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Serum Ferritin

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5841. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms Full Text available with Trip Pro

Ferrari F F Fermo I I Foglieni B B Levi S S Bozzini C C Camparini M M Ferrari M M Arosio P P eng GP0075Y01 Telethon Italy Case Reports Journal Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 0 Codon, Initiator 9007-73-2 Ferritins 9013-31-4 Apoferritins IM Apoferritins Base Sequence Cataract blood genetics pathology Chromatography, High Pressure Liquid methods Codon, Initiator genetics DNA Mutational Analysis Ferritins blood genetics Hematologic Diseases genetics (...) Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms 15173247 2004 09 27 2017 09 22 1468-6244 41 6 2004 Jun Journal of medical genetics J. Med. Genet. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms. e81 Cremonesi L L Genomics for the Diagnosis of Human Pathologies Unit, IRCCS H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy. Cozzi A A Girelli D D

2004 Journal of Medical Genetics

5842. Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? Full Text available with Trip Pro

eng Journal Article England BMJ 8900488 0959-8138 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Oct 6;323(7316):807-8 11669080 BMJ. 2001 Oct 6;323(7316):806-7; author reply 807-8 11669079 Anemia, Iron-Deficiency blood Animals Erythrocyte Count Female Ferritins blood Hemoglobins analysis Humans Male Menstruation blood Primates blood Reference Values Sex Characteristics 2001 6 2 10 0 2001 6 29 10 1 2001 6 2 10 0 ppublish 11387188 PMC1120434 Annu Rev Nutr. 1986;6:13-40 3524613 Lancet. 1996 Oct (...) Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 11387188 2001 06 28 2018 11 13 0959-8138 322 7298 2001 Jun 02 BMJ (Clinical research ed.) BMJ Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 1355-7 Rushton D H DH School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. rushton@btinternet.com Dover R R Sainsbury A W AW Norris M J MJ Gilkes J J JJ Ramsay I D ID

2001 BMJ : British Medical Journal

5843. Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Full Text available with Trip Pro

Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Placental ferritin is a tumour associated antigen present in the serum of patients with active Hodgkin's and non-Hodgkin's lymphoma, and the serum values fall during remission of the disease. There is no correlation between placental and total blood ferritin values. Because of the strong association between coeliac disease and lymphoma, 19 children with active and 25 (...) with inactive coeliac disease were screened for the presence of placental ferritin. Thirty two children with other intestinal disorders served as controls. Placental ferritin was identified by using a monoclonal antibody in an ELISA procedure. The mean (SEM) placental ferritin value in the control serum was 12.6 (2.4) while the values in serum of patients with active and inactive coeliac disease were 117 (22.8) and 43.8 (10.2) U/ml respectively. Patients with active coeliac disease differed significantly

1991 Gut

5844. Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it Full Text available with Trip Pro

Ferritins blood Hemoglobins analysis Humans Reference Values 2001 10 24 10 0 2001 11 3 10 1 2001 10 24 10 0 ppublish 11669079 PMC1121347 J Am Coll Nutr. 2001 Oct;20(5):477-84 11601562 N Z Med J. 2001 Mar 23;114(1128):134-8 11346162 BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Br J Haematol. 2001 Aug;114(2):474-84 11529872 Am J Clin Nutr. 1998 Feb;67(2):271-5 9459375 Annu Rev Nutr. 1986;6:13-40 3524613 Pediatr Res. 1993 Nov;34(5):680-7 8284110 JAMA. 1997 Mar 26;277(12):973-6 9091669 Am J Clin Nutr. 1997 Aug (...) Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it 11669079 2001 11 01 2018 11 13 0959-8138 323 7316 2001 Oct 06 BMJ (Clinical research ed.) BMJ Reference limits for haemoglobin and ferritin. If it's not broken, don't fix it. 806-7; author reply 807-8 Heath A L AL Fairweather-Tait S S Worwood M M eng Comment Letter England BMJ 8900488 0959-8138 0 Biomarkers 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Biomarkers analysis

2001 BMJ : British Medical Journal

5845. Zinc protoporphyrin/haem ratio and plasma ferritin in preterm infants Full Text available with Trip Pro

changes in plasma ferritin. Subjects with higher ZPP/H ratios tended to have lower ferritins, but changes in ZPP/H in a given subject were poorly reflected by changes in plasma ferritin. Between 6 and 9 months of age, ZPP/H correlated with other measures of iron status, but serum ferritin concentration did not.Use of the ZPP/H ratio as a measure of iron status during the first year of life appears to be confounded by the developmental changes in ZPP/H, but in the later half of this period it may (...) be a better measure of iron status than serum ferritin.

2002 Archives of disease in childhood Fetal and neonatal edition

5846. Synovial fluid ferritin in rheumatoid arthritis. Full Text available with Trip Pro

Synovial fluid ferritin in rheumatoid arthritis. 7427414 1981 01 29 2018 11 13 0007-1447 281 6242 1980 Sep 13 British medical journal Br Med J Synovial fluid ferritin in rheumatoid arthritis. 715-6 Blake D R DR Bacon P A PA Eastham E J EJ Brigham K K eng Journal Article England Br Med J 0372673 0007-1447 9007-73-2 Ferritins AIM IM Arthritis, Rheumatoid blood metabolism Ferritins metabolism Humans Osteoarthritis metabolism Synovial Fluid metabolism 1980 9 13 1980 9 13 0 1 1980 9 13 0 0 ppublish

1980 British medical journal

5847. Ferritin, finger clubbing, and lung disease. Full Text available with Trip Pro

Ferritin, finger clubbing, and lung disease. The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations (...) were similar to systemic venous concentrations. It is therefore unlikely that the tumour releases ferritin into the pulmonary circulation. Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis.

1981 Thorax

5848. The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. (Abstract)

The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. The usefulness of serum ferritin levels in assessing iron stores in pregnant women before and after supplementation with iron was studied. One hundred thirty-five healthy pregnant women between 22 to 28 wk were randomly allotted to daily dose regimes of 60, 120, or 240 mg of ferrous sulphate. The tablets were given after meals under strict personal supervision. Before supplementation, iron deficiency (...) (ferritin level less than 10 micrograms/L) was present in 54.8% of the pregnant women, compared to an incidence of 17.8% when assessed by serum iron concentration of less than 50 micrograms/dl. The mean ferritin level of pregnant women was 14.15 micrograms/L and was less than one-half that of healthy single women and one-sixth of that of healthy males. Supplementation with oral iron for 12 wk produced an increase in ferritin levels in all the groups, but significant increases were seen only in women

1982 The American journal of clinical nutrition Controlled trial quality: uncertain

5849. Calcium supplementation and plasma ferritin concentrations in premenopausal women. (Abstract)

intake (r = 0.21, P = 0.04), serum iron concentration (r = 0.19, P = 0.04), transferrin saturation (r = 0.31, P = 0.001), and hemoglobin concentration (r = 0.22, P = 0.02), and negatively correlated with total iron-binding capacity (TIBC, r = -0.42, P < 0.001). No significant differences in absolute or percent changes in plasma ferritin concentrations, serum iron concentrations, TIBC, transferrin saturation, hemoglobin concentrations, or hematocrit were observed between the treatment and control (...) Calcium supplementation and plasma ferritin concentrations in premenopausal women. The effect of calcium supplement use on iron stores was examined in a randomized controlled study in free-living, healthy, premenopausal women. Of 109 women who completed the study, 52 were in the control group and 57 took two tablets containing 250 mg Ca as the carbonate with each of two meals daily for 12 wk. In all subjects at baseline, plasma ferritin concentrations were positively correlated with heme-iron

1992 The American journal of clinical nutrition Controlled trial quality: uncertain

5850. [Ferritin level in newborn infants after prepartal iron medication]. (Abstract)

ferritin levels in the 30th week of pregnancy (p less than 0.048), higher levels measured in the cord blood at birth (p less than 0.001), and also the newborn of this group had statistically significant higher serum ferritin levels than the newborn of the control group (p less than 0.001). Our conclusion is that prepartal iron medication leads to increased iron stores in the newborn. (...) [Ferritin level in newborn infants after prepartal iron medication]. Aim of the study was to find out the influence of iron medication of pregnant women on the iron levels of their newborn. In a prospective randomised study the iron-substituted group (n = 57) was treated with 2 x 1 Aktiferrin comp. Kps. (Merckle) during pregnancy, starting from the 22nd week. The control group (n = 46) had no medication during pregnancy. The substituted group had statistically significantly higher serum

1991 Geburtshilfe und Frauenheilkunde Controlled trial quality: uncertain

5851. Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. (Abstract)

Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. Erythropoietin (rHuEPO) therapy has been shown to be beneficial in preventing and treating anaemia of prematurity and to decrease the need for blood transfusions. There is, however, only scanty data on the effect of rHuEPO therapy on iron metabolism. We studied 29 preterm infants (age 34 +/- 14 days) who were randomly assigned to receive either rHuEPO 900 U kg-1 week-1 with 6 mg kg (...) -1 day-1 of iron for 4 weeks (n = 15) or no therapy. The following parameters were evaluated and compared between and within groups at the beginning, during and at the end of the study: Haematocrit (SI), reticulocytes (10(9) micrograms l-1), serum ferritin (microgram 1-1) and iron (mumol l-1). The results were as follows. At the baseline, erythropoietin levels were similar in both groups: 7.2 +/- 5.6 versus 6.2 +/- 3.2 mU ml-1 (NS). In the treated infants the haematocrit remained stable during

1996 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

5852. Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Full Text available with Trip Pro

and 28 d and by red blood cell incorporation after 28 d.There was no significant difference in iron absorption between ferritin and ferrous sulfate: low-phosphate iron mineral ferritin (x +/- SD: 21.4 +/- 14.7%) compared with ferrous sulfate (21.9 +/- 14.6%), or high-phosphate iron mineral ferritin (22.2 +/- 19.2%) compared with ferrous sulfate (16.7 +/- 7.1%). Results obtained by using whole-body retention of iron and red blood cell incorporation differed with the type of iron, which suggests (...) Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Recent studies in humans suggest that ferritin iron in soybeans has high bioavailability. However, direct evidence for this is lacking because the soybeans were intrinsically labeled; thus, iron bound to other ligands, such as phytate, was also labeled.The objectives of the study were to evaluate the absorption of iron from extrinsically labeled, purified ferritin (horse spleen) reconstituted with either

2004 The American journal of clinical nutrition Controlled trial quality: uncertain

5853. Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). (Abstract)

chronic transfusion in a clinical trial of stroke prevention. A serum ferritin level of less than 500 ng/mL was required for study entry. Ferritin levels were obtained quarterly. Fifty patients who had four or more ferritin measurements were included in this analysis. Transfusions were administered as exchange or simple, with washed, reconstituted, or packed red blood cells, at the discretion of the site investigator.Serum ferritin levels increased linearly with cumulative transfusion volume during (...) Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). Chronic red cell transfusion has been used for prevention of recurrent stroke in patients with sickle cell disease for three decades, and its effectiveness in primary prevention was recently shown. Iron overload, the inevitable result of chronic transfusion, is commonly monitored with serum ferritin concentration.Sixty-one patients at high risk for stroke received

2002 Journal of pediatric hematology/oncology Controlled trial quality: uncertain

5854. Targeting higher ferritin concentrations with intravenous iron dextran lowers erythropoietin requirement in hemodialysis patients. (Abstract)

factors including functional iron deficiency. Since the optimal prescription for iron replacement is not yet known, we evaluated the effect of intravenous iron dextran (IVFe) infusion on serum ferritin (SFer) concentration and rHuEPO dose. Our objective was to raise and maintain serum ferritin concentrations to 2 different levels above the National Kidney Foundation Dialysis Outcome Quality Initiative standard of 100 ng/ml to determine whether, and by what degree rHuEPO dose could be lowered.HD (...) ng/ml. The mean decrease in rHuEPO dose for Group 1 was 31 U/kg body weight/week (250 - 219 U/kg bw/wk) while in Group 2 it was 154 U/kg body weight/week (312 - 158 U/kg bw/wk) (p < 0.001). There was no difference in HCT between groups. Our results suggest that higher target serum ferritin concentrations can be well tolerated and lower rHuEPO requirements.

2003 Clinical nephrology Controlled trial quality: uncertain

5855. Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. (Abstract)

Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. We have shown previously that melanoma cells in culture release heavy-chain ferritin (H-Ferritin) into supernatants and that this is responsible for the suppression of responses of peripheral blood lymphocytes stimulated by anti-CD3. These effects were mediated by activation of regulatory T cells to produce interleukin (IL)-10. In the present study, we examined (...) whether a similar relation might exist between levels of H-Ferritin and activation of regulatory T cells in patients with melanoma. Ferritin levels were evaluated by ELISA and regulatory T-cell numbers were assessed by three-color flow cytometry to identify CD4(+) CD25(+) CD69(-) T cells. CD69 positive cells were excluded to avoid inclusion of normal activated CD4, CD25 expressing T cells. Measurements of H- and light-chain (L)-Ferritin by ELISA revealed that H- but not L-Ferritin was elevated

2003 Clinical Cancer Research

5856. Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Full Text available with Trip Pro

Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Placenta immunomodulatory ferritin (PLIF) cDNA was recently cloned from the human placenta, where it is expressed in syncytiotrophoblast and decidual mononuclear cells. PLIF and its subcloned bioactive domain (C48), expressed in Escherichia coli, are immunosuppressive proteins and induce pronounced IL-10 production in vitro and in vivo.PLIF (...) serum level, measured by enzyme-linked immunosorbent assay, was elevated in pregnant mice throughout gestation and declined towards delivery. Blocking of PLIF activity by vaccination of mice with C48 prior to mating inhibited pregnancy development. Passive transfer of anti-C48 immunoglobulin (Ig) starting at 3.5-12.5 days post coitum (dpc) resulted in high rate of embryo resorption. Furthermore, treatment with anti-C48 Ig resulted in placental and embryonal growth restriction. At gestation day 13.5

2004 Human Reproduction

5857. Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection. (Abstract)

Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection. A high prevalence of diabetes has been reported in patients with hepatitis C virus (HCV) infection. Both diabetes and HCV infection are associated with high serum ferritin levels. Although HCV infection could be the main factor responsible for the high ferritin levels, it is also possible that diabetes rather than HCV infection might be a major contributor to the high ferritin (...) to those of group D. In multivariate analyses, diabetes but not HCV infection was independently related to serum ferritin concentrations.Diabetes rather than HCV infection itself is the main factor associated with the increased ferritin levels detected in patients with HCV infection. Therefore, the presence of diabetes should be taken into account when iron metabolism is evaluated in HCV-infected patients.

2004 Diabetes Care

5858. A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity?

storage status. Children ages 2-18 years should be monitored every 2-3 years with an iron profile if they have a diagnosed blood relative with hereditary hemochromatosis/iron overload….” [4] A search in the Medline databases found no information on the sensitivity and specificity of serum ferritin and iron binding capacity tests in children and adolescents for hereditary haemochromatosis. References 1. British Society for Haematology. Genetic haemochromatosis. February 2000. ( ) 2. Sfeir H (...) A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity? A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere

2007 TRIP Answers

5859. The impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Rationale and design of a randomised controlled trial: a study protocol. Full Text available with Trip Pro

benefit from iron supplementation. Our objective is to determine the clinical effect of iron supplementation on fatigue in female blood donors without anaemia, but with a mean serum ferritin < or = 30 ng/ml.In a double blind randomised controlled trial, we will measure blood count and ferritin level of women under age 50 yr, who donate blood to the University Hospital of Lausanne Blood Transfusion Department, at the time of the donation and after 1 week. One hundred and forty donors with a ferritin (...) The impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Rationale and design of a randomised controlled trial: a study protocol. There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females. Furthermore, some clinical trials have shown that non-anaemic women with unexplained fatigue may

2009 Trials Controlled trial quality: predicted high

5860. Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding

Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding capacity?. - Trip Database or use your Google+ account Find evidence fast ALL of these words (...) @tripdatabase.com Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding capacity?. There is a consensus that serum ferritin should be used to confirm a diagnosis of iron deficiency anaemia (IDA) in patients without concomitant disease. However, we found little information on when it is preferable to do a serum iron and total iron binding capacity (TIBC) over a serum

2007 TRIP Answers

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