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Six Item Cognitive Impairment Test

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41. A Systematic Evidence Review of the Signs and Symptoms of Dementia and Brief Cognitive Tests Available in VA

that was highly specific for AD, however, was impaired sense of touch for perceiving the form of an object (stereognosis), or the form of a letter or number written on the skin (graphesthesia).3 A Systematic Evidence Review of the Signs and Symptoms of Dementia and Brief Cognitive Tests Available in VA Evidence-based Synthesis Program KEY QUESTION #2. Which measures of cognitive function provide the optimal sensitivity, specificity, and time to completion among the measures available to V A providers? All 6 (...) patients with mild cognitive impairment (MCI). The SLUMS test was studied in a V A population and found to have high sensitivity (98-100%) and specificity (98-100%) with adjustment for education. The SLUMS takes longer to administer than other tests. It was developed more recently than the other tests and has not been widely studied. The STMS has been studied in a primary care setting. The STMS had sensitivity ranging from 86% to 95%, and specificity was highest (93.5%) when cut-off score was adjusted

2010 Veterans Affairs Evidence-based Synthesis Program Reports

42. Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients

laboratory testing once yearly for low-risk patients and twice yearly for higher-risk patients has been recommended, the same recommendations call for POC screening every six months Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients 11 for low-risk patients and every three months for higher-risk pa- tients(13), which is far more frequent than the previously cit- ed ASIPP recommendations(14, 15). Therefore, due to a lack of scientific evidence to suggest that random (...) Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients LABORATORY MEDICINE PRACTICE GUIDELINES EDITED BY LORALIE J. LANGMAN AND PAUL J. JANNETTO Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients Co-Sponsored byLABORATORY MEDICINE PRACTICE GUIDELINES Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients Loralie J. Langman Committee Chair Department of Laboratory Medicine and Pathology Mayo Clinic

2018 American Academy of Pain Medicine

43. CogStim, a Pilot Study : Cognitive Rehabilitation Management of HIV-1 Mild Cognitively Impaired Patients Controlled With Antiretroviral Therapy

penetration (Annex 15) With cognitive complaint objectified by the cognitive complaint questionnaire (Appendix 9: score 3 or 1 positive response among the items C4, C5, C7, C8) and cognitive impairment found by an alteration of at least two cognitive fields assessed by psychometric tests for at least 6 months 18 55 on the scale of Spielberger STAI-Y (Annex 14) Insured under (...) patients show asymptomatic neurocognitive impairment or minor cognitive disorder. These symptoms impact the compliance of the treatment, though its performance and daily life quality. To this day, no therapy tested has proved its efficiency, including the strategy of the antiretroviral therapy (cART) optimization according to the Cerebral Penetration effectiveness Score (CPE). Description of the study: an open prospective comparative monocentric pilote study, randomised in three groups which

2014 Clinical Trials

44. Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation

from baseline cognitive visual memory at 12 weeks and 6 months [ Time Frame: Baseline, 12 weeks, & 6 month ] The Brief Visuo-Spatial Memory Test (BVMT) will be used to measure visual memory Participants are presented with six abstract designs for 10 seconds, the display is then removed from view and participant are instructed to draw the designs from memory via pencil on paper. Each design is scored from 0 to 2 points representing accuracy and location. There are three learning trials. Test (...) by (Responsible Party): Dr. Anthony Feinstein, Sunnybrook Health Sciences Centre Study Details Study Description Go to Brief Summary: Given that up to 70% of people with secondary progressive MS are cognitively impaired, the search for effective treatments is considered a priority by people living with the disease. This proposal will address the effectiveness of cognitive rehabilitation (CR) and exercise, either alone, or in combination in this regard. A team of MS researchers has been assembled from the USA

2018 Clinical Trials

45. Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline

. In particular, we will be analyzing the total antioxidant capacity (TAC). Glucose indicator [ Time Frame: Baseline, posttest (an expected average of 3 months) ] HbA1C level will be tested to investigate the relationships between blood glucose level and aerobic exercise Plasma lipid level [ Time Frame: Baseline, posttest (an expected average of 3 months) ] The cholesterol ratio (total cholesterol divided by high-density lipid) will be evaluated to reflect the lipid level in the blood Montreal Cognitive (...) functions Wechsler Adult Intelligence Scale - Third Edition (WAIS-III) [ Time Frame: Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months) ] The WAIS-III is developed to measure an individual's intelligence level. It includes tests that evaluate cognitive functions in verbal comprehension, working memory, perceptual organization, and processing speed Useful Field of View (UFOV) [ Time Frame: Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months

2017 Clinical Trials

46. Properties of a brief assessment tool for longitudinal measurement of cognition in people living with HIV. (PubMed)

. The objective of this study is to estimate the extent of change on repeat administration of three different forms of a brief computerized cognitive assessment battery (B-CAM) developed for assessing cognitive ability in the mildly-impaired to normal range in people living with HIV. We hypothesized no change over a six-month period in people on effective antiretroviral therapy.102 HIV+ individuals completed a set of computerized cognitive tasks on three occasions over a six-month period. Rasch analysis (...) sessions, related to the different forms of the tasks. These two items were split by testing session. For all other items, the level of difficulty remained constant across all three time points. GBTA showed that the sample was composed of three distinct groups of people with unique trajectories, defined mainly by level of cognitive ability at baseline. Only the highest group showed an apparent improvement over time, but this change fell within measurement error.Rasch analysis provides mathematical

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2019 PLoS ONE

47. Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease

of 85 points (0: no cognitive impairment; 85: severe impairment). Change in functional performance as measured by the Clinical Dementia Rating (CDR) Scale [ Time Frame: Baseline, 3 months, 6 months ] The CDR is a 5-point scale used to characterize six domains of cognitive and functional performance applicable to Alzheimer disease and related dementias: Memory, Orientation, Judgment & Problem Solving, Community Affairs, Home & Hobbies, and Personal Care. Scores on the CDR range from 0 (no impairment (...) ) to 3 (severe impairment). The total CDR ratings for each of the six cognitive/functional domains can be added to create a CDR sum of boxes (SOB). Change in functional performance as measured by the Functional Activities Questionnaire (FAQ) [ Time Frame: Baseline, 3 months, 6 months ] The FAQ measures instrumental activities of daily living (IADLs), such as preparing balanced meals and managing personal finances. The FAQ is a sum of scores ranging from 0 (normal) to 30 (complete dependence on others

2015 Clinical Trials

48. An Investigation of Chemotherapy Induced Cognitive Impairments in Breast Cancer Survivors

An Investigation of Chemotherapy Induced Cognitive Impairments in Breast Cancer Survivors An Investigation of Chemotherapy Induced Cognitive Impairments in Breast Cancer Survivors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. An Investigation of Chemotherapy Induced Cognitive Impairments in Breast Cancer Survivors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02515487 Recruitment Status : Completed First Posted : August 4, 2015 Last Update Posted : February 6, 2018 Sponsor: New York University

2015 Clinical Trials

49. Evaluating cognitive screening instruments with the "likelihood to be diagnosed or misdiagnosed" measure

diagnostic test accuracy studies examining four commonly used cognitive screening instruments (Mini-Mental State Examination, MMSE; Montreal Cognitive Assessment, MoCA; Mini-Addenbrooke's Cognitive Examination, MACE; Six-item Cognitive Impairment Test, 6CIT) were analysed to calculate NND, NNP, and NNM, and from these derive values for LDM.Although all the tests had low NND and NNP as desired, NNM was also low. Hence, only MMSE and 6CIT achieved LDM > 1 for dementia diagnosis, and only MACE and 6CIT had (...) Evaluating cognitive screening instruments with the "likelihood to be diagnosed or misdiagnosed" measure To calculate "number needed to diagnose" (NND), "number needed to predict" (NNP), and "number needed to misdiagnose" (NNM) for cognitive screening instruments which are commonly used in suspected dementia and mild cognitive impairment, and from these to calculate a "likelihood to be diagnosed or misdiagnosed" (LDM) metric as the ratio of NNM to either NND or NNP.Datasets from pragmatic

2018 EvidenceUpdates

50. Galantamine and Memantine for Cognitive Impairments in Schizophrenia

. This is an open-label study to evaluate whether a six week course of galantamine ER and memantine XR is effective in improving the cognitive performance of patients with schizophrenia or schizoaffective disorder. The primary outcome measure will be the change in level of cognition as measured by the MATRICS Consensus Cognitive Battery (MCCB). The results of the MATRICS collaborative project recommended the need for standardized cognitive tests that better distinguish the different facets of cognitive (...) Galantamine and Memantine for Cognitive Impairments in Schizophrenia Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2014 Clinical Trials

51. Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans. (PubMed)

and followed through September 2015, we measured changes in cognition associated with baseline systolic and diastolic BP (SBP and DBP), as well as pulse pressure (PP) and mean arterial pressure, and we tested whether age, race, and sex modified the effects. Outcomes were global cognition (Six-Item Screener; primary outcome), new learning (Word List Learning), verbal memory (Word List Delayed Recall), and executive function (Animal Fluency Test). Median follow-up was 8.1 years. Significantly faster declines (...) Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans. Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex. In a prospective national study of 22 164 blacks and whites ≥45 years without baseline cognitive impairment or stroke from the REGARDS cohort study (Reasons for Geographic and Racial Differences in Stroke), enrolled 2003 to 2007

2019 Hypertension

52. Global & Community Health: Brief in-hospital cognitive screening anticipates complex admissions and may detect dementia. (PubMed)

Global & Community Health: Brief in-hospital cognitive screening anticipates complex admissions and may detect dementia. With the long-term goal of improving community health by screening for dementia, we tested the utility of integrating the Six-Item Screener (SIS) into our emergency department neurology consultations.In this cross-sectional observational study, we measured SIS performance within 24 hours of hospital arrival in 100 consecutive English-speaking patients aged ≥45 years (...) . Performance was compared to patient age, previously charted cognitive impairment, and proxies for in-hospital complexity: whether or not a patient was admitted to the hospital and the number of medical studies ordered.Those with poor SIS performance were older (p = 0.02) and more likely to have previously charted cognitive impairment (p < 0.01; sensitivity 86%, specificity 77%). Poor performers were more likely to be admitted to the hospital (p = 0.04; odds ratio 3.6) and were subjected to more tests once

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2019 Neurology

53. Audiometric Age-Related Hearing Loss and Cognition in the Hispanic Community Health Study. (PubMed)

with a -1.53 (95% CI, -2.11, -0.94) raw score point difference in the DSST, adjusting for demographics, hearing aid use, and cardiovascular disease. Similarly, a 20-dB increase in HL was associated with a -0.86 (-1.23, -0.49) point difference on the Word Frequency Test, -0.76 (-1.04, -0.47) on the SEVLT 3 trials, -0.45 (-0.60, -0.29) on the SELVT recall, and -0.07 (-0.12, -0.02) on the Six-Item Screener.In the largest study of formal, audiometric HL and cognition to date, HL was independently associated (...) Hispanic cohort.This was a multisite cross-sectional study of 5,277 subjects at least 50 years old (Hispanic Community Health Study, HCHS). The main exposure was audiometric HL. The main outcome measure was neurocognitive performance ascertained by the Digit Symbol Substitution Test (DSST), Word Frequency Test, Spanish-English Verbal Learning Test (SEVLT), and Six-Item Screener.The mean age was 58.4 years (SD = 6.2). A 20-dB (equivalent to a one-category worsening) increase in HL was associated

2019 Biological Sciences and Medical Sciences

54. Study protocol: associations between dietary patterns, cognitive function and metabolic syndrome in older adults - a cross-sectional study. (PubMed)

and Cognitive Health) study is to investigate associations between dietary patterns, cognitive function and metabolic syndrome, accounting for a range of covariates.This cross-sectional study design will recruit older, community-living adults (65-74 years) from Auckland, New Zealand. Dietary data will be collected via a 109-item food frequency questionnaire validated using a 4-day food record. Cognitive function will be assessed using the Montreal Cognitive Assessment (paper based) and the Computerised (...) Mental Performance Assessment System (COMPASS) - a testing suite covering six domains. Additional data will include genetic (Apolipoprotein E ε4) and biochemical markers (fasting glucose, HbA1c, lipids profile), anthropometric measurements (weight, height, waist and hip circumference, body composition using dual X-ray absorptiometry), blood pressure, physical activity (International Physical Activity Questionnaire - short form) and health and demographics (questionnaire). Dietary patterns

2019 BMC Public Health

55. Hearing Impairment, Strategies, and Outcomes in Emergency Departments

that decision makers in VAMCs, ED and Audiology Services need to commit to this approach Condition or disease Intervention/treatment Phase Hearing Loss Emergency Service Hospital Readmission Other: PockeTalker Other: No PockeTalker Not Applicable Detailed Description: The goal of this study is to test whether providing hearing assistance devices to older age hearing impaired patients in the ED setting will improve in-ED understanding and preparation for discharge. The proposed intervention, the Hearing (...) ] The investigators will observe and survey participants to determine whether or not they use the hearing assistance device while they are in the ED. This will be measured on a yes/no basis. Communication with providers during ED stay [ Time Frame: Duration of ED stay, average of 1-2 days ] Participants will self-rate their quality of hearing, understanding, and communication using a six item questionnaire. Scored on a 10-point Likert scale (1 = do not agree at all; 10 = completely agree) the questions

2018 Clinical Trials

56. Impaired Cerebral Haemodynamics in Vascular Depression: Insights From Transcranial Doppler Ultrasonography (PubMed)

function and severity of subcortical ischemic vascular disease in a sample of VD patients. Methods: Seventy six patients (mean age 72.5 ± 5.3 years; 53.9% females) met the DSM-5 diagnostic criteria for unipolar major depression. Mean blood flow velocity (MBFv) and pulsatility index (PI) were recorded from the middle cerebral artery. Quantification of depressive symptoms (17-item Hamilton Depression Rating Scale -HDRS), neuropsychological test evaluating frontal lobe abilities (Stroop Color-Word test (...) Impaired Cerebral Haemodynamics in Vascular Depression: Insights From Transcranial Doppler Ultrasonography Introduction: Late-life depression is a well-known risk factor for future dementia. Increasing evidences also show a link between cerebral hypoperfusion and neurodegeneration, although data on Transcranial Doppler ultrasonography (TCD)-derived measures in patients with "Vascular Depression" (VD) are lacking. The aim of this study was to assess and correlate TCD parameters with cognitive

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2018 Frontiers in Psychiatry

57. Effects of Group Cognitive Behavioural Therapy on Comorbid Insomnia and Depression in Youth

self-rated scale measuring suicidal ideation. Possible total scores range from 0 to 12, with higher scores indicating higher suicidal ideation. Change of subjective cognitive performance [ Time Frame: Baseline, post-treatment (week 8/at the conclusion of last group session) for all participants; and additionally at post-treatment one-month and six-months for those in the two active treatment groups ] Cognitive Failures Questionnaire (CFQ) is a 20-item self-rated scale measuring perceived failures (...) in daily cognitive tasks. Possible total scores range from 0 to 80, with higher scores indicating higher cognitive failures. Change of objective cognitive performance (visual attention & task switching) [ Time Frame: Baseline, post-treatment (week 8/at the conclusion of last group session) for all participants; and additionally at post-treatment one-month and six-months for those in the two active treatment groups ] Trail Making Test for assessing visual attention and task switching. In Trail Making

2018 Clinical Trials

58. Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder

[ Time Frame: baseline measure ] The Vancouver Obsessional-Compulsive Inventory (VOCI) is a 55-item self-report measure designed to assess a broad spectrum of OCD symptoms and associated personality characteristics. Items are rated on a 5-point Likert scale, ranging from 0 (not at all) to 4 (very much), and measure participants' agreement with a series of statements related to obsessions and compulsions (e.g., ''I am often very upset by my unwanted impulses to harm other people''). The VOCI has six (...) Obsessional-Compulsive Inventory (VOCI) is a 55-item self-report measure designed to assess a broad spectrum of OCD symptoms and associated personality characteristics. Items are rated on a 5-point Likert scale, ranging from 0 (not at all) to 4 (very much), and measure participants' agreement with a series of statements related to obsessions and compulsions (e.g., ''I am often very upset by my unwanted impulses to harm other people''). The VOCI has six component subscales: (a) Checking; (b) Contamination

2018 Clinical Trials

59. Cognitive Remediation in Late-Life Schizophrenia

). There will be baseline assessments (clinical and NP) prior to enrollment in the classes. In order to assess whether there has been a change in cognition, and some of the assessments will be repeated after the 12-week intervention. Condition or disease Intervention/treatment Phase Schizophrenia Cognitive Remediation Late Life Schizophrenia Functional Impairment Cognitive Deficit Other: Cognitive Remediation Therapy Not Applicable Detailed Description: Thirty late life schizophrenia (LLS) participants, age 55 and over (...) drills targeting different cognitive domains, (3) in-class strategic monitoring to enhance metacognitive skills, and (4) discussion of the generalization of cognitive skills to daily life. The Brain Gym includes electronic tablets for participant use both during classroom sessions in addition to elective, drop-in practice sessions offered three times per week. Each group will consist of 4-6 participants. A group will be started once four to six consecutively referred participants complete baseline

2018 Clinical Trials

60. Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). (PubMed)

through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score <5) and tested whether patient factors modified the effect. Median follow-up was 8.2 years.Incident stroke was associated with acute declines in global cognition, new learning, verbal memory, and executive function. Acute declines in global cognition after stroke were greater in survivors who were black (P=0.04), men (P=0.04), and had (...) Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors' prestroke cognitive trajectories are uncertain.Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed

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2018 Stroke

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