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1,313 results for

Six Item Cognitive Impairment Test

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81. Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease (PubMed)

Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease Alzheimer's disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testing using an odour stick identification test for Japanese (OSIT-J). OSIT-J scores were significantly correlated (...) was significantly better indicator of cognitive status than the ability to identify "non-cognitive subset", which consisted of the six remaining items. The ability to identify the gas leak odorant was decreased early in the aMCI stage, suggesting a need to reconsider the odours used to signal gas leaks. The "cognitive subset" would provide a more convenient and effective biomarker for diagnosing dementia in clinical settings.

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2017 Scientific reports

82. Evaluation of the Six Minute Walk Test and Other Instruments in Heart Failure

/treatment Heart Failure Autonomic Nervous System Imbalance Heart Rate and Rhythm Disorders Quality of Life Other: Six minute walk test Detailed Description: Heart failure and its treatment result in symptoms such as pulmonary or systemic congestion causing impairment to the effort, psychological and social commitment, and impact on quality of life. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 17 participants Observational Model: Case Control (...) ). They then will be taken to the hallway to perform the six minute walk test monitored with a heart rate monitor (Polar RS800 CX). After the test there will be a break of 20 to 30 minutes before repeating the walk test. During rest time, the patient will answer the general health survey questionnaire: Medical Outcome Study 36-item Short-Form Health Survey (SF-36). Other Names: MLHFQ SF-36 Heart rate variability (Polar RS800 CX) Control Group All control group participants will perform two walk tests at the same day

2012 Clinical Trials

83. Cognitive impairment and "invisible symptoms" are not associated with CCSVI in MS. (PubMed)

duration and EDSS score with MS patients without CCSVI, serving as controls. CI was assessed with the Brief Repeatable Battery (BRB) and the Stroop Test (ST) and it was defined by the presence of at least three impaired tests. Fatigue and depressive symptoms were assessed with Fatigue Severity Scale (FSS) and Hamilton Depressive Rating Scale (HDRS), respectively. Bladder and sexual symptoms were assessed with the respective items of the Italian version of Guy's Neurological Disability Scale (GNDS (...) Cognitive impairment and "invisible symptoms" are not associated with CCSVI in MS. We investigated the association between chronic cerebrospinal venous insufficiency (CCSVI) and cognitive impairment (CI) in multiple sclerosis (MS). Moreover, we evaluated the association between CCSVI and other frequent self-reported MS symptoms.We looked at the presence of CI in incident MS patients with CCVSI in a population-based cohort of Catania, Italy. All subjects were group-matched by age, sex, disease

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2013 BMC Neurology

84. Effects of a multimodal exercise program on balance, functional mobility and fall risk in older adults with cognitive impairment: a randomized controlled single-blind study. (PubMed)

balance, and risk of falls in older adults with mild or moderate cognitive impairment.A randomized controlled study.A long-term care institute.Cognitively impaired individuals aged over 60 years.Eighty-six participants were randomized to an exercise group providing multimodal exercise program for 12 months or a control group which did not participate in any exercise program. The Performance Oriented Mobility Assessment scale, Timed Up and Go test, and incidence of falls were measured at baseline, at 6 (...) Effects of a multimodal exercise program on balance, functional mobility and fall risk in older adults with cognitive impairment: a randomized controlled single-blind study. Exercise programs have important role in prevention of falls, but to date, there are conflicting findings about the effects of exercise programs on balance, functional performance and fall risk among cognitively impaired older adults. AIM. To investigate the effects of a multimodal exercise program on static and dynamic

2013 European journal of physical and rehabilitation medicine

85. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. (PubMed)

for six months. We measured verbal memory and learning using the Rey Auditory Verbal Learning Test (RAVLT) and spatial memory using a computerized test, before and after trial completion. We found that the aerobic training group remembered significantly more items in the loss after interference condition of the RAVLT compared with the control group after six months of training. In addition, both experimental groups showed improved spatial memory performance in the most difficult condition where (...) Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. We report secondary findings from a randomized controlled trial on the effects of exercise on memory in older adults with probable MCI. We randomized 86 women aged 70-80 years with subjective memory complaints into one of three groups: resistance training, aerobic training, or balance and tone (control). All participants exercised twice per week

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2013 Journal of aging research

86. Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly

deficits may reflect degeneration of cholinergic inputs to the olfactory bulb and other olfactory brain regions. Acetylcholinesterase inhibitors (ACheI) like donepezil show modest effects in improving cognition but can be associated with adverse effects and increased burden and costs because of the need for prolonged, often lifelong, treatment. Converging findings on odor identification test performance (UPSIT, scratch and sniff 40-item test) from four pilot studies, including two of our own, suggest (...) . In addition, an olfactory challenge test will be done at baseline. This project will be of value in the selection of patients with MCI and AD for treatment based on the evaluation of olfaction tests to predict response to donepezil. Since mild cognitive impairment is widespread and Alzheimer's disease represents a major public health problem, this study has considerable public purpose and significance. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2013 Clinical Trials

87. Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

elderly (50-90 years old) outpatients who meet study inclusion criteria for depression (DEP) (DSM-IV criteria for major depression, dysthymic disorder, or depression NOS) and mild cognitive impairment (MCI; e.g. operationally defined as between "normal" and "dementia"), i.e., Dep-MCI. The research plan includes: i) Obtaining a baseline psychiatric and neuropsychological test profile, ii) If currently on an ineffective antidepressant, having a one week washout (3 weeks for fluoxetine), iii) A treatment (...) trial beginning with a two-week es-citalopram lead-in period. At two weeks, memantine (Namenda) is added starting at 5 mg/day and increased until the maximum dose of 20 mg/day is reached by six weeks. The study psychiatrist administers: the 24-item Hamilton Depression Rating Scale (HAM-D); the Clinical Global Impression (CGI, 1-7 scale) initial severity and subsequent change ratings separately for depression, cognition, and overall clinical status; the Treatment Emergent Symptom Scale (TESS

2013 Clinical Trials

88. Effects of Horticultural Therapy on Elderly at Risk of Cognitive Decline

) at baseline and at 9 months [ Time Frame: Baseline, 9 months ] Clinical Dementia Rating (CDR ) is a 5-point scale used to characterize six domains of cognitive and functional performance applicable to Alzheimer disease and related dementias: Memory, Orientation, Judgment & Problem Solving, Community Affairs, Home & Hobbies, and Personal Care. Changes in Colour Trails Tests (CTT) scores at baseline, 3 months and 9 months [ Time Frame: Baseline, 3 months, 9 months ] Colour Trails Tests (CTT) 1 and 2 (...) Eligible for Study: 60 Years to 100 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 1. Community-living elderly aged 60 years and above, AND 2. Mild Cognitive Impairment based on clinical history and neuropsychological test scores (Z score <0 and >-1.5), OR Subjective Memory Impairment based on self-report, OR (C) 2 or more risk factors for dementia such as family history, cerebrovascular disease, and cardiovascular risk factors

2017 Clinical Trials

89. Putative Cognitive Enhancer VU319

): Paul Newhouse, Vanderbilt University Medical Center Study Details Study Description Go to Brief Summary: This is a safety study of the molecule VU319 to ascertain pharmacokinetic and pharmacodynamic data and test cognitive enhancement in healthy volunteers. Condition or disease Intervention/treatment Phase Cognitive Impairment Drug: Single Dose of VU319 Drug: Single Dose Placebo Other: Fed State Other: Fasted State Drug: Dose Escalation of VU319 Drug: Placebo Dose Escalation Phase 1 Detailed (...) the examination of acquisition, encoding and retrieval. This standard test has been widely used in studies of cognitive impairment and offers measures of storage into and retrieval from both short term and long-term memory and intrusion errors. In addition to the measures of recall, recall failure, and consistency we add a long-delay (20 min.) recall trial and a recognition trial to assess discrimination and response bias. This task shows excellent predictive validity and test-retest reliability. We have 10

2017 Clinical Trials

90. Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders

and cognitive aspects involved in adequate planning of action in a variety of everyday situations involving routing, complex tasks and both anticipation and enactment. change in dimensions of perfectionism and use as a predictive variable of treatment issues [ Time Frame: baseline ] The Frost Multidimensional Perfectionism Scale is a self-administered questionnaire of 35 items covering six dimensions of perfectionism. change in dimensions of perfectionism [ Time Frame: change from baseline ] The Frost (...) home practice and received strategies for the future. Behavioral: Cognitive psychophysiological Focus on the processes influencing thoughts and behaviors underlying tics. Other Name: CoPs Outcome Measures Go to Primary Outcome Measures : Yale Global Tic Severity Scale (YGTSS) [ Time Frame: baseline ] The YGTSS is a clinician-rated scale used to assess change in tic severity and impairment due to tics. Secondary Outcome Measures : determine style of planning actions [ Time Frame: baseline

2017 Clinical Trials

91. Integrated Cognitive, Sensory, and Motor Rehabilitation of Hand Functions

the intervention. Device: Robotic Glove Device: Electrical Stimulation Outcome Measures Go to Primary Outcome Measures : Motricity Index [ Time Frame: 9 weeks ] Outcome measure to evaluate motor impairment after stroke; subscale for arm only; the subscale ranges from 0 (maximal impairment) to 100 (no impairment). Secondary Outcome Measures : Action Research Arm Test [ Time Frame: baseline; 9 weeks; 13 weeks. ] 19-items outcome measure divided into 4 sub-tests (grasp, grip, pinch, and gross arm movement (...) ). Performance on each item is rated on a 4-point ordinal scale ranging from: 3: Performs test normally 2: Completes test, but takes abnormally long or has great difficulty 1: Performs test partially 0: Can perform no part of test Medical Research Council [ Time Frame: baseline, 9 weeks, 13 weeks. ] A standardized assessment to measure muscle strength; Score range 0-5 (minimum 0, maximum 5) 3: Performs test normally 2: Completes test, but takes abnormally long or has great difficulty 1: Performs test

2017 Clinical Trials

92. Promoting Independent Living in Frail Older Adults by Improving Cognition and Gait Ability and Using Assistive Products

to Additional Information: Publications: Paiva, Diana S; Apóstolo, João L. A. 2015. Estudo de adaptação transcultural e validação do Six Item Cognitive Impairment Test . In J. Apóstolo & M. Almeida (Eds). Elderly Health Care Nursing. Monographic Series - Health Sciences Education and Research, 3 - 18. ISBN: 978-989-99426-1-5. Coimbra: Unidade de Investigação em Ciências da Saúde: Enfermagem (UICISA: E) ESEnfC. Bandeira, M. L., Azevedo, A. B., Gomes, C. S., Tomé, L. P., Mendes, M. F., Baptista, M. I (...) program. Moreover, an auto-blocking mechanism for rolling walkers will be developed and implemented in this study. The results of the study and all the material that was used, will be disseminated in a web platform. Condition or disease Intervention/treatment Phase Frailty Cognition Mild Cognitive Impairment Other: Combined Intervention Group Not Applicable Detailed Description: In this growing context of aging societies, the number of institutionalized older adults tends to increase. Several reasons

2017 Clinical Trials

93. Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

. Condition or disease Intervention/treatment Phase Major Depressive Disorder Traumatic Brain Injury Behavioral: Cognitive Behavioral Therapy for individuals with TBI Other: Waitlist Control Not Applicable Detailed Description: The primary aim of this study is to develop a highly acceptable, manualized treatment (CBTx-TBI) for MDD in patients with moderate to severe TBI. After developing the manual (Phase 1), a nonrandomized trial (Phase 2) will be conducted to test its acceptability and tolerability (...) Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

94. Impact on QoL and Cognitive Functioning of New Antiviral Therapies in Subjects With Chronic Hepatitis HCV-related

activities, social relationships, and nutrition, and how these difficulties relate to biological rhythms Addenbrooke's Cognitive Examination (ACE-R) [ Time Frame: Baseline (T0), and change from baseline at three (T4) and six (T7) months ] short cognitive test, which evaluates five cognitive domains: attention/orientation, memory, verbal fluency, language, visual-spatial abilities. The test, with a maximum score of 100 and a mild cognitive impairment cut-off of 66, includes the Mini Mental State (...) Mania scale); BRIAN (Biological Rhythms Interview of Assessment in Neuropsychiatry). Assessment of Quality of Life: SF-12 (Short Form Health Survey-12 items). Neuropsychological screening: l) Addenbrooke's Cognitive Examination (ACE-R). Neuropsychiatric screening (treatment-) Subjects affected by chronic hepatitis HCV-related, in wait list for new antiviral drugs treatment, will be screened by psychiatric and neuropsychological questionnaires/tests Other: Neuropsychiatric screening Psychiatric

2017 Clinical Trials

95. Effects of Glucocorticoids on Cognition in HIV-infected Women

University Collaborator: National Institute of Mental Health (NIMH) Information provided by (Responsible Party): Johns Hopkins University Study Details Study Description Go to Brief Summary: Despite treatment with antiretroviral therapy, women living with HIV continue to experience cognitive impairment. Psychological risk factors, including stress, impair cognition more in HIV-infected women than HIV-uninfected women. This study plans to examine a novel intervention for cognitive dysfunction that targets (...) weeks on cognition and side effects. The clinical trial will include 100 virally suppressed HIV+ women who show elevated stress and cognitive impairment and who represent the range of psychological risk factors characteristic of this population. Next, to understand the mechanism and broader clinical significance of LDH on cognition, investigators will conduct a 4-week randomized study of the effects of daily treatment with LDH versus placebo on cognition in HIV+ women (targeted n=80). Women meeting

2017 Clinical Trials

96. Individualized Cognitive Training in HIV

domains (e.g., speed of processing, verbal memory, etc.) are used which are normed by age/education which are then use with the Frascati Criteria (a neurological algorithm to classify cognitive impairment) to determine HIV-Associated Neurocognitive Disorder, both presence and severity (i.e., Global Severity Rating). This is administered at baseline and posttest. Secondary Outcome Measures : Improvement on Everyday Functioning as Measured by the Timed Instrumental Activities of Daily Living Test [ Time (...) with HIV. Such cognitive training programs may be effective in older adults with HIV and therefore investigators may be able to change the diagnosis of HAND in such cognitively vulnerable adults. In this pre-post experimental study, 146 older adults (50+) with HAND will be randomized to be in either: 1) the Individualied-Targeted Cognitive Training, or 2) a no-contact control group. The investigators will focus on those cognitive domains in which participants express an impairment and train them

2017 Clinical Trials

97. Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)

-traumatic stress disorder (PTSD). The subjects will receive six TILS interventions and one sham intervention in a course of seven weeks. Condition or disease Intervention/treatment Phase Post-traumatic Stress Disorder (PTSD) Device: TILS Device: sham Not Applicable Detailed Description: Post-traumatic stress disorder (PTSD) is often associated with cognitive impairments. It has been indicated that hypoactivity of the prefrontal cortex plays a major role in the disrupted neural circuitry of mood (...) and cognition. Transcranial infrared laser stimulation (TILS) is a neural type of photobiomodulation that can elevate neuronal metabolism by exciting cytochrome c oxidase (CCO). Veterans with PTSD will receive prefrontal TILS interventions once-per-week for six weeks. They will also receive an additional sham intervention (laser power = 0) that will be randomly assigned into the first two sessions. Broadband near-infrared spectroscopy (bbNIRS) will be used to directly assess the CCO changes during every

2017 Clinical Trials

98. Omega-3 Fatty Acids and Exercise on Mobility and Cognition in Older Women

, spatial working memory, executive function and processing speed are assessed via a battery of cognitive tests. Mobility testing comprises three walking tests, some under single and dual task paradigms, as well as the five times sit to stand test, a measure of dynamic balance and functional mobility. Volunteers also provide two blood samples, one for fatty acids analysis and the other serum homocysteine levels. Participants also complete health-related quality of life questionnaire, the short form 36 (...) Omega-3 Fatty Acids and Exercise on Mobility and Cognition in Older Women Omega-3 Fatty Acids and Exercise on Mobility and Cognition in Older Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Omega-3

2017 Clinical Trials

99. The Effect of Exercise on Cognition in Older Adults At-risk for Diabetes: A Feasibility Pilot Study

/treatment Phase Cognitive Impairment Behavioral: Resistance Training Behavioral: Balance and Tone Training Not Applicable Detailed Description: Investigators will conduct a six-month randomized control trial (RCT) exercise intervention. Thirty older adults (aged 60-80) at-risk for diabetes will be randomly assigned into one of two groups: 1) Resistance training, or 2) Balance and Tone training (control). All participants will engage in three one-hour exercise classes per week. Once a month, a neutral (...) assessor will visit the classes to evaluate the quality of the classes for participants. Assessments will be made at baseline, midpoint (three months) and trial completion (six months), and will include cognitive testing, health questionnaires, physical testing, and magnetic resonance imaging (MRI; to assess structural and functional brain changes). Throughout the study, investigators will examine data for trends in successful recruitment strategies and rates of recruitment and adherence to inform

2017 Clinical Trials

100. Non-cardiac Chest Pain: Effect of Cognitive Therapy Administered as Guided Self-help

Information provided by (Responsible Party): Sorlandet Hospital HF Study Details Study Description Go to Brief Summary: This study aims to test an easily implementable web-based cognitive behaviour therapy (CBT) self-help intervention designed for non-cardiac chest pain patients, and compare effectiveness and cost-effectiveness to treatment as usual in an randomized controlled trial (RCT). Condition or disease Intervention/treatment Phase Chest Pain Behavioral: Guided self-help Not Applicable Detailed (...) : 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Non-Cardiac Chest Pain Exclusion Criteria: Language difficulties Unable to perform at least moderate physical activity due to physical constraints Obvious cognitive impairment (e.g mentally retarded, psychotic, dementia or intoxicated) no regular access to a computer/tablet computer with internet connection Contacts and Locations Go to Information from the National

2017 Clinical Trials

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