How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,435 results for

Serum Folate

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children

/treatment Anesthetic Toxicity Drug: Propofol Drug: Sevoflurane Detailed Description: Retrospective study: Study the medical history of infants and young children (less than 3 years old) who underwent sevoflurane or propofol general anesthesia for more than 3 hours from January 2018 to December 2018, and compare the preoperative and postoperative serum folate changes for retrospective analysis. Prospective study:Ten infants and young children (less than 3 years old) who underwent general anesthesia from (...) November 7, 2018 to December 31, 2018 in Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Inhalation of 1-8% concentration of sevoflurane for general anesthesia induced intubation, followed by sevoflurane 2.0 ~ 2.5 Vol% inhalation maintenance, according to the intraoperative situation to add opioids. Patients maintained a bispectral index (BIS) monitoring between 50 and 60. After induction of general anesthesia in all patients, Serum folate levels were

2018 Clinical Trials

182. Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study. (PubMed)

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study. Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP), and global DNA methylation levels of peripheral blood leukocytes.The subjects were 384 healthy Japanese women enrolled (...) as the control group of a case-control study for breast cancer conducted from 2001 to 2005. Global DNA methylation was quantified by Luminometric Methylation Assay (LUMA).With adjustment for lifestyle-related factors, including folate intake, the global DNA methylation level of peripheral blood leukocytes was significantly but weakly increased by 0.43% per quartile category for CRP (P for trend = 0.010). Estimated methylation levels stratified by CRP quartile were 70.0%, 70.8%, 71.4%, and 71.3%, respectively

Full Text available with Trip Pro

2018 BMC Cancer

183. Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005–2006 (PubMed)

. In females, folate concentrations (p for trend = 0.03) and vitamin B12 concentrations (p for trend = 0.02) were correlated with depression. In males, no significant association was found between depression and serum vitamin concentrations. The correlation of vitamins with depression deserves further investigation in larger and diverse populations, especially in females. (...) Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005–2006 Depression is one of the leading causes of disability around the world. Although several studies have been conducted to analyze the association between vitamins and depression, the results have been inconsistent. Based on the database of National Health and Nutrition Examination Survey (NHANES) (2005⁻2006), a cross-sectional analysis

Full Text available with Trip Pro

2018 International journal of environmental research and public health

184. Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients. (PubMed)

with each increment of TMAO level (per natural log [TMAO] increment: odds ratio, 1.22; 95% CI, 1.02-1.46). Consistently, compared with participants in the lowest tertile (<1.79 μmol/L) of serum TMAO levels, a significantly higher risk of first stroke was found in those in higher TMAO tertiles (≥1.79 μmol/L; odds ratio, 1.34; 95% CI, 1.00-1.81) or in TMAO tertile 3 (≥3.19 μmol/L; odds ratio, 1.43; 95% CI, 1.02-2.01). In the exploratory analysis, we observed an interaction between TMAO and folate levels (...) Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients. Background and Purpose- Trimethylamine N-oxide (TMAO)-a gut derived metabolite-has been shown to be atherogenic. It remains unknown whether TMAO is associated with the risk of first stroke. We aimed to determine the association between serum TMAO levels and first stroke in hypertensive patients without major cardiovascular diseases and examine any possible effect modifiers. Methods

Full Text available with Trip Pro

2018 Stroke

185. Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells (PubMed)

Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells The purpose of this study was to develop a method for targeted delivery of 10-hydroxycamptothecin (HCPT)-loaded nanoparticles (NPs) to cancer cells.We first used a supercritical antisolvent process to prepare micronized HCPT (nHCPT), and then folate-conjugated human serum albumin (HSA) nHCPT-loaded NPs (FA-HSA-nHCPT-NPs) were prepared using (...) a NP-coated method combined with a desolvation technique. The amount of folate conjugation was 16 μg · mg(-1) HSA.The particle size of the spherical nHCPT microparticles obtained was 118.5 ± 6.6 nm. The particle size and zeta potential of the FA-HSA-nHCPT-NPs were 233.9 ± 1.2 nm and -25.23 ± 2.98 mV, respectively. The FA-HSA-nHCPT-NPs exhibited a smooth surface and a distinct spherical shape, and the results of differential scanning calorimetry and X-ray diffraction indicated that the FA-HSA-nHCPT

Full Text available with Trip Pro

2011 International journal of nanomedicine

186. Determination of the minimal essential serum folate concentration for reduced risk of colorectal adenoma. (PubMed)

Determination of the minimal essential serum folate concentration for reduced risk of colorectal adenoma. There are no data regarding basal folate levels in patients without colorectal adenoma. This study aimed to determine the minimum serum folate concentration that associates with reduced risk of colorectal adenoma.1510 consecutive patients underwent total colonoscopy for suspected colorectal lesions after barium enema examination. Prior to colonoscopy, history of alcohol consumption (...) was noted and blood serum analyzed for folate and vitamin B12 levels. Polypoid lesions were evaluated histologically. We excluded patients with anemia, history of colonoscopy, overconsumption of alcohol, or malignancies. In all, 458/1510 patients (male/female; 258/200, 40-75 years) were determined eligible. Variables were compared between patients with adenoma and those without adenoma.Serum folate concentration was the variable with the most significant statistical variation between males with adenoma

2011 Clinical nutrition (Edinburgh, Scotland)

187. Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. (PubMed)

Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. We previously reported that elevated antiinflammatory cervical cytokines in early pregnancy were associated with spontaneous preterm birth. Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu.Pregnant women (n = 417) at <16 weeks' gestation had serum samples that were analyzed for folate species 5-methyltetrahydrofolate, 5 (...) with elevated antiinflammatory scores (both P < .05). Maternal folate was not associated with proinflammatory scores.Maternal serum folate vitamers are associated with cervical cytokine concentrations, which suggests a possible mechanistic link between folate and preterm birth risk.Copyright © 2011 Mosby, Inc. All rights reserved.

Full Text available with Trip Pro

2011 American Journal of Obstetrics and Gynecology

188. Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. (PubMed)

Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. Current methods for measuring folates in clinical laboratories are competitive folate binding protein assays. These assays show a considerable lack of agreement that has implications for the comparability of data across studies as well as for long-term population studies. The development of isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS (...) ) reference methods permitted the evaluation of method accuracy and consistency over time.We measured 3 pools of human serum by ID-LC-MS/MS, calculated values for total folate, and distributed the same pools to participants in a national External Quality Assessment scheme. We used linear regression to compare the all-laboratory and method data with reference method values. The exercise was repeated after 18 months to assess the stability of the all-laboratory and method data.The distributed serum pools

Full Text available with Trip Pro

2011 Clinical Chemistry

189. Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. (PubMed)

Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. High folate intake has been suggested as an important factor in cancer prevention; however, previous studies on the relation among folate intake, serum folate, and plasma homocysteine (hcy) are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6 and B (...) ) and GRS ≤ 3. The CIN2+ risk of lower serum vitamin B-6 and GRS ≥ 4 was 2.14 (0.92, 5.02) (P-trend = 0.05) and lower serum folate (below the median) and GRS ≥ 4 was 0.49 (0.20, 1.17) (P-trend = 0.05) after adjustment for confounding variables and human papillomavirus infection. Our data suggest that polymorphisms in genes related to folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia.

Full Text available with Trip Pro

2013 Journal of Nutrition

190. Purification of folate binding factor in normal umbilical cord serum. (PubMed)

Purification of folate binding factor in normal umbilical cord serum. Human umbilical cord serum was found to contain both free folate and folate complexed to a high-molecular weight factor. The complexed folate was bound to a very high affinity binder and was present in concentrations equivalent to as much as 60 ng of 5-methyltetrahydrofolic acid per ml of serum. Acidification of the serum caused disassociation of the folate-binder complex. Released folates were separated from binder (...) ]pteroylglutamic acid and nonradioactive folate derivatives. Oxidized folates were bound in preference to reduced derivatives, but only three to four times more unlabeled 5-methyltetrahydrofolic acid than pteroylglutamic acid was required to produce an equal level of competition. The strong affinity for 5-methyltetrahydrofolic acid, the main serum folate, suggests that the binder could be part of the mechanism by which the fetus concentrates maternally supplied folate for its growth and development.

Full Text available with Trip Pro

1975 Proceedings of the National Academy of Sciences of the United States of America

191. Serum folate values in 423 psychiatric patients. (PubMed)

Serum folate values in 423 psychiatric patients. 6065984 1968 02 13 2018 11 13 0007-1447 4 5578 1967 Dec 02 British medical journal Br Med J Serum folate values in 423 psychiatric patients. 512-6 Carney M W MW eng Journal Article England Br Med J 0372673 0007-1447 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Adolescent Adult Age Factors Aged Biological Assay Child Female Folic Acid blood Humans Male Mental Disorders blood drug therapy Middle Aged Sex Factors Vitamin B 12 blood 1967 12 2

Full Text available with Trip Pro

1967 British medical journal

192. Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases (PubMed)

Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases 5217755 1966 05 27 2018 11 13 0007-1447 1 5487 1966 Mar 05 British medical journal Br Med J Serum lactic dehydrogenase activity and folate deficiency in myelosclerosis and other haematological diseases. 577-81 Hoffbrand A V AV Kremenchuzky S S Butterworth P J PJ Mollin D L DL eng Journal Article England Br Med J 0372673 0007-1447 EC 1.1.1.27 L-Lactate Dehydrogenase AIM IM Anemia

Full Text available with Trip Pro

1966 British medical journal

193. Aseptic addition method for Lactobacillus casei assay of folate activity in human serum (PubMed)

Aseptic addition method for Lactobacillus casei assay of folate activity in human serum An ;aseptic addition' method is described for microbiological assay with Lactobacillis casei of folate activity in human serum. It has the following advantages over the previously reported ;standard' method. 1 The manipulations involved in the assay are halved, by deleting autoclaving of serum in buffers. 2 The use of 1 g.% ascorbate better preserves serum folates than the lower amounts of ascorbate which (...) are the maximum quantities usable in the standard methods. 3 Only 0.3 ml. of serum is required (0.1 ml. for one sample; 0.2 ml. for its duplicate).

Full Text available with Trip Pro

1966 Journal of Clinical Pathology

194. Serum folates in man. (PubMed)

Serum folates in man. In an aseptic microbiological assay of folate compounds and their breakdown compounds, using Lactobacillus casei, Streptococcus faecalis, and Pediococcus cerevisiae, 4a-hydroxy-5methyl-4,5,6,7-tetrahydrofolate and 5-methyl-5,8-dihydrofolate were inactive under all conditions to all three organisms and 5-methyl-5,6-dihydrofolate was inactive unless ascorbate was present in the incubation medium, and then only to L. casei. 5-Methyltetrahydrofolate was active only for L (...) folates in the serum. The findings of this study suggest that the availability for biological utilisation of the major dietary folate compounds will depend on the amount of gastric acidity and of ascorbate in the intestinal chyme. Many may be unavailable for metabolic utilization in the body.

Full Text available with Trip Pro

1977 Journal of Clinical Pathology

195. Continuous-flow automation of the Lactobacillus casei serum folate assay. (PubMed)

Continuous-flow automation of the Lactobacillus casei serum folate assay. A method is described for the continuous-flow automation of the serum folate assay using Lactobacillus casei. The total incubation period is approximately four hours. The growth response of the organism to folate is estimated by measuring the rate of reduction of 2,3,5-triphenyl tetrazolium chloride (TTC). A simple continuous culture apparatus is used to grow the inoculum. Supplementation of the assay medium is necessary (...) to obtain parallel results. A statistical assessment shows a favourable comparison with the whole-serum tube assay using a chloramphenicol resistant strain of L. casei. The method is less sensitive to inhibitory substances than the tube assay.

Full Text available with Trip Pro

1977 Journal of Clinical Pathology

196. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. (PubMed)

Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 604364 1978 04 17 2018 11 13 0021-9746 30 12 1977 Dec Journal of clinical pathology J. Clin. Pathol. Estimation of serum folate by a radioassay and a continuous-flow method, compared with an established microbiological tume assay. 1175-8 O'Donnell J E JE Tennant G B GB Jones B M BM eng Comparative Study Journal Article England J Clin Pathol 0376601 0021-9746 0

Full Text available with Trip Pro

1977 Journal of Clinical Pathology

197. Measurement of serum folate: experience with 75Se-selenofolate radioassay. (PubMed)

Measurement of serum folate: experience with 75Se-selenofolate radioassay. Three hundred and eighty-two serum samples were assayed for folate content by a standard Lactobacillus casei microbiological assay and by radioassay using the 75Se-selenofolate radioassay kit from the Radiochemical Centre, Amersham. Results showed encouraging concordance. Explanations were discovered for the few disparities. The radioassay procedure is simple and an assay batch can be completed in one working day.

Full Text available with Trip Pro

1977 Journal of Clinical Pathology

198. Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. (PubMed)

Effect of Tween 80 on incubation period of Lactobacillus casei assay of serum folate. Contamination of folic acid assay medium with oleate led to a lag phase when Lactobacillus casei cultures were grown on folic acid but not when whole serum provided the folate source. This led to high assay values when using 20-hour incubation periods but satisfactory results were obtained after 48 hours' incubation. The addition of Tween 80 to the medium eliminated the lag phase and the assay results were

Full Text available with Trip Pro

1978 Journal of Clinical Pathology

199. Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. (PubMed)

Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. Oral methionine supplements (8.0 g daily for 4 days) were given to five normal volunteers who continued to eat their usual diet. This treatment resulted in a significant fall in serum folate concentration. Three days after the end of treatment concentrations had not completely returned to control values. The fall in concentration was prevented by giving oral folic acid supplements

Full Text available with Trip Pro

1978 Postgraduate medical journal

200. STUDIES ON THE IDENTIFICATION OF A FOLATE COMPOUND OF HUMAN SERUM (PubMed)

STUDIES ON THE IDENTIFICATION OF A FOLATE COMPOUND OF HUMAN SERUM 13906633 1998 11 01 2018 12 01 0021-9738 41 1962 May The Journal of clinical investigation J. Clin. Invest. Studies on the identification of a folate compound of human serum. 1134-8 HERBERT V V LARRABEE A R AR BUCHANAN J M JM eng Journal Article United States J Clin Invest 7802877 0021-9738 935E97BOY8 Folic Acid OM Folic Acid blood Humans FOLIC ACID/blood 1962 5 1 1962 5 1 0 1 1962 5 1 0 0 ppublish 13906633 10.1172/JCI104565

Full Text available with Trip Pro

1962 Journal of Clinical Investigation

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>