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Serum Folate

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241. Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies. (Full text)

Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies. Folate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration; however, the dose-response between natural food folate and blood folate concentrations (...) criteria. For the six studies using microbiologic assay (MA) included in the meta-analysis, we estimate that a 6% (95% Credible Interval (CrI): 4%, 9%) increase in red blood cell (RBC) folate concentration and a 7% (95% CrI: 1%, 12%) increase in serum/plasma folate concentration can occur for every 10% increase in natural food folate intake. Using modeled results, we estimate that a natural food folate intake of ≥ 450 μg dietary folate equivalents (DFE)/day could achieve the lower bound of an RBC

2015 Nutrients PubMed abstract

242. The Effectiveness of Folate-Fortified Oral Contraceptives in Maintaining Optimal Folate Levels to Protect Against Neural Tube Defects: A Systematic Review. (Full text)

inception to June 2013 that evaluated oral contraceptive use and folate status. Case-control studies, cohort studies, and clinical trials were included. Efficacy and bioequivalence data were evaluated from included studies.Overall, efficacy and bioequivalence data for the folate-fortified oral contraceptive show that it is at least as effective as folic acid alone in raising blood folate concentrations, and that the concomitant administration of folate with the oral contraceptive component does (...) The Effectiveness of Folate-Fortified Oral Contraceptives in Maintaining Optimal Folate Levels to Protect Against Neural Tube Defects: A Systematic Review. To conduct a systematic review evaluating the effectiveness of a folate-fortified oral contraceptive preparation in increasing blood folate concentrations to levels providing optimal protection against neural tube defects (> 906 nmol/L).We searched Medline, EMBASE, Web of Science, and the Cochrane Library for human studies published from

2015 Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC PubMed abstract

243. Folic-acid Deficiency in Rheumatoid Arthritis: Relation of Levels of Serum Folic-acid Activity of Treatment with Phenylbutazone (Full text)

Folic-acid Deficiency in Rheumatoid Arthritis: Relation of Levels of Serum Folic-acid Activity of Treatment with Phenylbutazone 5910105 1966 06 26 2018 11 13 0007-1447 1 5490 1966 Mar 26 British medical journal Br Med J Folic-acid deficiency in rheumatoid arthritis: relation of levels of serum folic-acid activity to treatment with phenylbutazone. 765-7 Deller D J DJ Urban E E Ibbotson R N RN Horwood J J Milazzo S S Robson H N HN eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 (...) Folic Acid GN5P7K3T8S Phenylbutazone H806S4B3NS Oxyphenbutazone P6YC3EG204 Vitamin B 12 AIM IM Anemia, Macrocytic etiology Arthritis, Rheumatoid drug therapy metabolism Blood Female Folic Acid metabolism Folic Acid Deficiency etiology Humans Male Oxyphenbutazone Phenylbutazone adverse effects Vitamin B 12 1966 3 26 1966 3 26 0 1 1966 3 26 0 0 ppublish 5910105 PMC1844524 Med Klin (Munich). 1952 Oct 17;47(42):1397-1401 13001915 Proc R Soc Med. 1954 Jun;47(6):426-7 13177546 Ann Rheum Dis. 1955 Mar;14(1

1966 British medical journal PubMed abstract

244. Evaluation of Assessment of Folic-Acid Deficiency by Serum Folic-Acid Activity Measured with L. casei (Full text)

Evaluation of Assessment of Folic-Acid Deficiency by Serum Folic-Acid Activity Measured with L. casei 13881119 1998 11 01 2018 12 01 0008-4409 85 1961 Oct 28 Canadian Medical Association journal Can Med Assoc J Evaluation of assessment of folic-acid deficiency by serum folic-acid activity measured with L. casei. 987-8 COOPER B A BA LOWENSTEIN L L eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 935E97BOY8 Folic Acid OM Folic Acid Folic Acid Deficiency Hematologic Tests Humans (...) Lactobacillus chemistry FOLIC ACID/deficiency LACTOBACILLUS/chemistry 1961 10 28 1961 10 28 0 1 1961 10 28 0 0 ppublish 13881119 PMC1848491 J Clin Pathol. 1952 May;5(2):129-39 14938452 J Biol Chem. 1956 Aug;221(2):865-72 13357481 Proc Soc Exp Biol Med. 1960 Aug-Sep;104:536-9 13695343 J Clin Invest. 1961 Jan;40:81-91 13713522

1961 Canadian Medical Association Journal PubMed abstract

245. Comparative analysis of serum iron, serum ferritin and red cell folate levels among breast fed, fortified milk and cow’s milk fed infants (Full text)

Comparative analysis of serum iron, serum ferritin and red cell folate levels among breast fed, fortified milk and cow’s milk fed infants Iron and folic acid are essential nutrients needed for hematopoiesis. Infants' diet is commonly deficient in these micronutrients that lead to nutritional anemia. Aim of this study was to determine serum iron, serum ferritin and red cell folate levels among healthy breast fed, fortified milk and cow's milk fed infants.A total of 120 infants of 4-9 months (...) milk group (p<0.0001 and p<0.02) whereas serum iron level showed no significant difference, a p-value being 0.38.Healthy breast fed infants do not need any supplementation and fortification of iron and folic acid. Fortified milk appears to be an acceptable alternative in the absence of breast milk whereas cow's milk is a poor source of iron and folic acid in infants.

2015 Pakistan Journal Of Medical Sciences PubMed abstract

246. Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency (Full text)

Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency S-adenosyl methionine, which is formed from methionine, is an essential methyl donor within the central nervous system. Methionine is formed by the enzyme methionine synthase for which 5-methyltetrahydrofolate (5-MTHF) and homocysteine are substrates. Patients with severe (...) deficiency (enzyme activity ≤1% of controls) who had undetectable levels of CSF 5-MTHF at diagnosis and while on treatment with either folic acid or calcium folinate. Only treatment with oral 5-MTHF given as calcium mefolinate at doses of 15-60 mg/kg/day resulted in an increase in CSF 5-MTHF.

2016 JIMD reports PubMed abstract

247. Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice. (Full text)

metabolism and cognitive function in mice. Seven-week-old mice were fed with either a CFD or control diet for 25 weeks. Serum folate was significantly reduced, whereas serum total homocysteine was significantly increased in the CFD group. Moreover, CFD induced obesity after a 6-week diet treatment, glucose intolerance and insulin resistance after a 16-week-diet treatment. In addition, CFD reduced the hepatic p-Akt/Akt ratio in response to acute insulin administration. Moreover, CFD increased serum (...) Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice. Previous studies have shown that folate levels were decreased in patients with type 2 diabetes (T2D) and further lowered in T2D patients with cognitive impairment. However, whether folate deficiency could cause T2D and subsequent cognitive dysfunction is still unknown. The present study aimed to explore the effects of chronic folate deficiency (CFD) on glucose and lipid

2018 PLoS ONE PubMed abstract

248. Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. (Full text)

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. There is evidence that maternal genotypes in folate-related genes are associated with pediatric acute lymphoblastic leukemia (ALL) independent of offspring genotype. We evaluated the relationship between maternal genotypes in methionine synthase (MTR) and DNA methylation status in ALL to better characterize the molecular mechanism underlying this association.We obtained bone marrow samples from 51 (...) in ALL and Ingenuity Pathway Analysis to identify networks enriched for differentially methylated genes.Twenty-two cases (43%) demonstrated promoter hypermethylation, which was more frequent among those with ETV6-RUNX1 fusion and initial white blood cell count < 50 x 109/L. Maternal rs12759827 was associated with aberrant DNA methylation (odds ratio [OR] 4.67, 95% confidence interval 1.46-16.31); non-significantly elevated ORs were observed for all other SNPs. Aberrantly methylated promoter CpGs

2018 PLoS ONE PubMed abstract

249. The role of the folate pathway in pancreatic cancer risk. (Full text)

The role of the folate pathway in pancreatic cancer risk. Pancreatic cancer is the third leading cause of cancer related deaths in the United States. Several dietary factors have been identified that modify pancreatic cancer risk, including low folate levels. In addition to nutrition and lifestyle determinants, folate status may be influenced by genetic factors such as single nucleotide polymorphisms (SNPs). In the present study, we investigated the association between folate levels, genetic (...) polymorphisms in genes of the folate pathway, and pancreatic cancer.Serum and red blood cell (RBC) folate levels were measured in pancreatic cancer and control subjects. Genotypes were determined utilizing Taqman probes and SNP frequencies between cases and controls were assessed using Fisher's exact test. Logistic regression was used to estimate the odds ratio (OR) and corresponding 95% confidence intervals (CIs) to measure the association between genotypes and pancreatic cancer risk. The association

2018 PLoS ONE PubMed abstract

250. Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study. (Full text)

increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while (...) study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds

2018 PLoS ONE PubMed abstract

251. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials

High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

252. Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Asse (Full text)

Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Asse Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics (...) and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ

2009 DARE. PubMed abstract

253. The prevalence of low serum vitamin B-12 status in the absence of anemia or macrocytosis did not increase among older U.S. adults after mandatory folic acid fortification. (Full text)

The prevalence of low serum vitamin B-12 status in the absence of anemia or macrocytosis did not increase among older U.S. adults after mandatory folic acid fortification. Whether folic acid fortification and supplementation at the population level have led to a higher prevalence of vitamin B-12 deficiency in the absence of anemia remains to be examined among a nationally representative sample of older U.S. adults. We assessed the prevalence of low vitamin B-12 status in the absence of anemia (...) (95% CI): 0.82 (0.72, 0.94)] were both significantly lower after fortification. After fortification, higher folic acid intake was associated with a lower prevalence of low serum B-12 status in the absence of anemia or macrocytosis. Results suggest that the prevalence of low serum B-12 status in the absence of anemia or macrocytosis among older U.S. adults did not increase after fortification. Thus, at the population level, we found no evidence to support concerns that folic acid adversely affected

2014 Journal of Nutrition PubMed abstract

254. The association between high serum or red blood cell folate concentrations and negative health outcomes in humans

The association between high serum or red blood cell folate concentrations and negative health outcomes in humans Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2014 PROSPERO

255. Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. (Abstract)

Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. The aim of this meta-analysis is to explore the relationship between plasma total homocysteine (tHcy) levels, serum folic acid, vitamin B12 and vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype and risk of pseudoexfoliation glaucoma (PEXG).A systematic search of EMBASE and PubMed of relevant articles was carried out for all (...) published articles. Main outcome measures included the calculation of plasma tHcy levels, serum folic acid, vitamin B12, and vitamin B6 levels mean difference and odds ratios (OR) of MTHFR C677T genotype between cases and controls.There were 14 studies for tHcy (485 cases and 456 controls), five studies for folic acid (188 cases and 189 controls), six studies for vitamin B12 (199 cases and 225 controls), three studies for vitamin B6 (128 cases and 130 controls) and eight studies for MTHFR (479 cases

2012 Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

256. Impact of Iron/Folic Acid vs Folic Acid Supplements During Pregnancy on Maternal and Child Health

Impact of Iron/Folic Acid vs Folic Acid Supplements During Pregnancy on Maternal and Child Health Impact of Iron/Folic Acid vs Folic Acid Supplements During Pregnancy on Maternal and Child Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Impact of Iron/Folic Acid vs Folic Acid Supplements During Pregnancy on Maternal and Child Health The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02221752 Recruitment Status : Completed First Posted : August 20, 2014 Last Update Posted : August 20, 2014

2014 Clinical Trials

257. The role of folic acid supplementation and fortification in fetal outcomes: a systematic review and meta-analysis

The role of folic acid supplementation and fortification in fetal outcomes: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2017 PROSPERO

258. The effect of folic acid supplementation on pregnancy outcomes: a systematic review and meta-analysis

The effect of folic acid supplementation on pregnancy outcomes: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2017 PROSPERO

259. The effect of preconceptional paternal folic acid use on semen quality, fecundabililty and pregnancy outcomes a systematic review

The effect of preconceptional paternal folic acid use on semen quality, fecundabililty and pregnancy outcomes a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) , timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year

2017 PROSPERO

260. Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults [Cochrane protocol]

Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2017 PROSPERO

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