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21. The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function.

The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function. Obesity is associated with impaired microvascular endothelial function. We aimed to determine the effects of orlistat and sibutramine treatment on microvascular endothelial function, anthropometric and lipid profile, blood pressure (BP), and heart rate (HR).76 subjects were recruited and randomized to receive orlistat 120 mg three times daily or sibutramine 10 mg daily for 9 months (...) . AChmax, ACh % change and ACh peak were increased in orlistat-treated group but no difference was observed for sibutramine-treated group. BP and total cholesterol (TC) were reduced for orlistat-treated group. HR was reduced for orlistat-treated group but was increased in sibutramine-treated group.9 months treatment with orlistat significantly improved microvascular endothelial function. This was associated with reductions in weight, BMI, BP, HR, TC and low density lipoprotein cholesterol. No effect

2013 Clinical hemorheology and microcirculation

22. A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity. (PubMed)

A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity. In this study, we aimed to explore whether a common single nucleotide polymorphism (SNP), rs266729 (-11,377C > G), in the adiponectin C1Q and collagen domain containing (ADIPOQ) gene could influence weight reduction and fat change under sibutramine therapy in an obese population. There were 131 obese Taiwanese patients, including 44 in the placebo group and 87 in the sibutramine (...) (10 mg daily) group. We assessed the measures of weight loss and body fat reduction at the end of the 12-week treatment period by analysis of covariance (ANCOVA) models using gender, baseline weight, and baseline percent body fat as covariates. By comparing the placebo and sibutramine groups with ANCOVA, our data revealed a strong effect of sibutramine on percent body fat loss (1.9 ± 0.3 vs 4.6 ± 0.5%; P < 0.001) and on weight reduction (2.8 ± 2.0 vs 7.9 ± 1.6 kg; P < 0.001) for subjects

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2012 Clinical pharmacology : advances and applications

23. Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial. (PubMed)

Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial. Elevated levels of serum uric acid are associated with an increased risk of cardiovascular morbidity and mortality. The response of uric acid to weight loss therapy (lifestyle plus sibutramine) in an overweight and obese cardiovascular high risk population was studied.Data from a four week single-blind lead-in period (...) of the Sibutramine Cardiovascular OUTcomes (SCOUT) study were analyzed. 2584 patients (24%) had diabetes mellitus (DM) only, 1748 (16%) had cardiovascular disease (CVD) only and 6397 (60%) had both DM + CVD. Uric acid concentrations (mean +/- standard deviation) at screening were significantly higher among patients with CVD compared to patients without CVD (p < 0.0001): 369 +/- 86 mumol/L, 374 +/- 98 mumol/L and 342 +/- 87 mumol/L in CVD only, CVD+DM and DM only groups, respectively. During treatment uric acid

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2012 Nutrition & metabolism

24. Sibutramine

Sibutramine Sibutramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sibutramine Sibutramine Aka: Sibutramine , Meridia From (...) Related Chapters II. Background Sibutramine taken off the market October 2010 in United States due to risk of serious cardiovascular events Listed for historical purposes only III. Contraindications Severe Hepatic insufficiency Advanced cardiovascular disease Arrhythmias Narrow-Angle history IV. Dosing Continuous: Sibutramine 15 mg qd Intermittent (similar weight loss, less side effects) Weeks 1-12: Sibutramine 15 mg qd Weeks 19-30: Sibutamine 15 mg qd Weeks 37-48: Sibutramine 15 mg qd No medication

2015 FP Notebook

25. Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial. (PubMed)

Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial. The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity but not mortality. The relationship between 12-month weight loss and subsequent cardiovascular outcomes is explored.Overweight/obese subjects (N = 10 744), ≥55 years with cardiovascular disease and/or type 2 (...) diabetes mellitus, received sibutramine plus weight management during a 6-week Lead-in Period before randomization to continue sibutramine (N = 4906) or to receive placebo (N = 4898). The primary endpoint was the time from randomization to first occurrence of a primary outcome event (non-fatal myocardial infarction, non-fatal stroke, resuscitated cardiac arrest or cardiovascular death).For the total population, mean weight change during Lead-in Period (sibutramine) was -2.54 kg. Post-randomization

2012 obesity & metabolism

26. Sibutramine promotes amygdala activity under fasting conditions in obese women. (PubMed)

Sibutramine promotes amygdala activity under fasting conditions in obese women. Sibutramine, a centrally-acting selective monoamine reuptake inhibitor, has been used as an appetite suppressant drug in obesity.To gain insight into the central nervous actions of sibutramine, brain responses to pictures of food items after sibutramine vs placebo application were assessed by functional magnetic resonance imaging (fMRI) in obese women.In a randomized double-blind crossover design, 10 healthy obese (...) women (BMI 31.8-39.9 kg/m(2)) received 15 mg/d of sibutramine vs placebo for 14 d. Obese participants, and a group of 10 age-matched normal weight controls, viewed pictures of food items and control objects in hungry and satiated states while lying in the MR scanner. The paradigm followed a block design. In obese participants, fMRI measurements were conducted prior and after two weeks of daily sibutramine or placebo administration, whereas control participants were scanned only at one point

2012 Psychopharmacology

27. Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine. (PubMed)

Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine. The effects of linagliptin on fat content in diet-induced obese rats were compared with those of the appetite suppressant sibutramine. Female Wistar rats fed a high-fat diet (HFD) for 3 months received vehicle, linagliptin (10 mg/kg) or sibutramine (5 mg/kg) treatment orally, once daily for 6 additional weeks, while (...) continuing the HFD. Magnetic resonance spectroscopy analysis of fat content was performed at baseline and at the end of the 6-week treatment period. Linagliptin treatment profoundly reduced hepatic fat compared with vehicle, with an effect comparable to that of sibutramine. The vehicle-corrected mean change (95% CI) from baseline in hepatic fat and intramyocellular lipid was -59.0% (-104.3%, -13.6%; p = 0.015) and -62.1% (-131.6%, 7.4%; p = 0.073), respectively, for linagliptin compared with -54.3

2012 obesity & metabolism

28. Sibutramine on Cardiovascular Outcome (PubMed)

Sibutramine on Cardiovascular Outcome 21525441 2011 07 01 2018 11 13 1935-5548 34 Suppl 2 2011 May Diabetes care Diabetes Care Sibutramine on cardiovascular outcome. S114-9 10.2337/dc11-s205 Scheen André J AJ Division of Diabetes, Nutrition and Metabolic Disorders and Clinical Pharmacology Unit, Department of Medicine, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium. andre.scheen@chu.ulg.ac.be eng Journal Article Review United States Diabetes Care 7805975 0149 (...) -5992 0 Appetite Depressants 0 Cyclobutanes WV5EC51866 sibutramine IM Appetite Depressants adverse effects therapeutic use Cardiovascular Diseases chemically induced Cardiovascular System drug effects Cyclobutanes adverse effects therapeutic use Humans 2011 4 29 6 0 2011 5 6 6 0 2011 7 2 6 0 ppublish 21525441 34/Supplement_2/S114 10.2337/dc11-s205 PMC3632147 Obes Rev. 2010 Nov;11(11):777-91 20025693 N Engl J Med. 2010 Sep 2;363(10):905-17 20818901 CMAJ. 2002 May 14;166(10):1307-8 12041851 Obes Rev

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2011 Diabetes Care

29. Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects

Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects (sibu) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01421706 Recruitment Status : Completed First Posted : August 23, 2011 Last Update Posted

2011 Clinical Trials

30. Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. (PubMed)

Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. The prevalence of obesity, a serious public health problem, is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood.To provide a systematic review of the best evidence about the effect of sibutramine and orlistat in weight loss, quality of life and its adverse effects in adolescents diagnosed (...) with obesity.We searched electronic databases and bibliographies of selected articles were inspected for any further reference. We included only randomized controlled trials that met a set of predefined criteria. The studies were reviewed by a narrative synthesis.We included 6 randomized controlled trials of sibutramine and 3 of orlistat. The majority reached a moderate to high methodological quality. Sibutramine and orlistat showed a reduction in body mass index (BMI) that was significantly higher compared

2011 Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral

31. Variation of inflammatory parameters after sibutramine treatment compared to placebo in type 2 diabetic patients. (PubMed)

Variation of inflammatory parameters after sibutramine treatment compared to placebo in type 2 diabetic patients. The efficacy of sibutramine has been demonstrated in randomized trials in obese/overweight patients including those with type 2 diabetes mellitus (T2DM). Our objective was to evaluate the effects of 1-year treatment with sibutramine compared to placebo on body weight, glycaemic control, lipid profile, and inflammatory parameters in type 2 diabetic patients.Two hundred and forty-six (...) patients with uncontrolled T2DM [glycated haemoglobin (HbA(1c) ) > 8·0%] in therapy with different oral hypoglycaemic agents or insulin were randomized to take 10 mg of sibutramine or placebo for 12 months. We evaluated at baseline, and after 3, 6, 9, and 12 months these parameters: body weight, body mass index (BMI), HbA(1c) , fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total

2011 Journal of clinical pharmacy and therapeutics

32. Inverse Agonism at α2A Adrenoceptors Augments the Hypophagic Effect of Sibutramine in Rats. (PubMed)

Inverse Agonism at α2A Adrenoceptors Augments the Hypophagic Effect of Sibutramine in Rats. Because the use of monoamine reuptake inhibitors as weight-reducing agents is limited by adverse effects, novel antiobesity drugs are needed. We studied acute effects of the noradrenaline (NA) and serotonin (5-HT) reuptake inhibitor sibutramine (SIB), alone and after pretreatment with α1- and α2-adrenoceptor (AR), and 5-HT1/2/7, 5-HT1B and 5-HT2C receptor antagonists in order to determine which ARs and 5

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2011 Obesity

33. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. (PubMed)

Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established.We enrolled in our study 10,744 overweight or obese subjects, 55 years of age or older, with preexisting cardiovascular disease, type 2 diabetes mellitus, or both to assess the cardiovascular consequences of weight management (...) with and without sibutramine in subjects at high risk for cardiovascular events. All the subjects received sibutramine in addition to participating in a weight-management program during a 6-week, single-blind, lead-in period, after which 9804 subjects underwent random assignment in a double-blind fashion to sibutramine (4906 subjects) or placebo (4898 subjects). The primary end point was the time from randomization to the first occurrence of a primary outcome event (nonfatal myocardial infarction, nonfatal

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2010 NEJM

34. Weight and blood pressure response to weight management and sibutramine in diabetic and non-diabetic high-risk patients: an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial. (PubMed)

Weight and blood pressure response to weight management and sibutramine in diabetic and non-diabetic high-risk patients: an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial. To assess treatment responses to sibutramine and weight management in diabetic patients during the lead-in period of the Sibutramine Cardiovascular OUTcomes (SCOUT) trial.SCOUT is an ongoing, prospective, randomized, double-blind, placebo-controlled outcome trial (...) in cardiovascular high-risk overweight/obese patients. A total of 10 742 patients received single-blind sibutramine and individualized weight management during the 6-week lead-in period; 84% had a history of type 2 diabetes mellitus and additional co-morbidities. Post-hoc analyses assessed anthropomorphic and vital sign responses between patients with and without diabetes.Concomitant antidiabetic medication use was reported by 86% of the diabetic patients (approximately 30% required insulin-alone

2010 obesity & metabolism

35. Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women. (PubMed)

Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women. Sibutramine and metformin are drugs commonly used to obtain weight loss. We aimed to compare the effects of sibutramine alone with that of sibutramine plus metformin combination on weight loss, insulin sensitivity, leptin and C reactive protein in obese women. Seventy obese women were included. After a diet period of month (baseline), each individual was randomly assigned to receive 15 mg sibutramine (...) (sibutramine group; n = 36) or 15 mg sibutramine plus 1,700 mg metformin per day (sibutramine plus metformin group; n = 34) during the next 12 months. Body weight, insulin resistance by the homeostasis model assessment model (HOMA-IR), leptin and C reactive protein were measured at baseline, after 3 months and after 12 months. Mean weight losses in sibutramine and sibutramine plus metformin groups were 5.3 +/- 4.0% (P < 0.001) and 6.8 +/- 3.9% (P < 0.001) after 3 months, and 10.5 +/- 4.4% (P < 0.001

2010 Clinical and experimental medicine

36. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. (PubMed)

Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. To evaluate the effects of one year of treatment with sibutramine plus L-carnitine compared to sibutramine on body weight, glycemic control, and insulin resistance state in type 2 diabetic patients.Two hundred and fifty-four patients with uncontrolled type 2 diabetes mellitus (T2DM) [glycated hemoglobin (HbA(1c)) >8.0%] in therapy with different oral hypoglycemic agents or insulin were enrolled (...) in this study and randomised to take sibutramine 10 mg plus L-carnitine 2 g or sibutramine 10 mg in monotherapy. We evaluated at baseline, and after 3, 6, 9, and 12 months these parameters: body weight, body mass index (BMI), glycated hemoglobin (HbA(1c)), fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein

2010 Internal medicine (Tokyo, Japan)

37. Sibutramine should be excluded from use in obese patients with preexisting cardiovascular disease (PubMed)

Sibutramine should be excluded from use in obese patients with preexisting cardiovascular disease 21977163 2011 11 10 2011 10 06 2069-6116 5 3 2010 Jul Maedica Maedica (Buchar) Sibutramine should be excluded from use in obese patients with preexisting cardiovascular disease. 229-30 Constantinescu Maria Cristina MC Cardiology Department, Emergency University Hospital, Bucharest, Romania. eng Journal Article Romania Maedica (Buchar) 101526930 1841-9038 2011 10 7 6 0 2010 7 1 0 0 2010 7 1 0 1

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2010 Mædica

38. Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine

Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01184560 Recruitment Status : Completed First Posted : August 19, 2010 Last Update Posted : August 19, 2010 Sponsor: Gachon University

2010 Clinical Trials

39. Studying the Effects of Sibutramine on Eating Behavior

Studying the Effects of Sibutramine on Eating Behavior Studying the Effects of Sibutramine on Eating Behavior - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Studying the Effects of Sibutramine on Eating (...) Behavior The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01170364 Recruitment Status : Terminated (Terminated due to sibutramine being withdrawn from the market.) First Posted : July 27, 2010 Results First Posted : July 31, 2017 Last Update Posted : August 30, 2017 Sponsor: New York State Psychiatric

2010 Clinical Trials

40. The effects of sibutramine on the microstructure of eating behaviour and energy expenditure in obese women. (PubMed)

The effects of sibutramine on the microstructure of eating behaviour and energy expenditure in obese women. Given the suggestion that many potential anti-obesity drugs may enhance within-meal satiation, few studies have directly measured the effects of any drug on the microstructure of human eating behaviour. The effects of 7 days dosing with sibutramine 10 mg and 15 mg a day on appetite and energy balance were determined in 30 obese women (BMI 34.6 +/- 3.3 kg/m2, age 46.0 +/- 12.9 years) using (...) a Universal Eating Monitor (UEM) and indirect calorimetry, in a double-blind, placebo-controlled crossover study. At day 7, sibutramine 10 mg and 15 mg reduced food intake by 16.6% and 22.3%, respectively (p < 0.001), compared with placebo. Sibutramine reduced eating rate compared with placebo rather than meal length (10 mg p < 0.05; 15 mg p < 0.001). In addition, sibutramine 10 mg significantly reduced hunger later in the meal (p < 0.05) and sibutramine 15 mg increased fullness early in the meal (p

2010 Journal of psychopharmacology (Oxford, England)

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