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Serum Folate

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2421. Do folate induced changes in serum homocysteine affect leukocyte concentrations in patients with ischaemic heart disease? (PubMed)

Do folate induced changes in serum homocysteine affect leukocyte concentrations in patients with ischaemic heart disease? 11738076 2002 01 23 2013 11 21 0049-3848 104 5 2001 Dec 01 Thrombosis research Thromb. Res. Do folate induced changes in serum homocysteine affect leukocyte concentrations in patients with ischaemic heart disease? 343-5 Wald D S DS Wolfson Institute of Preventive Medicine, Charterhouse Square, EC1M 6BQ, London, UK. davidwald@hotmail.com Hennessy E E Law M M eng Clinical

2002 Thrombosis research

2422. Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects. (PubMed)

Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects. Serum folate and vitamin B12 concentrations in early pregnancy were compared for 32 mothers with pregnancies affected by neural tube defects and 395 randomly selected pregnant control women from the same maternity hospitals. No significant differences were found between the affected mothers and the controls in the median values and frequency distributions of either vitamin. Sixteen (...) of the samples from mothers whose infants had neural tube defects were taken between 9 and 13 weeks' gestation and 11 of these had both serum folate and vitamin B12 concentrations within the normal ranges for our laboratory. These findings are discussed in relation to the concept of folate deficiency as a major factor in the aetiology of neural tube defects.

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1985 Archives of Disease in Childhood

2423. Importance of low serum vitamin B12 and red cell folate concentrations in elderly hospital inpatients. (PubMed)

Importance of low serum vitamin B12 and red cell folate concentrations in elderly hospital inpatients. To determine the functional importance of the low B12 and red cell folate concentrations repeatedly observed in the elderly 200 consecutive patients admitted to a geriatric unit were studied. Forty six of the patients had low serum concentrations of B12 (15), red cell folate (26), or both (five). Serum B12 and red cell folate concentrations correlated with mean cell volume, and serum B12 (...) correlated with the neutrophil lobe count. Bone marrow deoxyuridine suppression was abnormal in 35% of the patients with low vitamin concentrations, but 55% of those with abnormal deoxyuridine suppression had morphologically normal bone marrow, and 73% had a normal mean cell volume. In patients with low vitamin values the deoxyuridine suppressed value correlated with the haemoglobin concentration and neutrophil lobe count. Thus synthesis of thymidylate was impaired by vitamin B12 or folate deficiency

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1985 Journal of Clinical Pathology

2424. Serum Vitamin B12 and Folate Levels in Women Taking Oral Contraceptives (PubMed)

Serum Vitamin B12 and Folate Levels in Women Taking Oral Contraceptives Serum vitamin B(12) and erythrocyte folate levels were determined in a group of healthy women eating a balanced diet. Approximately 50% were using oral contraceptives. Vitamin B(12) levels were lower in the oral contraceptive users. However, their folate levels were no different from those of non-users. Age had no effect on either vitamin B(12) or folate levels. Oral contraceptive users taking multiple vitamin tablets (...) containing vitamin B(12) and folate had slightly higher folate levels, but their vitamin B(12) levels were no different from those of OC users who were not taking vitamin tablets. Hemoglobin and hematocrit levels were not affected by oral contraceptive steroids. No case of megaloblastosis was found. Regular folate supplementation is not required for OC users. In fact, such supplementation may be dangerous.

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1986 Canadian Family Physician

2425. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. (PubMed)

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. To determine if levels of serum total homocysteine are elevated in patients with either cobalamin or folate deficiency, we utilized a new capillary gas chromatographic-mass spectrometric technique to measure total homocysteine in the serum of 78 patients with clinically confirmed cobalamin deficiency and 19 patients with clinically confirmed (...) folate deficiency. Values ranged from 11 to 476 mumol/liter in the cobalamin-deficient patients and 77 of the 78 patients had values above the normal range of 7-22 mumol/liter as determined for 50 normal blood donors. In the cobalamin-deficient patients, serum total homocysteine was positively correlated with serum folate, mean corpuscular volume, serum lactate dehydrogenase, serum methylmalonic acid, and the degree of neurologic involvement, and inversely correlated with platelets and hematocrit

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1988 Journal of Clinical Investigation

2426. An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy. (PubMed)

An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy. Lamotrigine (LTG) is a new antiepileptic drug which is effective in refractory epilepsy and which has been shown to have weak antifolate properties in vitro. The effect of LTG on serum folate and red cell folate (RBC) concentrations was assessed in a series of 14 patients on short-term LTG treatment during a placebo-controlled double-blind study. A further 14 patients who had been (...) treated with LTG for up to 5 years were also assessed. In the short-term double-blind study the baseline mean serum folate concentration was 2.7 ng/ml and mean RBC folate concentration was 295 ng/ml. After 12 weeks of LTG therapy mean concentrations were 3.3 ng/ml and 339 ng/ml respectively and corresponding levels after 12 weeks of placebo were 2.4 ng/ml and 288 ng/ml. Patients on chronic LTG therapy showed no significant difference in RBC folate concentrations compared to those prior to LTG therapy

1992 Epilepsy research

2427. Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial. (PubMed)

Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial. Photodegradation of certain vitamins such as riboflavins, carotinoids, tocopherol, and folate has been well-documented. Previous observations suggest that ultraviolet (UV) radiation may cause folate deficiency. This is of great importance since folate deficiency is also known to be linked with the development of neural tube defects. To investigate the influence of UVA radiation on serum folate levels (...) UVA exposures weekly within three weeks (cumulative UVA dose: 96 J/cm2). Volunteers of the control group had no UVA exposures. Serum folate was analysed with an automated immunoassay system.At all times of blood collection the differences between serum folate levels were insignificant (P > 0.05), except of the non-exposed controls at T2 (P < 0.05). We did not observed significant differences of folate levels between UVA exposed and non-exposed volunteers (P > 0.05).Our data suggest that both

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2001 BMC dermatology

2428. Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. (PubMed)

Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. To determine the minimum effective dose of folic acid required to appreciably increase serum folate and to produce a significant reduction in plasma total homocysteine (tHcy).Double-blind, randomised placebo-controlled intervention trial.Community-based project in a New Zealand city.Seventy free living men and women with tHcy> or =10 micromol (...) /l. Mean age (range) was 58 (29-90) y.Daily consumption over 4 weeks of 20 g breakfast cereal either unfortified (placebo) or fortified with 100, 200 or 300 microg folic acid. Dietary intake was determined by weighed diet records and consumption of commercially fortified products was avoided.Plasma tHcy and serum folate concentrations.Average serum folate concentrations (95% CI) increased significantly in the treatment groups relative to the control group by 28(9-51)%, 60(37-87)% and 79(51-114

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2002 European journal of clinical nutrition

2429. Serum folate and vitamin B12 levels in patients with small cell lung cancer. (PubMed)

Serum folate and vitamin B12 levels in patients with small cell lung cancer. Serum folate and vitamin B12 levels were evaluated in 80 patients with small cell lung cancer at diagnosis and during therapy over a 30-week period. Approximately one half of the patients were randomized to receive hyperalimentation. Folate and vitamin B12 intake was adequate without parenteral nutrition in these cancer patients. Serum folate and Vitamin B12 levels did not correlate with disease extent (...) . At the initiation of therapy, serum folate declined with increasing weight loss. During therapy, the intake of folate was adequate to maintain a normal serum folate despite marked weight loss.

1984 Cancer

2430. The effect of dietary levels of folate and cobalamin on the serum concentration of folate and cobalamin in the dog. (PubMed)

The effect of dietary levels of folate and cobalamin on the serum concentration of folate and cobalamin in the dog. 7996237 1995 01 19 2018 05 07 0022-3166 124 12 Suppl 1994 12 The Journal of nutrition J. Nutr. The effect of dietary levels of folate and cobalamin on the serum concentration of folate and cobalamin in the dog. 2559S-2562S 10.1093/jn/124.suppl_12.2559S Davenport D J DJ Mark Morris Associates, Topeka, Kansas 66617. Ching R J RJ Hunt J H JH Bruyette D S DS Gross K L KL eng Clinical

1995 The Journal of nutrition

2431. Folate status of gastrointestinal epithelial cells is not predicted by serum and red cell folate values in replete subjects. (PubMed)

Folate status of gastrointestinal epithelial cells is not predicted by serum and red cell folate values in replete subjects. Localised folate deficiency has been implicated in colonic carcinogenesis and supplementation has been proposed for certain populations at risk. However, identifying those groups that may benefit is difficult as the relation between blood folate and gut epithelial cell values is unknown. The aim of this study was to define this relation. Epithelial cells mean (SEM (...) = 11) than sigmoid values, whereas duodenal isolates mirrored those of the sigmoid (19.4 (2.9) v 20.5 (3.2), n = 5). Sigmoid folate values were consistent over one to three weeks (n = 3). In a single case with blood folate deficiency, colonic values were normal. Serum folate and red cell folate correlated poorly with sigmoid epithelial cell folate content (r = 0.41, p = 0.063 and r = 0.17, p > 0.05 respectively). This study reports a modified ion-chelation isolation method for colonic biopsy

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1996 Gut

2432. Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine. (PubMed)

Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine. The association between vascular disease and elevated plasma total homocysteine (tHcy) concentrations is caused, in part, by inadequate intakes of dietary folate. Increasing folate intake either through supplements or foods naturally rich in folates has been shown to decrease tHcy concentrations.The aim (...) of this study was to determine whether a similar reduction in tHcy was possible in free-living persons receiving dietary counseling.The study included a 4-wk placebo-controlled dietary intervention trial in which participants consumed either unfortified breakfast cereal (control group) or an extra 350 micro g folate derived from food/d (dietary group). Serum folate and tHcy concentrations in both groups were measured before and after the intervention period, and the concentrations in the dietary group were

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2002 The American journal of clinical nutrition

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