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Sinus Bradycardia

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1. Chinese Patent medicine to treat a 32-year-old man with sinus bradycardia and cardiac sinus arrests: A case report. Full Text available with Trip Pro

. An ambulatory electrocardiogram showed sinus arrhythmia, sinus bradycardia, and significant sinus arrhythmia. The minimum heart rate was 33 bpm (beats per minute). The number of sinus arrest was 42 and the maximum RR interval was 2216 ms.The patient was diagnosed with bradyarrhythmia in Western medicine and "palpitation" in TCM.The patient was treated with methods of benefiting qi and nourishing yin and activating blood circulation along with warming yan for nearly 5 months. CPM (Chinese patent medicine (...) Chinese Patent medicine to treat a 32-year-old man with sinus bradycardia and cardiac sinus arrests: A case report. Sinus bradycardia refers to a sinus heart rate <60 bpm. Cardiac sinus arrests refer to the omission of atrial activation caused by transient cessation of impulse generation at the sinoatrial node. Normally, drugs such as atropine, isoproterenol, dopamine, dobutamine, or epinephrine can be used for the acute treatment of bradycardia. Temporary pacing is used for treating severe

2019 Medicine

2. Dual chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome without atrioventricular block

occasionally does not generate electrical impulses, from a period lasting a couple of seconds to several minutes sinoatrial exit block, in which the sinus node generates electrical impulses normally, but the signal is blocked before it leaves the sinus node alternating bradyarrhythmias and tachyarrhythmias (a fast heart rate), such as bradycardia-tachycardia syndrome atrioventricular block (a condition in which electrical impulses from the sinus node are slowed or blocked). Atrioventricular block can occur (...) Dual chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome without atrioventricular block Dual-chamber pacemak Dual-chamber pacemakers for ers for symptomatic br symptomatic brady adycardia due to sick cardia due to sick sinus syndrome without atrio sinus syndrome without atriov ventricular entricular block block T echnology appraisal guidance Published: 26 November 2014 nice.org.uk/guidance/ta324 © NICE 2018. All rights reserved. Subject to Notice of rights (https

2014 National Institute for Health and Clinical Excellence - Technology Appraisals

3. ALK-rearranged lung adenocarcinoma patient with development of severe sinus bradycardia after treatment with crizotinib: A case report. Full Text available with Trip Pro

ALK-rearranged lung adenocarcinoma patient with development of severe sinus bradycardia after treatment with crizotinib: A case report. The anaplastic lymphoma kinase (ALK) rearrangements represent a subtype of nonsmall-cell lung cancer (NSCLC), and targeting ALK has radically changed the treatment of NSCLC. Crizotinib, as an ALK inhibitor, has been used in the treatment of ALK-rearranged NSCLC for several years and some adverse effects should be given attention.A 64-year-old woman (...) patient achieved partial response after 1-month treatment. However, this patient suffered a severe sinus bradycardia after 4 months of treatment. When reducing the dose of crizotinib, the side effect was alleviated and this patient showed stable disease until now.Given that the severe sinus bradycardia was an unusual adverse effect, physicians should be aware of these side effects when using crizotinib. Moreover, it should be noted that this patient harbored an intergenic ALK rearrangement identified

2019 Medicine

4. Acute Efficacy of a Traditional Chinese Medicine for Treatment of Frequent Premature Ventricular Contractions in Patients with Concomitant Sinus Bradycardia: Results from a Double-Blind, Placebo-Controlled, Multicentre, Randomized Clinical Trial. Full Text available with Trip Pro

Acute Efficacy of a Traditional Chinese Medicine for Treatment of Frequent Premature Ventricular Contractions in Patients with Concomitant Sinus Bradycardia: Results from a Double-Blind, Placebo-Controlled, Multicentre, Randomized Clinical Trial. Pharmacological antiarrhythmic therapy such as beta-blockers in patients with frequent premature ventricular contractions (PVCs) and concomitant bradycardia is challenging. A traditional Chinese medicine, Shensong Yangxin (SSYX), has been effective (...) in treatment of frequent PVCs and sinus bradycardia (SB) in separate patient cohorts. This double-blind, placebo-controlled, multicentre, randomized clinical trial investigates the acute efficacy of SSYX in reducing PVCs burden in patients with concomitant SB. Patients with symptomatic, frequent PVCs, and SB, defined as mean heart rate (MHR) of 45 to 59 beats per min (bpm), were recruited at 33 medical centres in mainland China and randomly assigned by computer to either SSYX or matching placebo for eight

2019 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: predicted high

5. Leadless cardiac pacemaker implantation for bradyarrhythmias

and procedure The condition, current treatments and procedure The condition 2.1 Bradyarrhythmias are abnormal heart rhythms that can result in a slow heart rate (bradycardia), usually defined as less than 60 beats per minute. There are a range of causes including diseases such as sick sinus syndrome or atrioventricular block. The most common causes are the natural ageing process, ischaemic heart disease, heart valve disorders and heart failure. If untreated, bradycardia may lead to fatigue, fainting (...) , palpitations, dizziness, heart failure and an increased risk of death. Current treatments 2.2 Bradyarrhythmias are managed with pacemakers, as described in NICE technology appraisal guidance. Dual-chamber pacing is recommended for symptomatic bradycardia caused by sick sinus syndrome, atrioventricular block, or a combination of sick sinus syndrome and/or atrioventricular block, and also for sick sinus syndrome in people without atrioventricular block. Single- chamber ventricular pacemakers may be used

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

6. Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling Full Text available with Trip Pro

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potassium current, IKs. However, the mechanism(s) underlying the increased atrial arrhythmogenesis and impaired cardiac pacemaking (...) , and reduced the DF in a dose-dependent manner under both mutation conditions. This study provides mechanistic insights into different AF/bradycardia phenotypes in SQT2 and the efficacy of quinidine pharmacotherapy.

2018 Frontiers in physiology

7. Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor Full Text available with Trip Pro

Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor 30479952 2019 02 26 2214-0271 4 11 2018 Nov HeartRhythm case reports HeartRhythm Case Rep Cyclical sinus bradycardia and atrioventricular block induced by ticagrelor. 527-529 10.1016/j.hrcr.2018.07.017 Waldmann Victor V Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada. Laredo Mikael M Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada (...) . Nigam Anil A Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada. Khairy Paul P Department of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Canada. eng Case Reports 2018 08 08 United States HeartRhythm Case Rep 101656239 2214-0271 AV block Adenosine Coronary artery disease Sinus node dysfunction Ticagrelor 2018 11 28 6 0 2018 11 28 6 0 2018 11 28 6 1 epublish 30479952 10.1016/j.hrcr.2018.07.017 S2214-0271(18)30185-4 PMC6241168 J Am

2018 HeartRhythm Case Reports

8. Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations Full Text available with Trip Pro

Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations The SCN5A gene encodes the pore-forming α-subunit of the ion channel that carries the cardiac fast sodium current (INa). The 1795insD mutation in SCN5A causes sinus bradycardia, with a mean heart rate of 70 beats/min in mutation carriers vs. 77 beats/min in non-carriers from the same family (lowest heart rate 41 vs. 47 beats/min). To unravel the underlying mechanism, we (...) -of-function effect of the reduction in INa conductance. The further loss-of-function effect of the shifts in steady-state activation and inactivation resulted in an overall loss-of-function effect of the 1795insD mutation. We conclude that the experimentally identified mutation-induced changes in INa can explain the clinically observed sinus bradycardia. Furthermore, we conclude that the Fabbri-Severi model may prove a useful tool in understanding cardiac pacemaker activity in humans.

2018 International journal of molecular sciences

9. Bradycardia

Bradycardia Bradycardia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bradycardia Last reviewed: February 2019 Last updated: March 2018 Summary Any heart rhythm slower than 50 bpm, even if transient, owing to sinus node dysfunction and/or atrioventricular (AV) conduction abnormalities. Causes include intrinsic sinus node and AV nodal disease, or extrinsic influences, which may be reversible. Common symptoms include (...) definition of normal sinus heart rate. Am J Cardiol. 1992;69:1245-1246. http://www.ncbi.nlm.nih.gov/pubmed/1575201?tool=bestpractice.com Spodick DH. Normal sinus heart rate: sinus tachycardia and sinus bradycardia redefined. Am Heart J. 1992;124:1119-1121. http://www.ncbi.nlm.nih.gov/pubmed/1529897?tool=bestpractice.com A slow heart rate is common under various circumstances and does not necessarily require treatment unless it causes symptoms. Nonetheless, some patients, even if asymptomatic, may require

2018 BMJ Best Practice

10. Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Full Text available with Trip Pro

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, If, underlies exercise training-induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased incidence of bradyarrhythmias in veteran athletes, and it will be important to understand the underlying (...) bradycardia via rescue of HCN4 and If. Further experiments showed that in the sinus node of swim-trained mice, upregulation of miR-423-5p (intronic miR) and its host gene, NSRP1, is driven by an upregulation of the transcription factor Nkx2.5.HCN remodeling likely occurs in human athletes, as well as in rodent models. miR-423-5p contributes to training-induced bradycardia by targeting HCN4. This work presents the first evidence of miR control of HCN4 and heart rate. miR-423-5p could be a therapeutic

2017 Circulation Research

11. Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia Full Text available with Trip Pro

Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the pacemaker activity in the heart, and its malfunction can result in heart disorders. One such disorder, familial sinus bradycardia, is caused by the S672R mutation in HCN, whose electrophysiological phenotypes include a negative shift in the channel activation voltage

2017 The Journal of biological chemistry

12. Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function Full Text available with Trip Pro

Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function 28684593 2019 03 21 1522-1601 123 3 2017 09 01 Journal of applied physiology (Bethesda, Md. : 1985) J. Appl. Physiol. Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function. 684-685 10.1152/japplphysiol.00604.2017 Boyett Mark R MR Wang Yanwen Y Nakao Shu S Ariyaratnam Jonathan J Hart George G Monfredi Oliver O D'Souza Alicia A eng RG/11/18/29257 British

2017 Journal of Applied Physiology

13. The impact of sinus-bradycardia during targeted temperature management on survival and neurological function of post-cardiac arrest patients

The impact of sinus-bradycardia during targeted temperature management on survival and neurological function of post-cardiac arrest patients Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

14. Atrial fibrillation was changed into sinus bradycardia in a ROS1-positive advanced lung adenocarcinoma patient who achieved durable response to Crizotinib: A case report and literature review. Full Text available with Trip Pro

Atrial fibrillation was changed into sinus bradycardia in a ROS1-positive advanced lung adenocarcinoma patient who achieved durable response to Crizotinib: A case report and literature review. The c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearrangements represent a new and rare genetic subtype of non-small-cell lung cancer. In recent years, the use of crizotinib in ROS1-rearranged lung cancer exhibits significant clinical efficacy. Crizotinib is generally well tolerated and the most (...) QTc interval prolongation and his persistent atrial fibrillation was changed into sinus bradycardia. Only 22 days after crizotinib treatment, the patient's tumor achieved a partial response. So far the patient has taken crizotinib for >19 months with no evidence of disease progression.The present study demonstrates dramatic benefit of crizotinib for patients with ROS1 rearrangement. Besides, we should caution the cardiac effects caused by crizotinb and our case provides evidence that crizotinib

2017 Medicine

15. Sinus Bradycardia in Habitual Cocaine Users. (Abstract)

Sinus Bradycardia in Habitual Cocaine Users. Common physiological manifestations of cocaine are related to its adrenergic effects, due to inhibition of dopamine and norepinephrine uptake at the postsynaptic terminal. Few studies have documented bradycardia secondary to cocaine use, representing the antithesis of its adrenergic effects. We assessed the prevalence of sinus bradycardia (SB) in habitual cocaine users and postulated a mechanism for this effect. One hundred sixty-two patients (...) with a history of cocaine use were analyzed and compared with age- and gender-matched controls. SB was defined as a rate of <60 beats/min and habitual cocaine use as 2 or more documented uses >30 days apart. Propensity score-matching analysis was applied to balance covariates between cocaine users and nonusers and reduce selection bias. Patients with a history of bradycardia, hypothyroidism, or concomitant beta-blocker use were excluded. Mean age of study patients was 44 ± 8 years. SB was observed in 43

2017 American Journal of Cardiology

16. ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay

Entities (Relevant) 121 Appendix 2. Abbreviated Reviewer Relationships With Industry and Other Entities 124 References 127 MANUSCRIPT ACCEPTED ACCEPTED MANUSCRIPT Kusumoto FM, et al. 2018 Bradycardia Clinical Practice Guidelines Page 5 Top 10 Take-Home Messages For the Management of Bradycardia and Cardiac Conduction Delay 1. Sinus node dysfunction is most often related to age-dependent progressive fibrosis of the sinus nodal tissue and surrounding atrial myocardium leading to abnormalities of sinus (...) , nocturnal bradycardia is not in itself an indication for permanent pacing. 3. The presence of left bundle branch block on electrocardiogram markedly increases the likelihood of underlying structural heart disease and of diagnosing left ventricular systolic dysfunction. Echocardiography is usually the most appropriate initial screening test for structural heart disease, including left ventricular systolic dysfunction. 4. In sinus node dysfunction, there is no established minimum heart rate or pause

2018 American College of Cardiology

17. Sinus Bradycardia

Sinus Bradycardia Sinus Bradycardia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sinus Bradycardia Sinus Bradycardia Aka: Sinus (...) Bradycardia From Related Chapters II. Pathophysiology Normal pattern in healthy adults and athletes Baseline suggests physical conditioning Other causes of Sinus Bradycardia See Severe infection Tight shirt collar Excessive parasympathetic stimulation Acute inferior wall Decreased sympathetic stimulation (medications) III. Diagnostics: EKG Findings Regular rhythm with rate at <50 to 60 beats per minute Normal and consistent P-wave morphology Normal PR-Interval duration IV. Differential Diagnosis See V

2018 FP Notebook

18. Normal Sinus Rhythm-Sinus Bradycardia is Common in Young Children Post-extracardiac Fontan. (Abstract)

Normal Sinus Rhythm-Sinus Bradycardia is Common in Young Children Post-extracardiac Fontan. We hypothesized that normal sinus rhythm-sinus bradycardia is common in young children following extracardiac Fontan. After excluding patients with sinus pauses, junctional rhythm, tachy-brady syndrome, frequent ectopics, or ectopic atrial rhythm, we found an ambulatory 24-h Holter monitor average heart rate of 78 ± 12 beats per minute (bpm) in 33 post-extracardiac Fontan children with a median age of 6 (...)  years (5-10). A 24-h average heart rate of 78 ± 12 bpm is statistically significantly lower than a 24-h average heart rate value of 90 ± 10 bpm derived from a similarly aged control population (p < 0.01). We conclude that after excluding those with significant arrhythmias, normal sinus rhythm-sinus bradycardia is common in children post-extracardiac Fontan.

2016 Pediatric Cardiology

19. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. (Abstract)

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Atrial fibrillation is the most frequent sustained arrhythmia. Atrial fibrillation often recurs after restoration of normal sinus rhythm. Antiarrhythmic drugs have been widely used to prevent recurrence. This is an update of a review previously published in 2006, 2012 and 2015.To determine the effects of long-term treatment with antiarrhythmic drugs on death, stroke, drug adverse effects and recurrence (...) of atrial fibrillation in people who had recovered sinus rhythm after having atrial fibrillation.We updated the searches of CENTRAL, MEDLINE and Embase in January 2019, and ClinicalTrials.gov and WHO ICTRP in February 2019. We checked the reference lists of retrieved articles, recent reviews and meta-analyses.Two authors independently selected randomised controlled trials (RCTs) comparing any antiarrhythmic drug with a control (no treatment, placebo, drugs for rate control) or with another

2019 Cochrane

20. 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhyth Full Text available with Trip Pro

Kimberly A KA Thompson Annemarie A Varosy Paul D PD eng Journal Article 2018 11 06 United States J Am Coll Cardiol 8301365 0735-1097 AIM IM J Am Coll Cardiol. 2019 Aug 20;74(7):1016-1018 31416524 ACC/AHA Clinical Practice Guidelines AV block Holter monitoring ablation ambulatory electrocardiography aminophylline atrioventricular block atropine beta-adrenergic agonist bradyarrhythmia bradycardia bundle branch block cardiac pacing cardiac resynchronization therapy cardiac sinus pause cardiac surgery (...) congenital heart disease digoxin antibodies Fab fragments electrocardiogram glucagon heart block intraoperative isoproterenol lamin A-C left bundle branch block muscular dystrophies myocardial infarction myotonic dystrophy pacemaker pacing preoperative quality of life right bundle branch block sarcoidosis shared decision-making sick sinus syndrome sinus arrest sinus bradycardia syndrome sinus node dysfunction spinal cord injuries syncope theophylline transcatheter aortic valve replacement 2018 11 10 6 0

2019 EvidenceUpdates

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