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Six Item Cognitive Impairment Test

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61. Cognitive Remediation in Late-Life Schizophrenia

). There will be baseline assessments (clinical and NP) prior to enrollment in the classes. In order to assess whether there has been a change in cognition, and some of the assessments will be repeated after the 12-week intervention. Condition or disease Intervention/treatment Phase Schizophrenia Cognitive Remediation Late Life Schizophrenia Functional Impairment Cognitive Deficit Other: Cognitive Remediation Therapy Not Applicable Detailed Description: Thirty late life schizophrenia (LLS) participants, age 55 and over (...) drills targeting different cognitive domains, (3) in-class strategic monitoring to enhance metacognitive skills, and (4) discussion of the generalization of cognitive skills to daily life. The Brain Gym includes electronic tablets for participant use both during classroom sessions in addition to elective, drop-in practice sessions offered three times per week. Each group will consist of 4-6 participants. A group will be started once four to six consecutively referred participants complete baseline

2018 Clinical Trials

62. Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

or 40Hz increased gamma brainwaves and led to clearing of beta amyloid plaques in the brain, a key abnormality in Alzheimer's disease. This project will test the ability of a novel iPad App ("ALZLIFE") that delivers light therapy at 40 Hz combined with cognitive therapy to improve cognition, function, and quality of life in Alzheimer's disease. Condition or disease Intervention/treatment Alzheimer Disease Mild Cognitive Impairment Dementia Cognition Disorders in Old Age Cognitive Decline Cognitive (...) with Alzheimer's and dementia, which could help avert some symptoms of cognitive decline. The synergistic combination of light and cognitive therapy utilized in AlzLife has the potential to improve the brain's function better than either of these therapies alone. This project will test the ability of a novel iPad App ("ALZLIFE") that delivers light therapy at 40 Hz combined with cognitive therapy to improve cognition, function, and quality of life in Alzheimer's disease. Study Design Go to Layout table

2018 Clinical Trials

63. TV-based Service to Support People Living With Mild Dementia or Mild Cognitive Impariment

baseline quality of life in people with mild cognitive impairment or mild dementia at 6 and 12 months. [ Time Frame: At baseline and then at 6 and 12 months. ] Quality of Life-Alzheimer's Disease Scale (QoL-AD Scale) (1-3) is an instrument specifically designed to measure quality of life in people with dementia from the perspective of both the patient and the informal caregiver. It is a 13-item measure, which includes assessments of the person´s relationships with friends and family, financial (...) divided by the prescribed ones, multiplied by 100 (expressed as a percentage). A good adherence is considered when the result of counting is between 80% (a twenty percent of doses/pills missed) and 110% (the patient takes ten percent more doses/pills) of dose/pill prescribed. Change from baseline treatment compliance in people with mild cognitive impairment or mild dementia at 6 and 12 months. [ Time Frame: At baseline and then at 6 and 12 months. ] The Morisky Green Test (11) consists of 4 contrast

2018 Clinical Trials

64. the Effects of Oxytocin on Negative Symptoms and Cognitive Tasks in Schizophrenia and it's Possible Mechanisms.

a randomized, placebo-controlled trial testing the effects of twice daily intranasal oxytocin treatment for 14 days on psychotic symptoms and social cognition in patients with schizophrenia. We hypothesize that PANSS scores will decline significantly and several social cognition measures will improved significantly or nearly significantly in oxytocin but not placebo recipients. We will collect blood samples and MRI data of patients to explore the mechanism of oxytocin . we will also recruit some age (...) - and Intelligence quotient-matched control subjects, give them a single dose of oxytocin to compare the effects of oxytocin in patients and health subjects. Condition or disease Intervention/treatment Phase Schizophrenia Drug: Oxytocin Drug: Saline Not Applicable Detailed Description: Social impairment is a primary cause of disability in schizophrenia, responds poorly to current antipsychotic medications and is related to deficits in social cognitive abilities, which include Theory of Mind, emotion recognition

2018 Clinical Trials

65. Cognitive Training to Promote Brain Health: Implementation and Engagement

to engagement with the exercises. Currently, little is known about how to apply intensive computerized cognitive training effectively in the health system, ensuring engagement and best progress. This project aims to tackle this challenge by developing, applying and testing personalized approaches to implement cognitive training in daily life of older adults that were recently evaluated at Memory Clinics and their care partners. The community readiness approach will be implemented using semi-structured (...) of the intervention for training adherence and individual gains on the computerized exercises. In order to gain insight about regional specificities of the approach the investigators will perform a parallel project using the same methodology in Brazil. This project is expected to inform the future implementation of cognitive training in public health policies for older adults. Condition or disease Intervention/treatment Phase Aging Mild Cognitive Impairment Behavioral: Computerized cognitive training Phase 2

2018 Clinical Trials

66. Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder

[ Time Frame: baseline measure ] The Vancouver Obsessional-Compulsive Inventory (VOCI) is a 55-item self-report measure designed to assess a broad spectrum of OCD symptoms and associated personality characteristics. Items are rated on a 5-point Likert scale, ranging from 0 (not at all) to 4 (very much), and measure participants' agreement with a series of statements related to obsessions and compulsions (e.g., ''I am often very upset by my unwanted impulses to harm other people''). The VOCI has six (...) Obsessional-Compulsive Inventory (VOCI) is a 55-item self-report measure designed to assess a broad spectrum of OCD symptoms and associated personality characteristics. Items are rated on a 5-point Likert scale, ranging from 0 (not at all) to 4 (very much), and measure participants' agreement with a series of statements related to obsessions and compulsions (e.g., ''I am often very upset by my unwanted impulses to harm other people''). The VOCI has six component subscales: (a) Checking; (b) Contamination

2018 Clinical Trials

67. Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Full Text available with Trip Pro

through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score <5) and tested whether patient factors modified the effect. Median follow-up was 8.2 years.Incident stroke was associated with acute declines in global cognition, new learning, verbal memory, and executive function. Acute declines in global cognition after stroke were greater in survivors who were black (P=0.04), men (P=0.04), and had (...) Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors' prestroke cognitive trajectories are uncertain.Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed

2018 Stroke

68. Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)

, memory, executive function, response speed and processing speed. Prevalence of self-reported cognitive impairment [ Time Frame: 1 year post recruitment ] Functional Assessment of Cancer Therapy-Cognition Function (FACT-Cog) a 37-item questionnaire which measures six cognitive domains: memory, concentration, mental acuity, verbal fluency, functional interference and multitasking ability. The response is based on the perceived cognitive function within the past 7 days using a 5-point Likert scale (...) for a period of 12 months. In addition, healthy individuals will also be recruited into the control arm of the study. The prevalence of cognitive impairment will be assessed via objective cognitive functional assessments in the form of the Cambridge Neuropsychological Test Automated Battery (Cantab) test scores and Functional Assessement of Cancer-Therapy Cognitive Function (FACT-Cog v3.0). The overall cognitive performance and post-treatment health issues measured by the assessment tools used would

2018 Clinical Trials

69. Thinking Skills at Work: Cognitive Remediation Therapy for Patients With Serious Mental Illness

illness, the Individual Placement and Support (IPS) Program is an effective approach to help people become employed. Despite its general success, still only 55% of clients find employment. Most of that success occurs in the first three months; after six months, the chances of finding competitive work are quite low. Among those who fail to find employment with IPS, cognitive dysfunction is often a significant problem. The proposed study will target IPS clients who have not found work after 3 months (...) modules and exercises that target thinking skills known to be impaired in severe mental illness. For example, working memory and cognitive flexibility are trained through real-world exercises that teach clients to organize and manage time, focus their attention, consider errors and their consequences, control answers and plan ahead. These skills are important to be successful in obtaining and maintaining employment. Purpose of Study: The primary purpose of this study is to assess, for people

2018 Clinical Trials

70. Transcranial Direct Current Stimulation (tDCS) to Improve Fatigue and Cognitive Function

for QOL will be the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The impact of tDCS on QOL will be assessed by the EORTC QLQ-C30. This 30-item questionnaire includes five functional scales (physical, role, emotional, social and cognitive), three symptom scales (fatigue, nausea/vomiting and pain), a global health status scale and six single items (dyspnea, constipation, diarrhea, appetite, sleep and financial difficulty). The first 28 (...) . People aged 18 or older who are currently receiving chemotherapy with docetaxel and who are experiencing fatigue may join. Condition or disease Intervention/treatment Phase Breast Cancer Fatigue Other: transcranial direct current stimulation Other: sham transcranial direct current stimulation Not Applicable Detailed Description: Fatigue and cognitive impairment are commonly reported symptoms associated with impaired quality of life (QOL) and productivity in breast cancer patients receiving

2018 Clinical Trials

71. Cognitive Behavioral Therapy for African Americans With Uncontrolled Type-2 Diabetes

the baseline visit subjects will be randomly assigned to undergo a six session group-based or web-based behavioral intervention (CT-CB) program or to general education (usual care). The intervention duration is 12 weeks. Condition or disease Intervention/treatment Phase Diabetes Mellitus, Type 2 Behavioral: Group-based Cognitive Behavioral Intervention Behavioral: Web-based Cognitive Behavioral Intervention Behavioral: Usual Care Not Applicable Detailed Description: African Americans are approximately (...) the feasibility and acceptability of a culturally tailored, cognitive behavioral intervention (CT-CB) program using a group-based vs. a web-based format, and determine if it can improve diabetes self-management among African Americans compared with usual individual based care at the clinic. Forty-five African American patients with uncontrolled type 2 diabetes (HbA1C > 8 %), aged > 18 years, will be randomly assigned to undergo a six session group-based or web-based behavioral intervention (CT-CB) program

2018 Clinical Trials

72. ArtontheBrain: An Inclusive Evidence-based Cognitive Health App for Older Adults to Promote Aging at Home

. with older adults with and without cognitive decline. The study will also examine how well that app can support different user play modalities and whether it can effect positive health outcomes similar to face-to-face arts interventions. Condition or disease Intervention/treatment Phase Cognitive Impairment Mild Cognitive Impairment Dementia Age-related Cognitive Decline Aging Device: ArtontheBrain Device: Seniors Online Victoria Not Applicable Detailed Description: Our project seeks to validate (...) domains including physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/ fatigue, emotional well-being, social functioning, pain and general health. Stanford Health Care Utilization [ Time Frame: Change from baseline health care utilization at 6 week ] The Stanford Chronic Disease Questionnaire Medical Care section evaluates individuals of health care utilization occurring in the previous six months. It comprises 4 items of three types

2018 Clinical Trials

73. Brain Fitness APP for Cognitive Enhancement

that will allow it to be used for neuro-cognitive rehabilitation by an individual without supervision The proposed APP will be tested on 30 individuals with cognitive impairment. Additionally, participants can receive an optional electrical stimulation called transcranial alternating current stimulation. This applies an alternating current to a person's brain by two electrodes placed on the scalp. The participants, who choose this option, will receive simultaneous stimulation during the brain exercise tutored (...) sessions. Studies have shown that simultaneous application of the electrical stimulation and cognitive exercises further enhances the cognitive function by boosting the working memory improvement. Thus, this may lead to further improvements from any potential positive effects of the brain exercises. We anticipate the frequent use of the proposed APP will help to slow and even reverse the progression of the cognition decline in individuals with mild cognitive impairment or dementia. Condition or disease

2018 Clinical Trials

74. Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances

Frame: Week 0, 18 and 26 ] The parent-reported SCAS comprises 38 items, rated on a four-point scale (0-1-2-3). The six subscales cover social phobia (SoP; six items), panic disorder and agoraphobia (Panic; nine items), generalized anxiety disorder (GAD; six items), obsessive-compulsive disorder (OCD; six items), separation anxiety disorder (SAD; six items) and fear of physical injury (Fear; five items). Each subscale is scored separately and added together for a total score reflecting overall (...) of children and adolescents aged 8-17 years, and the parent-reported MFQ has also demonstrated sensitivity for change with treatment. Weiss Functional impairment rating Scale (WFIRS) [ Time Frame: Week 0, 18 and 26 ] The Weiss Functional Impairment Rating Scale-Parent Report (WFIRS) was designed to evaluate to what degree a child's behavior or emotional problems impacted on various domains of daily functioning. The questionnaire comprises 50 items, each rated on a four-point scale (0-1-2-3). Although

2018 Clinical Trials

75. Guided Occupational Therapist Cognitive Interventions in Critically Ill Patients

Last Update Posted : July 31, 2018 See Sponsor: Alberta Health Services, Calgary Information provided by (Responsible Party): Kirsten Deemer, NP, Alberta Health Services, Calgary Study Details Study Description Go to Brief Summary: Title: Guided Occupational Therapist (OT) Cognitive Interventions for Critically Ill Patients Short Title: GOTCI Methodology: Randomized Control Trial Study Duration: Six months Study Centre: Single Center - South Health Campus, ICU, Calgary, Alberta, Canada Objectives (...) which is an average of 6.7 days. ] We will use the Montreal Cognitive Assessment Tool (MoCA). The MoCA is a well-known, global cognitive screening tool. It has been found to be superior to other cognitive screening tools for the detection of early stages of cognitive decline. It can be administered by anyone trained appropriately. It is relatively quick to administer, and does not cause cognitive fatigue as easily as full neurocognitive testing. ICU length of stay [ Time Frame: ICU admission date

2018 Clinical Trials

76. Emotional and Cognitive Determinants of Post-stroke Fatigue

scores indicate better function). The total score ranges from 49 to 245. Other Outcome Measures: Degree of cognitive impairment after stroke as measured with neuropsychological tests. [ Time Frame: 3-4 years after stroke ] Explanatory variables are specific domains of cognitive/neuropsychological function as measured with neuropsychological tests. Assessment includes a standard cognitive examination. The following tests will be applied: Matrix Reasoning, Vocabulary, Digit Span, Coding (WAIS-IV (...) impairments in cognitive functions such as attention and memory. This will often cause previously effortless activities of daily living to become strenuous and exhausting. Experiencing a stroke will also in many cases lead to a major change in life due to other related loss of function, grief and health-related concerns. Emotional reactions like depression and anxiety are widespread. Specific knowledge of how cognitive impairment, emotional reactions and coping strategies contribute to development

2018 Clinical Trials

77. Cognitive-motor Exergaming for Reducing Fall Risk in People With Chronic Stroke

control. It is a 14 item scale. Score for each item ranges from 0-4. Item score are then summed and maximum score of 54 can be obtained. Less than 45 on this scale indicates a greater risk for falling. Change in Timed Up and Go test and cognitive Timed up and Go test (seconds) [ Time Frame: Baseline (Week 0) and Immediate Post-training (Week 7) ] Assess mobility, balance and walking ability. It is a fall risk predictor. More than 14 seconds taken to complete the test indicates a greater risk (...) : National Institute on Aging (NIA) Midwest Roybal Center for Health Promotion and Translation Information provided by (Responsible Party): Tanvi Bhatt, University of Illinois at Chicago Study Details Study Description Go to Brief Summary: Post-stroke, people suffer various sensorimotor and cognitive deficits that lead to impaired balance control and gait functions thereby increasing the risk of falls. Despite undergoing exercise training in stroke rehabilitation to enhance balance control and gait

2018 Clinical Trials

78. Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. Full Text available with Trip Pro

of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge.The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated (...) Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients.This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use

2018 Dementia and Geriatric Cognitive Disorders

79. Effects of Group Cognitive Behavioural Therapy on Comorbid Insomnia and Depression in Youth

self-rated scale measuring suicidal ideation. Possible total scores range from 0 to 12, with higher scores indicating higher suicidal ideation. Change of subjective cognitive performance [ Time Frame: Baseline, post-treatment (week 8/at the conclusion of last group session) for all participants; and additionally at post-treatment one-month and six-months for those in the two active treatment groups ] Cognitive Failures Questionnaire (CFQ) is a 20-item self-rated scale measuring perceived failures (...) in daily cognitive tasks. Possible total scores range from 0 to 80, with higher scores indicating higher cognitive failures. Change of objective cognitive performance (visual attention & task switching) [ Time Frame: Baseline, post-treatment (week 8/at the conclusion of last group session) for all participants; and additionally at post-treatment one-month and six-months for those in the two active treatment groups ] Trail Making Test for assessing visual attention and task switching. In Trail Making

2018 Clinical Trials

80. CogStim, a Pilot Study : Cognitive Rehabilitation Management of HIV-1 Mild Cognitively Impaired Patients Controlled With Antiretroviral Therapy

penetration (Annex 15) With cognitive complaint objectified by the cognitive complaint questionnaire (Appendix 9: score 3 or 1 positive response among the items C4, C5, C7, C8) and cognitive impairment found by an alteration of at least two cognitive fields assessed by psychometric tests for at least 6 months 18 55 on the scale of Spielberger STAI-Y (Annex 14) Insured under (...) patients show asymptomatic neurocognitive impairment or minor cognitive disorder. These symptoms impact the compliance of the treatment, though its performance and daily life quality. To this day, no therapy tested has proved its efficiency, including the strategy of the antiretroviral therapy (cART) optimization according to the Cerebral Penetration effectiveness Score (CPE). Description of the study: an open prospective comparative monocentric pilote study, randomised in three groups which

2014 Clinical Trials

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