Trials

1369. Sodium Oxybate in Schizophrenia With Insomnia

in schizophrenia, two of which did not show any overall benefit in psychopathology. We noted multiple limitations in the controlled trials, including: requirement of cumbersome dosing patterns (up to six times a day) that could have led to incomplete compliance, lack of objective measures of subjective sleep or sleep architecture, lack of objective cognitive testing, use of GHB as monotherapy or only in conjunction with only low dose antipsychotics, short trial duration (less than 4 weeks), relatively low (...) Composite [ Time Frame: 1 month ] This is a series of neurocognitive tests developed by the National Institute of Mental Health to evaluate medications targeting cognition in an efficient and reliable manner. It will be modified by the deletion of the social competence domain. The six domains include speed of processing, attention/vigilance, working memory, verbal learning, visual learning and reasoning/problem solving. The primary outcome will be the mean T-score (mean of six domains). Slow Wave Sleep

2008 Clinical Trials

1370. Zonisamide vs. Placebo in the Treatment of Alcohol Dependence

-controlled trial of zonisamide for treatment of alcohol dependence. It is a randomized, double-blind trial of zonisamide vs. placebo at flexible dosages of 100-500mg/day in alcoholics receiving ambulatory psychosocial treatment. Participants will take part in six individual Cognitive-Behavioral based therapy sessions, which are focused on learning coping skills. Participants must endorse a goal of either cutting down their drinking to non-hazardous levels, or abstinence. Study Design Go to Layout table (...) Volunteers: No Criteria Inclusion Criteria: age 18 to 65 years, inclusive current Diagnostic & Statistical Manual of Mental Disorders 4th ed (DSM-IV) alcohol dependence (within the past month) have 2 heavy drinking days per week during the period between screening and baseline (defined as >4 standard drinks per day for males, and >3 standard drinks per day for females) able to read at the eighth grade or higher level and show no evidence of significant cognitive impairment if a woman of child-bearing

2008 Clinical Trials

1371. A Study With GW597599 And GR205171: Potential New Drugs For The Treatment Of Primary Insomnia

there is a corresponding geometric symbol. A series of boxes with numbers on top is shown to the participant. The participants then copy the specific geometric symbol next to the number. The correct items transcribed within the time limit were used to generate the score. The range of score was 0 to 63. Higher scores were indicative of good cognitive function. Verbal Learning Memory Test [ Time Frame: Day 1 and Day 2 of every treatment period (upto Day 63) ] Verbal learning and memory test comprised of four subscales (...) that one assessment was used Digit Symbol Substitution Test (DSST) Score as daytime cognitive function tests on the morning following dose [ Time Frame: Day 1 and Day 2 of every treatment period (Upto Day 63) ] The DSST test a subset of Wechsler Intelligence scale, which assesses the attention and psychomotor performance. During this test the participant needs to transcribe a geometric symbol with its corresponding Arabic number. The participant is initially shown numbers 1 to 9 and under each number

2008 Clinical Trials

1372. Ehlers-Danlos Syndrome

, and is usually diagnosed before the age of 2 years. Fragility, bruising and sagging are severe, but healing is not impaired. Diagnosis requires extreme skin fragility and the characteristic craniofacial features, plus either one other major criterion or three minor criteria. Confirmatory testing is needed for diagnosis. Major criteria Extreme skin fragility with congenital or postnatal skin tears. Characteristic craniofacial features. Redundant, almost lax skin, with excessive skin folds at wrists and ankles (...) subtypes and within subtypes. They are described in more detail below. There is some symptom overlap with and . The first presentation, at birth, may be premature rupture of the membranes. Investigations [ ] In the case of hEDS, diagnosis is normally made on the clinical presentation, by a specialist with expertise in the area. Molecular genetic testing is now recommended for the definitive diagnosis of the other subtypes, although not all patients with the specific condition will demonstrate

2008 Mentor

1373. Outcome measures for adult critical care: a systematic review. (Abstract)

to assessing depressive symptoms or also encompassed a measure of anxiety. Measures of neuropsychological functioning relate to a person's cognition, attention, ability to process information and memory. Apart from one single-item measure, which focused on communication level, six multi-item measures were used with critical care survivors. Such measures are particularly appropriate for use with survivors of head injury or other neurological insult and, in that sense, they are disease-specific rather than (...) of the upper airway (e.g. bronchoscopy). Multiple tests are often performed. Eight measures of physical functional status were used, five generic and three disease-specific. The most frequently used generic measures were multi-item scales. Two single-item global measures attempted to capture a person's overall activity level or functional status. Five multi-item measures of mental functional status were used, four generic and one specific to trauma patients. The generic measures were either confined

2000 Health technology assessment (Winchester, England)

1374. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial. (Abstract)

, reduced body mass index (BMI) and body fat, increased lean body mass and water, reduced waist/hip ratio and increased energy expenditure. The rh-GH therapy was also significantly better than placebo on depressive features as measured by the Hamilton Depression Scale (17-items) (p = 0.0431) and the Beck Depression Inventory (p = 0.0431). Neuropsychological evaluations showed significant improvements in measures of Attention: Digit Backward (p = 0.035), Verbal Fluency (FAS) (p = 0.02) and Cognitive (...) Efficiency (WAIS-R tests): Vocabulary (p = 0.027), Picture Arrangements (p = 0.017), and Comprehension (p = 0.01) following rh-GH therapy.The clinical, psychiatric, and neuropsychological impairments of untreated GH-deficient adults can be decreased by rh-GH therapy.

1999 Arquivos de neuro-psiquiatria Controlled trial quality: uncertain

1375. Raloxifene and Rimostil for Perimenopause-Related Depression

as a 17 item Hamilton Depression score greater than or equal to 10. Subjects will be excluded if they meet any of the following criteria: major depression of greater than moderate severity, DSM-IV criteria # 9 (suicide), or anyone requiring immediate treatment after clinical assessment or functional impairment ratings of five or six for more than seven consecutive days on daily ratings; Evidence of perimenopausal reproductive status; Age 40 to 60; No prior hormonal therapy for the treatment (...) in this protocol: 1) Severe major depression with any of the following: positive (threshold) response to SCID major depression section item # 9, suicidal ideation; anyone requiring immediate treatment after clinical assessment; severity ratings greater than moderate on the SCID IV interview; functional impairment ratings of five or six for more than seven consecutive days on daily ratings. 2) Current treatment with antidepressant medications. Our main concern is to exclude subjects taking medications

2002 Clinical Trials

1376. Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1

., rash, headache, gastrointestinal symptoms, nausea, dyspnea, muscle pain or cramp, acne) of nimodipine. SECONDARY: To assess the efficacy of nimodipine in stabilizing the progression of HIV-Associated Motor / Cognitive Complex by improvement in neuropsychological test performance, peripheral neuropathy, or other neurologic manifestations. HIV-infected patients may develop a condition known as HIV-Associated Motor / Cognitive Complex (also known as AIDS dementia complex) that causes damage (...) with clarithromycin, azithromycin, amikacin, ethambutol, clofazimine, ciprofloxacin, and rifampin for disseminated Mycobacterium avium infection. Maintenance therapy for opportunistic infections (e.g., PCP, MAI, CMV). Patients must have: Documented HIV infection. HIV-Associated Motor / Cognitive Complex. Acceptable neurological and neuropsychological impairment scores. Estimated premorbid IQ of 70 or greater, consistent with completion of the sixth grade or ability to read at the sixth grade level. Current

1999 Clinical Trials

1377. Contribution of informant and patient ratings to the accuracy of the mini-mental state examination in predicting probable Alzheimer's disease. (Abstract)

. Diagnosticians were blind to baseline scores.Age and education were included in all analyses as covariates. The best logistic regression model included the Informant Rating Scale and the MMSE (sensitivity = 83%, specificity = 79%). An empirically reduced six-item model that included two items each from the MMSE, the Patient Rating Scale, and the Informant Rating Scale produced a significantly better model than the one with the full test scores (sensitivity = 90%, specificity = 94%).Results indicate (...) research investigation by their family physicians because of concerns about memory impairment.One hundred sixty-five community-residing patients were included who did not have dementia or any identifiable cause for memory impairment. After 2 years, 29 met criteria for AD, and 95 were not demented.Baseline assessments included MMSE, an Informant Rating Scale, and a Patient Rating Scale of cognitive difficulties. After 2 years, patients were diagnosed following the reference standard for probable AD

2003 Journal of the American Geriatrics Society

1378. Personal Assistance for Children and Adolescents (0?18) with Both Physical and Intellectual Impairments Full Text available with Trip Pro

impairments and intellectual impairments ( ; ; ; ). Over six million (12.3%) American children and adolescents experience some type of functional limitation (as defined by ). Of the four million American children and adolescents who experience one serious functional limitation, about half experience one or more other functional limitations. About one million American children and adolescents experience serious limitations in two or more areas ( ). Impairments are more prevalent in boys than in girls (...) were considered, a review of global health measures found that ‘very few measures have been validated specifically for cognitively impaired respondents’ ( ) or for people with both physical and intellectual impairments. Other measures were included. 2) User satisfaction. Direct reports were preferred, though proxies might have been used if users were unable to communicate. 3) Participation, including social activities, ability to participate in spontaneous activities, time outside the home

2008 Campbell Collaboration

1379. Personal Assistance for Children and Adolescents (0?18) with Intellectual Impairments

in learning ability also experience functional limitations. Over six million (12.3%) American children and adolescents experience some type of functional limitation (as defined by ). Of the four million American children and adolescents who experience one serious functional limitation, about half experience one or more other functional limitations. About one million American children and adolescents experience serious limitations in two or more areas ( ). Impairments are more prevalent in boys than (...) for cognitively impaired respondents’ ( ). Other measures were included. 2) User satisfaction. Direct reports were preferred, though proxies were used if users were unable to communicate. 3) Participation, including social activities, ability to participate in spontaneous activities, time outside the home, and mobility. Secondary outcomes 1) Unmet needs, particularly the inability to perform activities of daily living. 2) Developmental outcomes, including cognitive milestones and acquisition of skills. 3

2008 Campbell Collaboration

1380. The Mini-Cog compares well with longer screening tests for detecting dementia in older people Full Text available with Trip Pro

age 73 years) randomly drawn from an age stratified random sample of 17 000 people from the Monongahela Valley Independent Elders Survey (MoVIES). Participants were aged >65 years, had a minimum of 6 years of formal education, and were living in the community. Test: The Mini-Cog is a rapid screening test comprising two cognitive tasks: a three item word memory test and clock drawing. The scores were combined with an empirical algorithm to yield a dementia screen score for each person as either (...) in sensitivity and specificity. Adding controlled learning with free and cued recall at retrieval would improve the three item recall portion of the Mini-Cog, reducing the number of individuals (68%) positively identified in error which, at present, may reduce relevance to practice. References Gifford DR, Cummings JL. Evaluating dementia screening tests. Neurol 1999 ; 52 : 224 –7. Buschke H, Kuslansky G, Katz M, et al . Screening for dementia with the memory impairment screen (MIS). Neurol 1999 ; 52 : 231 –7

2005 Evidence-Based Mental Health

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