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Six Item Cognitive Impairment Test

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21. Mild Cognitive Impairment and Endurance Exercise in Parkinson's Disease

Not Applicable Detailed Description: The overall purpose and objective of this project is to test the hypothesis that high intensity endurance exercise causes beneficial brain adaptation in patients with mild cognitive impairment in Parkinson's disease (PD-MCI). Aim 1 will determine the effect of high intensity endurance exercise on cognitive function and other clinical symptoms in PD-MCI. Aim 2 will determine the effect of high intensity endurance exercise on brain structure and function in PD-MCI. Aim 3 (...) generate within 60 seconds, the Category Verbal Fluency assesses the number of words within particular categories participants can generate within 60 seconds. Benton Judgement of Line Orientation Test [ Time Frame: Baseline and 6 Months ] Benton Judgment of Line Orientation Test is a standardized test with 30 items that is specific for visual spatial cognition. Tests will be administered at baseline, after 3, 6, 9 and 12 months of treatment. The minimum score is 0, indicating low visual spatial

2018 Clinical Trials

22. Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus

Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus (ClearMEMory) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03527472 Recruitment Status : Recruiting First Posted : May 17

2018 Clinical Trials

23. A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication

, working memory, verbal learning, speed of processing, attention/vigilance, visual learning, social cognition, reasoning and problem solving). The MCCB neurocognitive composite score is a standardized mean of the six domain scores (excluding social cognition). Raw scores are converted to age and sex adjusted t-scores which are standardized to normative data, and have a mean of 50 and standard deviation of 10 in the general healthy population. A higher score indicates less impairment. Safety (...) A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information

2018 Clinical Trials

24. Impact of Physical Activity in Vascular Cognitive Impairment ( AFIVASC )

in those subjects with previous stroke/TIA without criteria for vascular cognitive impairment no dementia. This cognitive criteria will be assessed by a clinical neurologist Cognitive Status measured by neuropsychological measures [ Time Frame: 1 year ] Change in neuropsychological evaluation (1.5 SD of initial medium score) for composite scores calculated by averaging all different domains of the tests applied or for global measures (MOCA). Secondary Outcome Measures : Impact of physical activity (...) (correlated with TIA clinical symptoms) in CT/MRI. Criteria B: No functional changes: IADL 0 (no item changed, or 1 single item with minimal change), according to the scoring methods of the LADIS study (minimum of 4 items applicable) or no cognitive changes regarding the suggested Montreal Cognitive Assessment Test (Moca) cut off point for dementia in clinical Portuguese samples (score < 17). Exclusion Criteria(Subjects cannot be included if they have at least one of the following): Diagnosis of dementia

2018 Clinical Trials

25. Efficacy Study of Yi-Zhi-An-Shen Granules For Older Adults With Amnestic Mild Cognitive Impairment

: Baseline, 8 weeks, 16 weeks, 10 months, 16 months, 22 months ] Changes in the global cognitive function will be accessed by MMSE to evaluate the severity of subjects' cognitive impairment. The MMSE includes orientation, registration, attention and calculation, recalling and language tests, for a total of 30 points. A score below 24 is considered abnormal for dementia screening. Change from Baseline in the Montreal Cognitive Assessment (MoCA) [ Time Frame: Baseline, 8 weeks, 16 weeks, 10 months, 16 (...) and related dementias: Memory, Orientation, Judgment and Problem Solving, Community Affairs, Home and Hobbies, and Personal Care. Scores on the CDR range from 0 (no impairment) to 3 (severe impairment). The total CDR ratings for each of the six cognitive/functional domains can be added to create a CDR sum of boxes (CDR-SB). Change from Baseline in the Activity of Daily Living (ADL) [ Time Frame: Baseline, 8 weeks, 16 weeks, 10 months, 16 months, 22 months ] ADLs will be assessed including basic activities

2018 Clinical Trials

26. The Six-Item Screener and AD8 for the Detection of Cognitive Impairment in Geriatric Emergency Department Patients Full Text available with Trip Pro

The Six-Item Screener and AD8 for the Detection of Cognitive Impairment in Geriatric Emergency Department Patients We evaluate the diagnostic test characteristics of the Six-Item Screener and the AD8 to detect cognitive dysfunction in adults older than 65 years and using the emergency department (ED) for any reason.We conducted an observational cross-sectional cohort study at a single academic urban university-affiliated hospital. Subjects were consenting, non--critically ill, English-speaking (...) adults older than 65 years and receiving care in the ED. We quantitatively assessed the diagnostic test characteristics of the Six-Item Screener and AD8 by using the Mini-Mental State Examination score less than 24 as the criterion standard for cognitive dysfunction.The prevalence of cognitive dysfunction was 35%, but only 6% of charts noted a pre-existing deficit. The Six-Item Screener was superior to either the caregiver-administered AD8 or the patient-administered AD8 for the detection

2011 EvidenceUpdates

27. Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia

Evidence for antidepressants 105 A3.5 Summary of NICE recommendations (cognitive impairment) 106 Appendix 4 A4.1 List of those invited to provide feedback 107 A4.2 Feedback received and resulting action 108 Appendix 5a A5.a.1 PICOS for economic search 122 A5.a.2 Inclusion and exclusion criteria 123 A5.a.3 BMJ checklist 125 A5.a.4 Consensus on health economic criteria 126 A5.a.5 Extraction summary 129 A5.a.6 Analysis and result detail 130 Appendix 5b A5.b.1.1 Direct implementation cost 136 A5.b.2.1 (...) Grading of Recommendations Assessment, Development and Evaluation GDG Guideline Development Group GDP Global Domestic Product MCI Mild Cognitive Impairment MHBC Ministry of Health British Columbia MHRA Medicines and Healthcare products Regulatory Agency NCEC National Clinical Effectiveness Committee NHMRC National Health and Medical Research Council NHS National Health Service NICE National Institute for Health and Care Excellence NPI Neuropsychiatric Inventory PBS Pharmaceutical Benefit Scheme PDD

2019 National Clinical Guidelines (Ireland)

28. Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning

Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning Key Points • Regular use refers to weekly or more frequent cannabis use over a period of months to years. Regular cannabis use is associated with mild cognitive difficulties, which are typically not apparent following about one month of abstinence. Heavy (daily) and long-term cannabis use is related to more noticeable cognitive impairment. • Cannabis use beginning prior to the age of 16 or 17 is one of the strongest (...) predictors of cognitive impairment. However, it is unclear which comes first — whether cognitive impairment leads to early onset cannabis use or whether beginning cannabis use early in life causes a progressive decline in cognitive abilities. • Regular cannabis use is associated with altered brain structure and function. Once again, it is currently unclear whether chronic cannabis exposure directly leads to brain changes or whether differences in brain structure precede the onset of chronic cannabis use

2019 Canadian Centre on Substance Abuse

29. Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning

Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning Key Points • Regular use refers to weekly or more frequent cannabis use over a period of months to years. Regular cannabis use is associated with mild cognitive difficulties, which are typically not apparent following about one month of abstinence. Heavy (daily) and long-term cannabis use is related to more noticeable cognitive impairment. • Cannabis use beginning prior to the age of 16 or 17 is one of the strongest (...) predictors of cognitive impairment. However, it is unclear which comes first — whether cognitive impairment leads to early onset cannabis use or whether beginning cannabis use early in life causes a progressive decline in cognitive abilities. • Regular cannabis use is associated with altered brain structure and function. Once again, it is currently unclear whether chronic cannabis exposure directly leads to brain changes or whether differences in brain structure precede the onset of chronic cannabis use

2019 Canadian Centre on Substance Abuse

30. Brain Gym® Exercises for Institutionalized Elderly People With Cognitive Impairment

not to be prone to participating in conventional exercise programs and might have a positive effect on their cognitive function. In spite of this, scientific evidence regarding the effects of BG on people with cognitive impairment is scarce. Behavioral: Brain Gym Exercises Participants in the BrainGym Exercises group performed six of the following BG exercises in every training session they took part in: "Cross Crawl", "Gravity Glider", "Arm Activation", "Belly Breathing", "Hook-ups", "Think of an X", "Lazy (...) Brain Gym® Exercises for Institutionalized Elderly People With Cognitive Impairment Brain Gym® Exercises for Institutionalized Elderly People With Cognitive Impairment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

31. Can an observational pain assessment tool improve time to analgesia for cognitively impaired older persons? A cluster randomised controlled trial. Full Text available with Trip Pro

bone fracture were screened for cognitive impairment using the Six-Item Screening (SIS) tool. Patients scoring 4 or less on SIS (intervention sites) were assessed for pain using PAINAD. Control sites, assessed pain using standard methods. The primary outcome was time to first dose of analgesia and was analysed on an intention-to-treat basis with a sensitivity analysis.We enrolled 602 patients, of which 323 (54%) were at intervention sites (n=4). The median time to analgesia was 82 min (IQR 45-151 (...) Can an observational pain assessment tool improve time to analgesia for cognitively impaired older persons? A cluster randomised controlled trial. The primary objective of the study was to measure the impact of an observational pain assessment dementia tool on time from ED arrival to first dose of analgesic medicine.A multisite cluster randomised controlled trial was conducted to test the Pain Assessment in Advanced Dementia (PAINAD) tool. Patients aged 65 years or older suspected of a long

2017 Emergency Medicine Journal Controlled trial quality: predicted high

32. Initial development of a patient-reported outcome measure of experience with cognitive impairment associated with schizophrenia Full Text available with Trip Pro

participants. Cognitive debriefing interviews (n=22) resulted in the removal of 18 items and modification of 22 other items. The remaining 35 items represented 23 concepts within six domains plus two items assessing bother. The draft PRO measure is currently undergoing psychometric testing as a precursor to broad-based clinical and research use. (...) Initial development of a patient-reported outcome measure of experience with cognitive impairment associated with schizophrenia Cognitive impairment is a serious, often distressing aspect of schizophrenia that affects patients' day-to-day lives. Although several interview-based instruments exist to assess cognitive functioning, a reliable measure developed based on the experiences of patients facing cognitive difficulties is needed to complement the objective performance-based assessments

2017 Patient related outcome measures

33. CBT for African Americans With Cognitive Impairment

Association Information provided by (Responsible Party): Ambar Kulshreshtha, Emory University Study Details Study Description Go to Brief Summary: The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve cognitive performance and reduce chronic stress in a randomized trial including 60 African American patients with Mild Cognitive (...) , improper diet and physical inactivity. Cognitive-behavioral therapy (CBT) is a collaborative psychological approach that addresses the interaction between people's thoughts, feelings and behavior. Existing evidence suggests that CBT can be an effective strategy for dementia patients with co-morbid anxiety. However, none of these studies have specifically evaluated African Americans with MCI. The aim of the study is to test the feasibility and acceptability of a six-month CBT program (group based

2017 Clinical Trials

34. Six decades of preventing and treating childhood anxiety disorders: a systematic review and meta-analysis to inform policy and practice Full Text available with Trip Pro

on at-risk children, that is, with temperamental inhibition, anxiety symptoms or a parent with an anxiety disorder. Six programmes used CBT techniques including psychoeducation, relaxation, cognitive restructuring and exposure exercises. Four CBT programmes were delivered to groups of children in schools, with 2 also providing parent sessions. The 2 other CBT programmes focused on parents; 1 was delivered to individual families and 1 trained parents to provide CBT to their young children. The 2 non-CBT (...) . Wang Z , Whiteside SPH , Sim L , et al . Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: a systematic review and meta-analysis . Zhou X , Zhang Y , Furukawa TA , et al . Different types and acceptability of psychotherapies for acute anxiety disorders in children and adolescents: a network meta-analysis . Moher D , Liberati A , Tetzlaff J , et al . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA

2019 Evidence-Based Mental Health

35. MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes

MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record (...) Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2015 Clinical Trials

36. Mindfulness?based interventions for improving cognition, academic achievement, behavior, and socioemotional functioning of primary and secondary school students Full Text available with Trip Pro

[CI 0.148, 0.305] and heterogeneity was not significant. Of the 12 moderators tested, only one moderator was significant—studies using clinical samples reported significantly larger effect sizes than studies using non‐clinical samples. Additional analyses performed found significantly greater effects for psychological symptoms than measures of other outcomes. conducted a systematic review and meta‐analysis of MBis in schools with a focus on psychological outcomes (cognitive performance, emotional (...) were excluded from this review. 3.1.4 Types of outcome measures Studies must have reported at least one of the following outcomes: 1. Cognition (e.g., executive function, memory, cognition, attention) 2. Academic performance (e.g., standardized achievement tests, measures of content mastery, reading, grades) 3. Behavior (e.g., disciplinary referrals, aggression and other externalizing behaviors, time on task, compliance, attendance) 4. Socioemotional (e.g., anxiety, stress, engagement, social

2017 Campbell Collaboration

37. Conceptual review of measuring functional impairment: findings from the Weiss Functional Impairment Rating Scale Full Text available with Trip Pro

are found with ADHD specific measures. The Impairment Rating Scale includes questions pertaining to peers, family, academics and self-esteem, but each domain is represented by a single item and the scale loads as a single factor. The ADHD-FX scale examines school, home and peer functioning, but is not specific to functional impairment and does not include a designated time frame. The Barkley Functional Impairment Scale (BFIS) for children and adults assesses impairment over the past 6 months (...) the research and the clinical populations in which it will be used. Psychometric validation must include empirical definitions of improvement as well as cut-offs from normal populations. A measure should include comparable versions appropriate to self, parent and collateral informants. To assure appropriate usage in varying cultures, a measure of functional impairment needs to include a breadth of potential items, while being scored in such a way as to only rate those items that are relevant

2018 Evidence-Based Mental Health

38. Optimizing the G8 Screening Tool for Older Patients With Cancer: Diagnostic Performance and Validation of a Six-Item Version Full Text available with Trip Pro

an optimized version of the G8.We used a prospective cohort of cancer patients aged ≥ 70 years referred to geriatricians for GA (2007-2012: n = 729 [training set]; 2012-2014: n = 414 [validation set]). Abnormal GA was defined as at least one impaired domain across seven validated tests. Multiple correspondence analysis, multivariate logistic regression, and bootstrapped internal validation were performed sequentially.The final model included six independent predictors for abnormal GA: weight loss (...) Optimizing the G8 Screening Tool for Older Patients With Cancer: Diagnostic Performance and Validation of a Six-Item Version A multidimensional geriatric assessment (GA) is recommended in older cancer patients to inventory health problems and tailor treatment decisions accordingly but requires considerable time and human resources. The G8 is among the most sensitive screening tools for selecting patients warranting a full GA but has limited specificity. We sought to develop and validate

2016 The oncologist

39. Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation

from baseline cognitive visual memory at 12 weeks and 6 months [ Time Frame: Baseline, 12 weeks, & 6 month ] The Brief Visuo-Spatial Memory Test (BVMT) will be used to measure visual memory Participants are presented with six abstract designs for 10 seconds, the display is then removed from view and participant are instructed to draw the designs from memory via pencil on paper. Each design is scored from 0 to 2 points representing accuracy and location. There are three learning trials. Test (...) by (Responsible Party): Dr. Anthony Feinstein, Sunnybrook Health Sciences Centre Study Details Study Description Go to Brief Summary: Given that up to 70% of people with secondary progressive MS are cognitively impaired, the search for effective treatments is considered a priority by people living with the disease. This proposal will address the effectiveness of cognitive rehabilitation (CR) and exercise, either alone, or in combination in this regard. A team of MS researchers has been assembled from the USA

2018 Clinical Trials

40. Properties of a brief assessment tool for longitudinal measurement of cognition in people living with HIV. Full Text available with Trip Pro

. The objective of this study is to estimate the extent of change on repeat administration of three different forms of a brief computerized cognitive assessment battery (B-CAM) developed for assessing cognitive ability in the mildly-impaired to normal range in people living with HIV. We hypothesized no change over a six-month period in people on effective antiretroviral therapy.102 HIV+ individuals completed a set of computerized cognitive tasks on three occasions over a six-month period. Rasch analysis (...) sessions, related to the different forms of the tasks. These two items were split by testing session. For all other items, the level of difficulty remained constant across all three time points. GBTA showed that the sample was composed of three distinct groups of people with unique trajectories, defined mainly by level of cognitive ability at baseline. Only the highest group showed an apparent improvement over time, but this change fell within measurement error.Rasch analysis provides mathematical

2019 PLoS ONE

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