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Sessile Serrated Adenomatous Polyposis

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1. Sessile Serrated Adenomatous Polyposis

Sessile Serrated Adenomatous Polyposis Sessile Serrated Adenomatous Polyposis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sessile (...) Serrated Adenomatous Polyposis Sessile Serrated Adenomatous Polyposis Aka: Sessile Serrated Adenomatous Polyposis From Related Chapters II. Epidemiology : one in 2000 to 3000 Diagnosed on average by age 62 years present at time of polyposis diagnosis in 25-70% III. Diagnosis Five of more Sessile Serrated Adenomatous Polyps proximal to sigmoid and two or more polyps >1 cm OR Any number of Sessile Serrated Adenomatous Polyps proximal to sigmoid and affected first degree relatives OR More than 20 Sessile

2018 FP Notebook

2. Sessile Serrated Adenomatous Polyposis

Sessile Serrated Adenomatous Polyposis Sessile Serrated Adenomatous Polyposis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sessile (...) Serrated Adenomatous Polyposis Sessile Serrated Adenomatous Polyposis Aka: Sessile Serrated Adenomatous Polyposis From Related Chapters II. Epidemiology : one in 2000 to 3000 Diagnosed on average by age 62 years present at time of polyposis diagnosis in 25-70% III. Diagnosis Five of more Sessile Serrated Adenomatous Polyps proximal to sigmoid and two or more polyps >1 cm OR Any number of Sessile Serrated Adenomatous Polyps proximal to sigmoid and affected first degree relatives OR More than 20 Sessile

2018 FP Notebook

3. Clinical predictors for sessile serrated polyposis syndrome: A case control study (PubMed)

Clinical predictors for sessile serrated polyposis syndrome: A case control study To compared individuals with serrated polyposis syndrome (SPS) to those with sessile serrated adenoma (SSA) and adenomas in the setting of endoscopists with high adenoma detection rates at a secondary and tertiary academic centre.Retrospectively we collated the clinical, endoscopic and histological features of all patients with SPS at St Vincent's public and private hospital in the last 3 years. Patients were (...) (97%) and patients with SSAs not meeting SPS criteria (98%) were significantly more likely to be Caucasian compared to patients with adenomas (79%), P = 0.01.The prevalence of SPS in our study was 0.26%. The vast majority of patients diagnosed with SPS were women. As a group, they were significantly younger compared to patients with SSA not meeting WHO criteria and patients with adenomatous polyps by more than a decade. Patients with SPS were no more likely to have a first degree relative

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2017 World journal of gastrointestinal endoscopy

4. Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas

Vision. Condition or disease Intervention/treatment Phase Sessile Serrated Adenoma Device: Endocuff Vision Assisted Colonoscopy Not Applicable Detailed Description: Colon cancer remains the second leading cause of death amongst both men and women in the United States(1). With the advent of screening colonoscopy, mortality from colorectal cancer has decreased, and colonoscopy is the current gold standard for colorectal cancer screening and prevention by removing adenomatous polyps. Different devices (...) Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

5. Aspects of the Natural History of Sessile Serrated Adenomas/Polyps: Risk Indicators for Carcinogenesis in the Colorectal Mucosa? (PubMed)

of serrated neoplasia to reflect this.The purpose of this study was to document the natural history of sessile serrated adenomas/polyps, including the ages at which they appear and the ranges of their number, size, and associated lesions.This was a retrospective cohort study.The study was conducted at a tertiary referral center.Consecutive patients with sessile serrated adenomas/polyps removed between 2006 and 2015 were included. Patients with IBD, familial adenomatous polyposis, Lynch syndrome, serrated (...) polyposis, and hereditary nonpolyposis colorectal cancer were excluded.Age at which polyps were first diagnosed, location and size of polyps, demographics, and family history were measured.A total of 440 patients had 668 sessile serrated adenomas/polyps, 257 (58%) also had ≥1 adenoma, and 28 (6%) had a history of colorectal cancer. Mean age at diagnosis was 68 ± 11 years, and 45% were men. Two hundred had had ≥1 colonoscopy before the diagnosis of the first sessile serrated adenomas/polyps. A total

2018 Diseases of the Colon & Rectum

6. Personalized Surveillance Protocol for Serrated Polyposis Syndrome

Personalized Surveillance Protocol for Serrated Polyposis Syndrome Personalized Surveillance Protocol for Serrated Polyposis Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Personalized (...) Surveillance Protocol for Serrated Polyposis Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03450889 Recruitment Status : Active, not recruiting First Posted : March 1, 2018 Last Update Posted : March 6, 2018 Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Information

2018 Clinical Trials

7. BSG position statement on serrated polyps in the colon and rectum

years) WL SL 41.8% HP 35.5% SSA 6.2% TSA 50 years) Assumed WL (no details) SL¶ 6.1% SL-DR 4% PSL-DR 2.8% *Dysplastic serrated polyps or large (=6 mm) proximal non-dysplastic serrated polyps. †HPs proximal to sigmoid colon plus all SSPs serrated adenomas. ‡Dysplastic PSP or large ( 1 cm in proximal colon. CE, chromoendoscopy; CRC, colorectal cancer; FAP, familial adenomatous polyposis; HD, high definition; HNPCC, hereditary non-polyposis colorectal cancer; HP, hyperplastic polyp; LSP, large (>1 cm (...) ) serrated polyp; M, magnification; NBI, narrow band imaging; PSP, proximal serrated polyp; S/HPS, serrated/hyperplastic polyposis syndrome; SA, serrated adenoma; SP, serrated polyp; SPS, serrated polyposis syndrome; SSA, sessile serrated adenoma; SSL, sessile serrated lesion; SSP, sessile serrated polyp; TSA, traditional serrated adenoma; WL, standard white light. 6 East JE, et al. Gut 2017;0:1–16. doi:10.1136/gutjnl-2017-314005 Guidelines group.bmj.com on May 2, 2017 - Published by http://gut.bmj.com

2017 British Society of Gastroenterology

8. Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population. (PubMed)

Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population. The incidence and mortality rates from right-sided colorectal cancers (CRCs) have not decreased in recent years. It is very likely that a significant proportion of these cancers evolve from undetected sessile serrated adenomas (SSAs). The prevalence and molecular features of the SSAs in the Chinese population have seldom been investigated.We retrospectively reviewed the colonoscopy (...) database and pathology archives in our medical centre. Adenomatous polyposis coli (APC) and β-catenin expressions were examined in 28 right hyperplastic polyps (RHPs) and 21 SSAs by immunohistochemical staining. The mutations of BRAF, KRAS, APC and β-CATENIN were analysed by direct sequencing. The methylation status of APC promoter in these polyps was analysed by methylation-specific PCR and bisulfite sequencing. Samples of left hyperplastic polyps, traditional adenomas and CRC were used

2014 Journal of Clinical Pathology

9. Molecular Features of Colorectal Hyperplastic Polyps and Sessile Serrated Adenoma/Polyps From Korea. (PubMed)

with similar lesions from American patients. One hundred and eleven serrated polyps, consisting of 45 HPs (30 microvesicular, 11 goblet cell, 4 mucin depleted) and 56 SSA/Ps (36 with dysplasia, 20 without dysplasia), were retrieved from the pathology files of a large medical center in Korea and 38 SSA/P from American patients were evaluated for BRAF and KRAS mutations, microsatellite instability, and hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT), hMLH1, adenomatous polyposis coli (APC (...) Molecular Features of Colorectal Hyperplastic Polyps and Sessile Serrated Adenoma/Polyps From Korea. Abundant recent data suggest that sessile serrated adenoma/polyp (SSA/P) is an early precursor lesion in the serrated pathway of carcinogenesis. It is believed that SSA/Ps develop cancer by an SSA/P-dysplasia-carcinoma sequence. Hyperplastic polyps (HPs) share some histologic and molecular characteristics with SSA/P, but it is unclear whether SSA/Ps are derived from HPs or whether they develop

2011 American Journal of Surgical Pathology

10. Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon

that colonoscopy is more effective in preventing cancer in the left side of the colon than the right side of the colon. The reasons for this difference may be partly biologic, in that a special group of polyps known as serrated polyps, particularly sessile serrated adenomas, are located primarily proximal to the splenic flexure. These lesions are endoscopically subtle in that they are often flat, have the same color as the surrounding mucosa, and are hard to differentiate from normal mucosa. LCI makes red (...) , Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: --Consecutive adult patients undergoing an outpatient colonoscopy Exclusion Criteria: unable to provide informed consent had undergone prior resection of the colon inflammatory bowel disease familial adenomatous polyposis, Peutz-Jeghers syndrome or other polyposis syndromes. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your

2016 Clinical Trials

11. Intestinal Polyposis Syndromes (Diagnosis)

, and other rare polyposis syndromes, such as hereditary-mixed polyposis syndrome (HMPS) and serrated polyposis syndrome (SPS). In 1859, Charelaigue described the first definitive accounts of adenomatous polyposis in a 16-year-old girl and a 21-year-old man. [ ] Several genetic disorders may present with GI polyps. FAP is the most common inherited polyposis syndrome, encompassing multiple phenotypes. These phenotypes range from a mild phenotype in attenuated polyposis syndrome to specific clinical (...) and managing a not-so-rare hereditary cancer syndrome. J Surg Oncol . 2015 Jan. 111 (1):125-30. . Kay M, Eng K, Wyllie R. Colonic polyps and polyposis syndromes in pediatric patients. Curr Opin Pediatr . 2015 Oct. 27 (5):634-41. . Media Gallery Familial adenomatous polyposis, total colectomy specimen. The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. Pedunculated tubular adenoma. Note the contrast between the goblet cell

2014 eMedicine Pediatrics

12. Intestinal Polyposis Syndromes (Treatment)

(adenocarcinoma) Serrated polyposis syndrome Prophylactic colectomy with ileorectal anastomosis is recommended for those with detection of cancer, inability of colonoscopy to control polyps, or patient preference. [ ] Previous Next: Consultations Familial adenomatous polyposis Patients with Gardner syndrome may require consultation with the following: Gastroenterologist - For monitoring and surveillance for malignancies Oncologist - For treatment of malignancies Surgeon - For biopsy or resection of suspicious (...) . . Kay M, Eng K, Wyllie R. Colonic polyps and polyposis syndromes in pediatric patients. Curr Opin Pediatr . 2015 Oct. 27 (5):634-41. . Media Gallery Familial adenomatous polyposis, total colectomy specimen. The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. Pedunculated tubular adenoma. Note the contrast between the goblet cell-rich glands along the pedicle of the polyp and in the underlying normal colonic mucosa

2014 eMedicine Pediatrics

13. Intestinal Polyposis Syndromes (Overview)

, and other rare polyposis syndromes, such as hereditary-mixed polyposis syndrome (HMPS) and serrated polyposis syndrome (SPS). In 1859, Charelaigue described the first definitive accounts of adenomatous polyposis in a 16-year-old girl and a 21-year-old man. [ ] Several genetic disorders may present with GI polyps. FAP is the most common inherited polyposis syndrome, encompassing multiple phenotypes. These phenotypes range from a mild phenotype in attenuated polyposis syndrome to specific clinical (...) and managing a not-so-rare hereditary cancer syndrome. J Surg Oncol . 2015 Jan. 111 (1):125-30. . Kay M, Eng K, Wyllie R. Colonic polyps and polyposis syndromes in pediatric patients. Curr Opin Pediatr . 2015 Oct. 27 (5):634-41. . Media Gallery Familial adenomatous polyposis, total colectomy specimen. The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. Pedunculated tubular adenoma. Note the contrast between the goblet cell

2014 eMedicine Pediatrics

14. Colon, Polyposis Syndromes

Med Assoc . 2001 Jun. 93(6):208-13. . East JE, Saunders BP, Jass JR. Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management. Gastroenterol Clin North Am . 2008 Mar. 37(1):25-46. . Bougatef K, Krichene A, Marrakchi R, Kourda N, Blondeau Lahely Y, Moussa A, et al. Do we know all there is to know about Familial Adenomatous Polyposis?. Gastroenterol Clin Biol . 2007 Dec. 31(12):1062-6. . Chen SC, Lu DS (...) , polyposis syndromes. Polyposis coli. Left lateral decubitus image obtained as part of a barium enema study shows multiple polyps in the transverse and descending colon. A variety of polyposis syndromes can affect the GI tract. These polyposis syndromes may be classified as familial inherited (autosomal dominant) or nonfamilial. The inherited polyposis syndromes can be further subdivided into 2 groups depending on whether the polyps are or hamartomas. The adenomatous polyposis syndromes include

2014 eMedicine Radiology

15. Intestinal Polyposis Syndromes (Follow-up)

polyps and polyposis syndromes in pediatric patients. Curr Opin Pediatr . 2015 Oct. 27 (5):634-41. . Media Gallery Familial adenomatous polyposis, total colectomy specimen. The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. Pedunculated tubular adenoma. Note the contrast between the goblet cell-rich glands along the pedicle of the polyp and in the underlying normal colonic mucosa at the bottom and the dysplastic (...) , and treatment of neoplasia. Patients with SPS may require inpatient treatment for rectal bleeding and surgical treatment of colorectal cancer. Previous Next: Transfer Patients with polyposis may require transfer for diagnosis and treatment if appropriate support is not available. Previous Next: Deterrence/Prevention Familial adenomatous polyposis Well-established guidelines published by the American Gastroenterological Association for surveillance in individuals with FAP, and are discussed above in medical

2014 eMedicine Pediatrics

16. Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel. (PubMed)

definitions, classification, and significance of serrated lesions. A consensus conference was held over 2 days reviewing the topic of serrated lesions from the perspectives of histology, molecular biology, epidemiology, clinical aspects, and serrated polyposis. Serrated lesions should be classified pathologically according to the World Health Organization criteria as hyperplastic polyp, sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia, or traditional serrated adenoma (TSA). SSA (...) /P and TSA are premalignant lesions, but SSA/P is the principal serrated precursor of CRCs. Serrated lesions have a distinct endoscopic appearance, and several lines of evidence suggest that on average they are more difficult to detect than conventional adenomatous polyps. Effective colonoscopy requires an endoscopist trained in the endoscopic appearance of serrated lesions. We recommend that all serrated lesions proximal to the sigmoid colon and all serrated lesions in the rectosigmoid > 5 mm

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2012 American Journal of Gastroenterology

17. Unexplained Polyposis: A Challenge for Geneticists, Pathologists and Gastroenterologists. (PubMed)

Unexplained Polyposis: A Challenge for Geneticists, Pathologists and Gastroenterologists. Two main colorectal polyposis syndromes have been described, familial adenomatous polyposis and MUTYH-associated polyposis syndromes. Some polyposis remains unexplained: 20% of adenomatous polyposis and serrated polyposis. The aim of this study was to evaluate in a cohort of patients with unexplained polyposis whether a genetic defect could be detected. Individuals presenting polyposis with more than 40 (...) adenomatous polyposis (familial or sporadic). Five pathogenic mutations were found: four in APC gene (with one case of mosaicism) and one in BMPR1A gene. The exploration of APC mosaicism was better performed from adenoma DNA with high-resolution melting. The screening of the candidate genes did not find any causative mutation. Thirteen individuals had an unexplained serrated polyposis and a frameshift on SMAD4 gene was identified. All mutations were identified in familial cases of polyposis. After new

2011 Clinical Genetics

18. Serrated polyps of the colon (PubMed)

Serrated polyps of the colon Until recently, colonic polyps were traditionally classified as either hyperplastic or adenomatous, and only the latter were believed to have the potential to progress to carcinoma. However, it is now appreciated that a subset of serrated polyps also appear to have malignant potential. Serrated polyps are a heterogeneous group of colon polyps that include hyperplastic polyps, sessile serrated adenomas (SSAs), traditional serrated adenomas, and mixed polyps. Insights (...) into these polyps were derived, in part, from studies of patients with the hyperplastic polyposis syndrome. SSAs show a predilection for the right colon, have a distinct histology, and their molecular genetic profile has recently been linked to a pathway for colon tumorigenesis that is characterized by microsatellite instability. Based upon available evidence, it is recommended that patients with serrated adenomas undergo colonoscopic follow-up at the same frequency as for conventional adenomas. It is important

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2010 F1000 medicine reports

19. Colorectal Cancer Screening

Gastroenterol. 2013 Mar;48(3):287-302. Schoen RE, Pinsky FP, Weissfeld JL, et al; PLCO Project Team. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012 Jun 21;366(25):2345-2357. Shussman N, Wexner SD. Colorectal polyps and polyposis syndromes. Gastroenterol Rep (Oxf). 2014 Feb;2(1):1-15. Snover DJ, Ahnen R, Burt W, et al, “Serrated polyps of the colon and rectum and serrated (’hyperplastic’) polyposis,” in in Bozma FT, Carneiro F, Hruban H et al., Eds., WHO (...) deaths in the United States. There is good evidence that CRC-related morbidity and mortality can be reduced through early detection and treatment of early-stage disease and through the identification and removal of adenomas, the precursor of colorectal cancers. Definitions: Neoplastic Colorectal Polyps and Adenomas Adenomatous polyps (also called adenomas) are growths with malignant potential, and are the most common type of colorectal polyp. Adenomatous polyps may be pathologically classified

2017 Kaiser Permanente Clinical Guidelines

20. Genetics of Colorectal Cancer (PDQ®): Health Professional Version

of the colon with adenocarcinomas in hyperplastic polyps after long-term follow-up. Endoscopy 34 (6): 499-502, 2002. [ ] Torlakovic E, Snover DC: Serrated adenomatous polyposis in humans. Gastroenterology 110 (3): 748-55, 1996. [ ] Torlakovic EE, Gomez JD, Driman DK, et al.: Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol 32 (1): 21-9, 2008. [ ] Snover DC, Jass JR, Fenoglio-Preiser C, et al.: Serrated polyps of the large intestine: a morphologic and molecular review (...) an increased risk of CRC in patients with hyperplastic polyposis syndrome (HPS), now referred to as serrated polyposis syndrome (SPS).[ , , - ] Only a minority of SPS appear to be familial, but no common germline variant has been identified in these families to date. A comparison of the hyperplastic polyps (HPs) found in SPS patients and controls revealed that SPS polyps are histologically distinct and are similar to previously described serrated adenomas, polyps with features of HPs and adenomatous polyps

2018 PDQ - NCI's Comprehensive Cancer Database

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