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Serum Folate

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281. Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women Full Text available with Trip Pro

Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed (...) according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included. After randomization to COC (n = 60) and myo-ins (n = 77) arms, anthropometric measurements, blood pressure, Modified Ferriman Gallwey scores were calculated. Biochemical and hormonal analysis were performed, and LH/FSH and Apo B/A1 ratios were calculated. Data analysis was carried out in demographically and clinically matched 106

2016 International journal of endocrinology

282. No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers Full Text available with Trip Pro

No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein expression of the transporter OATP1A2 were increased up to ninefold with 1,25(OH)2D3. We investigated whether these in vitro findings can (...) be confirmed in humans in vivo.Ten healthy volunteers (six women) received 5 mg folic acid orally once before and once together with the last intake of a 10-day course of 0.5 μg 1,25(OH)2D3 orally. One hundred twenty milligrams fexofenadine, an OATP1A2 substrate, was taken in 1 day before the first folic acid intake, and again on the ninth day of 1,25(OH)2D3 intake. Duodenal biopsies were taken for transporter mRNA assessments once before and once on the ninth or tenth day of the vitamin D3 course. Serum

2016 European journal of clinical pharmacology

283. Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia—A Cohort Study Full Text available with Trip Pro

participants and the patterns of supplementation of folic acid were described and occurrence of PE between women with folic acid supplementation during pregnancy and women without were compared. Multiple logistic regression was used in the estimation of the independent effect of supplementation of folic acid. Additional analyses assessing the effect of low RBC and serum folate and dose-response relationship were performed. Analyses were performed in all study participants, and then in high risk and low (...) risk sub-groups, respectively. A total of 7,669 participants were included in the final analysis. Ninety five percent of the study participants were taking folic acid supplementation in early second trimester. The rate of PE was lower in the supplementation group than in the no supplementation group, and the difference was statistically significant in high risk women. Similar patterns of associations were observed in analysis by RBC and serum folate levels and in dose-response analysis. Folic acid

2016 PloS one

284. Comparison of high dose and low dose folic acid supplementation on prevalence, onset and severity of preeclampsia Full Text available with Trip Pro

Comparison of high dose and low dose folic acid supplementation on prevalence, onset and severity of preeclampsia Folic acid supplementation had previously mentioned as a protective factor against the onset of preeclampsia (PE). In this study, we aimed to compare the effect of high dose (5 mg daily) and low dose (1 mg daily) of folic acid supplementation on prevalence, onset and severity of PE.Pregnant women who were in the first trimester and referred to prenatal care university hospitals (...) of Isfahan, Iran during October 2013-May 2015 were included in this study, then they were randomly divided into two groups of 5 mg and 1 mg (treated with daily 5 mg and 1 mg of folic acid, respectively), both groups received folic acid from the first trimester of pregnancy to 42 days after termination. Blood pressure, body mass index (BMI), and some urine and blood biochemistry parameters were measured. SPSS-22 used for statistical analysis.A total of 943 pregnant women participated in the study (450

2016 Advanced biomedical research Controlled trial quality: uncertain

285. Immune activity and biodistribution of polypeptide K237 and folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles radiolabeled with 99mTc Full Text available with Trip Pro

Immune activity and biodistribution of polypeptide K237 and folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles radiolabeled with 99mTc In a previous study, amphiphilic copolymer, polypeptide K237 (HTMYYHHYQHHL) and folic acid (FA) modified poly(ethylene glycol)-poly(lactic-co-glycolic acid) (K237/FA-PEG-PLGA) nanoparticles were developed and studied as a drug carrier. To further promote the clinical application of K237/FA-PEG-PLGA nanoparticles and provide guidance for future (...) research, we need to examine their specific biodistribution in vivo. In this study, K237/FA-PEG-PLGA nanoparticles were effectively labeled by a direct method with Technetium-99m (99mTc) using stannous chloride as a reducing agent. The optimal stability of the labeled nanoparticles was determined by evaluating their radiochemical purity in serum, physiological saline, diethylenetriaminepentaacetic acid (DTPA) and cysteine solutions. The affinity of ligands and receptors was elicited by cell binding

2016 Oncotarget

286. Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children Full Text available with Trip Pro

regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed.Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05).Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children. (...) Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched

2016 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

287. Acute portal vein thrombosis secondary to hyperhomocysteinemia with folic acid deficiency and methyl tetrahydrofolate reductase mutation: a case report and literature review Full Text available with Trip Pro

Acute portal vein thrombosis secondary to hyperhomocysteinemia with folic acid deficiency and methyl tetrahydrofolate reductase mutation: a case report and literature review 28905011 2018 11 13 2451-0629 1 1 2016 Archives of medical sciences. Atherosclerotic diseases Arch Med Sci Atheroscler Dis Acute portal vein thrombosis secondary to hyperhomocysteinemia with folic acid deficiency and methyl tetrahydrofolate reductase mutation: a case report and literature review. e1-e5 10.5114/amsad (...) . 2011 Oct;17(5):487-93 20699251 J Hepatol. 2004 May;40(5):736-41 15094219 Eur J Vasc Endovasc Surg. 2009 Sep;38(3):316-22 19560951 J Neurol Sci. 2010 Nov 15;298(1-2):153-7 20810133 Blood. 1997 Jul 1;90(1):1-11 9207431 JAMA. 1993 Dec 8;270(22):2693-8 8133587 World J Gastroenterol. 2006 Feb 28;12(8):1165-74 16534866 World J Gastroenterol. 2006 Apr 7;12(13):2115-9 16610067 Hepatology. 2010 Jan;51(1):210-8 19821530 Aliment Pharmacol Ther. 2005 Jan 1;21(1):1-9 15644039 Semin Thromb Hemost. 2006 Oct;32(7

2016 Archives of Medical Sciences. Atherosclerotic Diseases

288. Effectiveness of Folic Acid Fortified Flour for Prevention of Neural Tube Defects in a High Risk Region Full Text available with Trip Pro

Effectiveness of Folic Acid Fortified Flour for Prevention of Neural Tube Defects in a High Risk Region Despite efforts to tackle folate deficiency and Neural Tube Defects (NTDs) through folic acid fortification, its implementation is still lacking where it is needed most, highlighting the need for studies that evaluate the effectiveness of folic acid fortified wheat flour in a poor, rural, high-risk, NTD region of China. One of the most affected regions, Shanxi Province, was selected as a case (...) study. A community intervention was carried out in which 16,648 women of child-bearing age received fortified flour (eight villages) and a control group received ordinary flour (three villages). NTD birth prevalence and biological indicators were measured two years after program initiation at endline only. The effect on the NTD burden was calculated using the disability-adjusted life years (DALYs) method. In the intervention group, serum folate level was higher than in the control group. NTDs

2016 Nutrients

289. Effect of Iron and Folic Acid on Skin Fungal Pattern in Patients With Arsenicosis

contaminated water causes accumulation of arsenic in keratin rich tissues like skin, hair, nail and producing characteristic skin manifestations like melanosis and keratosis. Metabolism of arsenic depends on folate pathway and dietary deficiency of folic acid reduced the total arsenic excretion and leads to development of cancer. In different study results shown that folic acid reduces the blood arsenic level. As arsenicosis is a chronic disease condition, fungal infection is more common to them. Moreover (...) Effect of Iron and Folic Acid on Skin Fungal Pattern in Patients With Arsenicosis Effect of Iron and Folic Acid on Skin Fungal Pattern in Patients With Arsenicosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2016 Clinical Trials

290. An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery

An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03011320 Recruitment Status : Completed First Posted : January 5, 2017

2016 Clinical Trials

291. Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia

variants of one-carbon cycle pathway, psychopathology, including positive symptoms, negative symptoms, and cognition, and metabolic abnormalities in patients with schizophrenia. For patients with low folate levels, the investigators would like to conduct a 24-week double-blinded, placebo-controlled of folic acid (5 mg/d) and vitamin B12 (500 ug/d) supplementation study to know whether combination of folic acid and vitamin B12 can improve patients' psychopathology or metabolic profiles, and the effects (...) Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2016 Clinical Trials

292. Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes

Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02786823 Recruitment Status : Completed First Posted : June 1, 2016 Last Update Posted : September 19, 2017 Sponsor: All India Institute of Medical

2016 Clinical Trials

293. Stability of the human sperm DNA methylome to folic acid fortification and short-term supplementation. Full Text available with Trip Pro

compared.Excess dietary folate may be detrimental to health and DNA methylation profiles due to folate's role in one-carbon metabolism and the formation of S-adenosyl methionine, the universal methyl donor. DNA methylation patterns are established in developing male germ cells and have been suggested to be affected by high-dose (5 mg/day) folic acid supplementation.This is a control versus treatment study where genome-wide sperm DNA methylation patterns were examined prior to fortification of food (1996-1997 (...) ) in men with no history of infertility at baseline and following 90-day exposure to placebo (n = 9) or supplement containing 400 μg folic acid/day (n = 10). Additionally, pre-fortification sperm DNA methylation profiles (n = 19) were compared with those of a group of post-fortification (post-2004) men (n = 8) who had been exposed for several years to dietary folic acid fortification.Blood and seminal plasma folate levels were measured in participants before and following the 90-day treatment

2016 Human Reproduction Controlled trial quality: uncertain

294. Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial. Full Text available with Trip Pro

= 121; mild to severe; international criteria) and being treated with donepezil were randomly assigned into two groups with (intervention group) or without (control group) supplemental treatment with folic acid (1.25 mg/d) for 6 months. The Mini-Mental State Examination (MMSE) was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment. We quantified serum folate, amyloid beta (Aβ), interleukin-6 (IL-6), tumor necrosis factor α (TNFα), plasma (...) Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial. Background/Aims. Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation's effect on inflammation and cognitive function in patients with AD over the course of 6 months. Methods. Patients newly diagnosed with AD (age > 60 years; n

2016 Mediators of inflammation Controlled trial quality: uncertain

295. The Effect of Trimethoprim on Serum Folate Levels in Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Full Text available with Trip Pro

The Effect of Trimethoprim on Serum Folate Levels in Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Trimethoprim antagonize the actions of folate by inhibition of dihydrofolate reductase. This could diminish serum folate levels in humans and causes folate deficiency in some patients. We conducted a randomized, double-blind, placebo-controlled trial, to investigate the effect of trimethoprim on serum folate levels in healthy participants after a 7-day trial period. Thirty young (...) , healthy males were randomly allocated to receive trimethoprim, 200 mg twice daily, and 30 were randomly allocated to placebo. Before trial initiation, participant numbers were given randomly generated treatment allocations within sealed opaque envelopes. Participants and all staff were kept blinded to treatment allocations during the trial. Serum folate was measured at baseline and at end of trial. In the 58 participants analyzed (30 in the trimethoprim group and 28 in the placebo group), 8 had folate

2015 American journal of therapeutics Controlled trial quality: predicted high

296. Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer

Endometrioid Tumor Ovarian Neoplasm Ovarian Serous Tumor Recurrent Ovarian Carcinoma Drug: Dexamethasone Other: Laboratory Biomarker Analysis Drug: Valproic Acid Phase 1 Detailed Description: PRIMARY OBJECTIVES: I. To evaluate the pre- and post-induction correlation between soluble folate receptor and tumor-based receptor levels as a marker of malignancy in patients with newly diagnosed adnexal masses. (Arm I) II. To evaluate the ability to induce serum folate receptor (FR) with dexamethasone (Dex (...) Millicorten Mymethasone Orgadrone Spersadex Visumetazone Other: Laboratory Biomarker Analysis Analysis of serum and tissue samples Drug: Valproic Acid Given PO Other Names: Depakene Stavzor Valproate Outcome Measures Go to Primary Outcome Measures : Arm I: To evaluate the ability to increase serum Folate Receptor (FR) levels in patients with newly diagnosed adnexal masses or ovarian cancer utilizing Dexamethasone (DEX) and Valproic Acid (VA). [ Time Frame: Up to 14 days after induction ] FR

2015 Clinical Trials

297. Use of Folate-Based and Other Fortification Scenarios Illustrates Different Shifts for Tails of the Distribution of Serum 25-Hydroxyvitamin D Concentrations. Full Text available with Trip Pro

Use of Folate-Based and Other Fortification Scenarios Illustrates Different Shifts for Tails of the Distribution of Serum 25-Hydroxyvitamin D Concentrations. The purpose of food fortification is to affect those at the lower end of the distribution curve for nutrient status while avoiding unintended consequences for those at the high end of the distribution. Vitamin D presents challenges in this regard.We used scenarios to model changes in concentrations of serum 25-hydroxyvitamin D [25(OH)D (...) with the use of statistical modeling of changes in NHANES serum folate concentrations between prefortification and postfortification time periods.All scenarios suggested the possibility of increasing serum 25(OH)D above 125 nmol/L among the proportion of the population at the high end of baseline serum 25(OH)D distribution. The scenario based on serum folate change struck a middle ground between the 2 conceptual scenarios. It predicted a prevalence of 11% <40 nmol/L serum 25(OH)D compared with 17

2015 Journal of Nutrition

298. The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption Full Text available with Trip Pro

The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption The proton-coupled folate transporter (PCFT-SLC46A1) is the mechanism by which folates are absorbed across the brush-border membrane of the small intestine. The transporter is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of PCFT function, as occurs in the autosomal (...) recessive disorder "hereditary folate malabsorption" (HFM), results in a syndrome characterized by severe systemic and cerebral folate deficiency. Folate-receptor alpha (FRα) is expressed in the choroid plexus, and loss of function of this protein, as also occurs in an autosomal recessive disorder, results solely in "cerebral folate deficiency" (CFD), the designation for this disorder. This paper reviews the current understanding of the functional and structural properties and regulation of PCFT

2016 Molecular Aspects of Medicine

299. Serum Vitamin B12 Concentrations of Patients with Megaloblastic Anaemia After Treatment with Vitamin B12, Folic Acid, or Folinic Acid Full Text available with Trip Pro

Serum Vitamin B12 Concentrations of Patients with Megaloblastic Anaemia After Treatment with Vitamin B12, Folic Acid, or Folinic Acid 13082065 2003 05 01 2018 12 01 0007-1447 2 4837 1953 Sep 19 British medical journal Br Med J Serum vitamin B12 concentrations of patients with megaloblastic anaemia after treatment with vitamin B12, folic acid, or folinic acid. 640-5 MOLLIN D L DL ROSS G I GI eng Journal Article England Br Med J 0372673 0007-1447 0 Hematinics 12001-76-2 Vitamin B Complex (...) 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 Q573I9DVLP Leucovorin OM Anemia therapy Anemia, Megaloblastic Folic Acid therapeutic use Hematinics Humans Leucovorin Vitamin B 12 therapeutic use Vitamin B Complex 5425:2810:26:183:184:502 ANEMIA, HYPERCHROMIC/therapy FOLIC ACID/therapeutic use VITAMIN B12/therapeutic use 1953 9 19 1953 9 19 0 1 1953 9 19 0 0 ppublish 13082065 PMC2029515 Biochem J. 1951 Jan;48(1):1-11 14820776 J Clin Pathol. 1952 Aug;5(3):250-6 14955538 Bull Mem Soc Med Hop Paris. 1951 Feb

1953 British medical journal

300. Effect of ascorbic acid on the serum folic acid estimation Full Text available with Trip Pro

Effect of ascorbic acid on the serum folic acid estimation Ascorbic acid added to the basal medium increased the growth response of Lactobacillus casei in folic acid standards. The effect in the serum extracts was not marked, resulting in lowered serum folic acid estimations. However, results obtained on prolonged incubation were similar whether ascorbic acid was added or not. The presence or absence of ascorbic acid and variation of the incubation period may account for differences in reported (...) normal ranges of serum folic acid levels.

1966 Journal of Clinical Pathology

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