How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

44,889 results for

Shock

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy)

Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy) TAKE-HOME MESSAGE No studied corticosteroid regimen is superior to placebo or any other regimen in patient-centered outcomes including mortality; however, hydrocortisone infusion improves shock reversal compared with placebo or methylprednisolone. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? EBEM Commentators Brit Long, MD Michael D. April, MD, DPhil (...) Department of Emergency Medicine SAUSHEC Fort Sam Houston, TX Results Authorsincluded22studiesinthe network meta-analysis, excluding 11 from the 2015 Cochrane re- view. Hydrocortisone infusion demonstrated superior shock reversal compared with placebo (OR 3.68; 95% CI 1.52 to 8.93) (Table). Methylpredniso- lone bolus was less likely to reverse shock than hydrocorti- sone bolus (OR 0.37; 95% CI 0.19 to 0.72). No regimens demon- strated superiority for the out- comes of mortality at 28 days, hospital

2018 Annals of Emergency Medicine Systematic Review Snapshots

2. The 4 Physiologic Etiologies of Shock, and the 3 Etiologies of Cardiogenic Shock

The 4 Physiologic Etiologies of Shock, and the 3 Etiologies of Cardiogenic Shock Dr. Smith's ECG Blog: The 4 Physiologic Etiologies of Shock, and the 3 Etiologies of Cardiogenic Shock Friday, November 30, 2018 A 60-something presented with hypotension, bradycardia, chest pain and back pain. She had a h/o aortic aneurysm, aortic insufficiency, peripheral vascular disease, and hypertension. She had a mechanical aortic valve. She was on anti-hypertensives including atenolol, and on coumadin (...) in aVR: Is this pattern specific for global ischemia due to left main coronary artery disease? J Electrocardiol 2013;46:240-8. Case continued: The chest X-ray was consistent with pulmonary edema, and the ultrasound showed a "plump" inferior vena cava. (This data is all consistent with high right and left sided filling pressures, which is the hallmark of cardiogenic shock -- not obstructive, distributive, or hypovolemic) Aortic dissection was considered (with involvement of the coronary arteries

2019 Dr Smith's ECG Blog

3. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial. (PubMed)

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial. Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.To determine if a peripheral (...) perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality.Multicenter, randomized trial conducted at 28 intensive care units in 5 countries. Four-hundred twenty-four patients with septic shock were included between March 2017 and March 2018. The last date of follow-up was June 12, 2018.Patients were randomized to a step-by-step resuscitation protocol aimed at either normalizing capillary refill time (n = 212

2019 JAMA

4. Intraaortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-Term 6-Year Outcome of the Randomized IABP-SHOCK II Trial

Intraaortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-Term 6-Year Outcome of the Randomized IABP-SHOCK II Trial The role of intraaortic balloon counterpulsation (IABP) in cardiogenic shock is still a subject of intense debate despite the neutral results of the IABP-SHOCK II trial (Intraaortic Balloon Pump in Cardiogenic Shock II) with subsequent downgrading in international guidelines. So far, randomized data on the impact of IABP on long-term clinical (...) outcomes in patients with cardiogenic shock complicating acute myocardial infarction are lacking. Furthermore, only limited evidence is available on general long-term outcomes of patients with cardiogenic shock treated by contemporary practice.The IABP-SHOCK II trial is a multicenter, randomized, openlabel trial. Between 2009 and 2012, 600 patients with cardiogenic shock complicating acute myocardial infarction undergoing early revascularization were randomized to IABP versus control.Long-term follow

2019 EvidenceUpdates

5. Shock

Shock Shock - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Shock Last reviewed: February 2019 Last updated: January 2019 Summary Commonly diagnosed when signs of hypoperfusion are associated with low or declining blood pressure. It may result from a number of disease processes, including pump failure (cardiogenic), loss of intravascular volume (hypovolaemic), failure of vasoregulation (distributive), or obstruction (...) to blood flow (obstructive). Initial treatment aims to optimise oxygen delivery and reverse hypoperfusion through volume resuscitation, vasopressors for refractory hypotension due to vasodilation, management of cardiac dysfunction, and treatment of the underlying cause. Management of shock is best undertaken in a critical care environment. Definition Shock is most commonly defined as the life-threatening failure of adequate oxygen delivery to the tissues and may be due to decreased blood perfusion

2019 BMJ Best Practice

6. Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults?

Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 4, Pages 363–365 Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? x (...) all Collapse all Article Outline Take-Home Message No high- or moderate-level evidence shows that the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) hemodynamic interventions improve survival in sepsis. Methods Data Sources The authors searched PubMed, EMBASE, Scopus, Web of Science, and without language restrictions from inception to November 28, 2017. They also searched the references of analyzed studies and other review articles. Study Selection Investigators included randomized

Full Text available with Trip Pro

2019 Annals of Emergency Medicine Systematic Review Snapshots

7. Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. (PubMed)

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) as complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery are life-threatening conditions. While there is a broad body of evidence for the treatment of people with acute coronary syndrome under stable haemodynamic conditions, the treatment strategies for people who become (...) 2017. We also searched four registers of ongoing trials and scanned reference lists and contacted experts in the field to obtain further information. No language restrictions were applied.Randomised controlled trials in people with myocardial infarction, heart failure or cardiac surgery complicated by cardiogenic shock or LCOS.We used standard methodological procedures expected by Cochrane.We identified 13 eligible studies with 2001 participants (mean or median age range 58 to 73 years) and two

2018 Cochrane

8. Extracorporeal shock wave therapy for the healing and management of venous leg ulcers. (PubMed)

Extracorporeal shock wave therapy for the healing and management of venous leg ulcers. Leg ulcers are chronic wounds of the lower leg, caused by poor blood flow, that can take a long time to heal. The pooling of blood in the veins can damage the skin and surrounding tissues, causing an ulcer to form. Venous leg ulcers are associated with impaired quality of life, reduced mobility, pain, stress and loss of dignity. The standard treatment for venous leg ulcers is compression bandages or stockings (...) . Shock wave therapy may aid the healing of these wounds through the promotion of angiogenesis (the formation and development of blood vessels) and reduction of inflammation, though this process is poorly understood at present.To assess the effects of extracorporeal shock wave therapy on the healing and management of venous leg ulceration.In April 2018 we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process

2018 Cochrane

14. Toxic shock syndrome

Toxic shock syndrome Toxic shock syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Toxic shock syndrome Last reviewed: February 2019 Last updated: May 2018 Summary An exotoxin-mediated illness caused by bacterial infection, most commonly group A streptococcus or Staphylococcus aureus . Presenting signs and symptoms can be non-specific, but the course of the disease is precipitous and toxicity occurs early (...) , resulting in serious life-threatening disease and multi-organ system failure. Early diagnosis and treatment is essential. Streptococcal toxic shock syndrome (TSS) can occur with infection at any site but is more commonly associated with an infected cutaneous site. Staphylococcal TSS (menstrual or non-menstrual) is associated with extended tampon use, postpartum infections, and other sites of infection with the organism. Treatment includes supportive care in an ICU, early empirical antibiotic treatment

2018 BMJ Best Practice

15. Shock

Shock Shock - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Shock Last reviewed: February 2019 Last updated: January 2019 Summary Commonly diagnosed when signs of hypoperfusion are associated with low or declining blood pressure. It may result from a number of disease processes, including pump failure (cardiogenic), loss of intravascular volume (hypovolaemic), failure of vasoregulation (distributive), or obstruction (...) to blood flow (obstructive). Initial treatment aims to optimise oxygen delivery and reverse hypoperfusion through volume resuscitation, vasopressors for refractory hypotension due to vasodilation, management of cardiac dysfunction, and treatment of the underlying cause. Management of shock is best undertaken in a critical care environment. Definition Shock is most commonly defined as the life-threatening failure of adequate oxygen delivery to the tissues and may be due to decreased blood perfusion

2018 BMJ Best Practice

16. Assessment of shock

Assessment of shock Assessment of shock - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of shock Last reviewed: February 2019 Last updated: June 2018 Summary Shock is best defined as a state of reduced end-organ oxygenation caused by an imbalance between tissue oxygen delivery and demand resulting in an oxygen debt. Oxygen delivery is determined by cardiac output, vascular integrity, and oxygen content (...) of the blood. Oxygen content is a composite of haemoglobin and arterial oxygen saturation, and the cardiac output is a product of stroke volume and heart rate. Stroke volume is affected by preload (filling), left ventricular contractility (pump function), and afterload as measured by the systemic vascular resistance. Differences in the preload, afterload, and contractility generally differentiate the aetiologies of shock. These are broadly classified into hypovolaemic, cardiogenic, obstructive

2018 BMJ Best Practice

17. Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. (PubMed)

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear.To determine whether (...) , allergic reaction, and neurological sequelae). We used GRADE to assess the quality of evidence for each outcome.We identified no adult studies that met our selection criteria.This review included three paediatric RCTs (N = 3402), but we were able to extract data from only two of the three trials (n = 3288). These trials were conducted in India (two studies) and Africa. Participants were children from one month to 12 years old with sepsis or septic shock. All three included trials investigated liberal

2018 Cochrane

18. CRACKCast E197 – Shock

CRACKCast E197 – Shock CRACKCast E197 - Shock - CanadiEM CRACKCast E197 – Shock In , by Dillan Radomske January 7, 2019 This updated episode of CRACKCast covers Rosen’s Chapter 006, Shock (9th Ed.). These topics are core knowledge that we use every day in the Emergency Department. Shownotes – Rosen’s in Perspective As you can probably guess, this introductory chapter is exceedingly important for practitioners of emergency medicine. Chapter 6 in Rosen’s 9th Edition contains core knowledge (...) that anyone working in acute care must have a mastery of. If you ever even plan to walk through an ED, you need to put what you are doing aside and focus for the next 30-45 minutes. Shock, in its many forms, represents the danger zone, so knowing how to correctly identify what is causing this patient’s life threatening pathophysiologic demise is tantamount. Today, we will give you an organized approach that will allow you to classify shock into four categories. Additionally, we will give you a broad sense

2019 CandiEM

19. Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock

Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

20. CanadiEM MVP Infographic Series – Protocol-Based Care for Early Septic Shock

CanadiEM MVP Infographic Series – Protocol-Based Care for Early Septic Shock CanadiEM MVP Infographic Series - Protocol-Based Care for Early Septic Shock - CanadiEM CanadiEM MVP Infographic Series – Protocol-Based Care for Early Septic Shock In , by Anson Dinh March 8, 2019 In this issue of the MVP Infographic Series, we feature: “A randomized trial of protocol-based care for early septic shock” published by the ProCESS Investigators. 1 There are more than 750 000 cases of sepsis each year (...) that occur in the United States annually. Rates of associated mortality were high, but a huge break through to lowering morality rates shook the world of emergency medicine in 2001. Rivers et al. presented early goal-directed therapy (EGDT) for severe sepsis and septic shock, which demonstrated a decrease of morality rates from 46.5% to 30.5%. 2 Fast forward a decade and EGDT is still in use in various forms, but practice has changed drastically since this study. The ProCESS Investigators take a look

2019 CandiEM

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>