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Serum Folate

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221. Hepatic and serum folates in patients fasting and after oral folic acid (PubMed)

Hepatic and serum folates in patients fasting and after oral folic acid The hepatic folate in non-anaemic hospital patients was found to correlate poorly with the fasting serum folate. The rise in methylfolate in the systemic circulation following the absorption of folic acid was directly related to the folate content of the liver.

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1971 Journal of Clinical Pathology

222. Acute effect of phenytoin on serum folate concentration. (PubMed)

Acute effect of phenytoin on serum folate concentration. 5572309 1971 06 19 2018 11 13 0007-1188 41 2 1971 Feb British journal of pharmacology Br. J. Pharmacol. Acute effect of phenytoin on serum folate concentration. 414P-415P Richens A A Waters A H AH eng Journal Article England Br J Pharmacol 7502536 0007-1188 6158TKW0C5 Phenytoin 935E97BOY8 Folic Acid IM Folic Acid blood Humans Phenytoin blood pharmacology Time Factors 1971 2 1 1971 2 1 0 1 1971 2 1 0 0 ppublish 5572309 PMC1703288 Lancet

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1971 British journal of pharmacology

223. Diagnostic value of the serum folate assay (PubMed)

Diagnostic value of the serum folate assay The diagnostic value of the serum folate assay has been assessed in 90 patients, each of whom had a macrocytic anaemia and a low serum vitamin B(12) level. Twenty-nine (32%) patients were found to have anaemia due primarily to folate deficiency. The cause of the low serum vitamin B(12) levels is uncertain in the 22 (25%) patients with normal or borderline vitamin B(12) absorption. The effect of folic acid therapy was studied in four of these patients (...) , and in each case the serum vitamin B(12) rose slowly to a normal level. The serum folate was low in only four (7.5%) of the 54 patients with pernicious anaemia, and the levels rose to normal on treatment with vitamin B(12) alone. A high serum folate occurred in eight (15%) pernicious anaemia patients. A normal serum folate indicated the diagnosis of pernicious anaemia or megaloblastic anaemia following partial gastrectomy. However, a normal serum folate and a very low vitamin B(12) level was found in two

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1971 Journal of Clinical Pathology

224. Impaired utilization of serum folate in pernicious anemia: A study with radiolabeled 5-methyltetrahydrofolate (PubMed)

Impaired utilization of serum folate in pernicious anemia: A study with radiolabeled 5-methyltetrahydrofolate The possible role of cobalamins in the utilization of serum methyltetrahydrofolate has been investigated by means of radiolabeled methyltetrahydrofolate in subjects suffering from pernicious anemia. After intravenous administration, methyltetrahydrofolate-(3)H (SA 11,500 Ci/mole; dose 0.05 mug/kg) was cleared from the serum to tissues of B(12)-deficient subjects half as fast as after (...) the same subjects had received vitamin B(12) therapy. B(12) deficiency was also associated with an increased rate of renal excretion of methyltetrahydrofolate or its derivatives, and a decreased rate of renal metabolism of methyltetrahydrofolate to other urinary folate derivatives.Intravenously administered methyl-(14)C-tetrahydrofolate-(3)H at a higher dose (5 mug/kg) caused a severalfold elevation of the total serum folate concentration and, in B(12)-deficient subjects, it did not disappear from

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1972 Journal of Clinical Investigation

225. A comparison of serum folate estimations using two different methods. (PubMed)

A comparison of serum folate estimations using two different methods. 4632762 1973 05 23 2018 11 13 0021-9746 26 1 1973 Jan Journal of clinical pathology J. Clin. Pathol. A comparison of serum folate estimations using two different methods. 80-1 O'Broin J D JD Scott J M JM Temperley I J IJ eng Comparative Study Journal Article England J Clin Pathol 0376601 0021-9746 66974FR9Q1 Chloramphenicol 935E97BOY8 Folic Acid AIM IM Biological Assay Chloramphenicol Folic Acid blood Humans Lactobacillus

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1973 Journal of Clinical Pathology

226. Effect of Alcohol on Serum Folate Level (PubMed)

Effect of Alcohol on Serum Folate Level Alcohol was given orally and intravenously to normal and chronic alcoholic volunteers to study its effect on folate metabolism. Oral alcohol, given to nine subjects on a low folate diet, caused a greater fall in serum Lactobacillus casei folate levels than that seen in eight subjects on a low folate diet alone. This alcohol-induced fall in serum folate level occurred largely during the 1st day of the protocol. Although brief infusions of intravenous (...) ethanol had no effect on serum folate level, a 13 h infusion caused a striking fall in serum folate level between the 8th and 10th h. When ethanol was stopped, the serum folate level returned rapidly to normal. Two chronic alcoholic subjects with different basal levels of serum folate were studied for several weeks on a low folate diet plus alcohol. The serum folate level fell promptly in each subject, rose when alcohol was temporarily stopped, and fell when alcohol was resumed. Folate-deficient

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1973 Journal of Clinical Investigation

227. Folates in human serum (PubMed)

Folates in human serum Constituent serum folates have been shown to be altered and in some cases raised in diseases in which total folate levels are known to be frequently decreased. Absorption experiments showed that orally administered folate analogues affect the folate pool in different ways. The stability of the 10-formyltetrahydrofolate level in normal subjects is demonstrated.

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1974 Journal of Clinical Pathology

228. Coeliac disease during the teenage period: The value of serial serum folate estimations (PubMed)

Coeliac disease during the teenage period: The value of serial serum folate estimations A group of teenage coeliac patients has been followed at three monthly intervals in the Outpatient Department to assess their progress and also to monitor their ability to maintain a gluten-free diet. After a follow-up period of four to six years a detailed reassessment was carried out in hospital on 10 patients, only five of whom had persevered with a gluten-free diet. The jejunal mucosal histology of those (...) patients who did not persist with a gluten-free diet remained ;flat' although these patients appeared to have remitted clinically. Those subjects who did persist with a gluten-free regime had a normal or near normal mucosal histology. It was difficult on the basis of clinical, haematological, or biochemical criteria to separate the two groups. The best single assessment of whether these patients were maintaining a gluten-free diet was serial serum folate estimations. It is often extremely difficult

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1974 Gut

229. Serum and erythrocyte folate levels in low birthweight infants (PubMed)

Serum and erythrocyte folate levels in low birthweight infants 21032515 2012 10 02 2011 04 04 1468-2044 49 9 1974 Sep Archives of disease in childhood Arch. Dis. Child. Serum and erythrocyte folate levels in low birthweight infants. 749 Kenna A P AP Hibbard E D ED eng Journal Article England Arch Dis Child 0372434 0003-9888 2010 10 30 6 0 1974 9 1 0 0 1974 9 1 0 1 ppublish 21032515 PMC1649030

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1974 Archives of Disease in Childhood

230. Folic acid clearances and basal serum folate levels in patients with thyroid disease (PubMed)

Folic acid clearances and basal serum folate levels in patients with thyroid disease The plasma clearance of intravenously administered folic acid was abnormally rapid in all of five patients studied with untreated hyperthyroidism; in three, the basal serum L. casei folate level was subnormal. Four of these patients and another patient were studied at various intervals after partial or complete correction of the hyperthyroid state. Partial correction resulted in a continued fast clearance (...) in one patient, a return to borderline-normal values in the second, and a normal clearance in the third. Complete euthyroidism was achieved in two patients; their clearance values had returned to borderline-normal at this time. In two patients studied after partial correction, the serum L. casei folate levels had become normal whereas the clearance values remained abnormally rapid. These findings suggest that hyperthyroidism in man is associated with depletion of folate stores and subclinical

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1964 Journal of Clinical Pathology

231. Folic acid for depression: results of the FolATED study

Cost effectiveness No significant differences were found in resource use and costs between the folic acid and placebo groups – treatment taken by the folic acid group was just £48 cheaper on average, when costs were adjusted for group differences at baseline. Similarly, there were no significant differences between the folic acid and placebo groups in gain of quality-adjusted life years (QALYs). Biochemistry (undertaken through blood tests at 0, 12 and 25 weeks) Serum and red cell folate (...) Folic acid for depression: results of the FolATED study Folic acid for depression: FolATED study Search National Elf Service Search National Elf Service » » » » Folic acid for depression: results of the FolATED study Jan 14 2015 Posted by Depression is a common condition, affecting hundreds of millions of people around the world and has become the leading cause of disability in Europe. Although incredibly prevalent, treatment for depression is not always effective, with only one third

2015 The Mental Elf

232. A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults. (PubMed)

A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults. Background: The effects of high-dose folic acid (FA) supplementation in healthy individuals on blood folate concentrations and immune response are unknown.Objective: The aim of the study was to evaluate the effects of daily consumption of a tablet containing 5 mg FA on serum folate; number and cytotoxicity of natural (...) of the intervention. Serum folate concentrations were measured by microbiological assay and HPLC-tandem mass spectrometry [folate forms, including unmetabolized folic acid (UMFA)]. We used real-time polymerase chain reaction to assess mononuclear leukocyte mRNA expression and flow cytometry to measure the number and cytotoxicity of NK cells.Results: Serum folate concentrations increased by ∼5-fold after the intervention (P < 0.001), and UMFA concentrations increased by 11.9- and 5.9-fold at 45 and 90 d

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2017 Journal of Nutrition

233. Two International Round-Robin Studies Showed Good Comparability of 5-Methyltetrahydrofolate but Poor Comparability of Folic Acid Measured in Serum by Different High-Performance Liquid Chromatography-Tandem Mass Spectrometry Methods. (PubMed)

Two International Round-Robin Studies Showed Good Comparability of 5-Methyltetrahydrofolate but Poor Comparability of Folic Acid Measured in Serum by Different High-Performance Liquid Chromatography-Tandem Mass Spectrometry Methods. Background: Serum folate methods produce different results. The comparability of HPLC-mass spectrometry (MS)/MS methods is not well documented.Objective: We conducted an international "round-robin" investigation to assess the comparability, precision, and accuracy (...) of serum folate HPLC-MS/MS methods.Methods: The CDC laboratory, 7 laboratories with independently developed methods (group 1), and 6 laboratories with an adapted CDC method (group 2) analyzed folate forms in 6 serum pools and 6 calibrators from the CDC (duplicate analysis over 2 d) and in two 3-level reference materials (duplicate analysis).Results: All laboratories measured 5-methyltetrahydrofolate (5-methylTHF) and folic acid; some measured additional folate forms. The geometric mean (range

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2017 Journal of Nutrition

234. Association between serum unmetabolized folic acid concentrations and folic acid from fortified foods (PubMed)

Association between serum unmetabolized folic acid concentrations and folic acid from fortified foods To investigate the association between serum unmetabolized folic acid (UMFA) concentrations and folic acid from fortified foods and nutrients known as dietary methyl-group donors (folate, methionine, choline, betaine and vitamins B2, B6 and B12) in participants exposed to mandatory fortification of wheat and maize flours with folic acid.Cross-sectional study carried out with 144 healthy (...) Brazilian participants, both sexes, supplement nonusers. Serum folate, UMFA, vitamin B12 and total plasma homocysteine (tHcy) were biochemically measured. Dietary intake was assessed by 2 non-consecutive 24-hour dietary recalls (24-HRs) and deattenuated energy-adjusted nutrient data were used for statistical analysis.Ninety eight (68.1%) participants were women. Median (interquartile range) age was 35.5 (28.0-52.0) years. Elevated serum folate concentrations (>45 nmol/L) were found in 17 (11.8%), while

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2017 Journal of the American College of Nutrition

235. Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus (PubMed)

can lower homocysteine levels and improve parameters related with vascular complications.We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity.Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine (...) pulse wave velocity.In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.

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2017 Nutrition research and practice

236. Association between percent decline in serum total homocysteine and risk of first stroke. (PubMed)

decline in tHcy was assessed as tertiles, a significantly lower stroke risk was found in those in tertiles 2-3 (HR 0.79; 95% CI 0.64-0.97) compared with participants in tertile 1. Similar results were observed for the composite of cardiovascular events. The beneficial effect associated with greater tHcy reduction was observed across strata for age, sex, treatment group (with vs without folic acid), MTHFR C677T genotypes, baseline tHcy and serum folate levels, and blood pressure control.Percent (...) Association between percent decline in serum total homocysteine and risk of first stroke. To examine whether a change in serum total homocysteine (tHcy) levels is associated with first stroke risk in a post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT).We analyzed 16,867 participants of the CSPPT with tHcy measurements at both baseline and exit visits. The primary outcome was first stroke. The secondary outcome was a composite of cardiovascular events consisting

2017 Neurology Controlled trial quality: predicted high

237. Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer

Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02593227 Recruitment Status : Active, not recruiting First Posted : November 2, 2015 Last Update Posted : January 28, 2019

2015 Clinical Trials

238. Intraoperative Folate Targeted Fluorescence in Renal Cell Carcinoma

Intraoperative Folate Targeted Fluorescence in Renal Cell Carcinoma Intraoperative Folate Targeted Fluorescence in Renal Cell Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intraoperative Folate (...) participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Intraoperative Folate Targeted Fluorescence in Renal Cell Carcinoma Actual Study Start Date : December 29, 2015 Actual Primary Completion Date : March 20, 2018 Estimated Study Completion Date : April 2, 2019 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention

2015 Clinical Trials

239. Impact of folate metabolism on Parkinson's disease onset and pathology: a systematic review

Impact of folate metabolism on Parkinson's disease onset and pathology: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2018 PROSPERO

240. Associations between genetic polymorphisms in the folate metabolic pathway with methotrexate pharmacokinetics and methotrexate-induced toxicities in patients with osteosarcoma: a systematic review

Associations between genetic polymorphisms in the folate metabolic pathway with methotrexate pharmacokinetics and methotrexate-induced toxicities in patients with osteosarcoma: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) of reperfusion (if applicable). ">Data to be extracted: animal model Example: Dose, timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score

2018 PROSPERO

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