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Serum Folate

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201. Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. (PubMed)

Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. Current methods for measuring folates in clinical laboratories are competitive folate binding protein assays. These assays show a considerable lack of agreement that has implications for the comparability of data across studies as well as for long-term population studies. The development of isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS (...) ) reference methods permitted the evaluation of method accuracy and consistency over time.We measured 3 pools of human serum by ID-LC-MS/MS, calculated values for total folate, and distributed the same pools to participants in a national External Quality Assessment scheme. We used linear regression to compare the all-laboratory and method data with reference method values. The exercise was repeated after 18 months to assess the stability of the all-laboratory and method data.The distributed serum pools

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2011 Clinical Chemistry

202. Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. (PubMed)

Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. High folate intake has been suggested as an important factor in cancer prevention; however, previous studies on the relation among folate intake, serum folate, and plasma homocysteine (hcy) are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6 and B (...) ) and GRS ≤ 3. The CIN2+ risk of lower serum vitamin B-6 and GRS ≥ 4 was 2.14 (0.92, 5.02) (P-trend = 0.05) and lower serum folate (below the median) and GRS ≥ 4 was 0.49 (0.20, 1.17) (P-trend = 0.05) after adjustment for confounding variables and human papillomavirus infection. Our data suggest that polymorphisms in genes related to folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia.

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2013 Journal of Nutrition

203. Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review.

included 26 studies. We conclude that both serum and erythrocyte folate values reflect folate intake; however, serum folate reacts more rapidly to folate intake than erythrocyte folate. As to health outcomes, we found no evidence indicating that additional intake of folate can influence haematological parameters in non-anaemic paediatric patients. We were unable to find evidence of a favourable effect of folate supplementation on the growth of infants. However, the limited data available suggest (...) that supplementing the diet of low-birth-weight infants with folic acid may moderate the rapid fall of serum and red cell folate in the first months of life.

2013 International journal of food sciences and nutrition

204. Purification of folate binding factor in normal umbilical cord serum. (PubMed)

Purification of folate binding factor in normal umbilical cord serum. Human umbilical cord serum was found to contain both free folate and folate complexed to a high-molecular weight factor. The complexed folate was bound to a very high affinity binder and was present in concentrations equivalent to as much as 60 ng of 5-methyltetrahydrofolic acid per ml of serum. Acidification of the serum caused disassociation of the folate-binder complex. Released folates were separated from binder (...) ]pteroylglutamic acid and nonradioactive folate derivatives. Oxidized folates were bound in preference to reduced derivatives, but only three to four times more unlabeled 5-methyltetrahydrofolic acid than pteroylglutamic acid was required to produce an equal level of competition. The strong affinity for 5-methyltetrahydrofolic acid, the main serum folate, suggests that the binder could be part of the mechanism by which the fetus concentrates maternally supplied folate for its growth and development.

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1975 Proceedings of the National Academy of Sciences of the United States of America

205. Serum folate values in 423 psychiatric patients. (PubMed)

Serum folate values in 423 psychiatric patients. 6065984 1968 02 13 2018 11 13 0007-1447 4 5578 1967 Dec 02 British medical journal Br Med J Serum folate values in 423 psychiatric patients. 512-6 Carney M W MW eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Adolescent Adult Age Factors Aged Biological Assay Child Female Folic Acid blood Humans Male Mental Disorders blood drug therapy Middle Aged Sex Factors Vitamin B 12 blood 1967 12 2

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1967 British medical journal

206. Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases (PubMed)

Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases 5217755 1966 05 27 2018 11 13 0007-1447 1 5487 1966 Mar 05 British medical journal Br Med J Serum lactic dehydrogenase activity and folate deficiency in myelosclerosis and other haematological diseases. 577-81 Hoffbrand A V AV Kremenchuzky S S Butterworth P J PJ Mollin D L DL eng Journal Article England Br Med J 0372673 0007-1447 EC 1.1.1.27 L-Lactate Dehydrogenase AIM IM Anemia

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1966 British medical journal

207. Aseptic addition method for Lactobacillus casei assay of folate activity in human serum (PubMed)

Aseptic addition method for Lactobacillus casei assay of folate activity in human serum An ;aseptic addition' method is described for microbiological assay with Lactobacillis casei of folate activity in human serum. It has the following advantages over the previously reported ;standard' method. 1 The manipulations involved in the assay are halved, by deleting autoclaving of serum in buffers. 2 The use of 1 g.% ascorbate better preserves serum folates than the lower amounts of ascorbate which (...) are the maximum quantities usable in the standard methods. 3 Only 0.3 ml. of serum is required (0.1 ml. for one sample; 0.2 ml. for its duplicate).

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1966 Journal of Clinical Pathology

208. Serum folates in man. (PubMed)

Serum folates in man. In an aseptic microbiological assay of folate compounds and their breakdown compounds, using Lactobacillus casei, Streptococcus faecalis, and Pediococcus cerevisiae, 4a-hydroxy-5methyl-4,5,6,7-tetrahydrofolate and 5-methyl-5,8-dihydrofolate were inactive under all conditions to all three organisms and 5-methyl-5,6-dihydrofolate was inactive unless ascorbate was present in the incubation medium, and then only to L. casei. 5-Methyltetrahydrofolate was active only for L (...) folates in the serum. The findings of this study suggest that the availability for biological utilisation of the major dietary folate compounds will depend on the amount of gastric acidity and of ascorbate in the intestinal chyme. Many may be unavailable for metabolic utilization in the body.

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1977 Journal of Clinical Pathology

209. Continuous-flow automation of the Lactobacillus casei serum folate assay. (PubMed)

Continuous-flow automation of the Lactobacillus casei serum folate assay. A method is described for the continuous-flow automation of the serum folate assay using Lactobacillus casei. The total incubation period is approximately four hours. The growth response of the organism to folate is estimated by measuring the rate of reduction of 2,3,5-triphenyl tetrazolium chloride (TTC). A simple continuous culture apparatus is used to grow the inoculum. Supplementation of the assay medium is necessary (...) to obtain parallel results. A statistical assessment shows a favourable comparison with the whole-serum tube assay using a chloramphenicol resistant strain of L. casei. The method is less sensitive to inhibitory substances than the tube assay.

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1977 Journal of Clinical Pathology

210. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. (PubMed)

Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 604364 1978 04 17 2018 11 13 0021-9746 30 12 1977 Dec Journal of clinical pathology J. Clin. Pathol. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 1175-8 O'Donnell J E JE Tennant G B GB Jones B M BM eng Comparative Study Journal Article England J Clin Pathol 0376601 0021-9746 0

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1977 Journal of Clinical Pathology

211. Measurement of serum folate: experience with 75Se-selenofolate radioassay. (PubMed)

Measurement of serum folate: experience with 75Se-selenofolate radioassay. Three hundred and eighty-two serum samples were assayed for folate content by a standard Lactobacillus casei microbiological assay and by radioassay using the 75Se-selenofolate radioassay kit from the Radiochemical Centre, Amersham. Results showed encouraging concordance. Explanations were discovered for the few disparities. The radioassay procedure is simple and an assay batch can be completed in one working day.

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1977 Journal of Clinical Pathology

212. Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. (PubMed)

Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. Contamination of folic acid assay medium with oleate led to a lag phase when Lactobacillus casei cultures were grown on folic acid but not when whole serum provided the folate source. This led to high assay values when using 20-hour incubation periods but satisfactory results were obtained after 48 hours' incubation. The addition of Tween 80 to the medium eliminated the lag phase and the assay results were

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1978 Journal of Clinical Pathology

213. Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. (PubMed)

Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. Oral methionine supplements (8.0 g daily for 4 days) were given to five normal volunteers who continued to eat their usual diet. This treatment resulted in a significant fall in serum folate concentration. Three days after the end of treatment concentrations had not completely returned to control values. The fall in concentration was prevented by giving oral folic acid supplements

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1978 Postgraduate medical journal

214. STUDIES ON THE IDENTIFICATION OF A FOLATE COMPOUND OF HUMAN SERUM (PubMed)

STUDIES ON THE IDENTIFICATION OF A FOLATE COMPOUND OF HUMAN SERUM 13906633 1998 11 01 2018 12 01 0021-9738 41 1962 May The Journal of clinical investigation J. Clin. Invest. Studies on the identification of a folate compound of human serum. 1134-8 HERBERT V V LARRABEE A R AR BUCHANAN J M JM eng Journal Article United States J Clin Invest 7802877 0021-9738 935E97BOY8 Folic Acid OM Folic Acid blood Humans FOLIC ACID/blood 1962 5 1 1962 5 1 0 1 1962 5 1 0 0 ppublish 13906633 10.1172/JCI104565

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1962 Journal of Clinical Investigation

215. Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels (PubMed)

Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels It has been shown that the incidence of megaloblastic anaemia in a group of 463 randomly selected pregnant women receiving iron was 12 times as high as in a control group of 235 pregnant women receiving iron and folic acid. The incidence of all types of anaemia in the women receiving iron alone was more than three times the incidence in those having iron (...) and folic acid. Some women who were not anaemic or who had normoblastic anaemia had serum folate levels in the same range as the women with megaloblastic anaemia, but none of the women with megaloblastic anaemia had high serum folate levels. The labile fraction of the serum folate was no more reliable than the total serum folate as a diagnostic criterion of megaloblastic erythropoiesis in the individual case. The blood group distribution in the women with megaloblastic anaemia was the same

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1970 Journal of Clinical Pathology

216. Automation of the assay of folate in serum and whole blood (PubMed)

Automation of the assay of folate in serum and whole blood An automated system is described for the microbiological assay of serum and red cell folate concentrations using a chloramphenicol-resistant strain of L. casei. Both serum and whole-blood haemolysates are assayed directly without previous deproteinization. Results by this method are comparable to those obtained by standard manual folate assays. Reproducibility within and between assays is excellent. Special advantages of the method

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1970 Journal of Clinical Pathology

217. Vitamin B 12, serum folate, and hypochromic anaemia. (PubMed)

Vitamin B 12, serum folate, and hypochromic anaemia. 5766144 1969 04 09 2018 11 13 0007-1447 1 5644 1969 Mar 08 British medical journal Br Med J Vitamin B 12, serum folate, and hypochromic anaemia. 643 Johnson P H PH Forrest-Hay I I Giles C C eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Anemia, Hypochromic blood Biological Assay Female Folic Acid blood Humans Male Neutrophils Vitamin B 12 blood 1969 3 8 1969 3 8 0 1 1969 3 8 0 0

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1969 British medical journal

218. Normal serum folate. (PubMed)

Normal serum folate. 5649016 1968 07 04 2013 11 21 0007-1447 2 5602 1968 May 18 British medical journal Br Med J Normal serum folate. 430 Mavor W O WO Spence M P MP eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid AIM IM Folic Acid blood Humans 1968 5 18 1968 5 18 0 1 1968 5 18 0 0 ppublish 5649016 PMC1986018

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1968 British medical journal

219. Serum folate and FIGLU excretion in patients with trophoblastic tumours. (PubMed)

Serum folate and FIGLU excretion in patients with trophoblastic tumours. 4296101 1968 05 20 2018 11 13 0007-0920 22 1 1968 Mar British journal of cancer Br. J. Cancer Serum folate and FIGLU excretion in patients with trophoblastic tumours. 32-9 Hughes M M Bagshawe K D KD eng Journal Article England Br J Cancer 0370635 0007-0920 0 Chorionic Gonadotropin 0 Glutamates 4QD397987E Histidine 935E97BOY8 Folic Acid Q573I9DVLP Leucovorin YL5FZ2Y5U1 Methotrexate IM Adolescent Adult Chorionic Gonadotropin

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1968 British journal of cancer

220. Vitamin B12, Serum Folate, and Hypochromic Anaemia (PubMed)

Vitamin B12, Serum Folate, and Hypochromic Anaemia 5781482 1969 06 19 2018 11 13 0007-1447 2 5650 1969 Apr 19 British medical journal Br Med J Vitamin B12, serum folate, and hypochromic anemia. 187 Dawson D W DW Buckley A L AL eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Anemia, Hypochromic blood complications Folic Acid blood Folic Acid Deficiency complications Humans Vitamin B 12 blood Vitamin B 12 Deficiency complications 1969 4

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1969 British medical journal

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