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Serum Folate

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101. Serum homocysteine, vitamin B12 and folate and the prevalence and incidence of posterior subcapsular cataract. (Full text)

Serum homocysteine, vitamin B12 and folate and the prevalence and incidence of posterior subcapsular cataract. We assessed associations between serum levels of homocysteine, vitamin B12, and folate, and the prevalence and 5-year incidence of posterior subcapsular cataract (PSC) in Blue Mountains Eye Study participants.We examined 3508 participants aged 49+ years during 1997 to 2000, including 2334 (75.1% of survivors) original and 1174 (85.2% of those eligible) newly recruited subjects. Five (...) of homocysteine (per SD; OR, 1.17; 95% CI, 1.00-1.37) and lower levels of folate (per SD; OR, 1.24; 95% CI, 0.99-1.56) were associated with prevalent PSC. There was significant interaction (P < 0.05) between vitamin B12 and homocysteine; for B12 ≥125 pmol/L, 28% higher PSC prevalence was associated with homocysteine (per SD; OR, 1.28; 95% CI, 1.09-1.52); however, for B12 <125 pmol/L, nonsignificant lower PSC prevalence was associated with homocysteine (per SD; OR, 0.16; 95% CI, 0.02-1.57). The 5-year PSC

2014 Investigative Ophthalmology & Visual Science PubMed

102. Serum Cotinine and Whole Blood Folate Concentrations in Pregnancy (Full text)

Serum Cotinine and Whole Blood Folate Concentrations in Pregnancy Prenatal tobacco smoke exposure may be associated with low maternal folate levels that increase the risk of adverse infant and child health outcomes by reducing folate availability during fetal development.Using data from the Health Outcomes and Measures of the Environment Study, we examined the relationship between secondhand or active tobacco smoke exposure and whole blood folate concentrations in pregnant women from Cincinnati (...) , Ohio (n = 362) at approximately 16-week gestation. We used multivariable linear regression to examine the association between continuous or categorical serum cotinine levels and whole blood folate levels, adjusting for sociodemographic, dietary, and perinatal variables.After adjustment for potential confounders, an interquartile range increases in serum cotinine concentration (0.012-0.224 ng/mL) was suggestively associated with decreased whole blood folate levels (β, -23 nmol/L; 95% confidence

2014 Annals of Epidemiology PubMed

103. High serum folate might have a potential dual effect on risk of colorectal cancer. (PubMed)

High serum folate might have a potential dual effect on risk of colorectal cancer. The possible dual role of serum folate in the development and progression of colorectal cancer (CRC) has not been well established in human studies. This study investigated the association between serum folate and the risk of CRC in subjects with CRC or colorectal adenomatous polyps (AP, a precursor of CRC), and healthy subjects.This study has a case-control design. Two hundred and thirty-seven men and 171 women (...) were recruited with 156 subjects in the CRC group, 70 subjects in the AP group and 182 healthy subjects in the control group.The risk of CRC was significantly increased in the third (OR, 3.46; 95% CI, 1.16-10.34) and fourth (OR, 4.86; 95% CI, 1.42-16.58) quartiles of serum folate concentration after adjusting for potential confounders among subjects with AP or CRC. Furthermore, serum folate concentration had no significant effect on the risk of CRC among subjects in the control and CRC

2014 Clinical nutrition (Edinburgh, Scotland)

104. Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency. (PubMed)

Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency. Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load. However, the amount of methionine required for a loading test is non-physiological and is never reached with regular feeding. Therefore, CBS carriers do (...) not seem to be at an increased risk of cardiovascular diseases. However, the risk of cardiovascular diseases of CBS carriers with folate deficiency has not been studied. We recently found an extraordinarily high carrier rate (1/7.78) of a novel CBS mutation (p.D47E, c.T141A) in an Austronesian Taiwanese Tao tribe who live in a geographic area with folate deficiency. We evaluated if the CBS carriers tend to have higher fasting serum tHcy concentrations than non-carriers in presence of folate

2014 Clinical nutrition (Edinburgh, Scotland)

105. Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children. (Full text)

Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children. Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however, have reported inconsistent (...) findings.The aim of the study was to examine associations between serum vitamin B-12 and folate concentrations and intakes of B vitamins with body fat by using data on 1131 Mexican American children 8-15 y of age included in NHANES 2001-2004.Children's body mass index (BMI), trunk fat mass (TrFM), and total body fat mass (TBFM) were used as body adiposity (BA) measures. Serum concentrations of folate and vitamin B-12 were measured in blood samples collected from children. Intake of B vitamins was collected

2014 Journal of Nutrition PubMed

106. Estimation of serum and erythrocyte folate concentrations in the New Zealand adult population within a background of voluntary folic acid fortification. (Full text)

Estimation of serum and erythrocyte folate concentrations in the New Zealand adult population within a background of voluntary folic acid fortification. National data on the blood folate status of New Zealand adults is lacking. The objective of this study was to describe the blood folate status and examine the predictors of blood folate status in a national sample of adults from New Zealand, a country with voluntary folic acid fortification. The 2008/09 New Zealand Adult Nutrition Survey (...) was a nationwide multistage systematic random cross-sectional survey. Serum and erythrocyte folate concentrations were measured by microbiologic assay. The survey included 4721 participants aged ≥15 y, 3359 of whom provided a nonfasting blood sample. Biochemical folate status was measured in 3277 participants. The median serum and erythrocyte folate concentrations were 23 and 809 nmol/L, respectively. The prevalence of biochemical folate deficiency, defined as plasma folate <6.8 nmol/L or erythrocyte folate

2014 Journal of Nutrition PubMed

107. Detection of functional vitamin B12 and folate deficiencies, while serum levels are normal (Full text)

Detection of functional vitamin B12 and folate deficiencies, while serum levels are normal 23736913 2014 11 12 2018 12 02 1723-2007 12 Suppl 1 2014 Jan Blood transfusion = Trasfusione del sangue Blood Transfus Detection of functional vitamin B12 and folate deficiencies, while serum levels are normal. s164 10.2450/2013.0040-13 Cosar Alpaslan A Department of Clinical Biochemistry, GATA Haydarpasa Training Hospital, Istanbul, Turkey. Ipcioglu Osman Metin OM Department of Clinical Biochemistry

2014 Blood Transfusion PubMed

108. Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC

Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC (IMGN853) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03045393 Recruitment Status : Withdrawn (Inadequate enrollment) First Posted : February 7, 2017 Last Update Posted : July 4, 2018 Sponsor: Duke University Collaborator

2017 Clinical Trials

109. Vitamin B12, folate, and homocysteine levels and multiple sclerosis: A meta-analysis. (PubMed)

and serum or plasma Hcy, vitamin B12, and folate levels.The PubMed, MEDLINE, and EMBASE databases were searched for eligible case-control studies published until June 2017. After data extraction, separate analyses using mainly random-effects models were conducted to test for associations between MS and vitamin B12, Hcy, or folate blood levels.Twelve, 12, and 9 studies met the inclusion criteria for meta-analysis of MS and Hcy, vitamin B12, and folate levels, respectively. The standardized mean (...) Vitamin B12, folate, and homocysteine levels and multiple sclerosis: A meta-analysis. Multiple sclerosis (MS) is a demyelinating and disabling inflammatory disease of the central nervous system. Several factors contribute to MS pathogenesis including genetic-environmental interactions. Case-control studies suggest that there might be associations between MS and homocysteine (Hcy), vitamin B12, and folate blood levels.To meta-analyze all available data describing associations between MS

2017 Multiple sclerosis and related disorders

110. Folate and phototherapy: What should we inform our patients? (PubMed)

for in vivo studies comparing folate levels before and after phototherapy.There is no evidence of decreased folate levels after UVA exposure. Decreased folate levels after sun exposure were limited to subjects taking folate supplements. Studies using narrowband UVB showed mixed results, potentially explained by dose-dependent degradation of folate; exposure >40 J/cm2 cumulatively and >2 J/cm2 per treatment were associated with 19%-27% decreases in serum folate levels, while lower doses did not affect (...) Folate and phototherapy: What should we inform our patients? Ultraviolet (UV) degradation of folate has been studied in vitro and in vivo, but comprehensive reviews of the subject and recommendations for supplementing folate are lacking, especially for women of childbearing age, in whom decreases in folate predisposes newborns to neural tube defects.We reviewed the effects of phototherapy on folate and provide a recommendation for women of childbearing age on phototherapy.PubMed was searched

2017 Journal of American Academy of Dermatology

111. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. (PubMed)

of RBC and either lowest tertile of plasma B12 or highest tertile of MMA (p < 0.034 and 0.011, respectively). Lg HOMA-IR was negatively correlated with Lg homocysteine (p < 0.0001) and positively correlated with Lg serum folate (p < 0.001). The independent predictors for HOMA-IR at period 2 were either BMI and homocysteine (model 1 without serum folate, p = 0.010 and p = 0.002, respectively) or BMI and MMA (model 2 without homocysteine, p = 0.030 and p = 0.004, respectively). Age and RBC folate (...) Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Low vitamin B12 and high folate during pregnancy are associated with visceral obesity and insulin resistance in offspring. In the general population, high folate exacerbates the increase of methylmalonic acid, a marker of vitamin B12 deficiency. However, the influence of vitamin B12 and folate and their related markers on insulin resistance and metabolic syndrome remains unknown

2017 Clinical nutrition (Edinburgh, Scotland)

112. Prevalence and possible factors associated with anaemia, and vitamin B <sub><sub>12</sub></sub> and folate deficiencies in women of reproductive age in Pakistan: analysis of national-level secondary survey data. (Full text)

. Anaemia was defined as haemoglobin levels <12 g/dL, vitamin B12 deficiency as serum vitamin B12 levels of <203 pg/mL (150 pmol/L) and folate deficiency as serum folate levels <4 ng/mL (10 nmol/L).A total of 11 751 blood samples were collected and analysed. The prevalence of anaemia, vitamin B12 deficiency and folate deficiency was 50.4%, 52.4% and 50.8%, respectively. After adjustment, the following factors were positively associated with anaemia: living in Sindh province (RR 1.07; 95% CI 1.04 to 1.09 (...) Prevalence and possible factors associated with anaemia, and vitamin B 12 and folate deficiencies in women of reproductive age in Pakistan: analysis of national-level secondary survey data. To determine the prevalence and possible factors associated with anaemia, and vitamin B12 and folate deficiencies in women of reproductive age (WRA) in Pakistan.A secondary analysis was conducted on data collected through the large-scale National Nutrition Survey in Pakistan in 2011

2017 BMJ open PubMed

113. Evidence for potential underestimation of clinical folate deficiency in resource-limited countries using blood tests. (PubMed)

Evidence for potential underestimation of clinical folate deficiency in resource-limited countries using blood tests. Although a low serum folate concentration is a useful biomarker of pure folate deficiency, the presence of vitamin B12 deficiency or hemolysis or both in individuals with low folate status predictably raises serum folate levels. Therefore, in resource-limited settings where dietary folate deficiency can coexist with vitamin B12 deficiency or malaria or both, the serum folate (...) concentration can range from normal to high, leading to serious underestimation of tissue folate status. This review traces the genesis of an inappropriate overreliance on the serum folate concentration to rule out folate deficiency in vulnerable populations of women and children. Of significance, without due consideration of a chronically inadequate dietary folate intake, authors of influential studies have likely wrongly judged these populations to have an adequate folate status. Through repetition

2017 Nutrition reviews

114. Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis. (Full text)

Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis. The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis.Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic (...) regression models to obtain the odds ratios and 95% confidence interval (CIs). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model.In this case-control study, we included 58 men and 55 women with colorectal adenomas and sex and fasting status matched the controls. We did not find any significant association between the serum folate

2017 Nutrition research and practice PubMed

115. Nutrition research in cognitive impairment/dementia, with a focus on soya and folate. (Full text)

, was found to increase dementia risk. This association was not mediated by a vegetarian diet, socioeconomic status, formaldehyde, thyroid function, or loss of teeth. On the other hand, human observational and animal treatment studies suggested that tempe, a fermented soya product containing phytoestrogens and folate, reduced dementia risk and improved memory. High oestrogen levels were found to increase dementia risk in older women. However, in women with adequate serum folate, high oestrogen levels did (...) Nutrition research in cognitive impairment/dementia, with a focus on soya and folate. Observational studies and treatment trials investigating nutrition and cognitive function, with a focus on folate and soya and dementia, were reviewed. Data suggested that effects of folic acid based interventions may only be shown before cognitive decline is evident and/or if people are folate deficient. In older people in Indonesia, Hawai'i and China, tofu, which can contain high levels of phytoestrogens

2017 Proceedings of the Nutrition Society PubMed

116. Folate, homocysteine and the ovarian cycle among healthy regularly menstruating women. (Full text)

Folate, homocysteine and the ovarian cycle among healthy regularly menstruating women. How are concentrations of plasma homocysteine and serum folate associated with reproductive hormones and anovulation in regularly menstruating women?Higher homocysteine was associated with sporadic anovulation and hormonal changes that may be indicative of impaired ovulatory function, but higher serum folate was associated only with higher luteal phase progesterone.Higher folate levels as well as some (...) and reproductive hormones were measured up to eight times per cycle and plasma homocysteine up to three times. Linear mixed models were used to estimate associations between serum folate or plasma homocysteine and log-transformed reproductive hormone levels while accounting for multiple observations and cycles per woman. Generalized estimating equations were used to examine risk of sporadic anovulation. All models were adjusted for age, race, body mass index, cigarette and alcohol use, and energy and fiber

2017 Human Reproduction PubMed

117. Is Depression Related to Low Folate Levels in People with Epilepsy? An Observational Study and Meta-analysis. (Full text)

Is Depression Related to Low Folate Levels in People with Epilepsy? An Observational Study and Meta-analysis. Both depression and low serum levels of folate are common in people with epilepsy (PWE), the latter especially in patients on hepatic enzyme-inducing antiepileptic drugs (AEDs). We did a cross-sectional study and a meta-analysis to assess if lower folate levels have any relation with depression in PWE.Two hundred and one PWE were recruited and assessed for depression using the Inventory (...) of Depressive Symptomatology-Self-Rated (IDS-SR) and Inventory of Depressive Symptomatology-Clinician Rated; serum folate levels were measured in them at the same time. Literature search was carried out and studies with data on depression as well as folate levels in PWE were included. Statistical analysis to determine frequency of depression, low folate levels, and relation between them among our cases and the pooled data from the included studies was done.Depression was observed in 65.68% and low serum

2017 Journal of neurosciences in rural practice PubMed

118. Association between blood folate concentrations and depression in reproductive aged U.S. women, NHANES (2011-2012). (PubMed)

Association between blood folate concentrations and depression in reproductive aged U.S. women, NHANES (2011-2012). Blood folate concentrations have been linked to an increased risk of depression in adults. Depression is particularly pronounced among women; however, the association between folate concentration and depression is not well-examined among women of reproductive age. The purpose of our study was to assess the association between low serum and red blood cell folate concentration (...) and the risk of moderate to severe depression among non-pregnant women of reproductive age in the United States (U.S.).We used data from nationally representative, population-based U.S. National Health and Nutrition Examination Survey (NHANES) (2011-2012) examining non-pregnant women of reproductive age (20-44 years). We compared serum and red blood cell (RBC) folate concentrations between women with and without self-reported depression based on Patient Health Questionnaire-9 (PHQ-9) scores, and examined

2017 Journal of Affective Disorders

119. The association of folate and depression: A meta-analysis. (PubMed)

-analytic procedures were conducted in accordance with PRISMA guidelines. Studies evaluating folate levels in individuals with and without depression via red blood cell folate, serum folate, or dietary intake of folate methods were identified via PsycINFO and PubMed. Random-effects meta-analysis was conducted using Hedge's g, and moderation analysis was used for both folate measurement method and population type. Study heterogeneity was assessed with I2 and publication bias was qualitatively assessed (...) via funnel plot and quantitatively assessed with the trim-and-fill method and Begg's adjusted rank test.We found a significant, small effect size, such that individuals with depression had lower folate levels than those without depression, Hedge's g = -0.24 (95% CI = -0.31, -0.16), p < 0.001. Study heterogeneity was high (I2 = 84.88%), and neither folate measurement method nor population accounted for study heterogeneity.Individuals with depression have lower serum levels of folate and dietary

2017 Journal of psychiatric research

120. Correspondence of folate dietary intake and biomarker data. (Full text)

examined usual dietary intakes of folate by using the National Cancer Institute method to adjust two 24-h dietary recalls (including dietary supplements) for within-person variation and then compared these intakes with serum and red blood cell (RBC) folate among 4878 men and nonpregnant, nonlactating women aged ≥19 y in NHANES 2011-2012, a nationally representative, cross-sectional survey, with respect to consistency across prevalence estimates and rank order comparisons.Results: There was a very low (...) prevalence (<1%) of folate deficiency when serum (<7 nmol/L) and RBC (<305 nmol/L) folate were considered, whereas a higher proportion of the population reported inadequate total dietary folate intakes (6%). Similar patterns of change occurred between intakes and biomarkers of folate status when distributions were examined (i.e., dose response), particularly when diet was expressed in μg. Intakes greater than the Tolerable Upper Intake Level greatly increased the odds of having high serum folate

2017 American Journal of Clinical Nutrition PubMed

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