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261. Effect of Daily Glucomannan in Overweight Patients

of contraception Participation in any other formal or informal weight reduction program Currently enrolled in another weight loss study Currently enrolled in a weight loss program Active attempt to lose weight with diet and/or exercise within the last month Currently on one of the following medications known to cause weight loss: Alli/Xenical(orlistat) Adipex-P (phentermine) Bontril (phendimetrazine) Dexoxyn (methamphetamine) Didrex (benzphetamine) Tenuate (diethylpropion) Meridia (sibutramine) Byetta

2011 Clinical Trials

262. Study on Liver Fat Content and Visceral Fat Mass in Overweight and Obese Type 2 Diabetes Patients After Treatment With Basal Insulin

OADs (Oral Antidiabetic Drugs) in the last 6 months, except metformin (subjects currently treated with metformin within the interval of 1000-2000 mg daily may be included in the trial. The dose should have remained unchanged for a period of one month prior to randomisation and should be expected to remain unchanged throughout the trial period). Use of approved weight lowering pharmacotherapy (e.g. orlistat, sibutramine, rimonabant) or obesity induced by drug treatment (e.g. corticosteroids, NSAIDs

2011 Clinical Trials

263. Asthma Phenotypes in the Inner City

, nelfinavir); Calcium channel blockers (verapamil, diltiazem); Modafinil; Tamoxifen; non-nucleoside reverse transcriptase inhibitors; Macrolide antibiotics* (erythromycin, clarithromycin, dirithromycin, troleandomycin); chloramphenicol; nefazodone; aprepitant; St John's Wort; Rifampin*; Azole Antifungals* (ketoconazole, fluconazole, itraconazole); Sibutramine* ; bergamottin (constituent of grapefruit juice) (*may be rescreened if this therapy is short-lived); Should not be included in the study for any

2011 Clinical Trials

264. Effects of Novel Fiber on Glucose Metabolism and Insulin Sensitivity

of medications or herbal remedies for weight loss (e.g., sibutramine, orlistat, amphetamines, phentermine, and ma huang) or use of these substances within the past 3 months Current or recent history (past 12 months) of drug, alcohol or chemical abuse. Alcohol abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5 oz hard liquor) Pregnant, breast-feeding or female of child-bearing potential who is unwilling to commit to the use of a medically approved form of contraception

2011 Clinical Trials

265. Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations

, troleandomycin); chloramphenicol; nefazodone; aprepitant; St. John's Wort (hypericum); Rifampin*; Azole antifungals* (ketoconazole, fluconazole,itraconazole); Sibutramine*; bergamottin* (constituent of grapefruit juice).*may be rescreened if this therapy is short-lived; Will not allow the study clinician, an asthma specialist, to manage their disease for the duration of the study or who are not willing to change their asthma medications to follow the protocol. Participants who meet any of the following

2011 Clinical Trials

266. Exploring Biomarkers for Depression

, hydroxytryptophan (5-HTP), ginkgo, St. John's Wort (hypercium), naratriptan, rizatriptan, sibutramine, zolmitriptan and warfarin (Coumadin). Subjects who have failed two or more adequate antidepressant trials during the current Major Depressive Episode (MDE) If a subject is deemed eligible from the above criteria, there is additional exclusion criteria required to participate in Martinos Center study visits, listed below. Subjects meeting any of the below criteria will not be allowed to participate in visits

2011 Clinical Trials

267. Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI

; Phenylephrine; Pirbuterol; Propylhexedrine; Pseudoephedrine; Sibutramine; Terbutaline; Theophylline; Xylometazoline. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT01355991 Locations Layout table for location information United States, New Jersey Kessler

2011 Clinical Trials

268. Obesity in adults Full Text available with Trip Pro

bypass, gastric banding, mazindol, orlistat (alone and in combination with sibutramine), phentermine, sibutramine (alone and in combination with orlistat), sleeve gastrectomy, and vertical banded gastroplasty.

2011 BMJ Clinical Evidence

269. Comparative Efficiency and Safety of Pharmacological Approaches to the Management of Obesity Full Text available with Trip Pro

7805975 0149-5992 0 Anti-Obesity Agents 0 Bridged Bicyclo Compounds, Heterocyclic 0 Cyclobutanes 0 Lactones 95M8R751W8 Orlistat BLH9UKX9V1 Tesofensine WV5EC51866 sibutramine IM Anti-Obesity Agents therapeutic use Bridged Bicyclo Compounds, Heterocyclic therapeutic use Cyclobutanes therapeutic use Humans Lactones therapeutic use Obesity drug therapy Orlistat 2011 4 29 6 0 2011 5 6 6 0 2011 7 2 6 0 ppublish 21525481 34/Supplement_2/S349 10.2337/dc11-s255 PMC3632205 Obesity (Silver Spring). 2009 Jan;17(1

2011 Diabetes Care

270. Ideas Moving Parents and Adolescents to Change Together (IMPACT)

), Ziprasidone (Geodon), Carbamazepine (Tegretol), Valproic acid (Depakote/Depakene/Depacon), Aripiprazole (Abilify), Orlistat (Xenical), Sibutramine (Meridia), Phentermine, Diethylproprion (Tenuate), Topirimate (Topamax), glitazones (thiazolidinediones) Inability to understand English Stage 2 hypertension or stage 1 hypertension with end organ damage (left ventricular hypertrophy, microalbuminuria) Severe behavioral problems that preclude group participation (as reported by parent/guardian) Child

2011 Clinical Trials

271. Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study. Full Text available with Trip Pro

Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study. Low grade inflammation is a well-known characteristic in obese subjects. We investigated body weight changes and inflammatory markers after 12-week intervention trial.Twenty-six obese subjects were enrolled and 19 (13 men and 6 women) completed the study. Sibutramine is an FDA-approved drug for body weight control; therefore, we chose this drug

2011 Yonsei medical journal Controlled trial quality: uncertain

272. Effects of Different Exercise Training Regimens on Visceral Fat Dynamic and Resting Energy Expenditure in Obese Patients

pacemaker or other contraindication for MRI attendant therapy with oral antidiabetic medication, GLP-1 mimetics or analoga, Insulin, anti-obesity medication (orlistat, sibutramine), Falithrom, antipsychotic drugs, any chemotherapeutics pregnant or nursing women expected low compliance current participation in another investigational trial last exercise training <= 6 months ago Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your

2011 Clinical Trials

273. Safety and Efficacy of Exenatide Injection in Subjects With Type 2 Diabetes Mellitus

to participate and give written informed consent. Exclusion Criteria: Previous exposure to exenatide (anti-exenatide antibodies at screening) or a GLP-1 analogue. Used drugs for weight loss (for example, orlistat, sibutramine, phenylpropanolamine, rimonabant, or similar over-the-counter medications) within 3 months of screening. Received treatment within the last 30 days with a drug that has not received regulatory approval for any indication at the time of trial entry. Severe renal impairment (creatinine

2011 Clinical Trials

274. Hepatic PTP1B expression involvement in the effects of Chinese medicine formula xiao-gao-jiang-zhuo using an obese rat model. (Abstract)

, the high-dose XGJZ group, the middle-dose XGJZ group, the low-dose XGJZ group, and the sibutramine group. After 14 weeks of treatment, body weight, abdominal fat, blood lipid and serum insulin level were measured, and the protein and gene expression of PTP1B in liver tissue was tested. Our data showed that the body weight of the high-dose and middle-dose groups and the sibutramine group had significant differences in comparison with the model group (p < 0.05), and all three dose groups had (...) significantly reduced abdominal fat (p < 0.05). The triglyceride level of the three dose groups and the sibutramine group, and the total cholesterol level of the middle-dose group were all significantly reduced (p < 0.05). The serum insulin of the high-dose and middle-dose groups also decreased significantly (p < 0.05). The expression of hepatic PTP1B mRNA of the three dose groups decreased significantly in comparison with the model group (p < 0.05 or 0.01). The expression of hepatic PTP1B protein

2011 American Journal of Chinese Medicine

275. Management of obesity Full Text available with Trip Pro

, average weight loss on orlistat is 2.9 kg (6.4 lb), sibutramine is 4.2 kg (9.3 lb) and rimonabant is 4.7 kg (10 lb). Orlistat and rimonabant lead to a reduced incidence of diabetes, and all three drugs have some effect on . However, there is little information on how these drugs affect the longer-term complications or outcomes of obesity. In 2010 it was found that sibutramine increases the risk of and in people with a history of cardiovascular disease. There are a number of less commonly used (...) is not effective for inducing weight loss in the majority of people with obesity. It is being investigated to determine whether or not it helps with weight loss maintenance. The usefulness of certain drugs depends upon the comorbidities present. is preferred in overweight diabetics, as it may lead to mild weight loss in comparison to or . The , on the other hand, may cause weight gain, but decrease central obesity. Diabetics also achieve modest weight loss with , orlistat and sibutramine over 12–57 weeks

2012 Wikipedia

276. Serotonin syndrome Full Text available with Trip Pro

effects, and is therefore not a dual action drug. Bupropion has also been suggested to cause serotonin syndrome, although as there is no evidence that it has any significant serotonergic activity, it is thought unlikely to produce the syndrome. In 2006 the United States issued an alert suggesting that the combined use of SSRIs or SNRIs and triptan medications or sibutramine could potentially lead to severe cases of serotonin syndrome. This has been disputed by other researchers as none of the cases

2012 Wikipedia

277. What are the current evidence based guidelines for GP's to prescribe orlistat? What are the current NICE guidelines for initiation and continuing to prescribe? How efficient is it? "

pressure) are present. Prescribing should be started and monitored only in specialist paediatric settings7. In children aged 12 years and older, treatment with orlistat or sibutramine is recommended only if physical comorbidities (such as orthopaedic problems or sleep apnoea) or severe psychological comorbidities are present. Treatment should be started in a specialist paediatric setting, by multidisciplinary teams with experience of prescribing in this age group. Orlistat or sibutramine should (...) be prescribed for obesity in children only by a multidisciplinary team with expertise in: • drug monitoring • psychological support • behavioural interventions • interventions to increase physical activity • interventions to improve diet. Orlistat and sibutramine should be prescribed for young people only if the prescriber is willing to submit data to the proposed national registry on the use of these drugs in young people (see section 4.5.3). After drug treatment has been started in specialist care, it may

2009 TRIP Answers

278. Anti-Fibrotic Effects of Losartan In Nash Evaluation Study

, orlistat, sibutramine or rimonabant within 3 months of baseline liver biopsy and screening visit Intolerance of angiotensin receptor blockers (ARBs) or presence of multiple allergic reactions to drugs Use of angiotensin-converting enzyme (ACE) inhibitor or ARB in previous year Hypotension (systolic <100, diastolic <60) Renal failure (Cr >130) Participation in any clinical study of an investigational agent within 30 days or five half-lives of the investigational product, whichever is longer Presence

2010 Clinical Trials

279. Effects of Weight Loss in Obese Difficult-to-treat Asthmatics

orlistat and sibutramine Phase 3 Detailed Description: Study design: interventional, open label, randomized Patients selection Thirty-three difficult to control obese asthmatic patients, aged between 18 to 65 years old will be recruited from the outpatient clinics of the Pulmonary Division of the University of Sao Paulo Hospital. Difficult to control asthma will be defined as patients who do not achieve asthma control (according to GINA) despite best treatment regimen and checked adherence after (...) Behavioral: Low caloric diet plus orlistat and sibutramine All subjetcs No Intervention: Control Outcome Measures Go to Primary Outcome Measures : Asthma control questionnaire (ACQ) [ Time Frame: Baseline and six months ] Secondary Outcome Measures : Inflammatory parameters [ Time Frame: Baseline and after 6 months ] Pulmonary mechanics [ Time Frame: Baseline and after 6 months ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2010 Clinical Trials

280. Effects of Exenatide on Glycemic Control and Weight in Continuous Subcutaneous Insulin Infusion (CSII) Type 2 Treated Patients With Type 2 Diabetes

lost (orlistat, sibutramine, rimonabant may be interrupted at least 3 months prior to inclusion in the study) Use of corticosteroid therapy for more than 10 days within the 3-past months, or patient who ought to be treated by corticosteroid during the study period Clinically significant hepatic disease Documented gastroparesis, or current use of drugs that directly affect gastrointestinal motility, or any significant abdominal disease that may increase the risk of adverse gastrointestinal effects

2010 Clinical Trials

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