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Serum Folate

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201. The Effect of Folic Acid Supplementation and Pregnancy on the Folate Forms in Red Blood Cells

The Effect of Folic Acid Supplementation and Pregnancy on the Folate Forms in Red Blood Cells The Effect of Folic Acid Supplementation and Pregnancy on the Folate Forms in Red Blood Cells - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. The Effect of Folic Acid Supplementation and Pregnancy on the Folate Forms in Red Blood Cells The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01741077 Recruitment Status : Completed First Posted : December 4, 2012 Last Update Posted : December 5, 2013 Sponsor

2012 Clinical Trials

202. Hepatic and serum folates in patients fasting and after oral folic acid (Full text)

Hepatic and serum folates in patients fasting and after oral folic acid The hepatic folate in non-anaemic hospital patients was found to correlate poorly with the fasting serum folate. The rise in methylfolate in the systemic circulation following the absorption of folic acid was directly related to the folate content of the liver.

1971 Journal of Clinical Pathology PubMed abstract

203. Folic acid clearances and basal serum folate levels in patients with thyroid disease (Full text)

Folic acid clearances and basal serum folate levels in patients with thyroid disease The plasma clearance of intravenously administered folic acid was abnormally rapid in all of five patients studied with untreated hyperthyroidism; in three, the basal serum L. casei folate level was subnormal. Four of these patients and another patient were studied at various intervals after partial or complete correction of the hyperthyroid state. Partial correction resulted in a continued fast clearance (...) in one patient, a return to borderline-normal values in the second, and a normal clearance in the third. Complete euthyroidism was achieved in two patients; their clearance values had returned to borderline-normal at this time. In two patients studied after partial correction, the serum L. casei folate levels had become normal whereas the clearance values remained abnormally rapid. These findings suggest that hyperthyroidism in man is associated with depletion of folate stores and subclinical

1964 Journal of Clinical Pathology PubMed abstract

204. OS040. Effect of folic acid supplementation in pregnancy on preeclampsia- Folic acid clinical trial (FACT). (Abstract)

of gestation) until delivery in women with high risk of developing PE.FACT is an international, multi-centre, double-blind, placebo controlled clinical trial of 3656 women. Eligible women will be randomised in a 1:1 ratio to folic acid 4.0mg or placebo.Pregnant women (8(0/7)and 16(6/7) weeks of gestation) ⩾18 years of age, taking ⩽1.1mg of folic acid supplementation who fulfill at least one of the following identified risk factors for PE. Pre-existing hypertension (blood pressure ⩾90mmHg on two separate (...) OS040. Effect of folic acid supplementation in pregnancy on preeclampsia- Folic acid clinical trial (FACT). Observational studies suggest that folic acid supplementation during pregnancy can reduce the risk of preeclampsia (PE). No randomized controlled trial has been conducted to demonstrate the effect of folic acid supplementation on PE.FACT aims to determine efficacy on a new PE prevention strategy of high dose folic acid supplementation from early pregnancy (8(0/7) to 16(6/7)weeks

2015 Pregnancy Hypertension Controlled trial quality: predicted high

205. Folic Acid

of the water-soluble form of vitamin B9 (also known as folate). It requires metabolism to dihydrofolic acid and then to its biologically active form tetrahydrofolate. Folate is necessary for the production of blood cells and DNA. Folic acid is used in the treatment of nutritional megaloblastic anaemias and prophylactically in individuals at risk of deficiency e.g. due to chronic haemolysis or renal dialysis. During pregnancy folate requirements are increased 5- to 10-fold and pregnant women are therefore (...) at risk of folate deficiency. Maternal folate deficiency is an established risk factor for neural tube defects. There is good evidence that supplementation with folic acid (when used prior to conception and before closure of the neural tube at doses ≥360mcg) reduces the risk of primary and recurrent NTDs. Some studies have also suggested a reduced risk of spontaneous abortion and congenital heart defects with folic acid supplementation peri-conceptually, however there is no conclusive evidence

2014 UK Teratology Information Service

206. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. (Full text)

Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. This study is to examine the effects of folic acid supplementation on cognitive function in Chinese older adults with mild cognitive impairment who are unexposed to folic acid fortification and assess cognitive functioning in relation to folate, homocysteine, and vitamin B12 values at baseline.This was a single-center, randomized (...) models. This trial has been registered with the trial number ChiCTR-TRC-13003227.Total of 159 participants (intervention group: 80; control group: 79) completed the trial. Repeated-measure analysis of variance showed significant improvements in serum folate (ηp (2) = 0.712, p = .009), homocysteine (ηp (2) = 0.119, p = .017), serum vitamin B12 (ηp (2) = 0.144, p = .022), and S-adenosylmethionine (ηp (2) = 0.117, p = .033) in the intervention group over the control group. Folic acid supplementation

2015 The journals of gerontology. Series A, Biological sciences and medical sciences Controlled trial quality: uncertain PubMed abstract

207. An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of severe neutropenic toxicity. (Full text)

An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of severe neutropenic toxicity. Vitamin B12 and folic acid (referred to as vitamin supplementation) improves the toxicity profile of pemetrexed containing regimens. Low baseline vitamin B12 and folate levels are reflected in a raised total homocysteine level (HC). Studies have suggested (...) that pretreatment HC levels predict neutropenia toxicity. We have tested supplementation with vitamin B12 and folate in non-pemetrexed platinum-based regimens to decrease treatment-related toxicity and looked for a correlation between toxicity and change in homocysteine levels.Eighty-three patients with advanced lung cancer and malignant mesothelioma were randomly assigned to receive platinum-based chemotherapy with (arm A) or without (arm B) vitamin B12 and folic acid supplementation. The primary end point

2015 BMJ open respiratory research Controlled trial quality: uncertain PubMed abstract

208. Folic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial. (Full text)

Folic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial. The World Health Organization estimates that > 140 million people worldwide are exposed to arsenic (As)-contaminated drinking water. As undergoes biologic methylation, which facilitates renal As elimination. In folate-deficient individuals, this process is augmented by folic acid (FA) supplementation, thereby lowering blood As (bAs). Creatinine concentrations in urine are a robust predictor (...) ). There was no rebound in bAs related to cessation of FA supplementation. Declines in bAs observed in the remaining treatment arms were not significantly different from those of the placebo group.In this mixed folate-deficient/replete study population, 12- and 24-week treatment with 800 μg (but not 400 μg) FA lowered bAs to a greater extent than placebo; this was sustained 12 weeks after FA cessation. In future studies, we will evaluate whether FA and/or creatine altered As methylation profiles.

2015 Environmental health perspectives Controlled trial quality: predicted high PubMed abstract

209. Serum Folate

Serum Folate Serum Folate Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Serum Folate Serum Folate Aka: Serum Folate , RBC Folate (...) From Related Chapters II. Interpretation: Normal Range: 2-10 ng/ml III. Interpretation: Decreased Poor intake or malabsorption Medications Trimethoprim ( ) s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Serum Folate." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine About FPnotebook.com is a rapid

2018 FP Notebook

210. Serum homocysteine, folate and vitamin B12 levels in patients with vitiligo: a systematic review and meta-analysis

Serum homocysteine, folate and vitamin B12 levels in patients with vitiligo: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2018 PROSPERO

211. Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a systematic review and meta-analysis

Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2018 PROSPERO

212. Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant

, 2014 Sponsor: St. Michael's Hospital, Toronto Information provided by (Responsible Party): Young In Kim, St. Michael's Hospital, Toronto Study Details Study Description Go to Brief Summary: An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998. Folate is an important co-factor in the transfer of one-carbon units essential in DNA synthesis, repair, and methylation (...) and prior to delivery and a sample of umbilical cord blood was collected at parturition to measure levels of folate status. Global and gene-specific DNA methylation in umbilical cord blood will be correlated with cord and maternal folate status. The data will be analyzed using separate ordinary least squares (OLS) regressions. Results from this study will contribute to a better understanding of how maternal folate and folic acid intake can modulate epigenetic modifications in the offspring

2014 Clinical Trials

213. Folate supplementation in people with sickle cell disease. (Full text)

acid in people with sickle cell disease. A total of 117 children with homozygous sickle cell (SS) disease aged six months to four years of age participated over a one-year period (analysis was restricted to 115 children).Serum folate measures, obtained after trial entry at six and 12 months, were available in 80 of 115 (70%) participants. There were significant differences between the folic acid and placebo groups with regards to serum folate values above 18 µg/l and values below 5 µg/l (...) . In the folic acid group, values above 18 µg/l were observed in 33 of 41 (81 %) compared to six of 39 (15%) participants in the placebo (calcium lactate) group. Additionally, there were no participants in the folic acid group with serum folate levels below 5 µg/l, whereas in the placebo group, 15 of 39 (39%) participants had levels below this threshold. Haematological indices were measured in 100 of 115 (87%) participants at baseline and at one year. After adjusting for sex and age group, the investigators

2016 Cochrane PubMed abstract

214. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. (Abstract)

Effects and safety of periconceptional oral folate supplementation for preventing birth defects. It has been reported that neural tube defects (NTD) can be prevented with periconceptional folic acid supplementation. The effects of different doses, forms and schemes of folate supplementation for the prevention of other birth defects and maternal and infant outcomes are unclear.This review aims to examine whether periconceptional folate supplementation reduces the risk of neural tube and other (...) involving 7391 women (2033 with a history of a pregnancy affected by a NTD and 5358 with no history of NTDs) were included. Four comparisons were made: 1) supplementation with any folate versus no intervention, placebo or other micronutrients without folate (five trials); 2) supplementation with folic acid alone versus no treatment or placebo (one trial); 3) supplementation with folate plus other micronutrients versus other micronutrients without folate (four trials); and 4) supplementation with folate

2015 Cochrane

215. Systematic review and meta-analysis of maternal folic acid supplementation and the risk of orofacial clefts in offspring

Systematic review and meta-analysis of maternal folic acid supplementation and the risk of orofacial clefts in offspring Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2018 PROSPERO

216. Prevalence and determinants of adherence to prenatal iron-folic acid supplementation in Ethiopia: a systematic review and meta-analysis protocol

Prevalence and determinants of adherence to prenatal iron-folic acid supplementation in Ethiopia: a systematic review and meta-analysis protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) , timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year

2018 PROSPERO

217. Folic Acid

) , hematinics folic acid , 2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid , FOLIC ACID , Folic Acid [Chemical/Ingredient] , b c vitamin , vitamin m , pteroylglutamic acid , m vitamins , Vitamin B9 , B9, Vitamin , vitamin B complex , Pteroylglutamic acid , Pteroylmonoglutamic Acid , Pteroylmonoglutamic acid , Lactobacillus casei factor , Folic acid , Folic acid preparation , Folic acid product , Pteroylglutamic acid preparation , FA - Folic acid , Vitamin B>c< , Folic acid (...) in the prevention and treatment of cancer. Definition (NCI_CRCH) Synthetic folate in fortified foods and supplements containing a single glutamate molecule. Definition (NCI) A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05) Definition (MSH

2018 FP Notebook

218. A systematic review of cost-effectiveness studies of mandatory fortification of folic acid in flour for the prevention of neural tube defects

A systematic review of cost-effectiveness studies of mandatory fortification of folic acid in flour for the prevention of neural tube defects Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) , timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year

2018 PROSPERO

219. Adjunctive acid folic for major mental disorders: a meta-analysis of randomized controlled trials

Adjunctive acid folic for major mental disorders: a meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2018 PROSPERO

220. Folic acid for schizophrenia: a systematic review and meta-analysis

Folic acid for schizophrenia: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures (...) , route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted

2018 PROSPERO

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