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Serum Magnesium

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181. Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. (Abstract)

-label, randomized, parallel-group study. Eligible participants were adults more than 4 months after kidney transplantation on tacrolimus with persisting serum magnesium concentrations <1.8 mg/dL randomized to magnesium oxide supplementation up to a maximum of 3 times 450 mg daily (N=26) or no supplements (N=26). Insulin secretion was assessed by OGTT-derived, first-phase insulin secretion (FPIR). The primary endpoint was the mean difference in FPIR between baseline and 6 months after randomization (...) , and lower dietary magnesium intake (142±56 versus 202±90 mg; p=0.015) as compared to patients with a rise in serum magnesium over 6 months. CONCLUSIONS Magnesium supplementation does not improve insulin secretion in stable hypomagnesemic kidney transplant recipients on tacrolimus. Persisting hypomagnesemia is associated with impaired glucose tolerance, insulin hypo-secretion, and dietary factors.

2018 Annals of transplantation Controlled trial quality: uncertain

182. Magnesium Sulfate Reduces Incidence of Atrial Fibrillation after Coronary Arterial Bypass Surgery: What Is the Proper Dose? A Randomized Trial. (Abstract)

in high dose group (52.4% vs. 28.3%, p = 0.02). Intraoperative data were similar. No complications were related to MgSO4 except one patient in the high dose group that experienced flushing and abdominal discomfort during administration. Immediate postoperative serum magnesium was higher in the high dose group but rapidly returned to similar level one day postoperatively. AF occurred in nine patients (10.23%), four in the low dose and five in the high dose group and there was no statistical (...) Magnesium Sulfate Reduces Incidence of Atrial Fibrillation after Coronary Arterial Bypass Surgery: What Is the Proper Dose? A Randomized Trial. Atrial fibrillation (AF) is a common complication after cardiac surgery and impacts length of hospital stay, greater utilization of health care resources, and increases morbidity and mortality. Magnesium sulfate (MgSO4 ) has been well documented in its effect of AF reduction after cardiac surgery especially in coronary artery bypass grafting (CABG

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: uncertain

183. Effect of magnesium on arrhythmia incidence in patients undergoing coronary artery bypass grafting. (Abstract)

arrhythmia after CABG surgery.The clinical trial enrolled 250 patients who underwent CABG. Based on the initial serum levels of magnesium, patients were divided into two groups: hypomagnesium and normomagnesium. Based on bioethics committee requirements, patients in the hypo-magnesium group received magnesium treatments until they attained normal magnesium blood levels. Both groups underwent CABG with normal blood levels of magnesium. After surgery, each group was randomly divided into two subgroups: one (...) Effect of magnesium on arrhythmia incidence in patients undergoing coronary artery bypass grafting. Cardiac arrhythmia after coronary artery bypass grafting (CABG) surgery is a common complication of cardiac surgery. The effect of serum magnesium, hypomagnesaemia treatment and prophylactic administration of magnesium in the development and prevention of arrhythmias is controversial and there are many different ideas. This study evaluates the therapeutic effects of magnesium in cardiac

2018 ANZ journal of surgery Controlled trial quality: uncertain

184. The absolute bioavailability and the effect of food on a new magnesium lactate dihydrate extended-release caplet in healthy subjects. (Abstract)

caplet of 10 mEq strength of magnesium L-lactate dihydrate has been developed to increase the bioavailability of magnesium.An open label, single-dose, randomized, three-period, cross-over study in healthy adults was conducted with three treatments: (a) single oral dose of 20 mEq magnesium L-lactate dehydrate under fasting conditions, (b) single intravenous (IV) infusion of 20 mEq magnesium sulfate, and (c) single oral dose of 20 mEq magnesium L-lactate dehydrate under fed conditions. Urine and blood (...) samples were collected for analysis of urinary and serum magnesium concentrations.Absolute bioavailabilities of the caplets under fasted and fed conditions, compared to IV magnesium sulfate, were 20.26% (fasted) and 12.49% (fed) in serum, based on the geometric mean ratio (GMR) of the baseline-adjusted AUC0-72, and 38.11% (fasted) and 40.99% (fed) in urine, based on the GMR of the baseline-adjusted Ae0-72. Relative bioavailability of the caplets comparing the fed and fasted states was 61.67% in serum

2018 Drug development and industrial pharmacy Controlled trial quality: uncertain

185. Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial. (Abstract)

-supplementation on glycemic control and markers of cardiometabolic risk of GDM patients. Sixty patients with GDM, aged 18-40 years, were randomized into 2 groups to intake either magnesium-zinc-calcium-vitamin D co-supplements or placebo (n = 30 each group) for 6 weeks in a randomized, double-blind, placebo-controlled trial. Fasting blood samples were taken at baseline and week 6 to quantify related markers. After the 6-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co (...) -supplementation resulted in significant reductions in fasting plasma glucose (-0.37 ± 0.09 vs. +0.01 ± 0.09 mmol/L, P = 0.003), serum insulin levels (-21.0 ± 4.8 vs. +7.2 ± 4.8 pmol/L, P < 0.001), homeostatic model of assessment for insulin resistance (-1.0 ± 1.1 vs. +0.3 ± 1.3, P < 0.001), and a significant increase in quantitative insulin sensitivity check index (+0.02 ± 0.03 vs. -0.002 ± 0.03, P = 0.003). In addition, magnesium-zinc-calcium-vitamin D co-supplementation significantly decreased serum

2018 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Controlled trial quality: predicted high

186. The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome. (Abstract)

status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to take 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. Magnesium and vitamin E co (...) -supplementation resulted in a significant reduction in hirsutism (β - 0.37; 95% CI, - 0.70, - 0.05; P = 0.02) and serum high-sensitivity C-reactive protein (hs-CRP) (β - 0.67 mg/L; 95% CI, - 1.20, - 0.14; P = 0.01), and a significant increase in plasma nitric oxide (NO) (β 3.40 μmol/L; 95% CI, 1.46, 5.35; P = 0.001) and total antioxidant capacity (TAC) levels (β 66.32 mmol/L; 95% CI, 43.80, 88.84; P < 0.001). Overall, magnesium and vitamin E co-supplementation for 12 weeks may benefit women with PCOS

2018 Biological trace element research Controlled trial quality: predicted high

187. Evaluation of magnesium sulfate effects on fetus development in experimentally induced surgical fetal growth restriction in rat. (Abstract)

Evaluation of magnesium sulfate effects on fetus development in experimentally induced surgical fetal growth restriction in rat. The objective of this study was to evaluate the effect of magnesium sulfate in the prevention of fetal growth restriction due to the impaired uterine blood supply in the rat model.The total number of 24 female rats were used in this study. They were mated overnight and randomly divided into control and treatment groups. After anesthesia and incising abdominal midline (...) in day 17 of gestation, the uterine artery was occluded by an atraumatic clamp for 60 minutes. The rats of the control group received normal saline after surgery and the rats of treatment group received magnesium sulfate subcutaneously. The laparotomy was repeated on day 21 of gestation, and the number of alive and dead fetuses were counted in each horn. The viability of fetuses was evaluated. The weight of the placenta and fetuses and the distance between the head and tail as well as back

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

188. Therapeutic Effect of Adding Magnesium Sulfate in Treatment of Organophosphorus Poisoning. Full Text available with Trip Pro

. In the group receiving magnesium sulfate, diastolic blood pressure was lower when compared with another group, at 0 and 2 hours after intervention. Moreover, the mean of systolic blood pressure in both groups was determined to be the same at all hours. Furthermore, the heart rate in the group receiving sulfate was lower as compared to the control group for 8 hours, 16 and 24 hours after intervention.The use of magnesium sulfate in organophosphate poisoning reduces therapeutic costs an average hospital (...) Therapeutic Effect of Adding Magnesium Sulfate in Treatment of Organophosphorus Poisoning. In recent years, the prevalence of poisoning has increased dramatically due to population growth and access to drugs and toxins. Today poisoning is one of the important reasons for visiting hospitals.The present study aimed to investigate the effect of magnesium sulfate on organophosphorous toxicity.Patients who had inclusion criteria in the study were randomly assigned to one of two groups (control group

2018 Open access Macedonian journal of medical sciences Controlled trial quality: uncertain

189. Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. (Abstract)

with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in hirsutism (-2.4 ± 1.2 vs. -0.1 ± 0.4, P < 0.001), serum high sensitivity C-reactive protein (-0.7 ± 0.8 vs. +0.2 ± 1.8 mg/L, P < 0.001), and plasma malondialdehyde (-0.4 ± 0.3 vs. +0.2 ± 1.0 μmol/L, P = 0.01), and a significant increase in plasma total antioxidant capacity concentrations (+46.6 ± 66.5 vs. -7.7 ± 130.1 mmol/L, P = 0.04). We failed to find any significant effect of magnesium-zinc-calcium (...) Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS) are scarce. The objective of this study was to assess the effects of magnesium

2018 Biological trace element research Controlled trial quality: predicted high

190. Safety and efficacy of low dose intramuscular magnesium sulphate (MgSO4) compared to intravenous regimen for treatment of eclampsia. (Abstract)

Safety and efficacy of low dose intramuscular magnesium sulphate (MgSO4) compared to intravenous regimen for treatment of eclampsia. This study was performed to compare the safety and efficacy of low dose intramuscular magnesium sulphate (MgSO4) (Dhaka regimen) and intravenous (IV) MgSO4 (Zuspan regimen) for the prevention of eclampsia recurrence and to compare serum magnesium concentration.Forty one eligible patients with eclampsia were randomly divided into two groups: group I patients (...) received IV MgSO4 according to the Zuspan regime, while group II patients received intramuscular (IM) MgSO4 according to the Dhaka regimen (i.e. low dose MgSO4). The total dose MgSo4 requirements per patient were calculated and serum MgSo4 level was measured. Maternal and fetal outcomes were compared between the groups.The mean total dose of MgSO4 required for the treatment of eclampsia was higher in group I compared to group II (32 ± 6.8 g vs 25.4 ± 8.8 g, respectively; P < 0.5). The mean serum MgSO4

2018 The journal of obstetrics and gynaecology research Controlled trial quality: uncertain

191. SOLVE-ACS: Bioresorbable Magnesium-Stents Magmaris in ACS Lesions

SOLVE-ACS: Bioresorbable Magnesium-Stents Magmaris in ACS Lesions SOLVE-ACS: Bioresorbable Magnesium-Stents Magmaris in ACS Lesions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. SOLVE-ACS: Bioresorbable (...) Magnesium-Stents Magmaris in ACS Lesions (SOLVE-ACS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03773081 Recruitment Status : Recruiting First Posted : December 12, 2018 Last Update Posted : December 12, 2018 See Sponsor

2018 Clinical Trials

192. Alcohol: Thiamine and or Magnesium 1

metabolic processes, e. g. on the activity of the enzyme transketolase in red blood cells, is not routine practice in the treatment of these patients. Without correction of concomitant magnesium deficiency there may be impaired utilisation of thiamine resulting in a failure to treat WE. This study is designed to determine if administration of magnesium to AUD patients affects red cell transketolasae and serum lactate concentrations by itself, or only acts to increase the effect of thiamine (...) ] this is a biochemical marker of thiamine activity measured in units per gram of haemoglobin Secondary Outcome Measures : Change in serum lactate [ Time Frame: 0 and 2 hours ] Biochemical marker of metabolic dysfunction (expressed as mmol/L) lactate dehydrogenase [ Time Frame: 0 and 2 hours ] biochemical (expressed in mmol/L) pre and post magnesium [ Time Frame: 0 and 2 hours ] biochemical (expressed in mmol/L) pre and post red cell thiamine [ Time Frame: 0 and 2 hours ] biochemical Eligibility Criteria Go

2018 Clinical Trials

193. Efficacy of Oral Supplementation With Magnesium to Reduce Febrile Neutropenia

the apparition of febrile neutropenia [ Time Frame: After randomization until day 30 ] Total of days passed from the randomization up to the apparition of febrile neutropenia Safety of Oral Supplementation with Magnesium [ Time Frame: Evaluate the apparition of adverse effects of oral supplement of magnesium oxide Time Frame: After randomization until day 30 ] Evaluate the apparition of adverse effects of oral supplement of magnesium oxide Hypomagnesemia [ Time Frame: After randomization until day 30 ] Serum (...) Efficacy of Oral Supplementation With Magnesium to Reduce Febrile Neutropenia Efficacy of Oral Supplementation With Magnesium to Reduce Febrile Neutropenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

194. Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy

Library of Medicine related topics: related topics: available for: Groups and Cohorts Go to Intervention Details: Other: No Intervention. Study is Cross Sectional in nature No Intervention. Study is cross sectional in nature Outcome Measures Go to Primary Outcome Measures : Bone mineral density [ Time Frame: 1 time point - baseline ] Will be measured at Tibia, Hip and Total Body using a DXA scan Secondary Outcome Measures : Ionized Magnesium in serum [ Time Frame: 1 time point - baseline (...) Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2018 Clinical Trials

195. Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial

effects, including: Drowsiness, Feeling Anxious, Feeling Cold, Nervous, Numbness And Tingling, Signs And Symptoms At Injection Site, Twitching. Magnesium sulfate's side effects include: heart disturbances, breathing difficulties, poor reflexes, confusion, weakness, flushing (warmth, redness, or tingly feeling), sweating, lowered blood pressure, feeling like you might pass out, anxiety, cold feeling, extreme drowsiness, muscle tightness or contraction, or headache. Study Design Go to Layout table (...) Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

196. Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation

of surgery ] By 5-point sedation Ramsay score where 5:aroused only by shaking 4:difficult response to verbal 3:mostly sleeping but easily aroused 2:drowsy 1:awake Patient satisfaction level [ Time Frame: 48 hours after end of surgery ] By 5-point scale where 1: very unsatisfactory 2:unsatisfactory 3:neutral 4:satisfactory 5:Excellent Blood serum magnesium concentration [ Time Frame: 12 hours before operation ] from venous blood sample in mg/dl Blood serum magnesium concentration [ Time Frame: 15 minutes (...) Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

197. Effects of Magnesium Supplementation on Hemodynamic Parameters and Cognitive Function

span test, carotid artery flow velocity, ankle-brachial blood pressure ratio, and urinary magnesium. Condition or disease Intervention/treatment Phase Cognitive Function Dietary Supplement: Magnesium Citrate Other: Food grade citrate acid Other: Splenda(Sucralose) Not Applicable Detailed Description: Dementia is an important geriatric syndrome. The prevalence of dementia increases with age. According to the data of the Taiwan Alzheimer Disease Association, one out of 13 elderly people over 65 (...) group will receive 30cc solution containing 100 mg of citrate acid and flavored by 1g of Splenda. The magnesium citrate pure powder from NOW FOODS containing 300mg magnesium will be dissolved in 30cc of the above solution. Before and after two hours of intervention, participants will be interviewed and assessed for the following: questionnaires, cognitive function, carotid artery flow velocity, ankle-brachial blood pressure ratio, and urinary magnesium. Questionnaires include Montreal Cognitive

2018 Clinical Trials

198. Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy

Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03643666 Recruitment Status : Active

2018 Clinical Trials

199. Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia

Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03640390 Recruitment Status : Recruiting First Posted : August 21, 2018 Last Update Posted : October 19

2018 Clinical Trials

200. Role of Magnesium in Pediatric Cochlear Implant

Role of Magnesium in Pediatric Cochlear Implant Role of Magnesium in Pediatric Cochlear Implant - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Role of Magnesium in Pediatric Cochlear Implant The safety (...) : To determine the efficiency of addition of magnesium sulfate to total intravenous anesthesia (TIVA) in optimizing the surgical field during pediatric cochlear implant surgery. Also its effects on the intraoperative evoked stapedial reflex thresholds (ESRT) and the intraoperative anesthetic requirements were evaluated. Condition or disease Intervention/treatment Phase Anesthesia Drug: Magnesium sulphate Other: Na CL 0.9% Phase 4 Detailed Description: Sixty-six ASA I and II children (1-6 years) undergoing

2018 Clinical Trials

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