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Six Item Cognitive Impairment Test

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81. Thinking Skills at Work: Cognitive Remediation Therapy for Patients With Serious Mental Illness

illness, the Individual Placement and Support (IPS) Program is an effective approach to help people become employed. Despite its general success, still only 55% of clients find employment. Most of that success occurs in the first three months; after six months, the chances of finding competitive work are quite low. Among those who fail to find employment with IPS, cognitive dysfunction is often a significant problem. The proposed study will target IPS clients who have not found work after 3 months (...) modules and exercises that target thinking skills known to be impaired in severe mental illness. For example, working memory and cognitive flexibility are trained through real-world exercises that teach clients to organize and manage time, focus their attention, consider errors and their consequences, control answers and plan ahead. These skills are important to be successful in obtaining and maintaining employment. Purpose of Study: The primary purpose of this study is to assess, for people

2018 Clinical Trials

82. Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)

, memory, executive function, response speed and processing speed. Prevalence of self-reported cognitive impairment [ Time Frame: 1 year post recruitment ] Functional Assessment of Cancer Therapy-Cognition Function (FACT-Cog) a 37-item questionnaire which measures six cognitive domains: memory, concentration, mental acuity, verbal fluency, functional interference and multitasking ability. The response is based on the perceived cognitive function within the past 7 days using a 5-point Likert scale (...) for a period of 12 months. In addition, healthy individuals will also be recruited into the control arm of the study. The prevalence of cognitive impairment will be assessed via objective cognitive functional assessments in the form of the Cambridge Neuropsychological Test Automated Battery (Cantab) test scores and Functional Assessement of Cancer-Therapy Cognitive Function (FACT-Cog v3.0). The overall cognitive performance and post-treatment health issues measured by the assessment tools used would

2018 Clinical Trials

83. ArtontheBrain: An Inclusive Evidence-based Cognitive Health App for Older Adults to Promote Aging at Home

. with older adults with and without cognitive decline. The study will also examine how well that app can support different user play modalities and whether it can effect positive health outcomes similar to face-to-face arts interventions. Condition or disease Intervention/treatment Phase Cognitive Impairment Mild Cognitive Impairment Dementia Age-related Cognitive Decline Aging Device: ArtontheBrain Device: Seniors Online Victoria Not Applicable Detailed Description: Our project seeks to validate (...) domains including physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/ fatigue, emotional well-being, social functioning, pain and general health. Stanford Health Care Utilization [ Time Frame: Change from baseline health care utilization at 6 week ] The Stanford Chronic Disease Questionnaire Medical Care section evaluates individuals of health care utilization occurring in the previous six months. It comprises 4 items of three types

2018 Clinical Trials

84. Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. Full Text available with Trip Pro

of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge.The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated (...) Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients.This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use

2018 Dementia and Geriatric Cognitive Disorders

85. Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Full Text available with Trip Pro

through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score <5) and tested whether patient factors modified the effect. Median follow-up was 8.2 years.Incident stroke was associated with acute declines in global cognition, new learning, verbal memory, and executive function. Acute declines in global cognition after stroke were greater in survivors who were black (P=0.04), men (P=0.04), and had (...) Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors' prestroke cognitive trajectories are uncertain.Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed

2018 Stroke

86. Knee Stability and Movement Coordination Impairments: Knee Ligament Sprain

: randomized controlled trials SANE: single assessment numeric evaluation SF-12: Medical Outcomes Study 12-Item Short-Form Health Survey SF-36: Medical Outcomes Study 36-Item Short-Form Health Survey TSK-11: Tampa Scale of Kinesiophobia AIM OF THE GUIDELINES The Orthopaedic Section of the American Physical Therapy Association (APTA) has an ongoing effort to create evidence- based clinical practice guidelines (CPGs) for orthopaedic physical therapy management of patients with musculoskel- etal impairments (...) -Item Short-Form Health Survey (SF-36), and Tegner activity scales from baseline to 2 years. In the 5-year follow-up study, they had similar results, with no differences between groups in PROs, activity level, or radiographic incidence of osteoar- thritis in the surgical knee. II In a systematic review assessing outcomes after quadriceps autograft ACL reconstruction, Mulford et al 81 reported in 4 comparative studies that liga- ment stability testing and PROs were similar among quadri- ceps tendon

2017 The Orthopaedic Section of the American Physical Therapy Association (APTA), Inc.

87. Evaluation of the Six Minute Walk Test and Other Instruments in Heart Failure

/treatment Heart Failure Autonomic Nervous System Imbalance Heart Rate and Rhythm Disorders Quality of Life Other: Six minute walk test Detailed Description: Heart failure and its treatment result in symptoms such as pulmonary or systemic congestion causing impairment to the effort, psychological and social commitment, and impact on quality of life. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 17 participants Observational Model: Case Control (...) ). They then will be taken to the hallway to perform the six minute walk test monitored with a heart rate monitor (Polar RS800 CX). After the test there will be a break of 20 to 30 minutes before repeating the walk test. During rest time, the patient will answer the general health survey questionnaire: Medical Outcome Study 36-item Short-Form Health Survey (SF-36). Other Names: MLHFQ SF-36 Heart rate variability (Polar RS800 CX) Control Group All control group participants will perform two walk tests at the same day

2012 Clinical Trials

88. A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations

Measures : Two Minute Walk Test [ Time Frame: Administered at baseline and at 2-week follow up for each foot condition. ] Participants are asked to walk for 2 minutes at their fastest possible speed and distance walked is recorded. Prosthetic Limb Users Survey of Mobility (PLUS-M), tailored short-form [ Time Frame: Administered at baseline and at 2-week follow up for each foot condition. ] Standardized self-report item bank. Activities Specific Balance Confidence Scale (ABC) [ Time Frame: Administered (...) are unable to use test feet for any reason (e.g., excessively long residual limb that is not compatible with wearing study prosthetic feet) unable to walk under the minimal necessary study walking conditions in order to complete the study procedures without undo stress currently pregnant (determined via self-report during screening) current surgical, neurological, rheumatologic, or lower limb musculoskeletal problem that significantly impairs ambulation (e.g., current ulcer, terminal illness, lower

2018 Clinical Trials

89. CARESSES Testing and Evaluation Phases

and reliability have been widely established. The scale items examine burden associated with functional / behavioural impairments and care situations. Each item is scored on a 5-point Likert Scale ranging from "never" to "nearly always present." A total score is obtained with higher scores indicting higher care burden among informal carers. Short form University of California Los Angeles (UCLA) Loneliness Scale (ULS-8) [ Time Frame: 2 sessions, about 8 min each in length ] Loneliness will be measured using (...) CARESSES Testing and Evaluation Phases CARESSES Testing and Evaluation Phases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. CARESSES Testing and Evaluation Phases The safety and scientific validity

2018 Clinical Trials

90. Testing CBT Models and Change Mechanisms for Alcohol Dependent Women

Eligibility Description: Female participants only Accepts Healthy Volunteers: No Criteria Inclusion Criteria: age 18 or older have a current (past year) Diagnostic and Statistical Manual-IV (DSM-IV) alcohol dependence diagnosis used alcohol in the 60 days prior to telephone screening Exclusion Criteria: have psychotic symptoms in the past six months gross cognitive impairment current physiological dependence on any illicit drug Contacts and Locations Go to Information from the National Library of Medicine (...) ): Elizabeth Epstein, Ph.D., Rutgers, The State University of New Jersey Study Details Study Description Go to Brief Summary: The study has 4 specific aims: (1) To modify our existing Individual Female Specific Cognitive Behavioral Therapy (I-FS-CBT) for Alcohol Use Disorder (AUD) approach to treat women with alcohol dependence in a group format, Group Female Specific Cognitive Behavioral Therapy (G-FS-CBT); (2) To test the relative efficacy of I-FS-CBT and G-FS-CBT; (3) To test hypothesized mechanisms

2018 Clinical Trials

91. Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease Full Text available with Trip Pro

Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease Alzheimer's disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testing using an odour stick identification test for Japanese (OSIT-J). OSIT-J scores were significantly correlated (...) was significantly better indicator of cognitive status than the ability to identify "non-cognitive subset", which consisted of the six remaining items. The ability to identify the gas leak odorant was decreased early in the aMCI stage, suggesting a need to reconsider the odours used to signal gas leaks. The "cognitive subset" would provide a more convenient and effective biomarker for diagnosing dementia in clinical settings.

2017 Scientific reports

92. Cognitive impairment and "invisible symptoms" are not associated with CCSVI in MS. Full Text available with Trip Pro

duration and EDSS score with MS patients without CCSVI, serving as controls. CI was assessed with the Brief Repeatable Battery (BRB) and the Stroop Test (ST) and it was defined by the presence of at least three impaired tests. Fatigue and depressive symptoms were assessed with Fatigue Severity Scale (FSS) and Hamilton Depressive Rating Scale (HDRS), respectively. Bladder and sexual symptoms were assessed with the respective items of the Italian version of Guy's Neurological Disability Scale (GNDS (...) Cognitive impairment and "invisible symptoms" are not associated with CCSVI in MS. We investigated the association between chronic cerebrospinal venous insufficiency (CCSVI) and cognitive impairment (CI) in multiple sclerosis (MS). Moreover, we evaluated the association between CCSVI and other frequent self-reported MS symptoms.We looked at the presence of CI in incident MS patients with CCVSI in a population-based cohort of Catania, Italy. All subjects were group-matched by age, sex, disease

2013 BMC Neurology

93. Effects of a multimodal exercise program on balance, functional mobility and fall risk in older adults with cognitive impairment: a randomized controlled single-blind study. (Abstract)

balance, and risk of falls in older adults with mild or moderate cognitive impairment.A randomized controlled study.A long-term care institute.Cognitively impaired individuals aged over 60 years.Eighty-six participants were randomized to an exercise group providing multimodal exercise program for 12 months or a control group which did not participate in any exercise program. The Performance Oriented Mobility Assessment scale, Timed Up and Go test, and incidence of falls were measured at baseline, at 6 (...) Effects of a multimodal exercise program on balance, functional mobility and fall risk in older adults with cognitive impairment: a randomized controlled single-blind study. Exercise programs have important role in prevention of falls, but to date, there are conflicting findings about the effects of exercise programs on balance, functional performance and fall risk among cognitively impaired older adults. AIM. To investigate the effects of a multimodal exercise program on static and dynamic

2013 European journal of physical and rehabilitation medicine Controlled trial quality: uncertain

94. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. Full Text available with Trip Pro

for six months. We measured verbal memory and learning using the Rey Auditory Verbal Learning Test (RAVLT) and spatial memory using a computerized test, before and after trial completion. We found that the aerobic training group remembered significantly more items in the loss after interference condition of the RAVLT compared with the control group after six months of training. In addition, both experimental groups showed improved spatial memory performance in the most difficult condition where (...) Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. We report secondary findings from a randomized controlled trial on the effects of exercise on memory in older adults with probable MCI. We randomized 86 women aged 70-80 years with subjective memory complaints into one of three groups: resistance training, aerobic training, or balance and tone (control). All participants exercised twice per week

2013 Journal of aging research Controlled trial quality: uncertain

95. Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

elderly (50-90 years old) outpatients who meet study inclusion criteria for depression (DEP) (DSM-IV criteria for major depression, dysthymic disorder, or depression NOS) and mild cognitive impairment (MCI; e.g. operationally defined as between "normal" and "dementia"), i.e., Dep-MCI. The research plan includes: i) Obtaining a baseline psychiatric and neuropsychological test profile, ii) If currently on an ineffective antidepressant, having a one week washout (3 weeks for fluoxetine), iii) A treatment (...) trial beginning with a two-week es-citalopram lead-in period. At two weeks, memantine (Namenda) is added starting at 5 mg/day and increased until the maximum dose of 20 mg/day is reached by six weeks. The study psychiatrist administers: the 24-item Hamilton Depression Rating Scale (HAM-D); the Clinical Global Impression (CGI, 1-7 scale) initial severity and subsequent change ratings separately for depression, cognition, and overall clinical status; the Treatment Emergent Symptom Scale (TESS

2013 Clinical Trials

96. Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly

deficits may reflect degeneration of cholinergic inputs to the olfactory bulb and other olfactory brain regions. Acetylcholinesterase inhibitors (ACheI) like donepezil show modest effects in improving cognition but can be associated with adverse effects and increased burden and costs because of the need for prolonged, often lifelong, treatment. Converging findings on odor identification test performance (UPSIT, scratch and sniff 40-item test) from four pilot studies, including two of our own, suggest (...) . In addition, an olfactory challenge test will be done at baseline. This project will be of value in the selection of patients with MCI and AD for treatment based on the evaluation of olfaction tests to predict response to donepezil. Since mild cognitive impairment is widespread and Alzheimer's disease represents a major public health problem, this study has considerable public purpose and significance. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2013 Clinical Trials

97. Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)

-traumatic stress disorder (PTSD). The subjects will receive six TILS interventions and one sham intervention in a course of seven weeks. Condition or disease Intervention/treatment Phase Post-traumatic Stress Disorder (PTSD) Device: TILS Device: sham Not Applicable Detailed Description: Post-traumatic stress disorder (PTSD) is often associated with cognitive impairments. It has been indicated that hypoactivity of the prefrontal cortex plays a major role in the disrupted neural circuitry of mood (...) and cognition. Transcranial infrared laser stimulation (TILS) is a neural type of photobiomodulation that can elevate neuronal metabolism by exciting cytochrome c oxidase (CCO). Veterans with PTSD will receive prefrontal TILS interventions once-per-week for six weeks. They will also receive an additional sham intervention (laser power = 0) that will be randomly assigned into the first two sessions. Broadband near-infrared spectroscopy (bbNIRS) will be used to directly assess the CCO changes during every

2017 Clinical Trials

98. Individualized Cognitive Training in HIV

domains (e.g., speed of processing, verbal memory, etc.) are used which are normed by age/education which are then use with the Frascati Criteria (a neurological algorithm to classify cognitive impairment) to determine HIV-Associated Neurocognitive Disorder, both presence and severity (i.e., Global Severity Rating). This is administered at baseline and posttest. Secondary Outcome Measures : Improvement on Everyday Functioning as Measured by the Timed Instrumental Activities of Daily Living Test [ Time (...) with HIV. Such cognitive training programs may be effective in older adults with HIV and therefore investigators may be able to change the diagnosis of HAND in such cognitively vulnerable adults. In this pre-post experimental study, 146 older adults (50+) with HAND will be randomized to be in either: 1) the Individualied-Targeted Cognitive Training, or 2) a no-contact control group. The investigators will focus on those cognitive domains in which participants express an impairment and train them

2017 Clinical Trials

99. The Effect of Exercise on Cognition in Older Adults At-risk for Diabetes: A Feasibility Pilot Study

/treatment Phase Cognitive Impairment Behavioral: Resistance Training Behavioral: Balance and Tone Training Not Applicable Detailed Description: Investigators will conduct a six-month randomized control trial (RCT) exercise intervention. Thirty older adults (aged 60-80) at-risk for diabetes will be randomly assigned into one of two groups: 1) Resistance training, or 2) Balance and Tone training (control). All participants will engage in three one-hour exercise classes per week. Once a month, a neutral (...) assessor will visit the classes to evaluate the quality of the classes for participants. Assessments will be made at baseline, midpoint (three months) and trial completion (six months), and will include cognitive testing, health questionnaires, physical testing, and magnetic resonance imaging (MRI; to assess structural and functional brain changes). Throughout the study, investigators will examine data for trends in successful recruitment strategies and rates of recruitment and adherence to inform

2017 Clinical Trials

100. Putative Cognitive Enhancer VU319

): Paul Newhouse, Vanderbilt University Medical Center Study Details Study Description Go to Brief Summary: This is a safety study of the molecule VU319 to ascertain pharmacokinetic and pharmacodynamic data and test cognitive enhancement in healthy volunteers. Condition or disease Intervention/treatment Phase Cognitive Impairment Drug: Single Dose of VU319 Drug: Single Dose Placebo Other: Fed State Other: Fasted State Drug: Dose Escalation of VU319 Drug: Placebo Dose Escalation Phase 1 Detailed (...) the examination of acquisition, encoding and retrieval. This standard test has been widely used in studies of cognitive impairment and offers measures of storage into and retrieval from both short term and long-term memory and intrusion errors. In addition to the measures of recall, recall failure, and consistency we add a long-delay (20 min.) recall trial and a recognition trial to assess discrimination and response bias. This task shows excellent predictive validity and test-retest reliability. We have 10

2017 Clinical Trials

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