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Serum Folate

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181. Serum and red cell folates, and serum vitamin B12 in protein calorie malnutrition (Full text)

Serum and red cell folates, and serum vitamin B12 in protein calorie malnutrition 4634031 1973 07 09 2018 11 13 1468-2044 48 5 1973 May Archives of disease in childhood Arch. Dis. Child. Serum and red cell folates, and serum vitamin B 12 in protein calorie malnutrition. 366-9 Khalil M M Tanios A A Moghazy M M Aref M K MK Mahmoud S S el-Lozy M M eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Blood Proteins 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 IM Anemia, Macrocytic

1973 Archives of Disease in Childhood PubMed

182. Anaemia - B12 and folate deficiency

. Excessive urinary excretion. Liver disease. Diagnosis of anaemia caused by vitamin B12 or folate deficiency should be made through history, examination, and investigations, including taking a full blood count, blood film, and measuring serum concentrations of cobalamin and folate. If vitamin B12 deficiency is found, serum anti-intrinsic factor antibodies should be checked. If there are strong clinical features of B12 deficiency such as megaloblastic anaemia or subacute combined degeneration of the cord (...) , despite a normal serum vitamin B12 level, serum anti-intrinsic factor antibodies should also be checked. If folate levels are low, and the history suggests malabsorption, tests for anti-endomysial or anti-transglutaminase antibodies should be done (depending on the local laboratory) to exclude coeliac disease. Treatment of B12 deficiency in people with neurologic involvement should include: Seeking urgent specialist advice from a haematologist. If specialist advice is not immediately available

2014 NICE Clinical Knowledge Summaries

183. Associations of folate and folic acid supplementation with arsenic metabolism and arsenic-related health outcomes: a systematic review

Associations of folate and folic acid supplementation with arsenic metabolism and arsenic-related health outcomes: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) , timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year

2019 PROSPERO

184. Oxcarbazepine effect on serum levels of homocysteine, vitamin B12 and folate in patients with epilepsy

Oxcarbazepine effect on serum levels of homocysteine, vitamin B12 and folate in patients with epilepsy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2016 PROSPERO

185. Abdominal aortic aneurysm and the association with serum levels of Homocysteine, vitamins B6, B12 and Folate (Full text)

Abdominal aortic aneurysm and the association with serum levels of Homocysteine, vitamins B6, B12 and Folate Previous investigations have shown hyperhomocysteinemi in patients with abdominal aortic aneurysm (AAA). In the present study we evaluated the circulating level of homocysteine (Hcy) in relation to renal function, vitamins B6, B12 and folate status in AAA patients with special regard to aneurysm size, and rupture. Hcy, Creatinine, B6, B12 and folate were measured in 119 patients with AAA (...) and 36 controls without aneurysm matched by age, gender and smoking habit. As expected there was a weak correlation between Hcy and vitamins B6, B12 or folate. We found similar levels of Hcy, B6 and folic acid in patients with nonruptured AAA compared to the control group matched by age, gender and smoking habit. There was no correlation between maximum diameter of the nonruptured AAA (n=78) and Hcy, B6 or folate. However, the present study shows a significant inverse correlation between maximum

2012 American journal of cardiovascular disease PubMed

186. Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses? (PubMed)

Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses? To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese (...) adults.A total of 480 patients with mild or moderate essential hypertension were randomly assigned to three treatment groups: (a) enalapril only (10 mg, control group); (b) enalapril FA tablet [10 : 0.4 mg (10 mg of enalapril combined with 0.4 mg of FA), low-FA group]; (c) enalapril FA tablet (10 : 0.8 mg, high-FA group), once daily for 8 weeks. Individual serum folate levels were measured at baseline, and at 4 and 8 weeks posttreatment.After 4 or 8 weeks of treatment, increases in serum folate were

2012 Pharmacogenetics and genomics

187. Serum Folate and Cobalamin Levels in Women Using Combined Contraceptive Vaginal Ring (Full text)

Serum Folate and Cobalamin Levels in Women Using Combined Contraceptive Vaginal Ring Purpose: The aim of our study was to evaluate the effects of combined contraceptive vaginal rings on serum concentrations of folate and cobalamin in healthy users. Material and Methods: Case-control study on cobalamin and folate status of 45 healthy female nulligravidae using a combined contraceptive vaginal ring for > 3 months and 45 healthy controls. Factors interfering with vitamin metabolism were thoroughly (...) controlled. Results: Cobalamin and folate levels did not differ between the groups. Vegetarian diet, smoking or obesity did not have a significant influence. Conclusions: The use of a combined contraceptive vaginal ring provides an appropriate hormonal contraception in women with pre-existing cobalamin deficiency or restrictive diet habit in order to avoid interferences between vitamin B12 metabolism and exogenously applied estrogens.

2012 Geburtshilfe Und Frauenheilkunde PubMed

188. Serum Folate

Serum Folate Serum Folate Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Serum Folate Serum Folate Aka: Serum Folate , RBC Folate (...) From Related Chapters II. Interpretation: Normal Range: 2-10 ng/ml III. Interpretation: Decreased Poor intake or malabsorption Medications Trimethoprim ( ) s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Serum Folate." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine About FPnotebook.com is a rapid

2015 FP Notebook

189. [Effect of folate and related nutrients on cognitive function in older people; systematic review].

years 2010 and May 2011 and references of the selected articles looking specifically at serum and erythrocyte folate levels, and folate intake and cognitive function in older adults.Twelve cross-sectional studies, six cohort studies and six randomized double-blind clinical studies that met pre-established criteria were selected for analysis.This review doesn't support a benefit from folic acid supplementation on cognitive function in the elderly. Whereas low folate serum levels may be related (...) [Effect of folate and related nutrients on cognitive function in older people; systematic review]. Folate and other B complex vitamins play important roles in the synthesis of DNA, gene expression, homocysteine detoxification and synthesis of neurotransmitters necessary for the maintenance of cognitive function.Systematic literature review of benefit and/ risks of folate and related nutrients in cognitive function in older adults."Medline via Pubmed systematic review" of selected articles from

2013 Nutricion hospitalaria

190. The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia (Full text)

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia Increased plasma homocysteine may be associated with adverse pregnancy outcomes, such as preeclampsia. The aim of this study was to determine the plasma homocysteine, serum folate, and vitamin B12 levels in preeclamptic pregnant women.This case-control study was conducted in 2016 in Ahwaz on 51 pregnant women with preeclampsia and 51 healthy pregnant women of the same gestational age, who (...) demographic characteristics were found among the groups. Pregnant women complicated with preeclampsia displayed significantly higher serum homocysteine levels (p < 0.001) and lower serum folate (p = 0.005) and vitamin B12 levels (p < 0.001) compared to controls. A statistically significant inverse correlation was evident between serum homocysteine and serum folate levels in preeclamptic patients (p = 0.005; r = -0.389). In addition, an inverse correlation was identified between homocysteine and serum

2016 Electronic physician PubMed

191. One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans. (PubMed)

One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans. We aimed to study the effect of long-term supplementation of B-vitamins on folate forms in serum and whole blood (WB) in elderly German subjects.59 participants (mean age 67 years) were randomized to daily receive either vitamin D3 (1200 IU), folic acid (500 μg), vitamin B12 (500 μg), vitamin B6 (50 mg), and calcium carbonate (456 mg) or vitamin D3 plus calcium carbonate. Serum (...) and WB folate forms were measured before and after 6 and 12 months.B-vitamins supplementation for 6 months led to higher concentrations of 5-methyltetrahydrofolate (5-methylTHF) in serum (mean 49.1 vs. 19.6 nmol/L) and WB (1332 vs. 616 nmol/L). Also non-methyl-folate concentrations in serum and WB were higher after 6 months with B-vitamins supplementation. Unmetabolized folic acid (UFA) increased after supplementation. tHcy concentration was lowered after 1 year of B-vitamin supplementation (mean

2015 Clinical chemistry and laboratory medicine

192. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. (PubMed)

volunteers, aged 50-65, had normal serum folate and did not use supplements with B-vitamins for 6 months. Forty subjects were divided into two groups: receiving 400 μg/d FA or the equimolar amount of [6 S]-5-MTHF. Blood was collected at baseline and after 4 weeks. In both groups, a significant decrease in the mean Hcy level after intervention period was observed. Supplementation with [6 S]-5-MTHF was slightly less effective, but not significantly, in Hcy lowering than FA (p = .243 between the groups (...) Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Folic acid (FA) supplementation reduces the elevated serum homocysteine (Hcy) concentrations. [6 S]-5-methyltetrahydrofolate ([6 S]-5-MTHF) is an alternative to FA due to possible advantages, that is, no masking cobalamin deficiency. The study aim was to evaluate the effectiveness of [6 S]-5-MTHF in relations to FA supplementation in reducing the serum Hcy. Healthy

2018 International journal of food sciences and nutrition

193. The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children

/treatment Anesthetic Toxicity Drug: Propofol Drug: Sevoflurane Detailed Description: Retrospective study: Study the medical history of infants and young children (less than 3 years old) who underwent sevoflurane or propofol general anesthesia for more than 3 hours from January 2018 to December 2018, and compare the preoperative and postoperative serum folate changes for retrospective analysis. Prospective study:Ten infants and young children (less than 3 years old) who underwent general anesthesia from (...) November 7, 2018 to December 31, 2018 in Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Inhalation of 1-8% concentration of sevoflurane for general anesthesia induced intubation, followed by sevoflurane 2.0 ~ 2.5 Vol% inhalation maintenance, according to the intraoperative situation to add opioids. Patients maintained a bispectral index (BIS) monitoring between 50 and 60. After induction of general anesthesia in all patients, Serum folate levels were

2018 Clinical Trials

194. Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study. (Full text)

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study. Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP), and global DNA methylation levels of peripheral blood leukocytes.The subjects were 384 healthy Japanese women enrolled (...) as the control group of a case-control study for breast cancer conducted from 2001 to 2005. Global DNA methylation was quantified by Luminometric Methylation Assay (LUMA).With adjustment for lifestyle-related factors, including folate intake, the global DNA methylation level of peripheral blood leukocytes was significantly but weakly increased by 0.43% per quartile category for CRP (P for trend = 0.010). Estimated methylation levels stratified by CRP quartile were 70.0%, 70.8%, 71.4%, and 71.3%, respectively

2018 BMC Cancer PubMed

195. Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005–2006 (Full text)

. In females, folate concentrations (p for trend = 0.03) and vitamin B12 concentrations (p for trend = 0.02) were correlated with depression. In males, no significant association was found between depression and serum vitamin concentrations. The correlation of vitamins with depression deserves further investigation in larger and diverse populations, especially in females. (...) Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005–2006 Depression is one of the leading causes of disability around the world. Although several studies have been conducted to analyze the association between vitamins and depression, the results have been inconsistent. Based on the database of National Health and Nutrition Examination Survey (NHANES) (2005⁻2006), a cross-sectional analysis

2018 International journal of environmental research and public health PubMed

196. Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients. (Full text)

with each increment of TMAO level (per natural log [TMAO] increment: odds ratio, 1.22; 95% CI, 1.02-1.46). Consistently, compared with participants in the lowest tertile (<1.79 μmol/L) of serum TMAO levels, a significantly higher risk of first stroke was found in those in higher TMAO tertiles (≥1.79 μmol/L; odds ratio, 1.34; 95% CI, 1.00-1.81) or in TMAO tertile 3 (≥3.19 μmol/L; odds ratio, 1.43; 95% CI, 1.02-2.01). In the exploratory analysis, we observed an interaction between TMAO and folate levels (...) Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients. Background and Purpose- Trimethylamine N-oxide (TMAO)-a gut derived metabolite-has been shown to be atherogenic. It remains unknown whether TMAO is associated with the risk of first stroke. We aimed to determine the association between serum TMAO levels and first stroke in hypertensive patients without major cardiovascular diseases and examine any possible effect modifiers. Methods

2018 Stroke PubMed

197. Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells (Full text)

Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells The purpose of this study was to develop a method for targeted delivery of 10-hydroxycamptothecin (HCPT)-loaded nanoparticles (NPs) to cancer cells.We first used a supercritical antisolvent process to prepare micronized HCPT (nHCPT), and then folate-conjugated human serum albumin (HSA) nHCPT-loaded NPs (FA-HSA-nHCPT-NPs) were prepared using (...) a NP-coated method combined with a desolvation technique. The amount of folate conjugation was 16 μg · mg(-1) HSA.The particle size of the spherical nHCPT microparticles obtained was 118.5 ± 6.6 nm. The particle size and zeta potential of the FA-HSA-nHCPT-NPs were 233.9 ± 1.2 nm and -25.23 ± 2.98 mV, respectively. The FA-HSA-nHCPT-NPs exhibited a smooth surface and a distinct spherical shape, and the results of differential scanning calorimetry and X-ray diffraction indicated that the FA-HSA-nHCPT

2011 International journal of nanomedicine PubMed

198. Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. (Full text)

Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. We previously reported that elevated antiinflammatory cervical cytokines in early pregnancy were associated with spontaneous preterm birth. Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu.Pregnant women (n = 417) at <16 weeks' gestation had serum samples that were analyzed for folate species 5-methyltetrahydrofolate, 5 (...) with elevated antiinflammatory scores (both P < .05). Maternal folate was not associated with proinflammatory scores.Maternal serum folate vitamers are associated with cervical cytokine concentrations, which suggests a possible mechanistic link between folate and preterm birth risk.Copyright © 2011 Mosby, Inc. All rights reserved.

2011 American Journal of Obstetrics and Gynecology PubMed

199. Determination of the minimal essential serum folate concentration for reduced risk of colorectal adenoma. (PubMed)

Determination of the minimal essential serum folate concentration for reduced risk of colorectal adenoma. There are no data regarding basal folate levels in patients without colorectal adenoma. This study aimed to determine the minimum serum folate concentration that associates with reduced risk of colorectal adenoma.1510 consecutive patients underwent total colonoscopy for suspected colorectal lesions after barium enema examination. Prior to colonoscopy, history of alcohol consumption (...) was noted and blood serum analyzed for folate and vitamin B12 levels. Polypoid lesions were evaluated histologically. We excluded patients with anemia, history of colonoscopy, overconsumption of alcohol, or malignancies. In all, 458/1510 patients (male/female; 258/200, 40-75 years) were determined eligible. Variables were compared between patients with adenoma and those without adenoma.Serum folate concentration was the variable with the most significant statistical variation between males with adenoma

2011 Clinical nutrition (Edinburgh, Scotland)

200. Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. (Full text)

Isotope Dilution LC-MS/MS Reference Method Assessment of Serum Folate Assay Accuracy and Proficiency Testing Consensus Mean. Current methods for measuring folates in clinical laboratories are competitive folate binding protein assays. These assays show a considerable lack of agreement that has implications for the comparability of data across studies as well as for long-term population studies. The development of isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS (...) ) reference methods permitted the evaluation of method accuracy and consistency over time.We measured 3 pools of human serum by ID-LC-MS/MS, calculated values for total folate, and distributed the same pools to participants in a national External Quality Assessment scheme. We used linear regression to compare the all-laboratory and method data with reference method values. The exercise was repeated after 18 months to assess the stability of the all-laboratory and method data.The distributed serum pools

2011 Clinical Chemistry PubMed

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