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Serum Folate

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181. Folic acid clearances and basal serum folate levels in patients with thyroid disease Full Text available with Trip Pro

Folic acid clearances and basal serum folate levels in patients with thyroid disease The plasma clearance of intravenously administered folic acid was abnormally rapid in all of five patients studied with untreated hyperthyroidism; in three, the basal serum L. casei folate level was subnormal. Four of these patients and another patient were studied at various intervals after partial or complete correction of the hyperthyroid state. Partial correction resulted in a continued fast clearance (...) in one patient, a return to borderline-normal values in the second, and a normal clearance in the third. Complete euthyroidism was achieved in two patients; their clearance values had returned to borderline-normal at this time. In two patients studied after partial correction, the serum L. casei folate levels had become normal whereas the clearance values remained abnormally rapid. These findings suggest that hyperthyroidism in man is associated with depletion of folate stores and subclinical

1964 Journal of Clinical Pathology

182. Serum folate and FIGLU excretion in patients with trophoblastic tumours. Full Text available with Trip Pro

Serum folate and FIGLU excretion in patients with trophoblastic tumours. 4296101 1968 05 20 2018 11 13 0007-0920 22 1 1968 Mar British journal of cancer Br. J. Cancer Serum folate and FIGLU excretion in patients with trophoblastic tumours. 32-9 Hughes M M Bagshawe K D KD eng Journal Article England Br J Cancer 0370635 0007-0920 0 Chorionic Gonadotropin 0 Glutamates 4QD397987E Histidine 935E97BOY8 Folic Acid Q573I9DVLP Leucovorin YL5FZ2Y5U1 Methotrexate IM Adolescent Adult Chorionic Gonadotropin

1968 British journal of cancer

183. Normal serum folate. Full Text available with Trip Pro

Normal serum folate. 5649016 1968 07 04 2013 11 21 0007-1447 2 5602 1968 May 18 British medical journal Br Med J Normal serum folate. 430 Mavor W O WO Spence M P MP eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid AIM IM Folic Acid blood Humans 1968 5 18 1968 5 18 0 1 1968 5 18 0 0 ppublish 5649016 PMC1986018

1968 British medical journal

184. Serum folate values in 423 psychiatric patients. Full Text available with Trip Pro

Serum folate values in 423 psychiatric patients. 6065984 1968 02 13 2018 11 13 0007-1447 4 5578 1967 Dec 02 British medical journal Br Med J Serum folate values in 423 psychiatric patients. 512-6 Carney M W MW eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Adolescent Adult Age Factors Aged Biological Assay Child Female Folic Acid blood Humans Male Mental Disorders blood drug therapy Middle Aged Sex Factors Vitamin B 12 blood 1967 12 2

1967 British medical journal

185. Vitamin B 12, serum folate, and hypochromic anaemia. Full Text available with Trip Pro

Vitamin B 12, serum folate, and hypochromic anaemia. 5766144 1969 04 09 2018 11 13 0007-1447 1 5644 1969 Mar 08 British medical journal Br Med J Vitamin B 12, serum folate, and hypochromic anaemia. 643 Johnson P H PH Forrest-Hay I I Giles C C eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Anemia, Hypochromic blood Biological Assay Female Folic Acid blood Humans Male Neutrophils Vitamin B 12 blood 1969 3 8 1969 3 8 0 1 1969 3 8 0 0

1969 British medical journal

186. Serum Folate and Vitamine B12 Levels in Acute and Chronic Renal Disease. Effect of Peritoneal Dialysis Full Text available with Trip Pro

Serum Folate and Vitamine B12 Levels in Acute and Chronic Renal Disease. Effect of Peritoneal Dialysis Serum folate and vitamin B(12) levels have been measured in 32 patients with renal failure. The initial mean serum folate level was raised above normal in seven patients with acute renal failure whereas the mean level in eight patients severely ill from chronic renal failure was significantly lower than normal. Serum folate levels fell during peritoneal dialysis and rose between dialyses (...) in all these patients and also in one patient who was dialysed for acute pancreatitis.The mean serum B(12) level was raised in patients with both acute and chronic renal failure, but there was no consistent change in serum B(12) level during dialysis.Hypersegmented polymorphs were present in the peripheral blood film of most of the patients with acute or chronic renal failure. Their presence bore no relation to the clinical state, blood urea, serum folate, or serum B(12) level of the patients.

1969 British medical journal

187. Automation of the assay of folate in serum and whole blood Full Text available with Trip Pro

Automation of the assay of folate in serum and whole blood An automated system is described for the microbiological assay of serum and red cell folate concentrations using a chloramphenicol-resistant strain of L. casei. Both serum and whole-blood haemolysates are assayed directly without previous deproteinization. Results by this method are comparable to those obtained by standard manual folate assays. Reproducibility within and between assays is excellent. Special advantages of the method

1970 Journal of Clinical Pathology

188. Serum and Urinary Folate in Liver Disease Full Text available with Trip Pro

Serum and Urinary Folate in Liver Disease During the active phase of viral hepatitis urinary folate loss was found to be 8.0 to 48.3 (mean 31.1) mug./day, compared with a normal urinary folate excretion of 0.1 to 18.0 (mean 9.5) mug./day. In cirrhosis and cardiac failure with congestive hepatomegaly the corresponding values were 25.8 to 55.0 (mean 35.7) mug./day and 2.5 to 61.6 (mean 26.9) mug./day, respectively. Urinary folate loss may be a significant factor in the aetiology of folate (...) deficiency of chronic liver disease, particularly when dietary intake is poor.After prolonged dialysis in Visking casing urinary folate was almost totally dialysable, but an appreciable fraction of serum folate was not, even after 72 hours. The dialysable (free) folate fraction of serum and urine disappeared maximally during the first six hours' dialysis, and was virtually cleared after 24 hours' dialysis; clearance curves in normal individuals and in liver disease were comparable. The non-dialysable

1969 British medical journal

189. Vitamin B12, Serum Folate, and Hypochromic Anaemia Full Text available with Trip Pro

Vitamin B12, Serum Folate, and Hypochromic Anaemia 5781482 1969 06 19 2018 11 13 0007-1447 2 5650 1969 Apr 19 British medical journal Br Med J Vitamin B12, serum folate, and hypochromic anemia. 187 Dawson D W DW Buckley A L AL eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Anemia, Hypochromic blood complications Folic Acid blood Folic Acid Deficiency complications Humans Vitamin B 12 blood Vitamin B 12 Deficiency complications 1969 4

1969 British medical journal

190. Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels Full Text available with Trip Pro

Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels It has been shown that the incidence of megaloblastic anaemia in a group of 463 randomly selected pregnant women receiving iron was 12 times as high as in a control group of 235 pregnant women receiving iron and folic acid. The incidence of all types of anaemia in the women receiving iron alone was more than three times the incidence in those having iron (...) and folic acid. Some women who were not anaemic or who had normoblastic anaemia had serum folate levels in the same range as the women with megaloblastic anaemia, but none of the women with megaloblastic anaemia had high serum folate levels. The labile fraction of the serum folate was no more reliable than the total serum folate as a diagnostic criterion of megaloblastic erythropoiesis in the individual case. The blood group distribution in the women with megaloblastic anaemia was the same

1970 Journal of Clinical Pathology

191. Hepatic and serum folates in patients fasting and after oral folic acid Full Text available with Trip Pro

Hepatic and serum folates in patients fasting and after oral folic acid The hepatic folate in non-anaemic hospital patients was found to correlate poorly with the fasting serum folate. The rise in methylfolate in the systemic circulation following the absorption of folic acid was directly related to the folate content of the liver.

1971 Journal of Clinical Pathology

192. Acute effect of phenytoin on serum folate concentration. Full Text available with Trip Pro

Acute effect of phenytoin on serum folate concentration. 5572309 1971 06 19 2018 11 13 0007-1188 41 2 1971 Feb British journal of pharmacology Br. J. Pharmacol. Acute effect of phenytoin on serum folate concentration. 414P-415P Richens A A Waters A H AH eng Journal Article England Br J Pharmacol 7502536 0007-1188 6158TKW0C5 Phenytoin 935E97BOY8 Folic Acid IM Folic Acid blood Humans Phenytoin blood pharmacology Time Factors 1971 2 1 1971 2 1 0 1 1971 2 1 0 0 ppublish 5572309 PMC1703288 Lancet

1971 British journal of pharmacology

193. Diagnostic value of the serum folate assay Full Text available with Trip Pro

Diagnostic value of the serum folate assay The diagnostic value of the serum folate assay has been assessed in 90 patients, each of whom had a macrocytic anaemia and a low serum vitamin B(12) level. Twenty-nine (32%) patients were found to have anaemia due primarily to folate deficiency. The cause of the low serum vitamin B(12) levels is uncertain in the 22 (25%) patients with normal or borderline vitamin B(12) absorption. The effect of folic acid therapy was studied in four of these patients (...) , and in each case the serum vitamin B(12) rose slowly to a normal level. The serum folate was low in only four (7.5%) of the 54 patients with pernicious anaemia, and the levels rose to normal on treatment with vitamin B(12) alone. A high serum folate occurred in eight (15%) pernicious anaemia patients. A normal serum folate indicated the diagnosis of pernicious anaemia or megaloblastic anaemia following partial gastrectomy. However, a normal serum folate and a very low vitamin B(12) level was found in two

1971 Journal of Clinical Pathology

194. Purification of folate binding factor in normal umbilical cord serum. Full Text available with Trip Pro

Purification of folate binding factor in normal umbilical cord serum. Human umbilical cord serum was found to contain both free folate and folate complexed to a high-molecular weight factor. The complexed folate was bound to a very high affinity binder and was present in concentrations equivalent to as much as 60 ng of 5-methyltetrahydrofolic acid per ml of serum. Acidification of the serum caused disassociation of the folate-binder complex. Released folates were separated from binder (...) ]pteroylglutamic acid and nonradioactive folate derivatives. Oxidized folates were bound in preference to reduced derivatives, but only three to four times more unlabeled 5-methyltetrahydrofolic acid than pteroylglutamic acid was required to produce an equal level of competition. The strong affinity for 5-methyltetrahydrofolic acid, the main serum folate, suggests that the binder could be part of the mechanism by which the fetus concentrates maternally supplied folate for its growth and development.

1975 Proceedings of the National Academy of Sciences of the United States of America

195. Serum folates in man. Full Text available with Trip Pro

Serum folates in man. In an aseptic microbiological assay of folate compounds and their breakdown compounds, using Lactobacillus casei, Streptococcus faecalis, and Pediococcus cerevisiae, 4a-hydroxy-5methyl-4,5,6,7-tetrahydrofolate and 5-methyl-5,8-dihydrofolate were inactive under all conditions to all three organisms and 5-methyl-5,6-dihydrofolate was inactive unless ascorbate was present in the incubation medium, and then only to L. casei. 5-Methyltetrahydrofolate was active only for L (...) folates in the serum. The findings of this study suggest that the availability for biological utilisation of the major dietary folate compounds will depend on the amount of gastric acidity and of ascorbate in the intestinal chyme. Many may be unavailable for metabolic utilization in the body.

1977 Journal of Clinical Pathology

196. Measurement of serum folate: experience with 75Se-selenofolate radioassay. Full Text available with Trip Pro

Measurement of serum folate: experience with 75Se-selenofolate radioassay. Three hundred and eighty-two serum samples were assayed for folate content by a standard Lactobacillus casei microbiological assay and by radioassay using the 75Se-selenofolate radioassay kit from the Radiochemical Centre, Amersham. Results showed encouraging concordance. Explanations were discovered for the few disparities. The radioassay procedure is simple and an assay batch can be completed in one working day.

1977 Journal of Clinical Pathology

197. Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. Full Text available with Trip Pro

Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. Contamination of folic acid assay medium with oleate led to a lag phase when Lactobacillus casei cultures were grown on folic acid but not when whole serum provided the folate source. This led to high assay values when using 20-hour incubation periods but satisfactory results were obtained after 48 hours' incubation. The addition of Tween 80 to the medium eliminated the lag phase and the assay results were

1978 Journal of Clinical Pathology

198. Continuous-flow automation of the Lactobacillus casei serum folate assay. Full Text available with Trip Pro

Continuous-flow automation of the Lactobacillus casei serum folate assay. A method is described for the continuous-flow automation of the serum folate assay using Lactobacillus casei. The total incubation period is approximately four hours. The growth response of the organism to folate is estimated by measuring the rate of reduction of 2,3,5-triphenyl tetrazolium chloride (TTC). A simple continuous culture apparatus is used to grow the inoculum. Supplementation of the assay medium is necessary (...) to obtain parallel results. A statistical assessment shows a favourable comparison with the whole-serum tube assay using a chloramphenicol resistant strain of L. casei. The method is less sensitive to inhibitory substances than the tube assay.

1977 Journal of Clinical Pathology

199. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. Full Text available with Trip Pro

Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 604364 1978 04 17 2018 11 13 0021-9746 30 12 1977 Dec Journal of clinical pathology J. Clin. Pathol. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 1175-8 O'Donnell J E JE Tennant G B GB Jones B M BM eng Comparative Study Journal Article England J Clin Pathol 0376601 0021-9746 0

1977 Journal of Clinical Pathology

200. Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. Full Text available with Trip Pro

Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. Oral methionine supplements (8.0 g daily for 4 days) were given to five normal volunteers who continued to eat their usual diet. This treatment resulted in a significant fall in serum folate concentration. Three days after the end of treatment concentrations had not completely returned to control values. The fall in concentration was prevented by giving oral folic acid supplements

1978 Postgraduate medical journal

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