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Sick Sinus Syndrome

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2. Dual chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome without atrioventricular block

://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 4 of 532 2 Clinical need and pr Clinical need and practice actice 2.1 Bradycardia is a slow heart rate, defined as a heart rate of less than 60 beats per minute. Bradycardia can be caused by a range of factors, including diseases such as: sick sinus syndrome – a number of abnormal heart rhythms caused by an irreversible dysfunction of the sinus node (the heart's natural pacemaker), including: sinus arrest or pause, in which the sinus node (...) independently from sick sinus syndrome, and so people with symptomatic bradycardia due to sick sinus syndrome may also have or develop atrioventricular block. 2.2 The most commonly identified causes of abnormal heart rhythms are age, ischaemic heart disease, heart valve disorders and heart failure. If untreated, symptomatic bradycardia may lead to fatigue, fainting, palpitations, dizziness, heart failure and an increased risk of mortality. 2.3 Sick sinus syndrome is difficult to diagnose because

2014 National Institute for Health and Clinical Excellence - Technology Appraisals

3. Very long-term prognosis in patients with right ventricular apical pacing for sick sinus syndrome. (Abstract)

Very long-term prognosis in patients with right ventricular apical pacing for sick sinus syndrome. The impact of right ventricular (RV) apical pacing on very long-term cardiac prognosis is little known. In this study, we retrospectively evaluated the relationship between RV apical pacing and cardiovascular events (CEs) in patients with sick sinus syndrome (SSS) and left ventricular ejection fraction (LVEF) >35%.Total of 532 consecutive pacemaker recipients with SSS and LVEF >35% were divided (...) into two groups according to the mean cumulative per cent RV apical ventricular pacing (mean %VP) (<50%; non-VP group vs ≥50%; VP group) and occurrence of CE was compared using Kaplan-Meier analysis between two groups. Cox hazard model was used to assess predictors of CE after adjusting explanatory variables such as age, atrial fibrillation (AF) and structural heart disease (SHD).Mean %VP was 86.0% and 8.2% in VP and non-VP groups, respectively (p<0.001). During mean follow-up of 13.4±7.0 years, CE

2019 Heart

4. Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome Full Text available with Trip Pro

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome Background Brugada syndrome ( BS ) is known to be 9 times more prevalent in males than females. However, little is known about the development of sick sinus syndrome in female members with familial BS . Methods and Results Familial BS patients and family members, both from our institutions and collaborating sites that specialize in clinical care of BS , participated in this study. We collected (...) information on their clinical and genetic background, along with the inheritance patterns of BS . Detailed information on each case with familial BS is described. A total of 7 families, including 25 BS patients (12 females and 13 males), were included. Seven were probands and 18 were family members. Ten out of the 12 female patients and none of the 13 male patients developed sick sinus syndrome. Sudden death or spontaneous ventricular fibrillation occurred in 7 out of 13 male patients and 2 out of 12

2018 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

5. [Clinical Value of Algorithms of Minimization of Right Ventricular Pacing in Patients With Sick Sinus Syndrome and History of Atrial Fibrillation]. (Abstract)

[Clinical Value of Algorithms of Minimization of Right Ventricular Pacing in Patients With Sick Sinus Syndrome and History of Atrial Fibrillation]. to assess effectiveness of algorithms of minimization of right ventricular pacing (MRVP) for prevention of progression of atrial fibrillation (AF), lowering of frequency of hospitalizations due to cardiovascular causes, and mortality in patients with sick sinus syndrome (SSS) and history of paroxysmal AF compared with standard compared with dual

2018 Kardiologiia Controlled trial quality: uncertain

6. Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. Full Text available with Trip Pro

Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. Sick sinus syndrome (SSS) is one of the most common causes of cardiac impairment necessitating pacemaker implantation. However, studies of SSS pathogenesis are neither comprehensive nor conclusive due to limited success in achieving a stable rat SSS model. Here, we modified pinpoint press permeation to establish a stable rat SSS model.We randomly assigned 138 male Sprague-Dawley rats into three groups: normal

2018 BioMed research international

7. Sick sinus syndrome associated with anti-programmed cell death-1 Full Text available with Trip Pro

Sick sinus syndrome associated with anti-programmed cell death-1 Use of anti-programmed cell death-1 (anti-PD-1) has been successful in treating many types of cancers. Despite its promising efficacy, immune-related adverse events are still a major concern. Immune-related cardiotoxicity, which is rare but fatal, has recently become a focus of attention. Cardiotoxicities including myocarditis, cardiomyopathy, cardiac fibrosis, heart block and cardiac arrest have been reported. Of these toxicities (...) , myocarditis is often accompanied by dysrhythmia. The presentation of sick sinus syndrome as an immune-related adverse event has not yet been reported. Here, we reported the first case of sick sinus syndrome, a rare toxicity induced by anti-PD-1.A 42-year-old male patient who had metastatic hepatocellular carcinoma failed treatment with sorafenib. Pembrolizumab at a fixed dose of 100 mg every three weeks was given. His heart rate gradually slowed down and he presented sick sinus syndrome with a lowest

2018 Journal for immunotherapy of cancer

8. Sick Sinus Syndrome and Takotsubo Cardiomyopathy Full Text available with Trip Pro

Sick Sinus Syndrome and Takotsubo Cardiomyopathy Background. Takotsubo cardiomyopathy is associated with increased risk of ventricular arrhythmias, atrial fibrillation, and bradyarrhythmias. However, sinus node dysfunction is relatively infrequent in the setting of takotsubo cardiomyopathy. Case Report. We are reporting a case of a 73-year-old woman with a history of asymptomatic sinus bradycardia who developed sick sinus syndrome complicated by takotsubo cardiomyopathy. Conclusion. Acute (...) symptomatic sick sinus syndrome in patients with preexisting silent sinus node dysfunction can trigger takotsubo cardiomyopathy. Understanding precipitating factors of takotsubo cardiomyopathy and identifying the patients at risk of life-threatening arrhythmia can help in refining risk stratification and therapy planning. Patients with sick sinus syndrome complicated by takotsubo cardiomyopathy may benefit from pacemaker implantation. However, evaluation on a case-by-case basis is mandatory.

2018 Case reports in cardiology

9. TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling Full Text available with Trip Pro

TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS). Transient receptor potential (TRP) subfamily M member 7 (TRPM7) is implicated in cardiac fibrosis. However, the mechanisms underlying the regulation of sinoatrial node (SAN) fibrosis in SSS by TRPM7 remain unknown. The aim of this study was to investigate the role of angiotensin II (Ang II

2018 Heart and vessels

10. Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome Full Text available with Trip Pro

Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome Sick sinus syndrome (SSS) has multiple causes both familial and acquired. The most common cause is usually idiopathic. In the past literature, elevated intracranial pressure (ICP) has not been reported to be a cause of SSS. We present a case of a 55-year-old male that developed SSS after surgical resection of a brain tumor. We have investigated the causal relationship between increased ICP and SSS. We have concluded that elevated

2018 Case reports in cardiology

11. Sick sinus syndrome in cardiac noncompaction Full Text available with Trip Pro

Sick sinus syndrome in cardiac noncompaction 30112287 2019 02 26 2214-0271 4 8 2018 Aug HeartRhythm case reports HeartRhythm Case Rep Sick sinus syndrome in cardiac noncompaction. 359-361 10.1016/j.hrcr.2018.05.001 Nasir Usama Bin UB John Dempsey Hospital/University of Connecticut Health Center, Farmington, Connecticut. Balakumaran Kathir K John Dempsey Hospital/University of Connecticut Health Center, Farmington, Connecticut. Tabtabai Sara S John Dempsey Hospital/University of Connecticut (...) Health Center, Farmington, Connecticut. Pickett Christopher C John Dempsey Hospital/University of Connecticut Health Center, Farmington, Connecticut. Meng Joyce J John Dempsey Hospital/University of Connecticut Health Center, Farmington, Connecticut. eng Case Reports 2018 05 22 United States HeartRhythm Case Rep 101656239 2214-0271 Cardiomyopathy Noncompaction cardiomyopathy Sick sinus syndrome Sinoatrial node dysfunction Syncope 2018 8 17 6 0 2018 8 17 6 0 2018 8 17 6 1 epublish 30112287 10.1016

2018 HeartRhythm Case Reports

12. Safety and efficacy of AAIR pacing in selected patients with sick sinus syndrome. Full Text available with Trip Pro

Safety and efficacy of AAIR pacing in selected patients with sick sinus syndrome. The DANPACE study suggested implanting dual-pacing dual-sensing dual-response rate-adaptive (DDDR) pacemakers in patients with sick sinus syndrome, even though 90.7% of their atrial-pacing atrial-sensing inhibited-response rate-adaptive (AAIR) group did not require upgrade. Most centers implant DDDR pacemakers due to risk of future atrioventricular (AV) block. Given that AAIR pacemakers are less expensive, have (...) one less lead with potentially one less point of complication, we question whether DDDR pacemakers are superior to AAIR pacemakers. We aim to describe long-term outcomes of AAIR implants.Patients presenting to the Grey Nuns Hospital in Edmonton, Canada from 1990 to 2012 with sick sinus syndrome without AV block had AAIR pacemakers implanted. Outcomes that were measured over the follow-up time included need for ventricular lead reoperation, incidence of AV block and incidence of sudden cardiac

2018 Medicine

13. Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations Full Text available with Trip Pro

Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations Sick sinus syndrome (SSS) is a sinus node dysfunction characterized by severe sinus bradycardia. SSS results in insufficient blood supply to the brain, heart, kidneys, and other organs and is associated with the increased risk of sudden cardiac death. Bradyarrhythmia appears in the absence of any associated cardiac pathology and displays a genetic legacy. The present study identified a family (...) with primary manifestation of sinus bradycardia (five individuals) along with early repolarization (four individuals) and atrial fibrillation (one individual). Targeted exome sequencing was used to screen exons and adjacent splice sites of 61 inherited arrhythmia‑associated genes, to detect pathogenic genes and variant sites in the proband. Family members were sequenced by Sanger sequencing and protein functions predicted by Polyphen‑2 software. A total of three rare variants were identified in the family

2018 Molecular medicine reports

14. Complex regional pain syndrome induced by pacemaker implantation for sick sinus syndrome Full Text available with Trip Pro

Complex regional pain syndrome induced by pacemaker implantation for sick sinus syndrome A 53-year-old woman reported burning pain, muscle weakness, and dysesthesia of the left arm 2 months after permanent pacemaker insertion in the ipsilateral side for the treatment of sick sinus syndrome. Complex regional pain syndrome (CRPS) induced by pacemaker implantation was diagnosed. In 2017, her pulse generator became exhausted and was exchanged carefully to avoid exacerbation of CRPS, under

2017 Journal of arrhythmia

15. Sick Sinus Syndrome with HCN4 Mutations Shows Early Onset and Frequent Association with Atrial Fibrillation and Left Ventricular Non-compaction. (Abstract)

Sick Sinus Syndrome with HCN4 Mutations Shows Early Onset and Frequent Association with Atrial Fibrillation and Left Ventricular Non-compaction. Familial sick sinus syndrome (SSS) is often attributable to mutations in genes encoding the cardiac Na channel SCN5A and pacemaker channel HCN4. We previously found that SSS with SCN5A mutations shows early onset of manifestations and male predominance. Despite recent reports on the complications of atrial fibrillation (AF) and left ventricular

2017 Heart Rhythm

16. Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. Full Text available with Trip Pro

Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. More mature or older women are more likely to undergo in vitro fertilization and embryo implant. These women have a greater chance of receiving ergonovine therapy because of a suspected abortion. We present this case report to call attention to a latent lethal adverse effect in everyday obstetric practice using ergonovine. It requires more attention and close monitoring PATIENT (...) CONCERNS:: We presented the case of a 38-year-old female patient with general weakness and mild chest tightness after ergonovine use.She was diagnosed as transient sick sinus syndrome and complete atrioventricular block with junctional escape rhythm after diagnostic work up.Conservative treatment with discontinuation of ergonovine and bed rest.Her sinus rhythm returned to normal the day after ergonovine was discontinued. The patient remained symptom-free since recovery of her sinus rhythm.Ergonovine

2017 Medicine

17. Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation Full Text available with Trip Pro

Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation The CHA2DS2-VASc score is used clinically for stroke risk stratification in patients with atrial fibrillation (AF). We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in Chinese patients with sick sinus syndrome (SSS) after pacemaker implantation

2017 Chinese medical journal

18. Isolated Persistent Left Superior Vena Cava, Sick Sinus Syndrome, and Challenging Pacemaker Implantation Full Text available with Trip Pro

Isolated Persistent Left Superior Vena Cava, Sick Sinus Syndrome, and Challenging Pacemaker Implantation Persistent left superior vena cava with absent right superior vena cava is a very rare venous anomaly and is known as isolated PLSVC. It is usually an asymptomatic anomaly and is mostly detected during difficult central venous access or pacemaker implantation, though it could also be associated with an increased incidence of congenital heart disease, arrhythmias, and conduction disturbances (...) . Herein, we describe a dual-chamber pacemaker implantation in a patient with isolated PLSVC and sick sinus syndrome.

2017 Case reports in cardiology

19. Long term effects of cilostazol in a dog with sick sinus syndrome Full Text available with Trip Pro

Long term effects of cilostazol in a dog with sick sinus syndrome Sick sinus syndrome (SSS) is a type of bradyarrhythmia that can lead to syncope. Cilostazol has been reported to be an effective treatment for human patients with SSS and other bradyarrhythmias. This report describes the successful long-term treatment with cilostazol in a dog with SSS. A nine-year old intact male Miniature Schnauzer presented with a history of syncopal episodes and unsteady gait. After cilostazol treatment

2017 The Journal of Veterinary Medical Science

20. Persistent Sick Sinus Syndrome in Scrub Typhus Full Text available with Trip Pro

Persistent Sick Sinus Syndrome in Scrub Typhus 28500798 2018 12 11 2018 12 11 1476-1645 96 5 2017 May The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Persistent Sick Sinus Syndrome in Scrub Typhus. 1005-1006 10.4269/ajtmh.16-0909 Jung Lae-Young LY Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea. Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea. Yoon Ji-Young JY Department (...) Humans Male Middle Aged Scrub Typhus complications diagnosis pathology Sick Sinus Syndrome diagnosis etiology microbiology physiopathology Skin pathology 2017 5 14 6 0 2017 5 14 6 0 2018 12 12 6 0 ppublish 28500798 10.4269/ajtmh.16-0909 PMC5417185 Am J Trop Med Hyg. 2003 Apr;68(4):477-9 12875300 Southeast Asian J Trop Med Public Health. 1977 Dec;8(4):503-9 149373 Australas Med J. 2014 Mar 31;7(3):164-7 24719653

2017 The American journal of tropical medicine and hygiene

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